RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted zinc finger protein

Species:

Leishmania major

UniProt:

Q4Q1C6_LEIMA

TriTrypDb:

LmjF.36.2930 , LMJLV39_360038500 , LMJSD75_360038400

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q1C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1C6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	411	415	PF00656	0.733
CLV_NRD_NRD_1	345	347	PF00675	0.391
CLV_NRD_NRD_1	427	429	PF00675	0.582
CLV_NRD_NRD_1	442	444	PF00675	0.436
CLV_NRD_NRD_1	511	513	PF00675	0.564
CLV_NRD_NRD_1	547	549	PF00675	0.588
CLV_PCSK_FUR_1	511	515	PF00082	0.549
CLV_PCSK_KEX2_1	345	347	PF00082	0.391
CLV_PCSK_KEX2_1	427	429	PF00082	0.582
CLV_PCSK_KEX2_1	441	443	PF00082	0.454
CLV_PCSK_KEX2_1	511	513	PF00082	0.560
CLV_PCSK_KEX2_1	546	548	PF00082	0.536
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.554
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.572
CLV_PCSK_PC7_1	437	443	PF00082	0.547
CLV_PCSK_SKI1_1	114	118	PF00082	0.438
CLV_PCSK_SKI1_1	287	291	PF00082	0.450
DEG_APCC_DBOX_1	113	121	PF00400	0.617
DEG_Nend_Nbox_1	1	3	PF02207	0.507
DOC_CDC14_PxL_1	2	10	PF14671	0.488
DOC_MAPK_gen_1	441	447	PF00069	0.744
DOC_PP1_RVXF_1	270	276	PF00149	0.635
DOC_PP4_FxxP_1	71	74	PF00568	0.542
DOC_USP7_MATH_1	143	147	PF00917	0.310
DOC_USP7_MATH_1	348	352	PF00917	0.679
DOC_USP7_MATH_1	368	372	PF00917	0.805
DOC_USP7_MATH_1	401	405	PF00917	0.784
DOC_USP7_MATH_1	496	500	PF00917	0.793
DOC_USP7_MATH_1	532	536	PF00917	0.771
DOC_USP7_MATH_1	74	78	PF00917	0.496
DOC_WW_Pin1_4	258	263	PF00397	0.651
DOC_WW_Pin1_4	416	421	PF00397	0.800
DOC_WW_Pin1_4	461	466	PF00397	0.783
DOC_WW_Pin1_4	489	494	PF00397	0.764
DOC_WW_Pin1_4	497	502	PF00397	0.777
DOC_WW_Pin1_4	70	75	PF00397	0.485
LIG_14-3-3_CanoR_1	192	198	PF00244	0.415
LIG_14-3-3_CanoR_1	369	373	PF00244	0.761
LIG_14-3-3_CanoR_1	393	399	PF00244	0.730
LIG_14-3-3_CanoR_1	402	408	PF00244	0.787
LIG_14-3-3_CanoR_1	442	446	PF00244	0.706
LIG_14-3-3_CanoR_1	60	65	PF00244	0.515
LIG_14-3-3_CanoR_1	67	72	PF00244	0.456
LIG_Actin_WH2_2	179	194	PF00022	0.492
LIG_APCC_ABBA_1	230	235	PF00400	0.682
LIG_BRCT_BRCA1_1	76	80	PF00533	0.503
LIG_CSL_BTD_1	71	74	PF09270	0.487
LIG_CtBP_PxDLS_1	423	427	PF00389	0.781
LIG_EH_1	230	234	PF12763	0.727
LIG_eIF4E_1	24	30	PF01652	0.438
LIG_FHA_1	106	112	PF00498	0.492
LIG_FHA_1	171	177	PF00498	0.437
LIG_FHA_1	179	185	PF00498	0.316
LIG_FHA_1	2	8	PF00498	0.479
LIG_FHA_1	25	31	PF00498	0.467
