Clathrin coat assembly protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

clathrin coat assembly protein-like protein

Species:

Leishmania major

UniProt:

Q4Q1B6_LEIMA

TriTrypDb:

LmjF.36.3030 , LMJLV39_360039700 , LMJSD75_360039600

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030119	AP-type membrane coat adaptor complex	3	11
GO:0030131	clathrin adaptor complex	4	11
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0098796	membrane protein complex	2	11
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q1B6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1B6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0006897	endocytosis	5	2
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016192	vesicle-mediated transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.547
CLV_NRD_NRD_1	263	265	PF00675	0.335
CLV_PCSK_KEX2_1	100	102	PF00082	0.415
CLV_PCSK_KEX2_1	263	265	PF00082	0.335
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.415
CLV_PCSK_SKI1_1	100	104	PF00082	0.496
CLV_PCSK_SKI1_1	263	267	PF00082	0.427
CLV_PCSK_SKI1_1	318	322	PF00082	0.409
CLV_PCSK_SKI1_1	374	378	PF00082	0.246
CLV_PCSK_SKI1_1	392	396	PF00082	0.398
DEG_APCC_KENBOX_2	102	106	PF00400	0.487
DEG_Nend_Nbox_1	1	3	PF02207	0.343
DOC_CKS1_1	375	380	PF01111	0.208
DOC_MAPK_FxFP_2	119	122	PF00069	0.357
DOC_MAPK_gen_1	100	109	PF00069	0.486
DOC_MAPK_gen_1	301	308	PF00069	0.280
DOC_MAPK_gen_1	318	327	PF00069	0.280
DOC_MAPK_MEF2A_6	171	179	PF00069	0.325
DOC_MAPK_MEF2A_6	318	327	PF00069	0.351
DOC_MAPK_MEF2A_6	388	395	PF00069	0.288
DOC_MAPK_MEF2A_6	52	61	PF00069	0.384
DOC_PP1_RVXF_1	261	268	PF00149	0.331
DOC_PP1_RVXF_1	390	396	PF00149	0.325
DOC_PP1_RVXF_1	50	57	PF00149	0.423
DOC_PP4_FxxP_1	119	122	PF00568	0.357
DOC_PP4_FxxP_1	267	270	PF00568	0.357
DOC_USP7_MATH_1	22	26	PF00917	0.432
DOC_USP7_MATH_1	230	234	PF00917	0.335
DOC_USP7_MATH_1	244	248	PF00917	0.377
DOC_WW_Pin1_4	158	163	PF00397	0.539
DOC_WW_Pin1_4	311	316	PF00397	0.239
DOC_WW_Pin1_4	374	379	PF00397	0.271
LIG_14-3-3_CanoR_1	21	27	PF00244	0.536
LIG_14-3-3_CanoR_1	263	268	PF00244	0.326
LIG_14-3-3_CanoR_1	280	284	PF00244	0.196
LIG_14-3-3_CanoR_1	426	430	PF00244	0.296
LIG_Actin_WH2_2	241	259	PF00022	0.398
LIG_Actin_WH2_2	44	62	PF00022	0.471
LIG_AP2alpha_1	176	180	PF02296	0.406
LIG_APCC_ABBA_1	177	182	PF00400	0.398
LIG_BRCT_BRCA1_1	115	119	PF00533	0.430
LIG_BRCT_BRCA1_1	16	20	PF00533	0.338
LIG_BRCT_BRCA1_1	246	250	PF00533	0.335
LIG_CaM_IQ_9	77	93	PF13499	0.461
LIG_FHA_1	333	339	PF00498	0.311
LIG_FHA_1	38	44	PF00498	0.366
LIG_FHA_1	380	386	PF00498	0.367
LIG_FHA_2	123	129	PF00498	0.451
LIG_FHA_2	300	306	PF00498	0.280
LIG_FHA_2	375	381	PF00498	0.396
LIG_Integrin_RGD_1	11	13	PF01839	0.377
LIG_LIR_Apic_2	116	122	PF02991	0.348
LIG_LIR_Apic_2	266	270	PF02991	0.358
LIG_LIR_Apic_2	383	389	PF02991	0.281
LIG_LIR_Gen_1	104	113	PF02991	0.372
LIG_LIR_Gen_1	174	183	PF02991	0.280
LIG_LIR_Gen_1	271	279	PF02991	0.280
LIG_LIR_Gen_1	62	69	PF02991	0.382
LIG_LIR_LC3C_4	409	412	PF02991	0.398
LIG_LIR_Nem_3	104	109	PF02991	0.357
LIG_LIR_Nem_3	118	124	PF02991	0.367
