Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1A7_LEIMA

TriTrypDb:

LmjF.36.3120 , LMJLV39_360040700 , LMJSD75_360040600

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	2
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q1A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1A7

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0044782	cilium organization	5	2
GO:0060271	cilium assembly	6	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0005509	calcium ion binding	5	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.528
CLV_C14_Caspase3-7	442	446	PF00656	0.499
CLV_C14_Caspase3-7	69	73	PF00656	0.459
CLV_NRD_NRD_1	349	351	PF00675	0.540
CLV_NRD_NRD_1	357	359	PF00675	0.481
CLV_NRD_NRD_1	543	545	PF00675	0.573
CLV_PCSK_FUR_1	347	351	PF00082	0.602
CLV_PCSK_KEX2_1	349	351	PF00082	0.515
CLV_PCSK_KEX2_1	548	550	PF00082	0.530
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.597
CLV_PCSK_PC7_1	544	550	PF00082	0.601
CLV_PCSK_SKI1_1	240	244	PF00082	0.496
CLV_PCSK_SKI1_1	349	353	PF00082	0.522
CLV_PCSK_SKI1_1	430	434	PF00082	0.336
CLV_PCSK_SKI1_1	50	54	PF00082	0.662
CLV_PCSK_SKI1_1	517	521	PF00082	0.472
CLV_PCSK_SKI1_1	545	549	PF00082	0.491
CLV_PCSK_SKI1_1	557	561	PF00082	0.451
CLV_PCSK_SKI1_1	58	62	PF00082	0.456
DOC_MAPK_FxFP_2	213	216	PF00069	0.528
DOC_MAPK_gen_1	262	269	PF00069	0.635
DOC_MAPK_gen_1	358	366	PF00069	0.551
DOC_MAPK_gen_1	544	552	PF00069	0.520
DOC_MAPK_HePTP_8	88	100	PF00069	0.543
DOC_MAPK_MEF2A_6	333	341	PF00069	0.498
DOC_MAPK_MEF2A_6	359	368	PF00069	0.527
DOC_MAPK_MEF2A_6	80	88	PF00069	0.509
DOC_MAPK_MEF2A_6	91	100	PF00069	0.551
DOC_PP1_MyPhoNE_1	30	37	PF00149	0.578
DOC_PP1_RVXF_1	327	333	PF00149	0.411
DOC_PP4_FxxP_1	213	216	PF00568	0.606
DOC_USP7_MATH_1	290	294	PF00917	0.634
DOC_USP7_MATH_1	487	491	PF00917	0.503
DOC_USP7_MATH_1	505	509	PF00917	0.390
DOC_WW_Pin1_4	12	17	PF00397	0.491
DOC_WW_Pin1_4	366	371	PF00397	0.544
DOC_WW_Pin1_4	482	487	PF00397	0.403
LIG_14-3-3_CanoR_1	126	132	PF00244	0.429
LIG_14-3-3_CanoR_1	180	188	PF00244	0.582
LIG_14-3-3_CanoR_1	240	246	PF00244	0.462
LIG_14-3-3_CanoR_1	299	306	PF00244	0.606
LIG_14-3-3_CanoR_1	517	522	PF00244	0.492
LIG_Actin_WH2_2	164	182	PF00022	0.556
LIG_Actin_WH2_2	543	559	PF00022	0.605
LIG_BIR_II_1	1	5	PF00653	0.693
LIG_BRCT_BRCA1_1	422	426	PF00533	0.493
LIG_eIF4E_1	14	20	PF01652	0.471
LIG_FHA_1	126	132	PF00498	0.440
LIG_FHA_1	281	287	PF00498	0.668