LIG_FHA_1	301	307	PF00498	0.542
LIG_FHA_1	382	388	PF00498	0.737
LIG_FHA_1	490	496	PF00498	0.820
LIG_FHA_1	538	544	PF00498	0.824
LIG_FHA_2	120	126	PF00498	0.677
LIG_HP1_1	368	372	PF01393	0.777
LIG_LIR_Apic_2	70	74	PF02991	0.540
LIG_LIR_Gen_1	48	55	PF02991	0.373
LIG_LIR_LC3C_4	14	19	PF02991	0.259
LIG_LIR_Nem_3	238	243	PF02991	0.658
LIG_LIR_Nem_3	291	296	PF02991	0.606
LIG_LIR_Nem_3	48	54	PF02991	0.433
LIG_LIR_Nem_3	85	90	PF02991	0.526
LIG_NRBOX	143	149	PF00104	0.415
LIG_Pex14_1	264	268	PF04695	0.655
LIG_Pex14_2	51	55	PF04695	0.492
LIG_Pex14_2	68	72	PF04695	0.339
LIG_RPA_C_Fungi	28	40	PF08784	0.259
LIG_SH2_CRK	160	164	PF00017	0.636
LIG_SH2_CRK	180	184	PF00017	0.417
LIG_SH2_CRK	2	6	PF00017	0.625
LIG_SH2_CRK	286	290	PF00017	0.533
LIG_SH2_GRB2like	24	27	PF00017	0.357
LIG_SH2_NCK_1	2	6	PF00017	0.660
LIG_SH2_NCK_1	88	92	PF00017	0.666
LIG_SH2_SRC	243	246	PF00017	0.566
LIG_SH2_STAP1	13	17	PF00017	0.438
LIG_SH2_STAP1	180	184	PF00017	0.376
LIG_SH2_STAT5	160	163	PF00017	0.540
LIG_SH2_STAT5	180	183	PF00017	0.376
LIG_SH2_STAT5	185	188	PF00017	0.376
LIG_SH2_STAT5	243	246	PF00017	0.531
LIG_SH2_STAT5	256	259	PF00017	0.435
LIG_SH2_STAT5	274	277	PF00017	0.572
LIG_SH3_3	386	392	PF00018	0.704
LIG_SH3_3	417	423	PF00018	0.718
LIG_SH3_3	490	496	PF00018	0.718
LIG_SH3_3	498	504	PF00018	0.633
LIG_SUMO_SIM_anti_2	14	19	PF11976	0.422
LIG_SUMO_SIM_anti_2	173	178	PF11976	0.259
LIG_SUMO_SIM_anti_2	95	100	PF11976	0.438
LIG_TRAF2_1	164	167	PF00917	0.616
LIG_TRAF2_1	464	467	PF00917	0.776
LIG_TRFH_1	160	164	PF08558	0.596
LIG_UBA3_1	42	46	PF00899	0.492
LIG_WRC_WIRS_1	68	73	PF05994	0.690
MOD_CDK_SPxxK_3	461	468	PF00069	0.695
MOD_CK1_1	193	199	PF00069	0.469
MOD_CK1_1	212	218	PF00069	0.556
MOD_CK1_1	258	264	PF00069	0.596
MOD_CK1_1	456	462	PF00069	0.672
MOD_CK2_1	119	125	PF00069	0.521
MOD_CK2_1	132	138	PF00069	0.559
MOD_CK2_1	461	467	PF00069	0.774
MOD_Cter_Amidation	509	512	PF01082	0.804
MOD_GlcNHglycan	117	120	PF01048	0.572
MOD_GlcNHglycan	134	137	PF01048	0.524
MOD_GlcNHglycan	192	195	PF01048	0.410
MOD_GlcNHglycan	226	230	PF01048	0.625
MOD_GlcNHglycan	279	282	PF01048	0.588
MOD_GlcNHglycan	396	399	PF01048	0.632
MOD_GlcNHglycan	410	413	PF01048	0.652
MOD_GlcNHglycan	479	483	PF01048	0.755
MOD_GlcNHglycan	508	511	PF01048	0.827
MOD_GlcNHglycan	534	537	PF01048	0.773
MOD_GSK3_1	115	122	PF00069	0.589
MOD_GSK3_1	158	165	PF00069	0.552
MOD_GSK3_1	166	173	PF00069	0.595
MOD_GSK3_1	193	200	PF00069	0.465
MOD_GSK3_1	25	32	PF00069	0.410
