Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1B0_LEIMA

TriTrypDb:

LmjF.36.3090 , LMJLV39_360040300 , LMJSD75_360040200

Length:

823

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1B0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1B0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.707
CLV_C14_Caspase3-7	350	354	PF00656	0.792
CLV_C14_Caspase3-7	643	647	PF00656	0.592
CLV_NRD_NRD_1	53	55	PF00675	0.528
CLV_PCSK_KEX2_1	112	114	PF00082	0.553
CLV_PCSK_KEX2_1	245	247	PF00082	0.677
CLV_PCSK_KEX2_1	53	55	PF00082	0.528
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.553
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.677
CLV_PCSK_SKI1_1	107	111	PF00082	0.620
CLV_PCSK_SKI1_1	11	15	PF00082	0.527
CLV_PCSK_SKI1_1	118	122	PF00082	0.438
CLV_PCSK_SKI1_1	53	57	PF00082	0.649
CLV_PCSK_SKI1_1	531	535	PF00082	0.654
DEG_APCC_DBOX_1	129	137	PF00400	0.638
DEG_Kelch_Keap1_1	287	292	PF01344	0.749
DEG_MDM2_SWIB_1	528	535	PF02201	0.707
DEG_Nend_UBRbox_3	1	3	PF02207	0.818
DEG_SCF_FBW7_1	422	427	PF00400	0.774
DEG_SCF_FBW7_1	700	705	PF00400	0.535
DEG_SPOP_SBC_1	211	215	PF00917	0.635
DEG_SPOP_SBC_1	554	558	PF00917	0.636
DEG_SPOP_SBC_1	573	577	PF00917	0.385
DOC_CKS1_1	136	141	PF01111	0.652
DOC_CYCLIN_RxL_1	50	58	PF00134	0.646
DOC_CYCLIN_yCln2_LP_2	381	387	PF00134	0.854
DOC_USP7_MATH_1	217	221	PF00917	0.573
DOC_USP7_MATH_1	266	270	PF00917	0.857
DOC_USP7_MATH_1	297	301	PF00917	0.648
DOC_USP7_MATH_1	329	333	PF00917	0.796
DOC_USP7_MATH_1	424	428	PF00917	0.850
DOC_USP7_MATH_1	609	613	PF00917	0.559
DOC_USP7_UBL2_3	7	11	PF12436	0.704
DOC_WW_Pin1_4	135	140	PF00397	0.660
DOC_WW_Pin1_4	278	283	PF00397	0.667
DOC_WW_Pin1_4	418	423	PF00397	0.861
DOC_WW_Pin1_4	565	570	PF00397	0.666
DOC_WW_Pin1_4	698	703	PF00397	0.521
DOC_WW_Pin1_4	813	818	PF00397	0.850
LIG_14-3-3_CanoR_1	128	136	PF00244	0.441
LIG_14-3-3_CanoR_1	53	63	PF00244	0.658
LIG_14-3-3_CanoR_1	531	536	PF00244	0.652
LIG_14-3-3_CanoR_1	66	71	PF00244	0.490
LIG_Actin_WH2_2	690	706	PF00022	0.468
LIG_APCC_ABBA_1	633	638	PF00400	0.550
LIG_BIR_III_2	475	479	PF00653	0.784
LIG_BRCT_BRCA1_1	116	120	PF00533	0.660
LIG_BRCT_BRCA1_1	48	52	PF00533	0.631
LIG_eIF4E_1	615	621	PF01652	0.554
LIG_FHA_1	136	142	PF00498	0.649
LIG_FHA_1	206	212	PF00498	0.656
LIG_FHA_1	376	382	PF00498	0.862
LIG_FHA_1	453	459	PF00498	0.751
LIG_FHA_1	575	581	PF00498	0.612
LIG_FHA_1	733	739	PF00498	0.623
LIG_FHA_2	129	135	PF00498	0.439
LIG_FHA_2	152	158	PF00498	0.603
LIG_FHA_2	265	271	PF00498	0.749
LIG_FHA_2	272	278	PF00498	0.667
LIG_FHA_2	348	354	PF00498	0.783
LIG_FHA_2	449	455	PF00498	0.831
LIG_FHA_2	513	519	PF00498	0.787
LIG_FHA_2	532	538	PF00498	0.449
LIG_FHA_2	574	580	PF00498	0.673
LIG_FHA_2	726	732	PF00498	0.663
LIG_LIR_Gen_1	404	411	PF02991	0.865
LIG_LIR_Gen_1	529	540	PF02991	0.694
LIG_LIR_Gen_1	739	748	PF02991	0.575
LIG_LIR_Gen_1	765	776	PF02991	0.593
LIG_LIR_LC3C_4	688	691	PF02991	0.368
LIG_LIR_Nem_3	117	123	PF02991	0.523
LIG_LIR_Nem_3	404	410	PF02991	0.868
