B30.2/SPRY domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1D4_LEIMA

TriTrypDb:

LmjF.36.2850 , LMJLV39_360037600 , LMJSD75_360037500

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1D4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.743
CLV_PCSK_KEX2_1	175	177	PF00082	0.364
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.394
CLV_PCSK_SKI1_1	120	124	PF00082	0.487
CLV_PCSK_SKI1_1	40	44	PF00082	0.510
CLV_PCSK_SKI1_1	85	89	PF00082	0.491
DEG_Nend_Nbox_1	1	3	PF02207	0.745
DOC_CDC14_PxL_1	146	154	PF14671	0.534
DOC_CKS1_1	33	38	PF01111	0.607
DOC_MAPK_gen_1	175	183	PF00069	0.364
DOC_MAPK_HePTP_8	173	185	PF00069	0.332
DOC_MAPK_MEF2A_6	176	185	PF00069	0.443
DOC_PP1_RVXF_1	38	45	PF00149	0.516
DOC_PP1_RVXF_1	96	102	PF00149	0.512
DOC_PP2B_LxvP_1	181	184	PF13499	0.434
DOC_PP4_FxxP_1	2	5	PF00568	0.666
DOC_PP4_FxxP_1	249	252	PF00568	0.452
DOC_USP7_MATH_1	10	14	PF00917	0.685
DOC_USP7_MATH_1	138	142	PF00917	0.659
DOC_USP7_MATH_1	151	155	PF00917	0.420
DOC_USP7_MATH_1	237	241	PF00917	0.572
DOC_WW_Pin1_4	26	31	PF00397	0.689
DOC_WW_Pin1_4	32	37	PF00397	0.544
LIG_14-3-3_CanoR_1	91	99	PF00244	0.457
LIG_BRCT_BRCA1_1	165	169	PF00533	0.522
LIG_BRCT_BRCA1_1	40	44	PF00533	0.449
LIG_FHA_1	101	107	PF00498	0.412
LIG_FHA_1	163	169	PF00498	0.393
LIG_FHA_2	153	159	PF00498	0.335
LIG_LIR_Gen_1	158	168	PF02991	0.495
LIG_LIR_Gen_1	41	52	PF02991	0.383
LIG_LIR_Nem_3	154	160	PF02991	0.514
LIG_LIR_Nem_3	177	182	PF02991	0.479
LIG_LIR_Nem_3	224	229	PF02991	0.399
LIG_LIR_Nem_3	41	47	PF02991	0.430
LIG_LIR_Nem_3	67	73	PF02991	0.462
LIG_LYPXL_S_1	225	229	PF13949	0.428
LIG_LYPXL_SIV_4	69	77	PF13949	0.480
LIG_LYPXL_yS_3	226	229	PF13949	0.429
LIG_Pex14_2	178	182	PF04695	0.520
LIG_PTB_Apo_2	112	119	PF02174	0.553
LIG_PTB_Apo_2	203	210	PF02174	0.339
LIG_PTB_Phospho_1	203	209	PF10480	0.365
LIG_REV1ctd_RIR_1	85	95	PF16727	0.493
LIG_SH2_CRK	70	74	PF00017	0.441
LIG_SH2_GRB2like	107	110	PF00017	0.377
LIG_SH2_SRC	31	34	PF00017	0.575
LIG_SH2_STAP1	107	111	PF00017	0.581
LIG_SH2_STAT5	209	212	PF00017	0.452
LIG_SH2_STAT5	31	34	PF00017	0.588
LIG_SH2_STAT5	53	56	PF00017	0.454
LIG_SH2_STAT5	86	89	PF00017	0.421
LIG_SH3_3	134	140	PF00018	0.683
LIG_SH3_3	147	153	PF00018	0.500
LIG_SH3_3	27	33	PF00018	0.699
LIG_SH3_3	4	10	PF00018	0.664
LIG_SH3_3	66	72	PF00018	0.509
LIG_TYR_ITIM	68	73	PF00017	0.528
LIG_TYR_ITSM	222	229	PF00017	0.470
LIG_UBA3_1	1	9	PF00899	0.742
LIG_WRC_WIRS_1	189	194	PF05994	0.456
MOD_CK1_1	126	132	PF00069	0.593
MOD_CK1_1	240	246	PF00069	0.598
MOD_CK1_1	38	44	PF00069	0.471
MOD_CK2_1	152	158	PF00069	0.449
MOD_GlcNHglycan	185	188	PF01048	0.426
MOD_GlcNHglycan	217	220	PF01048	0.534
MOD_GlcNHglycan	231	234	PF01048	0.384
MOD_GlcNHglycan	242	245	PF01048	0.563
MOD_GSK3_1	10	17	PF00069	0.772
MOD_GSK3_1	34	41	PF00069	0.522
MOD_N-GLC_1	237	242	PF02516	0.579
MOD_NEK2_1	101	106	PF00069	0.456
MOD_NEK2_1	163	168	PF00069	0.508
MOD_NEK2_2	51	56	PF00069	0.559
MOD_PK_1	56	62	PF00069	0.510
MOD_PKA_1	20	26	PF00069	0.691
MOD_PKA_2	14	20	PF00069	0.733
MOD_Plk_1	237	243	PF00069	0.626
MOD_Plk_1	94	100	PF00069	0.476
MOD_Plk_4	128	134	PF00069	0.730
MOD_Plk_4	138	144	PF00069	0.584
MOD_Plk_4	188	194	PF00069	0.395
MOD_Plk_4	221	227	PF00069	0.407
MOD_Plk_4	56	62	PF00069	0.507
MOD_ProDKin_1	26	32	PF00069	0.681
TRG_ENDOCYTIC_2	160	163	PF00928	0.482
TRG_ENDOCYTIC_2	209	212	PF00928	0.403
TRG_ENDOCYTIC_2	226	229	PF00928	0.297
TRG_ENDOCYTIC_2	70	73	PF00928	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCH2	Leptomonas seymouri	66%	100%
A0A0S4IV73	Bodo saltans	35%	100%
A0A1X0NKA4	Trypanosomatidae	45%	100%
A0A3R7L2T5	Trypanosoma rangeli	37%	100%
A0A3S7XB21	Leishmania donovani	93%	100%
A4HPF2	Leishmania braziliensis	76%	100%
A4ICJ3	Leishmania infantum	93%	100%
D0A3G4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AT63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%