Putative ATP-dependent RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase, putative

Species:

Leishmania major

UniProt:

Q4Q1B9_LEIMA

TriTrypDb:

LmjF.36.3000 , LMJLV39_360039300 , LMJSD75_360039200

Length:

968

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1B9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1B9

Function

Biological processes
Term	Name	Level	Count
GO:0000460	maturation of 5.8S rRNA	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006401	RNA catabolic process	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	2
GO:0019439	aromatic compound catabolic process	4	12
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034655	nucleobase-containing compound catabolic process	4	12
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0044270	cellular nitrogen compound catabolic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0046700	heterocycle catabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901361	organic cyclic compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003724	RNA helicase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008186	ATP-dependent activity, acting on RNA	2	12
GO:0016787	hydrolase activity	2	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.460
CLV_C14_Caspase3-7	54	58	PF00656	0.434
CLV_C14_Caspase3-7	670	674	PF00656	0.552
CLV_NRD_NRD_1	29	31	PF00675	0.547
CLV_NRD_NRD_1	355	357	PF00675	0.468
CLV_NRD_NRD_1	446	448	PF00675	0.237
CLV_NRD_NRD_1	529	531	PF00675	0.314
CLV_NRD_NRD_1	746	748	PF00675	0.352
CLV_NRD_NRD_1	782	784	PF00675	0.370
CLV_NRD_NRD_1	794	796	PF00675	0.247
CLV_NRD_NRD_1	922	924	PF00675	0.247
CLV_PCSK_FUR_1	27	31	PF00082	0.597
CLV_PCSK_KEX2_1	26	28	PF00082	0.598
CLV_PCSK_KEX2_1	29	31	PF00082	0.556
CLV_PCSK_KEX2_1	369	371	PF00082	0.247
CLV_PCSK_KEX2_1	446	448	PF00082	0.237
CLV_PCSK_KEX2_1	506	508	PF00082	0.252
CLV_PCSK_KEX2_1	529	531	PF00082	0.305
CLV_PCSK_KEX2_1	746	748	PF00082	0.296
CLV_PCSK_KEX2_1	782	784	PF00082	0.370
CLV_PCSK_KEX2_1	85	87	PF00082	0.248
CLV_PCSK_KEX2_1	922	924	PF00082	0.247
CLV_PCSK_KEX2_1	957	959	PF00082	0.247
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.616
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.258
CLV_PCSK_PC1ET2_1	506	508	PF00082	0.297
CLV_PCSK_PC1ET2_1	746	748	PF00082	0.296
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.248
CLV_PCSK_PC1ET2_1	957	959	PF00082	0.247
CLV_PCSK_SKI1_1	135	139	PF00082	0.247
CLV_PCSK_SKI1_1	321	325	PF00082	0.385
CLV_PCSK_SKI1_1	397	401	PF00082	0.247
