ACT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1B4_LEIMA

TriTrypDb:

LmjF.36.3050 , LMJLV39_360039900 , LMJSD75_360039800

Length:

142

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q1B4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1B4

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	11
GO:0007031	peroxisome organization	5	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	109	111	PF00082	0.615
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.607
CLV_PCSK_SKI1_1	75	79	PF00082	0.448
DOC_CYCLIN_RxL_1	72	82	PF00134	0.524
DOC_MAPK_gen_1	109	117	PF00069	0.580
DOC_MAPK_MEF2A_6	90	98	PF00069	0.452
DOC_PP1_RVXF_1	73	79	PF00149	0.467
DOC_USP7_MATH_1	41	45	PF00917	0.510
DOC_USP7_UBL2_3	28	32	PF12436	0.603
LIG_14-3-3_CanoR_1	110	116	PF00244	0.589
LIG_DCNL_PONY_1	1	4	PF03556	0.473
LIG_FHA_1	112	118	PF00498	0.583
LIG_FHA_1	87	93	PF00498	0.557
LIG_LIR_Gen_1	82	92	PF02991	0.579
LIG_LIR_Nem_3	82	88	PF02991	0.576
LIG_SH2_STAT5	47	50	PF00017	0.434
LIG_SUMO_SIM_anti_2	114	119	PF11976	0.505
LIG_UBA3_1	1	7	PF00899	0.609
MOD_Cter_Amidation	10	13	PF01082	0.573
MOD_GSK3_1	92	99	PF00069	0.504
MOD_NEK2_1	96	101	PF00069	0.651
MOD_Plk_4	111	117	PF00069	0.468
MOD_Plk_4	92	98	PF00069	0.502
MOD_SUMO_rev_2	54	61	PF00179	0.470
TRG_ENDOCYTIC_2	85	88	PF00928	0.431
TRG_ER_diArg_1	73	76	PF00400	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N3	Leptomonas seymouri	74%	68%
A0A0S4JN26	Bodo saltans	28%	73%
A0A1X0NKF5	Trypanosomatidae	47%	72%
A0A3S7XB48	Leishmania donovani	96%	100%
A0A422NM43	Trypanosoma rangeli	41%	71%
A4HPH1	Leishmania braziliensis	92%	68%
A4ID93	Leishmania infantum	96%	100%
D0A3I1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	72%
E9AT83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BKE1	Trypanosoma cruzi	41%	71%