LeishMANIAdb
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Putative ATP-binding cassette protein subfamily G,member 6

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ATP-binding cassette protein subfamily G,member 6
Gene product:
ATP-binding cassette protein subfamily G, member 6, putative
Species:
Leishmania major
UniProt:
Q4Q1D0_LEIMA
TriTrypDb:
LmjF.36.2890 , LMJLV39_360038000 , LMJSD75_360037900
Length:
668

Annotations

LeishMANIAdb annotations

Proteins belonging to the subfamily G of Eukaryotic ABC transporters. Probably functional as dimers, with broad substrate specificity.. Expanded in Kinetoplastids (also in free-living forms)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

Q4Q1D0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1D0

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0009987 cellular process 1 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0005215 transporter activity 1 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0015399 primary active transmembrane transporter activity 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0022804 active transmembrane transporter activity 3 12
GO:0022857 transmembrane transporter activity 2 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0042626 ATPase-coupled transmembrane transporter activity 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140359 ABC-type transporter activity 3 12
GO:0140657 ATP-dependent activity 1 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 9 13 PF00656 0.667
CLV_MEL_PAP_1 161 167 PF00089 0.268
CLV_NRD_NRD_1 194 196 PF00675 0.281
CLV_NRD_NRD_1 405 407 PF00675 0.298
CLV_NRD_NRD_1 96 98 PF00675 0.334
CLV_PCSK_FUR_1 402 406 PF00082 0.295
CLV_PCSK_KEX2_1 196 198 PF00082 0.232
CLV_PCSK_KEX2_1 404 406 PF00082 0.300
CLV_PCSK_PC1ET2_1 196 198 PF00082 0.232
CLV_PCSK_SKI1_1 108 112 PF00082 0.320
CLV_PCSK_SKI1_1 259 263 PF00082 0.289
CLV_PCSK_SKI1_1 369 373 PF00082 0.471
CLV_PCSK_SKI1_1 582 586 PF00082 0.408
CLV_PCSK_SKI1_1 591 595 PF00082 0.425
CLV_PCSK_SKI1_1 97 101 PF00082 0.234
CLV_Separin_Metazoa 142 146 PF03568 0.434
DEG_MDM2_SWIB_1 579 587 PF02201 0.249
DOC_CDC14_PxL_1 204 212 PF14671 0.504
DOC_CYCLIN_RxL_1 517 526 PF00134 0.316
DOC_MAPK_gen_1 440 448 PF00069 0.225
DOC_MAPK_gen_1 635 644 PF00069 0.234
DOC_MAPK_MEF2A_6 237 244 PF00069 0.552
DOC_MAPK_MEF2A_6 440 447 PF00069 0.257
DOC_MAPK_MEF2A_6 638 646 PF00069 0.234
DOC_PP1_RVXF_1 518 525 PF00149 0.257
DOC_PP1_RVXF_1 583 590 PF00149 0.214
DOC_PP2B_LxvP_1 332 335 PF13499 0.665
DOC_USP7_MATH_1 27 31 PF00917 0.700
DOC_USP7_MATH_1 317 321 PF00917 0.615
DOC_USP7_MATH_1 34 38 PF00917 0.673
DOC_USP7_MATH_1 348 352 PF00917 0.547
