Endoplasmic reticulum transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1C2_LEIMA

TriTrypDb:

LmjF.36.2970 , LMJLV39_360038900 , LMJSD75_360038800

Length:

171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q1C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1C2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.601
CLV_NRD_NRD_1	146	148	PF00675	0.465
CLV_NRD_NRD_1	154	156	PF00675	0.421
CLV_PCSK_FUR_1	155	159	PF00082	0.447
CLV_PCSK_KEX2_1	145	147	PF00082	0.432
CLV_PCSK_KEX2_1	157	159	PF00082	0.447
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.432
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.447
DEG_Nend_Nbox_1	1	3	PF02207	0.768
DOC_MAPK_gen_1	145	153	PF00069	0.603
DOC_MAPK_gen_1	27	35	PF00069	0.391
DOC_MAPK_gen_1	77	85	PF00069	0.524
DOC_MAPK_MEF2A_6	52	61	PF00069	0.407
DOC_MAPK_MEF2A_6	77	85	PF00069	0.524
DOC_PP4_FxxP_1	20	23	PF00568	0.376
LIG_Actin_RPEL_3	62	81	PF02755	0.376
LIG_DCNL_PONY_1	1	4	PF03556	0.593
LIG_EH1_1	111	119	PF00400	0.359
LIG_eIF4E_1	112	118	PF01652	0.382
LIG_FHA_1	114	120	PF00498	0.340
LIG_FHA_2	135	141	PF00498	0.686
LIG_GBD_Chelix_1	25	33	PF00786	0.536
LIG_Integrin_RGD_1	30	32	PF01839	0.600
LIG_LIR_Nem_3	7	13	PF02991	0.558
LIG_SH2_GRB2like	48	51	PF00017	0.407
LIG_SH2_PTP2	56	59	PF00017	0.430
LIG_SH2_STAT5	112	115	PF00017	0.357
LIG_SH2_STAT5	13	16	PF00017	0.487
LIG_SH2_STAT5	48	51	PF00017	0.461
LIG_SH2_STAT5	56	59	PF00017	0.391
LIG_SH2_STAT5	84	87	PF00017	0.444
LIG_SH2_STAT5	96	99	PF00017	0.301
LIG_SUMO_SIM_anti_2	116	121	PF11976	0.503
LIG_SUMO_SIM_anti_2	149	155	PF11976	0.631
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.544
LIG_SUMO_SIM_par_1	84	90	PF11976	0.429
LIG_TYR_ITIM	54	59	PF00017	0.430
LIG_WRC_WIRS_1	88	93	PF05994	0.501
MOD_CK2_1	134	140	PF00069	0.639
MOD_N-GLC_1	120	125	PF02516	0.470
MOD_NEK2_1	2	7	PF00069	0.695
MOD_NEK2_1	65	70	PF00069	0.430
MOD_Plk_1	120	126	PF00069	0.470
MOD_Plk_4	113	119	PF00069	0.350
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.424
TRG_ENDOCYTIC_2	56	59	PF00928	0.380
TRG_ER_diLys_1	168	171	PF00400	0.693
TRG_NLS_Bipartite_1	145	159	PF00514	0.632
TRG_NLS_MonoCore_2	154	159	PF00514	0.696
TRG_NLS_MonoExtC_3	154	160	PF00514	0.695
TRG_Pf-PMV_PEXEL_1	27	32	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P795	Leptomonas seymouri	53%	100%
A0A1X0NL06	Trypanosomatidae	28%	100%
A0A3Q8IJG9	Leishmania donovani	92%	100%
A4HPG3	Leishmania braziliensis	81%	100%
A4ID85	Leishmania infantum	92%	100%
E9AT75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%