CLV_PCSK_SKI1_1	430	434	PF00082	0.247
CLV_PCSK_SKI1_1	469	473	PF00082	0.439
CLV_PCSK_SKI1_1	518	522	PF00082	0.258
CLV_PCSK_SKI1_1	568	572	PF00082	0.260
CLV_PCSK_SKI1_1	767	771	PF00082	0.536
CLV_PCSK_SKI1_1	819	823	PF00082	0.247
CLV_PCSK_SKI1_1	866	870	PF00082	0.251
CLV_PCSK_SKI1_1	899	903	PF00082	0.258
CLV_PCSK_SKI1_1	948	952	PF00082	0.258
CLV_Separin_Metazoa	132	136	PF03568	0.447
CLV_Separin_Metazoa	143	147	PF03568	0.447
CLV_Separin_Metazoa	926	930	PF03568	0.491
DEG_APCC_DBOX_1	445	453	PF00400	0.508
DOC_ANK_TNKS_1	935	942	PF00023	0.447
DOC_CYCLIN_RxL_1	394	404	PF00134	0.447
DOC_MAPK_gen_1	446	454	PF00069	0.500
DOC_MAPK_gen_1	529	537	PF00069	0.508
DOC_MAPK_gen_1	676	684	PF00069	0.538
DOC_MAPK_MEF2A_6	29	38	PF00069	0.534
DOC_MAPK_MEF2A_6	304	312	PF00069	0.377
DOC_MAPK_MEF2A_6	384	391	PF00069	0.447
DOC_MAPK_MEF2A_6	447	456	PF00069	0.500
DOC_PP1_RVXF_1	162	169	PF00149	0.447
DOC_PP1_RVXF_1	326	332	PF00149	0.405
DOC_PP1_RVXF_1	395	401	PF00149	0.447
DOC_PP1_RVXF_1	412	419	PF00149	0.447
DOC_PP1_RVXF_1	956	963	PF00149	0.447
DOC_PP2B_LxvP_1	409	412	PF13499	0.447
DOC_PP4_FxxP_1	608	611	PF00568	0.525
DOC_PP4_FxxP_1	847	850	PF00568	0.447
DOC_PP4_FxxP_1	853	856	PF00568	0.447
DOC_USP7_MATH_1	249	253	PF00917	0.432
DOC_USP7_MATH_1	347	351	PF00917	0.515
DOC_USP7_MATH_1	538	542	PF00917	0.441
DOC_USP7_MATH_1	600	604	PF00917	0.460
DOC_USP7_MATH_1	625	629	PF00917	0.473
DOC_USP7_MATH_1	63	67	PF00917	0.447
DOC_USP7_MATH_1	868	872	PF00917	0.458
DOC_USP7_MATH_1	939	943	PF00917	0.458
DOC_WW_Pin1_4	631	636	PF00397	0.547
DOC_WW_Pin1_4	730	735	PF00397	0.533
DOC_WW_Pin1_4	840	845	PF00397	0.447
DOC_WW_Pin1_4	88	93	PF00397	0.447
DOC_WW_Pin1_4	934	939	PF00397	0.447
LIG_14-3-3_CanoR_1	507	515	PF00244	0.475
LIG_14-3-3_CanoR_1	584	591	PF00244	0.464
LIG_14-3-3_CanoR_1	86	92	PF00244	0.447
LIG_14-3-3_CanoR_1	866	871	PF00244	0.458
LIG_14-3-3_CanoR_1	929	938	PF00244	0.533
LIG_Actin_WH2_2	130	148	PF00022	0.447
LIG_Actin_WH2_2	780	797	PF00022	0.368
LIG_BRCT_BRCA1_1	104	108	PF00533	0.458
LIG_Clathr_ClatBox_1	493	497	PF01394	0.387
LIG_deltaCOP1_diTrp_1	590	599	PF00928	0.508
LIG_FAT_LD_1	924	932	PF03623	0.508
LIG_FHA_1	128	134	PF00498	0.453
LIG_FHA_1	140	146	PF00498	0.447
LIG_FHA_1	169	175	PF00498	0.458
LIG_FHA_1	202	208	PF00498	0.511
LIG_FHA_1	611	617	PF00498	0.512
LIG_FHA_1	69	75	PF00498	0.447
LIG_FHA_1	7	13	PF00498	0.541
LIG_FHA_1	733	739	PF00498	0.458
LIG_FHA_1	812	818	PF00498	0.447
LIG_FHA_1	825	831	PF00498	0.447
LIG_FHA_1	88	94	PF00498	0.447
LIG_FHA_2	26	32	PF00498	0.646