DOC_USP7_MATH_1 611 615 PF00917 0.415
DOC_USP7_UBL2_3 98 102 PF12436 0.468
DOC_WW_Pin1_4 150 155 PF00397 0.416
DOC_WW_Pin1_4 19 24 PF00397 0.798
DOC_WW_Pin1_4 303 308 PF00397 0.667
DOC_WW_Pin1_4 333 338 PF00397 0.716
DOC_WW_Pin1_4 377 382 PF00397 0.614
LIG_14-3-3_CanoR_1 145 151 PF00244 0.524
LIG_14-3-3_CanoR_1 164 172 PF00244 0.536
LIG_14-3-3_CanoR_1 178 186 PF00244 0.385
LIG_14-3-3_CanoR_1 387 396 PF00244 0.475
LIG_14-3-3_CanoR_1 591 597 PF00244 0.275
LIG_Actin_WH2_2 136 153 PF00022 0.434
LIG_BIR_II_1 1 5 PF00653 0.750
LIG_BRCT_BRCA1_1 208 212 PF00533 0.422
LIG_BRCT_BRCA1_1 575 579 PF00533 0.249
LIG_Clathr_ClatBox_1 210 214 PF01394 0.439
LIG_eIF4E_1 536 542 PF01652 0.339
LIG_FHA_1 104 110 PF00498 0.481
LIG_FHA_1 215 221 PF00498 0.490
LIG_FHA_1 370 376 PF00498 0.597
LIG_FHA_1 38 44 PF00498 0.532
LIG_FHA_1 388 394 PF00498 0.462
LIG_FHA_1 414 420 PF00498 0.422
LIG_FHA_1 423 429 PF00498 0.302
LIG_FHA_1 549 555 PF00498 0.516
LIG_FHA_1 58 64 PF00498 0.433
LIG_FHA_1 86 92 PF00498 0.481
LIG_FHA_2 137 143 PF00498 0.414
LIG_FHA_2 153 159 PF00498 0.472
LIG_FHA_2 216 222 PF00498 0.488
LIG_FHA_2 42 48 PF00498 0.538
LIG_FHA_2 87 93 PF00498 0.414
LIG_LIR_Apic_2 268 274 PF02991 0.453
LIG_LIR_Gen_1 136 144 PF02991 0.457
LIG_LIR_Gen_1 221 231 PF02991 0.479
LIG_LIR_Gen_1 251 262 PF02991 0.493
LIG_LIR_Gen_1 411 420 PF02991 0.304
LIG_LIR_Gen_1 44 52 PF02991 0.602
LIG_LIR_Gen_1 453 463 PF02991 0.301
LIG_LIR_Gen_1 588 597 PF02991 0.298
LIG_LIR_LC3C_4 639 644 PF02991 0.255
LIG_LIR_Nem_3 136 140 PF02991 0.442
LIG_LIR_Nem_3 221 226 PF02991 0.521
LIG_LIR_Nem_3 251 257 PF02991 0.458
LIG_LIR_Nem_3 411 415 PF02991 0.305
LIG_LIR_Nem_3 427 432 PF02991 0.144
LIG_LIR_Nem_3 44 48 PF02991 0.505
LIG_LIR_Nem_3 453 458 PF02991 0.313
LIG_LIR_Nem_3 588 592 PF02991 0.222
LIG_LIR_Nem_3 601 605 PF02991 0.264
LIG_NRBOX 227 233 PF00104 0.579
LIG_PCNA_PIPBox_1 515 524 PF02747 0.257
LIG_Pex14_2 579 583 PF04695 0.226
LIG_SH2_PTP2 137 140 PF00017 0.516
LIG_SH2_PTP2 412 415 PF00017 0.394
LIG_SH2_STAP1 480 484 PF00017 0.516
LIG_SH2_STAP1 536 540 PF00017 0.271
LIG_SH2_STAP1 633 637 PF00017 0.322
LIG_SH2_STAT3 127 130 PF00017 0.414
LIG_SH2_STAT5 127 130 PF00017 0.440
LIG_SH2_STAT5 137 140 PF00017 0.425
LIG_SH2_STAT5 271 274 PF00017 0.453
LIG_SH2_STAT5 298 301 PF00017 0.570
LIG_SH2_STAT5 412 415 PF00017 0.422
LIG_SH2_STAT5 486 489 PF00017 0.289
LIG_SH2_STAT5 50 53 PF00017 0.541
LIG_SH2_STAT5 509 512 PF00017 0.251
LIG_SH2_STAT5 563 566 PF00017 0.285
LIG_SH2_STAT5 651 654 PF00017 0.271
LIG_SH2_STAT5 656 659 PF00017 0.261
LIG_SH2_STAT5 70 73 PF00017 0.322
LIG_SH3_3 1 7 PF00018 0.735
LIG_SH3_3 112 118 PF00018 0.465
LIG_SH3_3 17 23 PF00018 0.639
LIG_SH3_3 202 208 PF00018 0.414
