ATPase_AAA_core domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1C9_LEIMA

TriTrypDb:

LmjF.36.2900 , LMJLV39_360038100 , LMJSD75_360038000

Length:

952

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q1C9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1C9

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0032392	DNA geometric change	7	2
GO:0032508	DNA duplex unwinding	8	2
GO:0051276	chromosome organization	5	2
GO:0071103	DNA conformation change	6	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.484
CLV_C14_Caspase3-7	474	478	PF00656	0.499
CLV_NRD_NRD_1	266	268	PF00675	0.529
CLV_NRD_NRD_1	305	307	PF00675	0.439
CLV_NRD_NRD_1	406	408	PF00675	0.467
CLV_NRD_NRD_1	502	504	PF00675	0.597
CLV_NRD_NRD_1	674	676	PF00675	0.492
CLV_NRD_NRD_1	799	801	PF00675	0.482
CLV_NRD_NRD_1	82	84	PF00675	0.568
CLV_NRD_NRD_1	944	946	PF00675	0.518
CLV_PCSK_KEX2_1	266	268	PF00082	0.529
CLV_PCSK_KEX2_1	305	307	PF00082	0.439
CLV_PCSK_KEX2_1	406	408	PF00082	0.467
CLV_PCSK_KEX2_1	419	421	PF00082	0.272
CLV_PCSK_KEX2_1	502	504	PF00082	0.671
CLV_PCSK_KEX2_1	674	676	PF00082	0.492
CLV_PCSK_KEX2_1	799	801	PF00082	0.482
CLV_PCSK_KEX2_1	82	84	PF00082	0.659
CLV_PCSK_KEX2_1	883	885	PF00082	0.432
CLV_PCSK_KEX2_1	944	946	PF00082	0.518
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.270
CLV_PCSK_PC1ET2_1	883	885	PF00082	0.457
CLV_PCSK_SKI1_1	235	239	PF00082	0.576
CLV_PCSK_SKI1_1	370	374	PF00082	0.655
CLV_PCSK_SKI1_1	419	423	PF00082	0.363
CLV_PCSK_SKI1_1	458	462	PF00082	0.350
CLV_PCSK_SKI1_1	760	764	PF00082	0.414
CLV_PCSK_SKI1_1	886	890	PF00082	0.441
CLV_Separin_Metazoa	767	771	PF03568	0.479
CLV_Separin_Metazoa	814	818	PF03568	0.557
DEG_APCC_DBOX_1	266	274	PF00400	0.490
DEG_APCC_DBOX_1	419	427	PF00400	0.447
DEG_APCC_DBOX_1	442	450	PF00400	0.422
DEG_APCC_DBOX_1	883	891	PF00400	0.502
DEG_Nend_Nbox_1	1	3	PF02207	0.468
DOC_CDC14_PxL_1	270	278	PF14671	0.509
DOC_CDC14_PxL_1	40	48	PF14671	0.442
DOC_CDC14_PxL_1	55	63	PF14671	0.440
DOC_CKS1_1	877	882	PF01111	0.477
DOC_CKS1_1	97	102	PF01111	0.475
DOC_CYCLIN_RxL_1	229	240	PF00134	0.569
DOC_CYCLIN_RxL_1	319	329	PF00134	0.342
DOC_CYCLIN_RxL_1	757	767	PF00134	0.519
DOC_CYCLIN_yCln2_LP_2	46	52	PF00134	0.430
DOC_MAPK_gen_1	266	275	PF00069	0.488
DOC_MAPK_gen_1	419	427	PF00069	0.286
DOC_MAPK_gen_1	674	682	PF00069	0.396
DOC_MAPK_gen_1	8	17	PF00069	0.432
DOC_MAPK_gen_1	882	890	PF00069	0.409
DOC_MAPK_MEF2A_6	222	230	PF00069	0.419