LIG_LIR_Nem_3	49	55	PF02991	0.639
LIG_LIR_Nem_3	529	535	PF02991	0.706
LIG_LIR_Nem_3	612	618	PF02991	0.567
LIG_LIR_Nem_3	739	745	PF02991	0.572
LIG_LIR_Nem_3	765	771	PF02991	0.473
LIG_NRBOX	617	623	PF00104	0.480
LIG_PCNA_PIPBox_1	235	244	PF02747	0.408
LIG_PCNA_yPIPBox_3	146	159	PF02747	0.588
LIG_PCNA_yPIPBox_3	233	242	PF02747	0.400
LIG_PDZ_Class_3	818	823	PF00595	0.842
LIG_Pex14_1	168	172	PF04695	0.627
LIG_Pex14_2	52	56	PF04695	0.634
LIG_Pex14_2	528	532	PF04695	0.733
LIG_PTB_Apo_2	522	529	PF02174	0.728
LIG_SH2_CRK	615	619	PF00017	0.393
LIG_SH2_CRK	742	746	PF00017	0.577
LIG_SH2_NCK_1	594	598	PF00017	0.518
LIG_SH2_STAT5	158	161	PF00017	0.631
LIG_SH2_STAT5	586	589	PF00017	0.625
LIG_SH2_STAT5	676	679	PF00017	0.400
LIG_SH2_STAT5	775	778	PF00017	0.449
LIG_SH3_1	279	285	PF00018	0.677
LIG_SH3_3	253	259	PF00018	0.819
LIG_SH3_3	279	285	PF00018	0.673
LIG_SH3_3	357	363	PF00018	0.843
LIG_SH3_3	383	389	PF00018	0.746
LIG_SH3_3	416	422	PF00018	0.764
LIG_SH3_3	423	429	PF00018	0.779
LIG_SH3_3	664	670	PF00018	0.531
LIG_SH3_3	84	90	PF00018	0.772
LIG_SUMO_SIM_anti_2	619	624	PF11976	0.558
LIG_SUMO_SIM_par_1	619	624	PF11976	0.480
LIG_SUMO_SIM_par_1	722	735	PF11976	0.647
LIG_TRAF2_1	259	262	PF00917	0.775
LIG_TRAF2_1	274	277	PF00917	0.610
LIG_TRAF2_1	300	303	PF00917	0.724
LIG_TRAF2_1	321	324	PF00917	0.730
LIG_TRAF2_1	355	358	PF00917	0.861
LIG_TRAF2_1	406	409	PF00917	0.803
LIG_TRAF2_1	429	432	PF00917	0.787
LIG_TRAF2_1	437	440	PF00917	0.687
LIG_TRAF2_1	536	539	PF00917	0.684
LIG_TRAF2_1	685	688	PF00917	0.517
LIG_TYR_ITIM	592	597	PF00017	0.601
LIG_TYR_ITIM	613	618	PF00017	0.565
LIG_UBA3_1	238	245	PF00899	0.487
LIG_UBA3_1	599	607	PF00899	0.593
LIG_UBA3_1	696	704	PF00899	0.560
LIG_UBA3_1	714	722	PF00899	0.279
LIG_WRC_WIRS_1	102	107	PF05994	0.540
LIG_WRC_WIRS_1	224	229	PF05994	0.638
LIG_WRC_WIRS_1	238	243	PF05994	0.407
MOD_CDC14_SPxK_1	281	284	PF00782	0.674
MOD_CDK_SPK_2	135	140	PF00069	0.660
MOD_CDK_SPxK_1	278	284	PF00069	0.669
MOD_CDK_SPxK_1	698	704	PF00069	0.526
MOD_CK1_1	170	176	PF00069	0.644
MOD_CK1_1	215	221	PF00069	0.682
MOD_CK1_1	287	293	PF00069	0.802
MOD_CK1_1	645	651	PF00069	0.601
MOD_CK1_1	732	738	PF00069	0.445
MOD_CK1_1	753	759	PF00069	0.361
MOD_CK1_1	98	104	PF00069	0.620
MOD_CK2_1	128	134	PF00069	0.438
MOD_CK2_1	14	20	PF00069	0.627
MOD_CK2_1	151	157	PF00069	0.613
MOD_CK2_1	170	176	PF00069	0.404
MOD_CK2_1	192	198	PF00069	0.691
MOD_CK2_1	264	270	PF00069	0.758
MOD_CK2_1	271	277	PF00069	0.721
MOD_CK2_1	297	303	PF00069	0.697
MOD_CK2_1	402	408	PF00069	0.818
MOD_CK2_1	433	439	PF00069	0.681
MOD_CK2_1	531	537	PF00069	0.694
MOD_CK2_1	579	585	PF00069	0.624
MOD_CK2_1	725	731	PF00069	0.656
MOD_GlcNHglycan	194	197	PF01048	0.708
MOD_GlcNHglycan	214	217	PF01048	0.418
MOD_GlcNHglycan	219	222	PF01048	0.550
MOD_GlcNHglycan	230	233	PF01048	0.410
MOD_GlcNHglycan	286	289	PF01048	0.796
MOD_GlcNHglycan	404	407	PF01048	0.792
MOD_GlcNHglycan	414	417	PF01048	0.666
MOD_GlcNHglycan	439	444	PF01048	0.777