LIG_FHA_2	431	437	PF00498	0.447
LIG_FHA_2	46	52	PF00498	0.316
LIG_FHA_2	545	551	PF00498	0.533
LIG_FHA_2	802	808	PF00498	0.447
LIG_FHA_2	909	915	PF00498	0.538
LIG_LIR_Apic_2	845	850	PF02991	0.447
LIG_LIR_Apic_2	852	856	PF02991	0.447
LIG_LIR_Gen_1	105	114	PF02991	0.447
LIG_LIR_Gen_1	229	237	PF02991	0.371
LIG_LIR_Gen_1	415	424	PF02991	0.447
LIG_LIR_Gen_1	436	444	PF02991	0.447
LIG_LIR_Gen_1	486	494	PF02991	0.323
LIG_LIR_Gen_1	508	515	PF02991	0.458
LIG_LIR_Gen_1	652	661	PF02991	0.455
LIG_LIR_Nem_3	105	111	PF02991	0.447
LIG_LIR_Nem_3	212	217	PF02991	0.393
LIG_LIR_Nem_3	229	235	PF02991	0.370
LIG_LIR_Nem_3	415	421	PF02991	0.447
LIG_LIR_Nem_3	486	490	PF02991	0.323
LIG_LIR_Nem_3	508	512	PF02991	0.447
LIG_LIR_Nem_3	540	546	PF02991	0.447
LIG_LIR_Nem_3	652	658	PF02991	0.457
LIG_LIR_Nem_3	740	745	PF02991	0.461
LIG_LIR_Nem_3	815	821	PF02991	0.447
LIG_LYPXL_S_1	306	310	PF13949	0.331
LIG_LYPXL_yS_3	307	310	PF13949	0.332
LIG_NRBOX	812	818	PF00104	0.447
LIG_PDZ_Class_2	963	968	PF00595	0.382
LIG_Pex14_2	104	108	PF04695	0.447
LIG_PTB_Apo_2	602	609	PF02174	0.552
LIG_PTB_Apo_2	95	102	PF02174	0.447
LIG_SH2_CRK	214	218	PF00017	0.390
LIG_SH2_CRK	487	491	PF00017	0.329
LIG_SH2_CRK	89	93	PF00017	0.458
LIG_SH2_PTP2	181	184	PF00017	0.447
LIG_SH2_SRC	222	225	PF00017	0.338
LIG_SH2_SRC	75	78	PF00017	0.458
LIG_SH2_STAP1	649	653	PF00017	0.451
LIG_SH2_STAT5	181	184	PF00017	0.447
LIG_SH2_STAT5	222	225	PF00017	0.352
LIG_SH2_STAT5	431	434	PF00017	0.440
LIG_SH2_STAT5	437	440	PF00017	0.434
LIG_SH2_STAT5	546	549	PF00017	0.488
LIG_SH2_STAT5	641	644	PF00017	0.461
LIG_SH2_STAT5	649	652	PF00017	0.429
LIG_SH2_STAT5	786	789	PF00017	0.358
LIG_SH2_STAT5	89	92	PF00017	0.458
LIG_SH2_STAT5	895	898	PF00017	0.488
LIG_SH3_3	666	672	PF00018	0.454
LIG_SUMO_SIM_anti_2	169	177	PF11976	0.458
LIG_SUMO_SIM_anti_2	385	391	PF11976	0.447
LIG_SUMO_SIM_par_1	307	313	PF11976	0.328
LIG_SUMO_SIM_par_1	826	835	PF11976	0.447
LIG_TRAF2_1	52	55	PF00917	0.497
LIG_TRAF2_1	520	523	PF00917	0.517
LIG_TRAF2_1	531	534	PF00917	0.488
LIG_TYR_ITIM	485	490	PF00017	0.335
LIG_TYR_ITSM	210	217	PF00017	0.392
LIG_UBA3_1	231	238	PF00899	0.454
LIG_UBA3_1	294	299	PF00899	0.388
LIG_UBA3_1	379	384	PF00899	0.493
LIG_UBA3_1	812	819	PF00899	0.447
LIG_WRC_WIRS_1	311	316	PF05994	0.346
LIG_WRC_WIRS_1	42	47	PF05994	0.419
LIG_WRC_WIRS_1	480	485	PF05994	0.477
MOD_CDC14_SPxK_1	91	94	PF00782	0.447
MOD_CDK_SPxK_1	88	94	PF00069	0.447
MOD_CK1_1	290	296	PF00069	0.574
MOD_CK1_1	401	407	PF00069	0.447
MOD_CK1_1	6	12	PF00069	0.518
MOD_CK1_1	609	615	PF00069	0.466