LIG_LIR_Nem_3	174	179	PF02991	0.295
LIG_LIR_Nem_3	422	427	PF02991	0.287
LIG_LIR_Nem_3	93	97	PF02991	0.418
LIG_LYPXL_yS_3	121	124	PF13949	0.449
LIG_Pex14_2	176	180	PF04695	0.406
LIG_SH2_CRK	347	351	PF00017	0.406
LIG_SH2_NCK_1	347	351	PF00017	0.406
LIG_SH2_SRC	347	350	PF00017	0.390
LIG_SH2_STAP1	427	431	PF00017	0.337
LIG_SH2_STAT5	419	422	PF00017	0.300
LIG_SH2_STAT5	427	430	PF00017	0.259
LIG_SH2_STAT5	65	68	PF00017	0.373
LIG_SH3_3	282	288	PF00018	0.406
LIG_SH3_3	324	330	PF00018	0.307
LIG_SH3_3	409	415	PF00018	0.325
LIG_SUMO_SIM_par_1	65	72	PF11976	0.402
LIG_TRAF2_1	259	262	PF00917	0.335
LIG_TRAF2_1	363	366	PF00917	0.390
MOD_CDK_SPxK_1	158	164	PF00069	0.528
MOD_CDK_SPxxK_3	311	318	PF00069	0.239
MOD_CK1_1	25	31	PF00069	0.417
MOD_CK2_1	122	128	PF00069	0.451
MOD_CK2_1	25	31	PF00069	0.406
MOD_CK2_1	256	262	PF00069	0.456
MOD_CK2_1	299	305	PF00069	0.280
MOD_CK2_1	360	366	PF00069	0.347
MOD_CK2_1	374	380	PF00069	0.385
MOD_DYRK1A_RPxSP_1	311	315	PF00069	0.239
MOD_GlcNHglycan	208	211	PF01048	0.311
MOD_GlcNHglycan	258	261	PF01048	0.398
MOD_GlcNHglycan	292	295	PF01048	0.383
MOD_GlcNHglycan	362	365	PF01048	0.364
MOD_GSK3_1	190	197	PF00069	0.335
MOD_GSK3_1	25	32	PF00069	0.470
MOD_GSK3_1	275	282	PF00069	0.331
MOD_GSK3_1	297	304	PF00069	0.322
MOD_GSK3_1	396	403	PF00069	0.284
MOD_GSK3_1	413	420	PF00069	0.308
MOD_NEK2_1	16	21	PF00069	0.342
MOD_NEK2_1	185	190	PF00069	0.339
MOD_NEK2_1	194	199	PF00069	0.304
MOD_NEK2_1	29	34	PF00069	0.312
MOD_NEK2_1	384	389	PF00069	0.457
MOD_NEK2_1	400	405	PF00069	0.321
MOD_NEK2_1	417	422	PF00069	0.232
MOD_NEK2_1	7	12	PF00069	0.339
MOD_NEK2_2	22	27	PF00069	0.498
MOD_NEK2_2	246	251	PF00069	0.344
MOD_PIKK_1	185	191	PF00454	0.280
MOD_PKA_1	263	269	PF00069	0.335
MOD_PKA_2	147	153	PF00069	0.495
MOD_PKA_2	155	161	PF00069	0.419
MOD_PKA_2	263	269	PF00069	0.380
MOD_PKA_2	279	285	PF00069	0.261
MOD_PKA_2	425	431	PF00069	0.351
MOD_Plk_1	113	119	PF00069	0.398
MOD_Plk_1	306	312	PF00069	0.406
MOD_Plk_4	194	200	PF00069	0.341
MOD_Plk_4	263	269	PF00069	0.367
MOD_Plk_4	413	419	PF00069	0.409
MOD_Plk_4	425	431	PF00069	0.413
MOD_ProDKin_1	158	164	PF00069	0.528
MOD_ProDKin_1	311	317	PF00069	0.239
MOD_ProDKin_1	374	380	PF00069	0.271
MOD_SUMO_rev_2	331	340	PF00179	0.393
MOD_SUMO_rev_2	93	102	PF00179	0.480
TRG_DiLeu_BaEn_1	181	186	PF01217	0.302
TRG_DiLeu_BaEn_1	380	385	PF01217	0.335
TRG_DiLeu_BaEn_4	240	246	PF01217	0.314
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.448
TRG_ENDOCYTIC_2	121	124	PF00928	0.449
TRG_ENDOCYTIC_2	347	350	PF00928	0.406
TRG_ENDOCYTIC_2	427	430	PF00928	0.453
TRG_ENDOCYTIC_2	65	68	PF00928	0.373
TRG_ENDOCYTIC_2	94	97	PF00928	0.539
TRG_ER_diArg_1	263	265	PF00400	0.335
TRG_NES_CRM1_1	166	181	PF08389	0.367
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.366
TRG_PTS1	435	438	PF00515	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6F2	Leptomonas seymouri	25%	92%
A0A0N1I7F0	Leptomonas seymouri	28%	100%
A0A0N1ILY9	Leptomonas seymouri	71%	100%
A0A0N1PAY6	Leptomonas seymouri	23%	97%
A0A0S4INT9	Bodo saltans	26%	96%