LIG_SH3_3 605 611 PF00018 0.393
LIG_SH3_3 76 82 PF00018 0.516
LIG_SUMO_SIM_anti_2 238 245 PF11976 0.558
LIG_SUMO_SIM_anti_2 258 264 PF11976 0.439
LIG_SUMO_SIM_anti_2 556 563 PF11976 0.395
LIG_SUMO_SIM_anti_2 75 81 PF11976 0.421
LIG_SUMO_SIM_anti_2 88 95 PF11976 0.399
LIG_SUMO_SIM_par_1 203 209 PF11976 0.520
LIG_SUMO_SIM_par_1 529 535 PF11976 0.325
LIG_SUMO_SIM_par_1 570 576 PF11976 0.358
LIG_SUMO_SIM_par_1 642 647 PF11976 0.230
LIG_TRAF2_1 139 142 PF00917 0.516
LIG_TRAF2_1 307 310 PF00917 0.579
LIG_TRAF2_2 339 344 PF00917 0.622
LIG_TYR_ITIM 507 512 PF00017 0.266
LIG_TYR_ITIM 654 659 PF00017 0.266
LIG_TYR_ITSM 425 432 PF00017 0.394
LIG_UBA3_1 541 547 PF00899 0.303
LIG_UBA3_1 90 98 PF00899 0.449
LIG_WRC_WIRS_1 220 225 PF05994 0.500
LIG_WRC_WIRS_1 452 457 PF05994 0.397
MOD_CDC14_SPxK_1 380 383 PF00782 0.602
MOD_CDK_SPxK_1 377 383 PF00069 0.609
MOD_CK1_1 136 142 PF00069 0.457
MOD_CK1_1 163 169 PF00069 0.434
MOD_CK1_1 26 32 PF00069 0.786
MOD_CK1_1 289 295 PF00069 0.608
MOD_CK1_1 37 43 PF00069 0.568
MOD_CK1_1 388 394 PF00069 0.478
MOD_CK1_1 414 420 PF00069 0.398
MOD_CK1_1 435 441 PF00069 0.296
MOD_CK1_1 453 459 PF00069 0.319
MOD_CK1_1 543 549 PF00069 0.409
MOD_CK1_1 573 579 PF00069 0.304
MOD_CK1_1 622 628 PF00069 0.211
MOD_CK2_1 136 142 PF00069 0.414
MOD_CK2_1 152 158 PF00069 0.446
MOD_CK2_1 188 194 PF00069 0.407
MOD_CK2_1 19 25 PF00069 0.733
MOD_CK2_1 303 309 PF00069 0.585
MOD_GlcNHglycan 124 127 PF01048 0.239
MOD_GlcNHglycan 146 149 PF01048 0.323
MOD_GlcNHglycan 183 186 PF01048 0.248
MOD_GlcNHglycan 190 193 PF01048 0.211
MOD_GlcNHglycan 237 240 PF01048 0.323
MOD_GlcNHglycan 28 32 PF01048 0.520
MOD_GlcNHglycan 288 291 PF01048 0.402
MOD_GlcNHglycan 319 322 PF01048 0.491
MOD_GlcNHglycan 416 419 PF01048 0.388
MOD_GlcNHglycan 482 485 PF01048 0.320
MOD_GlcNHglycan 52 55 PF01048 0.391
MOD_GlcNHglycan 621 624 PF01048 0.575
MOD_GlcNHglycan 67 70 PF01048 0.177
MOD_GlcNHglycan 72 75 PF01048 0.157
MOD_GlcNHglycan 82 85 PF01048 0.221
MOD_GSK3_1 146 153 PF00069 0.528
MOD_GSK3_1 177 184 PF00069 0.477
MOD_GSK3_1 19 26 PF00069 0.787
MOD_GSK3_1 215 222 PF00069 0.496
MOD_GSK3_1 227 234 PF00069 0.477
MOD_GSK3_1 285 292 PF00069 0.617
MOD_GSK3_1 33 40 PF00069 0.724
MOD_GSK3_1 333 340 PF00069 0.727
MOD_GSK3_1 365 372 PF00069 0.629
MOD_GSK3_1 450 457 PF00069 0.291
MOD_GSK3_1 46 53 PF00069 0.580
MOD_GSK3_1 618 625 PF00069 0.392
MOD_N-GLC_1 543 548 PF02516 0.230
MOD_NEK2_1 146 151 PF00069 0.540
MOD_NEK2_1 231 236 PF00069 0.524
MOD_NEK2_1 364 369 PF00069 0.629
MOD_NEK2_1 375 380 PF00069 0.611
MOD_NEK2_1 424 429 PF00069 0.261
MOD_NEK2_1 450 455 PF00069 0.304
MOD_NEK2_1 479 484 PF00069 0.510
MOD_NEK2_1 514 519 PF00069 0.261