MOD_CK1_1	62	68	PF00069	0.458
MOD_CK1_1	628	634	PF00069	0.383
MOD_CK1_1	639	645	PF00069	0.479
MOD_CK1_1	824	830	PF00069	0.472
MOD_CK1_1	871	877	PF00069	0.447
MOD_CK1_1	908	914	PF00069	0.552
MOD_CK2_1	25	31	PF00069	0.710
MOD_CK2_1	290	296	PF00069	0.552
MOD_CK2_1	347	353	PF00069	0.529
MOD_CK2_1	430	436	PF00069	0.447
MOD_CK2_1	528	534	PF00069	0.556
MOD_CK2_1	544	550	PF00069	0.506
MOD_CK2_1	802	808	PF00069	0.447
MOD_CK2_1	878	884	PF00069	0.463
MOD_CK2_1	886	892	PF00069	0.426
MOD_CK2_1	908	914	PF00069	0.508
MOD_Cter_Amidation	444	447	PF01082	0.237
MOD_GlcNHglycan	184	187	PF01048	0.247
MOD_GlcNHglycan	376	379	PF01048	0.247
MOD_GlcNHglycan	440	443	PF01048	0.247
MOD_GlcNHglycan	540	543	PF01048	0.341
MOD_GlcNHglycan	61	64	PF01048	0.249
MOD_GlcNHglycan	630	633	PF01048	0.297
MOD_GlcNHglycan	65	68	PF01048	0.245
MOD_GlcNHglycan	700	703	PF01048	0.325
MOD_GlcNHglycan	870	873	PF01048	0.255
MOD_GlcNHglycan	932	935	PF01048	0.333
MOD_GSK3_1	112	119	PF00069	0.447
MOD_GSK3_1	197	204	PF00069	0.485
MOD_GSK3_1	283	290	PF00069	0.640
MOD_GSK3_1	399	406	PF00069	0.447
MOD_GSK3_1	41	48	PF00069	0.480
MOD_GSK3_1	412	419	PF00069	0.447
MOD_GSK3_1	479	486	PF00069	0.348
MOD_GSK3_1	55	62	PF00069	0.405
MOD_GSK3_1	606	613	PF00069	0.479
MOD_GSK3_1	63	70	PF00069	0.440
MOD_GSK3_1	636	643	PF00069	0.488
MOD_GSK3_1	649	656	PF00069	0.392
MOD_GSK3_1	659	666	PF00069	0.474
MOD_GSK3_1	709	716	PF00069	0.496
MOD_GSK3_1	862	869	PF00069	0.479
MOD_GSK3_1	930	937	PF00069	0.533
MOD_N-GLC_1	268	273	PF02516	0.702
MOD_N-GLC_1	606	611	PF02516	0.297
MOD_N-GLC_1	879	884	PF02516	0.303
MOD_NEK2_1	1	6	PF00069	0.539
MOD_NEK2_1	184	189	PF00069	0.447
MOD_NEK2_1	324	329	PF00069	0.443
MOD_NEK2_1	45	50	PF00069	0.497
MOD_NEK2_1	479	484	PF00069	0.355
MOD_NEK2_1	505	510	PF00069	0.447
MOD_NEK2_1	891	896	PF00069	0.428
MOD_NEK2_1	962	967	PF00069	0.499
MOD_NEK2_2	116	121	PF00069	0.447
MOD_NEK2_2	197	202	PF00069	0.331
MOD_NEK2_2	660	665	PF00069	0.469
MOD_PIKK_1	288	294	PF00454	0.528
MOD_PIKK_1	3	9	PF00454	0.526
MOD_PIKK_1	507	513	PF00454	0.548
MOD_PIKK_1	713	719	PF00454	0.495
MOD_PK_1	107	113	PF00069	0.447
MOD_PKA_2	13	19	PF00069	0.753
MOD_PKA_2	139	145	PF00069	0.447
MOD_PKA_2	528	534	PF00069	0.560
MOD_PKA_2	583	589	PF00069	0.469
MOD_Plk_1	116	122	PF00069	0.447
MOD_Plk_1	168	174	PF00069	0.447
MOD_Plk_1	558	564	PF00069	0.543
MOD_Plk_1	878	884	PF00069	0.436
MOD_Plk_1	891	897	PF00069	0.385
MOD_Plk_2-3	879	885	PF00069	0.472
MOD_Plk_4	290	296	PF00069	0.552
MOD_Plk_4	55	61	PF00069	0.447
MOD_Plk_4	8	14	PF00069	0.545
