BSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1A8_LEIMA

TriTrypDb:

LmjF.36.3110 , LMJLV39_360040600 , LMJSD75_360040500

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q1A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1A8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.427
CLV_NRD_NRD_1	342	344	PF00675	0.474
CLV_NRD_NRD_1	45	47	PF00675	0.458
CLV_PCSK_KEX2_1	342	344	PF00082	0.510
CLV_PCSK_SKI1_1	191	195	PF00082	0.487
CLV_PCSK_SKI1_1	325	329	PF00082	0.406
CLV_PCSK_SKI1_1	343	347	PF00082	0.437
CLV_PCSK_SKI1_1	37	41	PF00082	0.533
DEG_SPOP_SBC_1	219	223	PF00917	0.589
DOC_PP1_RVXF_1	306	313	PF00149	0.450
DOC_USP7_MATH_1	115	119	PF00917	0.495
DOC_USP7_MATH_1	219	223	PF00917	0.589
DOC_USP7_MATH_1	278	282	PF00917	0.620
DOC_USP7_UBL2_3	172	176	PF12436	0.500
DOC_WW_Pin1_4	155	160	PF00397	0.436
DOC_WW_Pin1_4	209	214	PF00397	0.571
DOC_WW_Pin1_4	299	304	PF00397	0.724
LIG_14-3-3_CanoR_1	205	215	PF00244	0.551
LIG_14-3-3_CanoR_1	336	340	PF00244	0.453
LIG_Actin_WH2_2	100	116	PF00022	0.420
LIG_Actin_WH2_2	143	158	PF00022	0.531
LIG_BRCT_BRCA1_1	189	193	PF00533	0.461
LIG_Clathr_ClatBox_1	253	257	PF01394	0.592
LIG_FHA_1	138	144	PF00498	0.493
LIG_FHA_1	156	162	PF00498	0.538
LIG_FHA_1	219	225	PF00498	0.671
LIG_FHA_1	239	245	PF00498	0.596
LIG_FHA_1	38	44	PF00498	0.477
LIG_FHA_2	132	138	PF00498	0.567
LIG_FHA_2	190	196	PF00498	0.498
LIG_LIR_Gen_1	126	136	PF02991	0.558
LIG_LIR_Gen_1	139	146	PF02991	0.581
LIG_LIR_Gen_1	177	187	PF02991	0.448
LIG_LIR_Gen_1	21	32	PF02991	0.511
LIG_LIR_LC3C_4	30	34	PF02991	0.375
LIG_LIR_Nem_3	126	132	PF02991	0.573
LIG_LIR_Nem_3	139	144	PF02991	0.488
LIG_LIR_Nem_3	177	182	PF02991	0.444
LIG_LIR_Nem_3	21	27	PF02991	0.496
LIG_LIR_Nem_3	266	270	PF02991	0.690
LIG_Pex14_2	189	193	PF04695	0.441
LIG_Pex14_2	267	271	PF04695	0.661
LIG_SH2_CRK	24	28	PF00017	0.533
LIG_SH2_CRK	349	353	PF00017	0.354
LIG_SH2_NCK_1	24	28	PF00017	0.423
LIG_SH2_NCK_1	349	353	PF00017	0.354
LIG_SH2_STAP1	24	28	PF00017	0.573
LIG_SH2_STAT5	186	189	PF00017	0.404
LIG_SH2_STAT5	349	352	PF00017	0.492
LIG_SH2_STAT5	61	64	PF00017	0.480
LIG_SH3_3	301	307	PF00018	0.593
LIG_SUMO_SIM_anti_2	221	228	PF11976	0.570
LIG_SUMO_SIM_par_1	30	36	PF11976	0.320
LIG_TRFH_1	141	145	PF08558	0.502
LIG_WRC_WIRS_1	19	24	PF05994	0.536
LIG_WRC_WIRS_1	331	336	PF05994	0.410
MOD_CDK_SPxxK_3	299	306	PF00069	0.552
MOD_CK1_1	206	212	PF00069	0.512
MOD_CK1_1	218	224	PF00069	0.685
MOD_CK2_1	174	180	PF00069	0.429
MOD_CK2_1	189	195	PF00069	0.386
MOD_CK2_1	86	92	PF00069	0.616
MOD_GlcNHglycan	117	120	PF01048	0.557
MOD_GlcNHglycan	215	218	PF01048	0.675
MOD_GlcNHglycan	280	283	PF01048	0.691
MOD_GSK3_1	209	216	PF00069	0.538
MOD_GSK3_1	218	225	PF00069	0.742
MOD_GSK3_1	295	302	PF00069	0.710
MOD_GSK3_1	33	40	PF00069	0.467
MOD_GSK3_1	330	337	PF00069	0.447
MOD_N-GLC_1	227	232	PF02516	0.621
MOD_N-GLC_1	37	42	PF02516	0.527
MOD_NEK2_1	187	192	PF00069	0.428
MOD_NEK2_1	215	220	PF00069	0.704
MOD_NEK2_1	23	28	PF00069	0.504
MOD_NEK2_1	263	268	PF00069	0.649
MOD_NEK2_1	334	339	PF00069	0.461
MOD_NEK2_1	42	47	PF00069	0.435
MOD_NEK2_1	74	79	PF00069	0.493
MOD_NEK2_2	327	332	PF00069	0.536
MOD_NEK2_2	335	340	PF00069	0.417
MOD_PIKK_1	37	43	PF00454	0.413
MOD_PKA_2	137	143	PF00069	0.588
MOD_PKA_2	335	341	PF00069	0.487
MOD_PKA_2	350	356	PF00069	0.463
MOD_Plk_1	227	233	PF00069	0.600
MOD_Plk_1	37	43	PF00069	0.413
MOD_Plk_1	9	15	PF00069	0.412
MOD_Plk_4	131	137	PF00069	0.413
MOD_Plk_4	174	180	PF00069	0.558
MOD_Plk_4	222	228	PF00069	0.674
MOD_Plk_4	280	286	PF00069	0.555
MOD_Plk_4	57	63	PF00069	0.440
MOD_Plk_4	74	80	PF00069	0.438
MOD_ProDKin_1	155	161	PF00069	0.430
MOD_ProDKin_1	209	215	PF00069	0.573
MOD_ProDKin_1	299	305	PF00069	0.723
MOD_SUMO_for_1	63	66	PF00179	0.413
MOD_SUMO_rev_2	167	177	PF00179	0.583
TRG_DiLeu_BaEn_1	139	144	PF01217	0.626
TRG_DiLeu_BaEn_3	111	117	PF01217	0.489
TRG_ENDOCYTIC_2	186	189	PF00928	0.407
TRG_ENDOCYTIC_2	24	27	PF00928	0.514
TRG_ENDOCYTIC_2	349	352	PF00928	0.361
TRG_ER_diArg_1	305	308	PF00400	0.656
TRG_ER_diArg_1	43	46	PF00400	0.448
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2M7	Leptomonas seymouri	63%	100%
A0A1X0P3J0	Trypanosomatidae	35%	97%
A0A3S5IRD4	Trypanosoma rangeli	39%	100%
A0A3S7XB77	Leishmania donovani	93%	100%
A4HPH7	Leishmania braziliensis	81%	99%
A4ID99	Leishmania infantum	94%	100%
D0A8D9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AT89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B9K7	Trypanosoma cruzi	39%	87%