MOD_GlcNHglycan	480	483	PF01048	0.792
MOD_GlcNHglycan	663	666	PF01048	0.432
MOD_GlcNHglycan	751	755	PF01048	0.386
MOD_GlcNHglycan	772	775	PF01048	0.403
MOD_GlcNHglycan	810	813	PF01048	0.718
MOD_GSK3_1	153	160	PF00069	0.603
MOD_GSK3_1	211	218	PF00069	0.634
MOD_GSK3_1	418	425	PF00069	0.842
MOD_GSK3_1	448	455	PF00069	0.810
MOD_GSK3_1	509	516	PF00069	0.867
MOD_GSK3_1	561	568	PF00069	0.672
MOD_GSK3_1	607	614	PF00069	0.618
MOD_GSK3_1	698	705	PF00069	0.524
MOD_GSK3_1	725	732	PF00069	0.476
MOD_LATS_1	44	50	PF00433	0.665
MOD_LATS_1	64	70	PF00433	0.496
MOD_N-GLC_1	11	16	PF02516	0.520
MOD_N-GLC_1	114	119	PF02516	0.675
MOD_N-GLC_1	513	518	PF02516	0.862
MOD_N-GLC_1	564	569	PF02516	0.681
MOD_N-GLC_2	762	764	PF02516	0.569
MOD_NEK2_1	167	172	PF00069	0.620
MOD_NEK2_1	192	197	PF00069	0.686
MOD_NEK2_1	23	28	PF00069	0.503
MOD_NEK2_1	48	53	PF00069	0.638
MOD_NEK2_1	656	661	PF00069	0.549
MOD_NEK2_1	663	668	PF00069	0.473
MOD_NEK2_1	703	708	PF00069	0.532
MOD_NEK2_1	736	741	PF00069	0.579
MOD_NEK2_2	329	334	PF00069	0.758
MOD_PIKK_1	128	134	PF00454	0.438
MOD_PIKK_1	14	20	PF00454	0.627
MOD_PIKK_1	23	29	PF00454	0.458
MOD_PIKK_1	452	458	PF00454	0.831
MOD_PIKK_1	736	742	PF00454	0.579
MOD_PK_1	66	72	PF00069	0.489
MOD_Plk_1	434	440	PF00069	0.637
MOD_Plk_1	519	525	PF00069	0.791
MOD_Plk_1	732	738	PF00069	0.516
MOD_Plk_1	750	756	PF00069	0.344
MOD_Plk_2-3	271	277	PF00069	0.613
MOD_Plk_2-3	362	368	PF00069	0.733
MOD_Plk_2-3	448	454	PF00069	0.787
MOD_Plk_2-3	579	585	PF00069	0.624
MOD_Plk_4	223	229	PF00069	0.637
MOD_Plk_4	237	243	PF00069	0.404
MOD_Plk_4	519	525	PF00069	0.791
MOD_Plk_4	555	561	PF00069	0.669
MOD_Plk_4	616	622	PF00069	0.405
MOD_Plk_4	636	642	PF00069	0.288
MOD_Plk_4	645	651	PF00069	0.453
MOD_Plk_4	732	738	PF00069	0.639
MOD_Plk_4	98	104	PF00069	0.608
MOD_ProDKin_1	135	141	PF00069	0.651
MOD_ProDKin_1	278	284	PF00069	0.669
MOD_ProDKin_1	418	424	PF00069	0.859
MOD_ProDKin_1	565	571	PF00069	0.670
MOD_ProDKin_1	698	704	PF00069	0.526
MOD_ProDKin_1	813	819	PF00069	0.844
MOD_SUMO_rev_2	268	274	PF00179	0.788
MOD_SUMO_rev_2	624	633	PF00179	0.615
MOD_SUMO_rev_2	78	87	PF00179	0.714
MOD_SUMO_rev_2	787	797	PF00179	0.802
TRG_DiLeu_BaEn_1	629	634	PF01217	0.627
TRG_DiLeu_BaEn_2	766	772	PF01217	0.599
TRG_DiLeu_BaLyEn_6	775	780	PF01217	0.607
TRG_ENDOCYTIC_2	407	410	PF00928	0.867
TRG_ENDOCYTIC_2	594	597	PF00928	0.600
TRG_ENDOCYTIC_2	615	618	PF00928	0.393
TRG_ENDOCYTIC_2	742	745	PF00928	0.569
TRG_ER_diArg_1	52	54	PF00400	0.534
TRG_ER_diArg_1	744	747	PF00400	0.496
TRG_NES_CRM1_1	61	71	PF08389	0.601
TRG_Pf-PMV_PEXEL_1	146	151	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	284	289	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	53	58	PF00026	0.654
TRG_Pf-PMV_PEXEL_1	778	782	PF00026	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJ98	Leishmania donovani	93%	100%
A4HPH5	Leishmania braziliensis	76%	100%
A4ID97	Leishmania infantum	92%	100%
E9AT87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%