TLC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1C3_LEIMA

TriTrypDb:

LmjF.36.2960 , LMJLV39_360038800 , LMJSD75_360038700

Length:

132

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q1C3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1C3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	71	75	PF00082	0.512
CLV_PCSK_SKI1_1	84	88	PF00082	0.500
DEG_APCC_DBOX_1	83	91	PF00400	0.333
DEG_Nend_Nbox_1	1	3	PF02207	0.698
DOC_CYCLIN_RxL_1	68	78	PF00134	0.361
DOC_PP4_FxxP_1	65	68	PF00568	0.309
LIG_APCC_ABBA_1	62	67	PF00400	0.227
LIG_APCC_ABBAyCdc20_2	61	67	PF00400	0.227
LIG_BRCT_BRCA1_1	59	63	PF00533	0.330
LIG_BRCT_BRCA1_1	88	92	PF00533	0.324
LIG_FHA_1	101	107	PF00498	0.329
LIG_FHA_1	6	12	PF00498	0.572
LIG_FHA_2	76	82	PF00498	0.358
LIG_GBD_Chelix_1	45	53	PF00786	0.382
LIG_LIR_Gen_1	109	116	PF02991	0.410
LIG_LIR_Gen_1	15	25	PF02991	0.581
LIG_LIR_Gen_1	60	69	PF02991	0.385
LIG_LIR_Nem_3	109	114	PF02991	0.304
LIG_LIR_Nem_3	15	20	PF02991	0.583
LIG_LIR_Nem_3	60	66	PF02991	0.429
LIG_NRBOX	86	92	PF00104	0.339
LIG_Pex14_2	2	6	PF04695	0.528
LIG_SH2_CRK	50	54	PF00017	0.382
LIG_SH2_CRK	88	92	PF00017	0.367
LIG_SH2_STAP1	7	11	PF00017	0.515
LIG_SH2_STAP1	88	92	PF00017	0.367
LIG_SH2_STAT3	116	119	PF00017	0.435
LIG_SH2_STAT5	121	124	PF00017	0.532
LIG_SH2_STAT5	7	10	PF00017	0.583
LIG_SUMO_SIM_par_1	102	107	PF11976	0.332
LIG_SUMO_SIM_par_1	72	78	PF11976	0.381
LIG_TYR_ITIM	86	91	PF00017	0.384
LIG_WRC_WIRS_1	105	110	PF05994	0.403
MOD_CK1_1	96	102	PF00069	0.414
MOD_CK2_1	75	81	PF00069	0.394
MOD_GlcNHglycan	95	98	PF01048	0.672
MOD_GSK3_1	106	113	PF00069	0.297
MOD_GSK3_1	86	93	PF00069	0.325
MOD_GSK3_1	96	103	PF00069	0.346
MOD_NEK2_1	106	111	PF00069	0.246
MOD_NEK2_1	57	62	PF00069	0.403
MOD_NEK2_1	75	80	PF00069	0.256
MOD_NEK2_1	90	95	PF00069	0.377
MOD_PIKK_1	90	96	PF00454	0.405
MOD_Plk_4	100	106	PF00069	0.255
MOD_Plk_4	110	116	PF00069	0.334
MOD_Plk_4	31	37	PF00069	0.591
MOD_Plk_4	86	92	PF00069	0.398
TRG_DiLeu_BaEn_1	81	86	PF01217	0.358
TRG_ENDOCYTIC_2	121	124	PF00928	0.545
TRG_ENDOCYTIC_2	17	20	PF00928	0.616
TRG_ENDOCYTIC_2	50	53	PF00928	0.395
TRG_ENDOCYTIC_2	88	91	PF00928	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Z5	Leptomonas seymouri	57%	100%
A0A1X0NKL9	Trypanosomatidae	39%	99%
A0A3Q8IP15	Leishmania donovani	95%	100%
A0A3R7KH99	Trypanosoma rangeli	40%	100%
A4HPG2	Leishmania braziliensis	83%	100%
A4ID84	Leishmania infantum	94%	100%
E9AT74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%