MOD_GSK3_1	254	261	PF00069	0.546
MOD_GSK3_1	402	409	PF00069	0.695
MOD_GSK3_1	414	421	PF00069	0.625
MOD_GSK3_1	518	525	PF00069	0.741
MOD_GSK3_1	70	77	PF00069	0.615
MOD_GSK3_1	82	89	PF00069	0.682
MOD_N-GLC_1	25	30	PF02516	0.438
MOD_NEK2_1	1	6	PF00069	0.601
MOD_NEK2_1	148	153	PF00069	0.422
MOD_NEK2_1	178	183	PF00069	0.393
MOD_NEK2_1	197	202	PF00069	0.576
MOD_NEK2_1	225	230	PF00069	0.631
MOD_NEK2_1	29	34	PF00069	0.573
MOD_NEK2_1	38	43	PF00069	0.334
MOD_NEK2_1	383	388	PF00069	0.677
MOD_NEK2_1	408	413	PF00069	0.602
MOD_NEK2_1	53	58	PF00069	0.417
MOD_NEK2_1	80	85	PF00069	0.697
MOD_NEK2_2	322	327	PF00069	0.417
MOD_PIKK_1	130	136	PF00454	0.624
MOD_PIKK_1	166	172	PF00454	0.668
MOD_PIKK_1	212	218	PF00454	0.647
MOD_PIKK_1	362	368	PF00454	0.531
MOD_PIKK_1	414	420	PF00454	0.694
MOD_PIKK_1	80	86	PF00454	0.636
MOD_PK_1	292	298	PF00069	0.514
MOD_PKA_1	441	447	PF00069	0.697
MOD_PKA_2	368	374	PF00069	0.693
MOD_PKA_2	401	407	PF00069	0.771
MOD_PKA_2	441	447	PF00069	0.643
MOD_Plk_1	124	130	PF00069	0.679
MOD_Plk_1	25	31	PF00069	0.379
MOD_Plk_1	74	80	PF00069	0.499
MOD_Plk_4	143	149	PF00069	0.476
MOD_Plk_4	158	164	PF00069	0.519
MOD_Plk_4	172	178	PF00069	0.243
MOD_Plk_4	179	185	PF00069	0.330
MOD_Plk_4	197	203	PF00069	0.588
MOD_Plk_4	25	31	PF00069	0.399
MOD_Plk_4	38	44	PF00069	0.303
MOD_Plk_4	60	66	PF00069	0.657
MOD_ProDKin_1	258	264	PF00069	0.567
MOD_ProDKin_1	416	422	PF00069	0.772
MOD_ProDKin_1	461	467	PF00069	0.755
MOD_ProDKin_1	489	495	PF00069	0.727
MOD_ProDKin_1	497	503	PF00069	0.742
MOD_ProDKin_1	70	76	PF00069	0.617
TRG_DiLeu_BaLyEn_6	490	495	PF01217	0.754
TRG_ENDOCYTIC_2	159	162	PF00928	0.578
TRG_ENDOCYTIC_2	180	183	PF00928	0.420
TRG_ENDOCYTIC_2	2	5	PF00928	0.632
TRG_ENDOCYTIC_2	207	210	PF00928	0.556
TRG_ENDOCYTIC_2	286	289	PF00928	0.558
TRG_ENDOCYTIC_2	432	435	PF00928	0.709
TRG_ER_diArg_1	345	347	PF00400	0.482
TRG_ER_diArg_1	426	428	PF00400	0.752
TRG_ER_diArg_1	511	514	PF00400	0.705
TRG_ER_diArg_1	546	548	PF00400	0.757
TRG_NLS_Bipartite_1	427	445	PF00514	0.714
TRG_NLS_MonoExtC_3	511	516	PF00514	0.736
TRG_NLS_MonoExtN_4	511	517	PF00514	0.734
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9B9	Leptomonas seymouri	54%	100%
A0A3Q8IJ86	Leishmania donovani	94%	100%
A0A3R7NH33	Trypanosoma rangeli	24%	100%
A4HPF9	Leishmania braziliensis	77%	100%
A4ID81	Leishmania infantum	94%	100%
E9AT71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BKC4	Trypanosoma cruzi	22%	99%