Bromo domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

bromodomain factor 2 protein, putative

Species:

Leishmania major

UniProt:

Q4Q1C1_LEIMA

TriTrypDb:

LmjF.36.2980 , LMJLV39_360039100 , LMJSD75_360039000

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1C1

PDB structure(s): 5c4q_A , 5c4q_B

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.684
CLV_C14_Caspase3-7	218	222	PF00656	0.659
CLV_NRD_NRD_1	134	136	PF00675	0.507
CLV_NRD_NRD_1	169	171	PF00675	0.594
CLV_NRD_NRD_1	57	59	PF00675	0.404
CLV_PCSK_KEX2_1	169	171	PF00082	0.558
CLV_PCSK_KEX2_1	5	7	PF00082	0.528
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.528
CLV_PCSK_SKI1_1	98	102	PF00082	0.412
DEG_Nend_UBRbox_2	1	3	PF02207	0.670
DEG_SCF_TRCP1_1	205	210	PF00400	0.716
DOC_CKS1_1	48	53	PF01111	0.287
DOC_MAPK_FxFP_2	32	35	PF00069	0.287
DOC_MAPK_gen_1	98	107	PF00069	0.494
DOC_PP4_FxxP_1	32	35	PF00568	0.266
DOC_USP7_MATH_1	108	112	PF00917	0.413
DOC_USP7_UBL2_3	136	140	PF12436	0.580
DOC_USP7_UBL2_3	98	102	PF12436	0.461
DOC_WW_Pin1_4	47	52	PF00397	0.287
LIG_APCC_ABBAyCdc20_2	8	14	PF00400	0.365
LIG_BRCT_BRCA1_1	179	183	PF00533	0.498
LIG_CtBP_PxDLS_1	51	55	PF00389	0.266
LIG_FHA_1	122	128	PF00498	0.558
LIG_FHA_2	211	217	PF00498	0.595
LIG_FHA_2	48	54	PF00498	0.302
LIG_FHA_2	66	72	PF00498	0.411
LIG_GBD_Chelix_1	76	84	PF00786	0.281
LIG_LIR_Gen_1	91	100	PF02991	0.411
LIG_LIR_Nem_3	91	96	PF02991	0.393
LIG_SH2_NCK_1	45	49	PF00017	0.411
LIG_SH2_STAT5	104	107	PF00017	0.367
LIG_SH3_3	45	51	PF00018	0.331
LIG_SUMO_SIM_anti_2	75	81	PF11976	0.418
LIG_SUMO_SIM_par_1	75	81	PF11976	0.287
LIG_TRAF2_1	198	201	PF00917	0.616
LIG_TRAF2_1	7	10	PF00917	0.485
MOD_CK1_1	111	117	PF00069	0.495
MOD_CK1_1	181	187	PF00069	0.647
MOD_CK1_1	210	216	PF00069	0.659
MOD_CK1_1	219	225	PF00069	0.588
MOD_CK2_1	194	200	PF00069	0.620
MOD_CK2_1	34	40	PF00069	0.281
MOD_CK2_1	65	71	PF00069	0.373
MOD_GlcNHglycan	110	113	PF01048	0.387
MOD_GlcNHglycan	184	187	PF01048	0.676
MOD_GlcNHglycan	205	208	PF01048	0.787
MOD_GlcNHglycan	223	226	PF01048	0.754
MOD_GlcNHglycan	36	39	PF01048	0.294
MOD_GSK3_1	177	184	PF00069	0.646
MOD_GSK3_1	201	208	PF00069	0.654
MOD_GSK3_1	219	226	PF00069	0.677
MOD_NEK2_1	1	6	PF00069	0.700
MOD_NEK2_1	52	57	PF00069	0.360
MOD_NEK2_1	78	83	PF00069	0.360
MOD_PIKK_1	88	94	PF00454	0.324
MOD_PKA_1	169	175	PF00069	0.596
MOD_PKA_2	108	114	PF00069	0.363
MOD_PKA_2	168	174	PF00069	0.578
MOD_Plk_1	129	135	PF00069	0.504
MOD_Plk_1	216	222	PF00069	0.696
MOD_Plk_1	52	58	PF00069	0.266
MOD_Plk_2-3	216	222	PF00069	0.741
MOD_Plk_4	15	21	PF00069	0.427
MOD_ProDKin_1	47	53	PF00069	0.287
MOD_SUMO_rev_2	138	145	PF00179	0.527
TRG_ENDOCYTIC_2	104	107	PF00928	0.349
TRG_ENDOCYTIC_2	44	47	PF00928	0.266

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7A0	Leptomonas seymouri	70%	100%
A0A0S4KPA6	Bodo saltans	39%	91%
A0A1X0NM37	Trypanosomatidae	54%	100%
A0A3Q8IW45	Leishmania donovani	92%	99%
A0A422NLU0	Trypanosoma rangeli	52%	100%
A4HPG4	Leishmania braziliensis	77%	99%
A4ID86	Leishmania infantum	92%	99%
D0A3H5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AT76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	98%
V5BPW0	Trypanosoma cruzi	54%	100%