LIG_FHA_1	371	377	PF00498	0.505
LIG_FHA_1	398	404	PF00498	0.555
LIG_FHA_1	469	475	PF00498	0.463
LIG_FHA_1	51	57	PF00498	0.559
LIG_FHA_1	526	532	PF00498	0.515
LIG_FHA_2	204	210	PF00498	0.610
LIG_FHA_2	312	318	PF00498	0.287
LIG_FHA_2	437	443	PF00498	0.524
LIG_FHA_2	471	477	PF00498	0.428
LIG_FHA_2	520	526	PF00498	0.636
LIG_FHA_2	67	73	PF00498	0.438
LIG_LIR_Apic_2	210	216	PF02991	0.591
LIG_LIR_Apic_2	501	505	PF02991	0.455
LIG_LIR_Gen_1	127	136	PF02991	0.525
LIG_LIR_Gen_1	166	175	PF02991	0.395
LIG_LIR_Gen_1	479	487	PF02991	0.457
LIG_LIR_Gen_1	491	498	PF02991	0.387
LIG_LIR_Nem_3	127	132	PF02991	0.545
LIG_LIR_Nem_3	166	171	PF02991	0.389
LIG_LIR_Nem_3	475	480	PF02991	0.386
LIG_LIR_Nem_3	491	497	PF02991	0.349
LIG_NRBOX	363	369	PF00104	0.481
LIG_Pex14_2	457	461	PF04695	0.375
LIG_SH2_CRK	413	417	PF00017	0.510
LIG_SH2_CRK	8	12	PF00017	0.467
LIG_SH2_GRB2like	8	11	PF00017	0.594
LIG_SH2_NCK_1	186	190	PF00017	0.546
LIG_SH2_NCK_1	481	485	PF00017	0.376
LIG_SH2_NCK_1	8	12	PF00017	0.584
LIG_SH2_SRC	481	484	PF00017	0.524
LIG_SH2_STAP1	186	190	PF00017	0.421
LIG_SH2_STAP1	255	259	PF00017	0.608
LIG_SH2_STAT3	37	40	PF00017	0.623
LIG_SH2_STAT3	411	414	PF00017	0.514
LIG_SH2_STAT5	113	116	PF00017	0.532
LIG_SH2_STAT5	170	173	PF00017	0.388
LIG_SH2_STAT5	255	258	PF00017	0.600
LIG_SH2_STAT5	259	262	PF00017	0.649
LIG_SH2_STAT5	276	279	PF00017	0.443
LIG_SH2_STAT5	510	513	PF00017	0.595
LIG_SH2_STAT5	85	88	PF00017	0.474
LIG_SH3_3	265	271	PF00018	0.565
LIG_SH3_3	42	48	PF00018	0.652
LIG_SH3_3	528	534	PF00018	0.604
LIG_SUMO_SIM_anti_2	221	228	PF11976	0.465
LIG_SUMO_SIM_par_1	221	228	PF11976	0.473
LIG_SUMO_SIM_par_1	470	476	PF11976	0.471
LIG_SUMO_SIM_par_1	517	522	PF11976	0.561
LIG_TRAF2_1	486	489	PF00917	0.512
MOD_CK1_1	107	113	PF00069	0.645
MOD_CK1_1	127	133	PF00069	0.219
MOD_CK1_1	173	179	PF00069	0.571
MOD_CK1_1	298	304	PF00069	0.662
MOD_CK2_1	203	209	PF00069	0.500
MOD_CK2_1	311	317	PF00069	0.281
MOD_CK2_1	366	372	PF00069	0.543
MOD_CK2_1	470	476	PF00069	0.504
MOD_CK2_1	482	488	PF00069	0.398
MOD_CK2_1	60	66	PF00069	0.569
MOD_GlcNHglycan	115	118	PF01048	0.558
MOD_GlcNHglycan	146	149	PF01048	0.627
MOD_GlcNHglycan	163	166	PF01048	0.480
MOD_GlcNHglycan	176	179	PF01048	0.481
MOD_GlcNHglycan	277	280	PF01048	0.496
MOD_GlcNHglycan	300	303	PF01048	0.616
MOD_GlcNHglycan	507	510	PF01048	0.550
MOD_GlcNHglycan	511	514	PF01048	0.555
MOD_GSK3_1	107	114	PF00069	0.580
MOD_GSK3_1	170	177	PF00069	0.495