DOC_MAPK_MEF2A_6	322	330	PF00069	0.382
DOC_MAPK_MEF2A_6	419	427	PF00069	0.350
DOC_MAPK_MEF2A_6	443	450	PF00069	0.421
DOC_MAPK_MEF2A_6	8	17	PF00069	0.432
DOC_MAPK_NFAT4_5	419	427	PF00069	0.346
DOC_MAPK_RevD_3	931	945	PF00069	0.411
DOC_PP1_RVXF_1	215	221	PF00149	0.447
DOC_PP1_RVXF_1	884	890	PF00149	0.494
DOC_PP2B_LxvP_1	46	49	PF13499	0.430
DOC_PP2B_LxvP_1	717	720	PF13499	0.574
DOC_PP4_FxxP_1	188	191	PF00568	0.499
DOC_PP4_FxxP_1	925	928	PF00568	0.429
DOC_USP7_MATH_1	176	180	PF00917	0.501
DOC_USP7_MATH_1	208	212	PF00917	0.662
DOC_USP7_MATH_1	357	361	PF00917	0.653
DOC_USP7_MATH_1	438	442	PF00917	0.600
DOC_USP7_MATH_1	490	494	PF00917	0.620
DOC_USP7_MATH_1	595	599	PF00917	0.555
DOC_USP7_MATH_1	615	619	PF00917	0.376
DOC_USP7_MATH_1	62	66	PF00917	0.438
DOC_USP7_MATH_1	638	642	PF00917	0.671
DOC_USP7_MATH_1	655	659	PF00917	0.542
DOC_USP7_MATH_1	735	739	PF00917	0.575
DOC_USP7_MATH_1	77	81	PF00917	0.427
DOC_USP7_MATH_1	806	810	PF00917	0.671
DOC_USP7_MATH_1	864	868	PF00917	0.741
DOC_USP7_MATH_1	93	97	PF00917	0.454
DOC_USP7_UBL2_3	8	12	PF12436	0.433
DOC_USP7_UBL2_3	878	882	PF12436	0.454
DOC_WW_Pin1_4	182	187	PF00397	0.548
DOC_WW_Pin1_4	260	265	PF00397	0.600
DOC_WW_Pin1_4	53	58	PF00397	0.451
DOC_WW_Pin1_4	634	639	PF00397	0.669
DOC_WW_Pin1_4	876	881	PF00397	0.499
DOC_WW_Pin1_4	96	101	PF00397	0.449
LIG_14-3-3_CanoR_1	502	508	PF00244	0.642
LIG_14-3-3_CanoR_1	621	627	PF00244	0.617
LIG_14-3-3_CanoR_1	64	72	PF00244	0.410
LIG_14-3-3_CanoR_1	663	671	PF00244	0.649
LIG_14-3-3_CanoR_1	799	807	PF00244	0.515
LIG_14-3-3_CanoR_1	817	822	PF00244	0.431
LIG_14-3-3_CanoR_1	83	91	PF00244	0.613
LIG_14-3-3_CanoR_1	863	871	PF00244	0.493
LIG_BIR_III_4	827	831	PF00653	0.533
LIG_BRCT_BRCA1_1	184	188	PF00533	0.520
LIG_BRCT_BRCA1_1	215	219	PF00533	0.416
LIG_BRCT_BRCA1_1	821	825	PF00533	0.544
LIG_BRCT_BRCA1_1	921	925	PF00533	0.460
LIG_Clathr_ClatBox_1	468	472	PF01394	0.397
LIG_Clathr_ClatBox_1	887	891	PF01394	0.493
LIG_CSL_BTD_1	873	876	PF09270	0.574
LIG_DCNL_PONY_1	1	4	PF03556	0.465
LIG_deltaCOP1_diTrp_1	153	160	PF00928	0.537
LIG_eIF4E_1	55	61	PF01652	0.419
LIG_FAT_LD_1	134	142	PF03623	0.366
LIG_FHA_1	190	196	PF00498	0.582
LIG_FHA_1	232	238	PF00498	0.534
LIG_FHA_1	294	300	PF00498	0.395
LIG_FHA_1	515	521	PF00498	0.473
LIG_FHA_1	594	600	PF00498	0.445
LIG_FHA_1	8	14	PF00498	0.433
LIG_FHA_2	148	154	PF00498	0.616
LIG_FHA_2	191	197	PF00498	0.496
LIG_FHA_2	238	244	PF00498	0.500