MOD_Plk_4	886	892	PF00069	0.447
MOD_Plk_4	962	968	PF00069	0.504
MOD_ProDKin_1	631	637	PF00069	0.547
MOD_ProDKin_1	730	736	PF00069	0.533
MOD_ProDKin_1	840	846	PF00069	0.447
MOD_ProDKin_1	88	94	PF00069	0.447
MOD_ProDKin_1	934	940	PF00069	0.447
MOD_SUMO_for_1	315	318	PF00179	0.408
MOD_SUMO_for_1	758	761	PF00179	0.486
MOD_SUMO_rev_2	349	359	PF00179	0.477
MOD_SUMO_rev_2	517	526	PF00179	0.533
MOD_SUMO_rev_2	771	777	PF00179	0.414
TRG_DiLeu_BaEn_1	170	175	PF01217	0.458
TRG_DiLeu_BaEn_1	296	301	PF01217	0.458
TRG_DiLeu_BaEn_1	335	340	PF01217	0.397
TRG_DiLeu_BaEn_1	808	813	PF01217	0.447
TRG_DiLeu_BaEn_3	772	778	PF01217	0.407
TRG_DiLeu_BaEn_4	353	359	PF01217	0.505
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.379
TRG_ENDOCYTIC_2	181	184	PF00928	0.447
TRG_ENDOCYTIC_2	214	217	PF00928	0.391
TRG_ENDOCYTIC_2	307	310	PF00928	0.332
TRG_ENDOCYTIC_2	437	440	PF00928	0.447
TRG_ENDOCYTIC_2	487	490	PF00928	0.317
TRG_ER_diArg_1	27	30	PF00400	0.584
TRG_ER_diArg_1	528	530	PF00400	0.545
TRG_ER_diArg_1	781	783	PF00400	0.370
TRG_ER_diArg_1	921	923	PF00400	0.447
TRG_NES_CRM1_1	292	303	PF08389	0.403
TRG_NLS_Bipartite_1	782	799	PF00514	0.374
TRG_NLS_MonoExtC_3	25	30	PF00514	0.615
TRG_NLS_MonoExtN_4	23	30	PF00514	0.618
TRG_Pf-PMV_PEXEL_1	530	534	PF00026	0.269
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.258
TRG_Pf-PMV_PEXEL_1	858	862	PF00026	0.258
TRG_Pf-PMV_PEXEL_1	922	926	PF00026	0.247

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDH1	Leptomonas seymouri	89%	100%
A0A0S4JCF9	Bodo saltans	70%	100%
A0A1X0NKW0	Trypanosomatidae	77%	100%
A0A3R7NR74	Trypanosoma rangeli	76%	100%
A0A3S7XB63	Leishmania donovani	97%	100%
A4HPG6	Leishmania braziliensis	92%	100%
A4ID88	Leishmania infantum	97%	100%
D0A3H7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
E9AT78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
F4JAA5	Arabidopsis thaliana	35%	72%
O13799	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	94%
O14232	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	87%
O59801	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	80%
P35207	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	75%
P42285	Homo sapiens	47%	93%
P47047	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	90%
Q15477	Homo sapiens	36%	78%
Q23223	Caenorhabditis elegans	44%	94%
Q9CZU3	Mus musculus	47%	93%
Q9XIF2	Arabidopsis thaliana	42%	98%
Q9ZBD8	Mycobacterium leprae (strain TN)	29%	100%
Q9ZVW2	Arabidopsis thaliana	42%	97%
V5BPT8	Trypanosoma cruzi	75%	100%