MOD_GSK3_1	199	206	PF00069	0.552
MOD_GSK3_1	249	256	PF00069	0.429
MOD_GSK3_1	291	298	PF00069	0.647
MOD_GSK3_1	307	314	PF00069	0.440
MOD_GSK3_1	366	373	PF00069	0.422
MOD_GSK3_1	505	512	PF00069	0.524
MOD_GSK3_1	56	63	PF00069	0.526
MOD_N-GLC_1	138	143	PF02516	0.628
MOD_N-GLC_1	144	149	PF02516	0.624
MOD_N-GLC_2	192	194	PF02516	0.554
MOD_NEK2_1	115	120	PF00069	0.494
MOD_NEK2_1	199	204	PF00069	0.537
MOD_NEK2_1	225	230	PF00069	0.477
MOD_NEK2_1	275	280	PF00069	0.498
MOD_NEK2_1	304	309	PF00069	0.544
MOD_NEK2_1	380	385	PF00069	0.507
MOD_NEK2_1	397	402	PF00069	0.460
MOD_NEK2_1	498	503	PF00069	0.483
MOD_NEK2_1	6	11	PF00069	0.678
MOD_NEK2_1	60	65	PF00069	0.572
MOD_NEK2_2	527	532	PF00069	0.650
MOD_PIKK_1	105	111	PF00454	0.657
MOD_PIKK_1	538	544	PF00454	0.553
MOD_PIKK_1	60	66	PF00454	0.597
MOD_PIKK_1	89	95	PF00454	0.547
MOD_PK_1	333	339	PF00069	0.494
MOD_PKA_2	125	131	PF00069	0.426
MOD_PKA_2	179	185	PF00069	0.605
MOD_PKA_2	290	296	PF00069	0.722
MOD_PKA_2	298	304	PF00069	0.564
MOD_PKA_2	397	403	PF00069	0.515
MOD_PKA_2	420	426	PF00069	0.514
MOD_PKB_1	289	297	PF00069	0.687
MOD_Plk_1	138	144	PF00069	0.636
MOD_Plk_1	560	566	PF00069	0.635
MOD_Plk_2-3	67	73	PF00069	0.373
MOD_Plk_4	311	317	PF00069	0.510
MOD_Plk_4	533	539	PF00069	0.576
MOD_ProDKin_1	12	18	PF00069	0.485
MOD_ProDKin_1	366	372	PF00069	0.543
MOD_ProDKin_1	482	488	PF00069	0.402
MOD_SUMO_for_1	269	272	PF00179	0.578
MOD_SUMO_rev_2	419	429	PF00179	0.469
MOD_SUMO_rev_2	540	547	PF00179	0.538
TRG_DiLeu_BaEn_1	372	377	PF01217	0.495
TRG_DiLeu_BaEn_1	514	519	PF01217	0.554
TRG_DiLeu_BaLyEn_6	546	551	PF01217	0.557
TRG_DiLeu_LyEn_5	514	519	PF01217	0.554
TRG_ENDOCYTIC_2	413	416	PF00928	0.473
TRG_ENDOCYTIC_2	481	484	PF00928	0.377
TRG_ENDOCYTIC_2	8	11	PF00928	0.612
TRG_ENDOCYTIC_2	85	88	PF00928	0.528
TRG_ER_diArg_1	155	158	PF00400	0.474
TRG_ER_diArg_1	288	291	PF00400	0.769
TRG_ER_diArg_1	347	350	PF00400	0.588
TRG_NES_CRM1_1	392	407	PF08389	0.544
TRG_Pf-PMV_PEXEL_1	549	553	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW03	Leptomonas seymouri	61%	99%
A0A0S4JII0	Bodo saltans	28%	97%
A0A1X0P3R1	Trypanosomatidae	44%	100%
A0A3Q8IJI1	Leishmania donovani	95%	100%
A0A422NKK1	Trypanosoma rangeli	43%	100%
A4HPH8	Leishmania braziliensis	85%	100%
A4IDA0	Leishmania infantum	95%	100%
D0A8E0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	86%
E9AT90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5AU55	Trypanosoma cruzi	41%	100%