LIG_FHA_2	663	669	PF00498	0.519
LIG_LIR_Apic_2	185	191	PF02991	0.511
LIG_LIR_Apic_2	922	928	PF02991	0.435
LIG_LIR_Gen_1	11	22	PF02991	0.431
LIG_LIR_Nem_3	11	17	PF02991	0.433
LIG_LIR_Nem_3	111	117	PF02991	0.467
LIG_LIR_Nem_3	165	170	PF02991	0.441
LIG_LIR_Nem_3	30	35	PF02991	0.410
LIG_LIR_Nem_3	56	61	PF02991	0.489
LIG_LIR_Nem_3	780	786	PF02991	0.408
LIG_LIR_Nem_3	913	919	PF02991	0.497
LIG_LYPXL_yS_3	58	61	PF13949	0.461
LIG_LYPXL_yS_3	841	844	PF13949	0.492
LIG_MLH1_MIPbox_1	822	826	PF16413	0.546
LIG_NRBOX	133	139	PF00104	0.508
LIG_NRBOX	167	173	PF00104	0.362
LIG_Pex14_1	821	825	PF04695	0.524
LIG_Rb_LxCxE_1	360	380	PF01857	0.471
LIG_RPA_C_Fungi	301	313	PF08784	0.409
LIG_SH2_NCK_1	117	121	PF00017	0.418
LIG_SH2_NCK_1	335	339	PF00017	0.370
LIG_SH2_STAP1	692	696	PF00017	0.396
LIG_SH2_STAT5	167	170	PF00017	0.385
LIG_SH2_STAT5	300	303	PF00017	0.425
LIG_SH2_STAT5	335	338	PF00017	0.476
LIG_SH2_STAT5	428	431	PF00017	0.426
LIG_SH2_STAT5	586	589	PF00017	0.433
LIG_SH2_STAT5	671	674	PF00017	0.488
LIG_SH3_2	59	64	PF14604	0.445
LIG_SH3_3	125	131	PF00018	0.401
LIG_SH3_3	46	52	PF00018	0.454
LIG_SH3_3	56	62	PF00018	0.449
LIG_SH3_3	726	732	PF00018	0.744
LIG_SH3_3	904	910	PF00018	0.361
LIG_Sin3_3	759	766	PF02671	0.388
LIG_SUMO_SIM_anti_2	135	143	PF11976	0.463
LIG_SUMO_SIM_anti_2	927	934	PF11976	0.494
LIG_SUMO_SIM_par_1	516	521	PF11976	0.489
LIG_SUMO_SIM_par_1	678	684	PF11976	0.401
LIG_SUMO_SIM_par_1	742	748	PF11976	0.504
LIG_TRAF2_1	573	576	PF00917	0.536
LIG_TRFH_1	58	62	PF08558	0.450
LIG_UBA3_1	1	9	PF00899	0.446
MOD_CDC14_SPxK_1	263	266	PF00782	0.447
MOD_CDK_SPxK_1	260	266	PF00069	0.455
MOD_CDK_SPxK_1	876	882	PF00069	0.489
MOD_CDK_SPxxK_3	260	267	PF00069	0.455
MOD_CDK_SPxxK_3	876	883	PF00069	0.483
MOD_CK1_1	179	185	PF00069	0.497
MOD_CK1_1	25	31	PF00069	0.677
MOD_CK1_1	265	271	PF00069	0.492
MOD_CK1_1	493	499	PF00069	0.533
MOD_CK1_1	511	517	PF00069	0.457
MOD_CK1_1	617	623	PF00069	0.554
MOD_CK1_1	628	634	PF00069	0.566
MOD_CK1_1	648	654	PF00069	0.651
MOD_CK1_1	658	664	PF00069	0.599
MOD_CK1_1	684	690	PF00069	0.645
MOD_CK1_1	7	13	PF00069	0.431
MOD_CK1_1	801	807	PF00069	0.643
MOD_CK1_1	820	826	PF00069	0.459
MOD_CK1_1	84	90	PF00069	0.476
MOD_CK1_1	845	851	PF00069	0.669
MOD_CK1_1	96	102	PF00069	0.430
MOD_CK2_1	237	243	PF00069	0.533
MOD_CK2_1	334	340	PF00069	0.387
MOD_CK2_1	656	662	PF00069	0.504
MOD_CK2_1	863	869	PF00069	0.560
MOD_Cter_Amidation	80	83	PF01082	0.646