MOD_NEK2_1 540 545 PF00069 0.345
MOD_NEK2_1 570 575 PF00069 0.360
MOD_NEK2_1 592 597 PF00069 0.246
MOD_NEK2_2 348 353 PF00069 0.582
MOD_PIKK_1 163 169 PF00454 0.523
MOD_PIKK_1 337 343 PF00454 0.621
MOD_PIKK_1 388 394 PF00454 0.421
MOD_PIKK_1 432 438 PF00454 0.316
MOD_PIKK_1 626 632 PF00454 0.365
MOD_PKA_2 144 150 PF00069 0.490
MOD_PKA_2 163 169 PF00069 0.516
MOD_PKA_2 177 183 PF00069 0.516
MOD_PKA_2 365 371 PF00069 0.594
MOD_PKA_2 662 668 PF00069 0.652
MOD_Plk_1 46 52 PF00069 0.539
MOD_Plk_4 133 139 PF00069 0.464
MOD_Plk_4 206 212 PF00069 0.427
MOD_Plk_4 227 233 PF00069 0.525
MOD_Plk_4 408 414 PF00069 0.313
MOD_Plk_4 424 430 PF00069 0.165
MOD_Plk_4 554 560 PF00069 0.415
MOD_Plk_4 603 609 PF00069 0.341
MOD_Plk_4 86 92 PF00069 0.414
MOD_ProDKin_1 150 156 PF00069 0.416
MOD_ProDKin_1 19 25 PF00069 0.799
MOD_ProDKin_1 303 309 PF00069 0.671
MOD_ProDKin_1 333 339 PF00069 0.711
MOD_ProDKin_1 377 383 PF00069 0.611
TRG_ENDOCYTIC_2 137 140 PF00928 0.425
TRG_ENDOCYTIC_2 254 257 PF00928 0.557
TRG_ENDOCYTIC_2 412 415 PF00928 0.394
TRG_ENDOCYTIC_2 429 432 PF00928 0.122
TRG_ENDOCYTIC_2 509 512 PF00928 0.251
TRG_ENDOCYTIC_2 651 654 PF00928 0.251
TRG_ENDOCYTIC_2 656 659 PF00928 0.251
TRG_ER_diArg_1 249 252 PF00400 0.581
TRG_ER_diArg_1 401 404 PF00400 0.503
TRG_ER_diArg_1 439 442 PF00400 0.225
TRG_NES_CRM1_1 344 356 PF08389 0.501
TRG_Pf-PMV_PEXEL_1 359 363 PF00026 0.334

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HSP2 Leptomonas seymouri 26% 91%
A0A0N1HZC7 Leptomonas seymouri 67% 98%
A0A0S4IJ55 Bodo saltans 27% 88%
A0A0S4IQG2 Bodo saltans 28% 100%
A0A0S4IUG8 Bodo saltans 27% 100%
A0A0S4IUY5 Bodo saltans 47% 100%
A0A0S4IZ09 Bodo saltans 23% 100%
A0A0S4J724 Bodo saltans 28% 100%
A0A0S4J7U2 Bodo saltans 29% 96%
A0A0S4JPA7 Bodo saltans 29% 89%
A0A0S4KMF6 Bodo saltans 23% 83%
A0A1X0NKI4 Trypanosomatidae 50% 100%
A0A1X0NM50 Trypanosomatidae 28% 99%
A0A1X0NTW9 Trypanosomatidae 26% 100%
A0A1X0P4K0 Trypanosomatidae 23% 100%
A0A3Q8IA65 Leishmania donovani 27% 90%
A0A3Q8IHD8 Leishmania donovani 93% 98%
A0A3R7KEQ6 Trypanosoma rangeli 46% 100%
A0A3R7MNM8 Trypanosoma rangeli 27% 100%
A0A3S5H5N0 Leishmania donovani 29% 100%
A0A3S7WPB9 Leishmania donovani 29% 100%
A0A422N4V5 Trypanosoma rangeli 28% 96%
A4H4G9 Leishmania braziliensis 30% 100%
A4H4H6 Leishmania braziliensis 30% 100%
A4H862 Leishmania braziliensis 27% 89%
A4HPF5 Leishmania braziliensis 78% 98%
A4HSQ0 Leishmania infantum 30% 100%
A4HSQ1 Leishmania infantum 29% 100%
A4HWI7 Leishmania infantum 27% 90%
A4ID77 Leishmania infantum 93% 98%
B8ALI0 Oryza sativa subsp. indica 29% 85%
C9ZXW1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
D0A3G8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