A0A0S4JHW9	Bodo saltans	42%	95%
A0A0S4JX54	Bodo saltans	22%	90%
A0A1X0NJW3	Trypanosomatidae	28%	97%
A0A1X0NL86	Trypanosomatidae	47%	100%
A0A1X0NTD3	Trypanosomatidae	31%	100%
A0A3Q8IB94	Leishmania donovani	28%	100%
A0A3Q8IKF7	Leishmania donovani	95%	100%
A0A3R7NKK1	Trypanosoma rangeli	28%	97%
A0A3S7X806	Leishmania donovani	25%	94%
A0A422NHS3	Trypanosoma rangeli	30%	100%
A0A422NLU9	Trypanosoma rangeli	47%	90%
A4HAX6	Leishmania braziliensis	24%	94%
A4HCF3	Leishmania braziliensis	28%	100%
A4HPG9	Leishmania braziliensis	84%	100%
A4HZY5	Leishmania infantum	30%	100%
A4IA35	Leishmania infantum	25%	94%
A4ID91	Leishmania infantum	95%	100%
C9ZM64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZSM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZWJ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	96%
D3ZRP6	Rattus norvegicus	30%	100%
E2RED8	Canis lupus familiaris	24%	97%
E9AT81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AVU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B550	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	94%
F4I562	Arabidopsis thaliana	24%	100%
O00189	Homo sapiens	24%	97%
O22715	Arabidopsis thaliana	32%	100%
O23140	Arabidopsis thaliana	36%	100%
P35585	Mus musculus	32%	100%
P35602	Caenorhabditis elegans	29%	100%
P35603	Caenorhabditis elegans	34%	99%
P38700	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	72%
P47795	Diplobatis ommata	25%	100%
P53676	Rattus norvegicus	26%	100%
P53677	Homo sapiens	26%	100%
P53678	Rattus norvegicus	26%	100%
P54672	Dictyostelium discoideum	36%	100%
P84091	Mus musculus	35%	100%
P84092	Rattus norvegicus	35%	100%
Q00776	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	92%
Q09718	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	98%
Q24K11	Bos taurus	26%	100%
Q29RY8	Bos taurus	23%	97%
Q2KJ81	Bos taurus	32%	100%
Q2PWT8	Rattus norvegicus	23%	97%
Q32Q06	Rattus norvegicus	32%	100%
Q3SYW1	Bos taurus	30%	100%
Q3ZC13	Bos taurus	35%	100%
Q4Q2T6	Leishmania major	24%	94%
Q4QBN3	Leishmania major	29%	100%
Q4R706	Macaca fascicularis	35%	100%
Q54HS9	Dictyostelium discoideum	31%	100%
Q5NVF7	Pongo abelii	35%	100%
Q5R478	Pongo abelii	26%	100%
Q5ZMP6	Gallus gallus	35%	100%
Q5ZMP7	Gallus gallus	25%	100%
Q6NWK2	Danio rerio	34%	100%
Q6P856	Xenopus tropicalis	35%	100%
Q750L8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	24%	97%
Q7ZW98	Danio rerio	35%	100%
Q801Q8	Xenopus laevis	35%	100%
Q8R2R9	Mus musculus	26%	100%
Q96CW1	Homo sapiens	35%	100%
Q99186	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	89%
Q9BXS5	Homo sapiens	32%	100%
Q9GPF0	Dictyostelium discoideum	23%	83%
Q9GPF1	Dictyostelium discoideum	24%	100%
Q9HFE5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q9JKC7	Mus musculus	23%	98%
Q9JKC8	Mus musculus	26%	100%
Q9SAC9	Arabidopsis thaliana	31%	100%
Q9SB50	Arabidopsis thaliana	26%	97%
Q9WVP1	Mus musculus	30%	100%
Q9Y2T2	Homo sapiens	26%	100%
Q9Y6Q5	Homo sapiens	30%	100%
V5BKQ8	Trypanosoma cruzi	22%	100%
V5BLL2	Trypanosoma cruzi	30%	100%
V5D569	Trypanosoma cruzi	26%	88%
V5DGM7	Trypanosoma cruzi	46%	100%