MOD_GlcNHglycan	118	121	PF01048	0.540
MOD_GlcNHglycan	142	145	PF01048	0.454
MOD_GlcNHglycan	178	181	PF01048	0.510
MOD_GlcNHglycan	210	213	PF01048	0.665
MOD_GlcNHglycan	24	27	PF01048	0.721
MOD_GlcNHglycan	336	339	PF01048	0.378
MOD_GlcNHglycan	359	362	PF01048	0.715
MOD_GlcNHglycan	395	398	PF01048	0.481
MOD_GlcNHglycan	458	461	PF01048	0.362
MOD_GlcNHglycan	485	488	PF01048	0.610
MOD_GlcNHglycan	495	498	PF01048	0.405
MOD_GlcNHglycan	503	506	PF01048	0.478
MOD_GlcNHglycan	510	513	PF01048	0.324
MOD_GlcNHglycan	549	552	PF01048	0.550
MOD_GlcNHglycan	575	579	PF01048	0.526
MOD_GlcNHglycan	633	636	PF01048	0.635
MOD_GlcNHglycan	720	723	PF01048	0.588
MOD_GlcNHglycan	732	735	PF01048	0.497
MOD_GlcNHglycan	79	82	PF01048	0.438
MOD_GlcNHglycan	803	806	PF01048	0.660
MOD_GlcNHglycan	847	850	PF01048	0.582
MOD_GlcNHglycan	899	902	PF01048	0.544
MOD_GlcNHglycan	904	907	PF01048	0.438
MOD_GlcNHglycan	922	925	PF01048	0.417
MOD_GSK3_1	190	197	PF00069	0.619
MOD_GSK3_1	204	211	PF00069	0.676
MOD_GSK3_1	237	244	PF00069	0.478
MOD_GSK3_1	245	252	PF00069	0.431
MOD_GSK3_1	287	294	PF00069	0.366
MOD_GSK3_1	3	10	PF00069	0.436
MOD_GSK3_1	476	483	PF00069	0.472
MOD_GSK3_1	595	602	PF00069	0.480
MOD_GSK3_1	610	617	PF00069	0.420
MOD_GSK3_1	62	69	PF00069	0.431
MOD_GSK3_1	621	628	PF00069	0.550
MOD_GSK3_1	634	641	PF00069	0.655
MOD_GSK3_1	643	650	PF00069	0.700
MOD_GSK3_1	658	665	PF00069	0.706
MOD_GSK3_1	77	84	PF00069	0.451
MOD_GSK3_1	815	822	PF00069	0.576
MOD_GSK3_1	92	99	PF00069	0.513
MOD_LATS_1	619	625	PF00433	0.602
MOD_NEK2_1	140	145	PF00069	0.446
MOD_NEK2_1	2	7	PF00069	0.445
MOD_NEK2_1	237	242	PF00069	0.520
MOD_NEK2_1	27	32	PF00069	0.546
MOD_NEK2_1	333	338	PF00069	0.406
MOD_NEK2_1	476	481	PF00069	0.487
MOD_NEK2_1	508	513	PF00069	0.489
MOD_NEK2_1	599	604	PF00069	0.609
MOD_NEK2_1	633	638	PF00069	0.654
MOD_NEK2_1	681	686	PF00069	0.460
MOD_NEK2_1	706	711	PF00069	0.561
MOD_NEK2_1	816	821	PF00069	0.559
MOD_NEK2_1	919	924	PF00069	0.432
MOD_NEK2_2	735	740	PF00069	0.538
MOD_NEK2_2	821	826	PF00069	0.525
MOD_PIKK_1	154	160	PF00454	0.428
MOD_PIKK_1	179	185	PF00454	0.595
MOD_PIKK_1	241	247	PF00454	0.562
MOD_PIKK_1	249	255	PF00454	0.596
MOD_PIKK_1	277	283	PF00454	0.441
MOD_PIKK_1	603	609	PF00454	0.480
MOD_PIKK_1	628	634	PF00454	0.695
MOD_PIKK_1	638	644	PF00454	0.674
MOD_PIKK_1	645	651	PF00454	0.575
MOD_PIKK_1	706	712	PF00454	0.681
MOD_PIKK_1	931	937	PF00454	0.584
MOD_PK_1	643	649	PF00069	0.569
MOD_PKA_1	8	14	PF00069	0.433
MOD_PKA_2	265	271	PF00069	0.523
MOD_PKA_2	501	507	PF00069	0.659
MOD_PKA_2	615	621	PF00069	0.578
MOD_PKA_2	628	634	PF00069	0.557
MOD_PKA_2	63	69	PF00069	0.412
MOD_PKA_2	662	668	PF00069	0.637
MOD_PKA_2	72	78	PF00069	0.459
MOD_PKA_2	798	804	PF00069	0.543
MOD_PKA_2	81	87	PF00069	0.633
MOD_PKA_2	816	822	PF00069	0.473
MOD_PKA_2	845	851	PF00069	0.598
MOD_PKB_1	861	869	PF00069	0.491
MOD_Plk_1	476	482	PF00069	0.533
MOD_Plk_1	599	605	PF00069	0.501
MOD_Plk_1	87	93	PF00069	0.502
MOD_Plk_2-3	194	200	PF00069	0.474
MOD_Plk_2-3	656	662	PF00069	0.504
MOD_Plk_4	28	34	PF00069	0.446
MOD_Plk_4	287	293	PF00069	0.369
MOD_Plk_4	476	482	PF00069	0.459
MOD_Plk_4	514	520	PF00069	0.429
MOD_Plk_4	565	571	PF00069	0.579
MOD_Plk_4	681	687	PF00069	0.501
MOD_Plk_4	821	827	PF00069	0.549
MOD_ProDKin_1	182	188	PF00069	0.545
MOD_ProDKin_1	260	266	PF00069	0.599
MOD_ProDKin_1	53	59	PF00069	0.449
MOD_ProDKin_1	634	640	PF00069	0.667
MOD_ProDKin_1	876	882	PF00069	0.489
MOD_ProDKin_1	96	102	PF00069	0.444
TRG_DiLeu_BaEn_1	136	141	PF01217	0.450
TRG_DiLeu_BaEn_1	464	469	PF01217	0.420
TRG_DiLeu_BaEn_1	938	943	PF01217	0.472
TRG_DiLeu_BaEn_4	938	944	PF01217	0.535
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.541
TRG_DiLeu_BaLyEn_6	417	422	PF01217	0.273
TRG_DiLeu_BaLyEn_6	532	537	PF01217	0.480
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.568
TRG_ENDOCYTIC_2	300	303	PF00928	0.485
TRG_ENDOCYTIC_2	58	61	PF00928	0.551
TRG_ENDOCYTIC_2	586	589	PF00928	0.433
TRG_ENDOCYTIC_2	692	695	PF00928	0.450
TRG_ENDOCYTIC_2	841	844	PF00928	0.492
TRG_ER_diArg_1	266	269	PF00400	0.505
TRG_ER_diArg_1	406	408	PF00400	0.467
TRG_ER_diArg_1	501	503	PF00400	0.605
TRG_ER_diArg_1	673	675	PF00400	0.422
TRG_ER_diArg_1	884	887	PF00400	0.467
TRG_ER_diArg_1	893	896	PF00400	0.471
TRG_ER_diArg_1	943	945	PF00400	0.484
TRG_NLS_MonoExtC_3	881	886	PF00514	0.518
TRG_NLS_MonoExtN_4	880	887	PF00514	0.477
TRG_Pf-PMV_PEXEL_1	173	178	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	760	764	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P797	Leptomonas seymouri	46%	100%
A0A3R7LZS8	Trypanosoma rangeli	28%	100%
A0A3S5H829	Leishmania donovani	89%	100%
A4HPF6	Leishmania braziliensis	75%	100%
A4ID78	Leishmania infantum	90%	100%
D0A3G9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AT68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B0C2	Trypanosoma cruzi	26%	100%