D0A3K9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
D3ZCM3 Rattus norvegicus 27% 100%
E9AKN6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AKN7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AQ88 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 90%
E9AT67 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 98%
H9BZ66 Petunia hybrida 29% 100%
O80946 Arabidopsis thaliana 28% 90%
P10090 Drosophila melanogaster 29% 97%
P45843 Drosophila melanogaster 27% 100%
P45844 Homo sapiens 28% 99%
P58428 Rattus norvegicus 28% 96%
Q05360 Lucilia cuprina 30% 99%
Q09466 Caenorhabditis elegans 26% 100%
Q11180 Caenorhabditis elegans 30% 100%
Q16928 Anopheles albimanus 29% 94%
Q17320 Ceratitis capitata 29% 98%
Q27256 Anopheles gambiae 29% 96%
Q3E9B8 Arabidopsis thaliana 26% 100%
Q4GZT4 Bos taurus 29% 100%
Q4QF95 Leishmania major 28% 90%
Q4QJ70 Leishmania major 30% 100%
Q4QJ71 Leishmania major 30% 100%
Q55DA0 Dictyostelium discoideum 29% 100%
Q55DW4 Dictyostelium discoideum 27% 84%
Q5MB13 Macaca mulatta 29% 100%
Q64343 Mus musculus 29% 100%
Q7TMS5 Mus musculus 31% 100%
Q7XA72 Arabidopsis thaliana 29% 99%
Q80W57 Rattus norvegicus 30% 100%
Q84TH5 Arabidopsis thaliana 30% 100%
Q86HQ2 Dictyostelium discoideum 29% 100%
Q8H8V7 Oryza sativa subsp. japonica 29% 85%
Q8MIB3 Sus scrofa 31% 100%
Q8RWI9 Arabidopsis thaliana 31% 97%
Q8RXN0 Arabidopsis thaliana 30% 95%
Q8T685 Dictyostelium discoideum 29% 100%
Q8T686 Dictyostelium discoideum 27% 82%
Q8T689 Dictyostelium discoideum 29% 84%
Q91WA9 Mus musculus 27% 100%
Q93YS4 Arabidopsis thaliana 28% 89%
Q99P81 Mus musculus 25% 100%
Q99PE7 Rattus norvegicus 26% 100%
Q99PE8 Mus musculus 26% 100%
Q9C6W5 Arabidopsis thaliana 28% 100%
Q9C8J8 Arabidopsis thaliana 29% 99%
Q9C8K2 Arabidopsis thaliana 32% 97%
Q9DBM0 Mus musculus 28% 99%
Q9FLX5 Arabidopsis thaliana 28% 100%
Q9FNB5 Arabidopsis thaliana 28% 92%
Q9FT51 Arabidopsis thaliana 30% 91%
Q9H172 Homo sapiens 28% 100%
Q9H221 Homo sapiens 28% 99%
Q9H222 Homo sapiens 27% 100%
Q9LFG8 Arabidopsis thaliana 28% 90%
Q9LK50 Arabidopsis thaliana 29% 98%
Q9M2V5 Arabidopsis thaliana 28% 94%
Q9M2V6 Arabidopsis thaliana 28% 100%
Q9M2V7 Arabidopsis thaliana 27% 91%
Q9M3D6 Arabidopsis thaliana 27% 92%
Q9MAH4 Arabidopsis thaliana 28% 100%
Q9SIT6 Arabidopsis thaliana 28% 100%
Q9SW08 Arabidopsis thaliana 26% 100%
Q9SZR9 Arabidopsis thaliana 29% 100%
Q9UNQ0 Homo sapiens 29% 100%
Q9ZU35 Arabidopsis thaliana 31% 92%
Q9ZUT0 Arabidopsis thaliana 28% 88%
Q9ZUU9 Arabidopsis thaliana 23% 92%
V5B0X3 Trypanosoma cruzi 21% 100%
V5BPQ0 Trypanosoma cruzi 27% 95%
V5D8T8 Trypanosoma cruzi 28% 100%
V5DGN9 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS