Peptidyl-prolyl cis-trans isomerase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 10, putative

Species:

Leishmania major

UniProt:

Q4Q1A6_LEIMA

TriTrypDb:

LmjF.36.3130 , LMJLV39_360040800 , LMJSD75_360040700

Length:

266

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1A6

PDB structure(s): 7aih_BI , 7am2_Bl , 7ane_BI

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	11
GO:0006457	protein folding	2	2
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	2
GO:0018193	peptidyl-amino acid modification	5	11
GO:0018208	peptidyl-proline modification	6	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	2
GO:0016018	cyclosporin A binding	4	2
GO:0016853	isomerase activity	2	11
GO:0016859	cis-trans isomerase activity	3	11
GO:0033218	amide binding	2	2
GO:0042277	peptide binding	3	2
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.286
CLV_C14_Caspase3-7	44	48	PF00656	0.418
CLV_PCSK_KEX2_1	103	105	PF00082	0.224
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.357
CLV_PCSK_SKI1_1	17	21	PF00082	0.580
DEG_Nend_UBRbox_1	1	4	PF02207	0.413
DOC_CKS1_1	35	40	PF01111	0.436
DOC_CYCLIN_yCln2_LP_2	35	41	PF00134	0.394
DOC_MAPK_gen_1	188	197	PF00069	0.308
DOC_PP1_RVXF_1	93	99	PF00149	0.291
DOC_PP4_FxxP_1	181	184	PF00568	0.244
DOC_USP7_MATH_1	106	110	PF00917	0.442
DOC_USP7_MATH_1	123	127	PF00917	0.182
DOC_USP7_MATH_1	28	32	PF00917	0.462
DOC_USP7_MATH_1	55	59	PF00917	0.425
DOC_USP7_MATH_1	87	91	PF00917	0.299
DOC_WW_Pin1_4	24	29	PF00397	0.457
DOC_WW_Pin1_4	34	39	PF00397	0.396
LIG_14-3-3_CanoR_1	147	152	PF00244	0.322
LIG_14-3-3_CanoR_1	95	99	PF00244	0.308
LIG_AP2alpha_1	136	140	PF02296	0.264
LIG_APCC_ABBA_1	174	179	PF00400	0.262
LIG_BRCT_BRCA1_1	108	112	PF00533	0.308
LIG_BRCT_BRCA1_1	209	213	PF00533	0.244
LIG_BRCT_BRCA1_2	108	114	PF00533	0.308
LIG_deltaCOP1_diTrp_1	62	68	PF00928	0.442
LIG_EVH1_2	12	16	PF00568	0.441
LIG_FHA_1	169	175	PF00498	0.262
LIG_FHA_1	44	50	PF00498	0.476
LIG_FHA_1	55	61	PF00498	0.492
LIG_FHA_1	95	101	PF00498	0.274
LIG_FHA_2	42	48	PF00498	0.424
LIG_LIR_Apic_2	179	184	PF02991	0.245
LIG_LIR_Gen_1	109	119	PF02991	0.266
LIG_LIR_Gen_1	190	198	PF02991	0.317
LIG_LIR_Gen_1	235	245	PF02991	0.377
LIG_LIR_Gen_1	29	40	PF02991	0.405
LIG_LIR_Gen_1	97	106	PF02991	0.306
LIG_LIR_Nem_3	109	115	PF02991	0.266
LIG_LIR_Nem_3	15	19	PF02991	0.526
LIG_LIR_Nem_3	210	215	PF02991	0.244
LIG_LIR_Nem_3	235	240	PF02991	0.363
LIG_LIR_Nem_3	29	35	PF02991	0.398
LIG_LIR_Nem_3	37	43	PF02991	0.376
LIG_LIR_Nem_3	97	101	PF02991	0.306
LIG_MLH1_MIPbox_1	209	213	PF16413	0.244
LIG_Pex14_2	136	140	PF04695	0.287
LIG_Pex14_2	16	20	PF04695	0.482
LIG_SH2_SRC	40	43	PF00017	0.394
LIG_SH2_STAT3	158	161	PF00017	0.262
LIG_SH2_STAT5	158	161	PF00017	0.271
LIG_SH2_STAT5	40	43	PF00017	0.446
LIG_SH2_STAT5	52	55	PF00017	0.381
LIG_SH3_3	199	205	PF00018	0.287
LIG_SH3_3	2	8	PF00018	0.448
LIG_SH3_3	22	28	PF00018	0.376
LIG_SUMO_SIM_anti_2	256	262	PF11976	0.379
LIG_SUMO_SIM_par_1	256	262	PF11976	0.370
LIG_TRAF2_1	183	186	PF00917	0.282
LIG_TRFH_1	32	36	PF08558	0.418
MOD_CK1_1	26	32	PF00069	0.524
MOD_GlcNHglycan	166	169	PF01048	0.312
MOD_GlcNHglycan	202	205	PF01048	0.275
MOD_GSK3_1	142	149	PF00069	0.244
MOD_GSK3_1	164	171	PF00069	0.262
MOD_GSK3_1	24	31	PF00069	0.551
MOD_N-GLC_1	147	152	PF02516	0.322
MOD_N-GLC_1	207	212	PF02516	0.259
MOD_N-GLC_1	223	228	PF02516	0.192
MOD_NEK2_1	197	202	PF00069	0.244
MOD_NEK2_1	207	212	PF00069	0.244
MOD_NEK2_1	223	228	PF00069	0.219
MOD_NEK2_1	41	46	PF00069	0.430
MOD_NEK2_1	68	73	PF00069	0.555
MOD_NEK2_2	172	177	PF00069	0.377
MOD_NEK2_2	28	33	PF00069	0.462
MOD_NEK2_2	63	68	PF00069	0.404
MOD_NEK2_2	69	74	PF00069	0.350
MOD_PIKK_1	207	213	PF00454	0.244
MOD_PIKK_1	87	93	PF00454	0.265
MOD_PKA_2	146	152	PF00069	0.322
MOD_PKA_2	69	75	PF00069	0.495
MOD_PKA_2	94	100	PF00069	0.308
MOD_Plk_1	147	153	PF00069	0.288
MOD_Plk_4	172	178	PF00069	0.244
MOD_Plk_4	55	61	PF00069	0.425
MOD_Plk_4	63	69	PF00069	0.401
MOD_ProDKin_1	24	30	PF00069	0.458
MOD_ProDKin_1	34	40	PF00069	0.395
MOD_SUMO_rev_2	180	190	PF00179	0.328
TRG_ENDOCYTIC_2	40	43	PF00928	0.394
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P364	Leptomonas seymouri	32%	100%
A0A0N0P523	Leptomonas seymouri	38%	96%
A0A0N0P839	Leptomonas seymouri	36%	100%
A0A0N1I6E6	Leptomonas seymouri	37%	100%
A0A0N1I8P9	Leptomonas seymouri	33%	90%
A0A0N1IAQ4	Leptomonas seymouri	40%	75%
A0A0N1IL84	Leptomonas seymouri	34%	83%
A0A0N1PC19	Leptomonas seymouri	78%	100%
A0A0N1PDY0	Leptomonas seymouri	28%	100%
A0A0S4IKA5	Bodo saltans	31%	88%
A0A0S4J378	Bodo saltans	36%	100%
A0A0S4J8W7	Bodo saltans	36%	100%
A0A0S4J9U9	Bodo saltans	58%	100%
A0A0S4JAB5	Bodo saltans	35%	75%
A0A0S4KGS8	Bodo saltans	35%	100%
A0A0S4KLH0	Bodo saltans	36%	100%
A0A1X0NJS0	Trypanosomatidae	35%	100%
A0A1X0NTQ9	Trypanosomatidae	38%	100%
A0A1X0NTS4	Trypanosomatidae	35%	100%
A0A1X0NXG7	Trypanosomatidae	39%	100%
A0A1X0P184	Trypanosomatidae	38%	100%
A0A1X0P2K2	Trypanosomatidae	30%	100%
A0A1X0P4X3	Trypanosomatidae	72%	100%
A0A1X0P563	Trypanosomatidae	36%	75%
A0A3Q8ICB3	Leishmania donovani	33%	100%
A0A3Q8IIG9	Leishmania donovani	40%	75%
A0A3R7M7E5	Trypanosoma rangeli	33%	86%
A0A3R7MP70	Trypanosoma rangeli	72%	100%
A0A3R7RC31	Trypanosoma rangeli	37%	100%
A0A3R7RE54	Trypanosoma rangeli	39%	100%
A0A3R7RI88	Trypanosoma rangeli	35%	100%
A0A3S5H5N2	Leishmania donovani	39%	100%
A0A3S5H7U6	Leishmania donovani	37%	100%
A0A3S5IQL2	Trypanosoma rangeli	31%	100%
A0A3S7WXF4	Leishmania donovani	40%	90%
A0A3S7WYY5	Leishmania donovani	41%	96%
A0A3S7X325	Leishmania donovani	28%	100%
A0A3S7X410	Leishmania donovani	35%	100%
A0A3S7XB52	Leishmania donovani	94%	100%
A0A422N1Z9	Trypanosoma rangeli	39%	100%
A0A422N490	Trypanosoma rangeli	33%	100%
A0A422P185	Trypanosoma rangeli	37%	75%
A0A451EJ79	Leishmania donovani	34%	80%
A4FV72	Bos taurus	35%	88%
A4H346	Leishmania braziliensis	33%	79%
A4H4H8	Leishmania braziliensis	35%	100%
A4H8P7	Leishmania braziliensis	34%	76%
A4HCI8	Leishmania braziliensis	32%	100%
A4HCL8	Leishmania braziliensis	39%	90%
A4HE26	Leishmania braziliensis	39%	96%
A4HHU7	Leishmania braziliensis	27%	100%
A4HIW9	Leishmania braziliensis	36%	100%
A4HLM4	Leishmania braziliensis	37%	100%
A4HNE1	Leishmania braziliensis	40%	75%
A4HPH9	Leishmania braziliensis	88%	100%
A4HRE3	Leishmania infantum	34%	80%
A4HSQ3	Leishmania infantum	39%	100%
A4I004	Leishmania infantum	33%	100%
A4I042	Leishmania infantum	40%	90%
A4I1D2	Leishmania infantum	41%	96%
A4I4Z7	Leishmania infantum	27%	100%
A4I698	Leishmania infantum	35%	100%
A4I935	Leishmania infantum	37%	100%
A4IC14	Leishmania infantum	40%	75%
A4IDA1	Leishmania infantum	93%	100%
A8X8D0	Caenorhabditis briggsae	36%	85%
B3A0R0	Lottia gigantea	36%	100%
C9ZIV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZQE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZRQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZSQ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZT99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZUX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	88%
C9ZVY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	94%
C9ZYI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	75%
D0A8E1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
D4AY02	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	35%	100%
E9AC11	Leishmania major	33%	79%
E9AFV2	Leishmania major	40%	75%
E9AJA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	80%
E9AKP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AT91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9AVX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AW05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	92%
E9AXG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	96%
E9B0C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B1F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B400	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B705	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	75%
O02614	Leishmania major	41%	96%
O49605	Arabidopsis thaliana	36%	100%
O93826	Arthroderma benhamiae	35%	100%
O94273	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
P0C1H9	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	38%	100%
P0C1I0	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	33%	100%
P0C1I1	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	40%	73%
P0C1I2	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	37%	84%
P0C1I3	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	39%	100%
P0C1I9	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	38%	79%
P0CP78	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	34%	100%
P0CP79	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	34%	100%
P0CP80	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	39%	71%
P0CP81	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	39%	71%
P0CP82	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	42%	100%
P0CP83	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	42%	100%
P15425	Drosophila melanogaster	35%	100%
P23284	Homo sapiens	36%	100%
P23285	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
P24367	Gallus gallus	34%	100%
P24368	Rattus norvegicus	37%	100%
P24369	Mus musculus	35%	100%
P25007	Drosophila melanogaster	34%	100%
P25334	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	84%
P25719	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
P26882	Bos taurus	38%	72%
P28517	Calliphora vicina	35%	100%
P29117	Rattus norvegicus	36%	100%
P30404	Bos taurus	36%	100%
P30405	Homo sapiens	35%	100%
P30412	Mus musculus	36%	100%
P34791	Arabidopsis thaliana	32%	100%
P35176	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P45877	Homo sapiens	37%	100%
P47103	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	68%
P52009	Caenorhabditis elegans	38%	100%
P52013	Caenorhabditis elegans	33%	100%
P52014	Caenorhabditis elegans	34%	100%
P52018	Caenorhabditis elegans	36%	100%
P53691	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	72%
P80311	Bos taurus	34%	100%
P84343	Neospora caninum	33%	100%
Q01490	Orpinomyces sp. (strain PC-2)	36%	100%
Q08752	Homo sapiens	38%	72%
Q08E11	Bos taurus	37%	100%
Q09637	Caenorhabditis elegans	36%	86%
Q11004	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	75%
Q1RMP7	Bos taurus	33%	87%
Q26516	Schistosoma japonicum	39%	100%
Q26548	Schistosoma mansoni	39%	97%
Q26551	Schistosoma mansoni	33%	100%
Q27774	Schistosoma japonicum	35%	100%
Q2TZ33	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	39%	100%
Q2U0E0	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	40%	72%
Q2UGK2	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	36%	100%
Q4G338	Haemonchus contortus	35%	82%
Q4HXF6	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	39%	72%
Q4I5R9	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	36%	100%
Q4IPH4	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	37%	100%
Q4P0V4	Ustilago maydis (strain 521 / FGSC 9021)	38%	67%
Q4Q424	Leishmania major	37%	100%
Q4Q6Q9	Leishmania major	34%	100%
Q4Q7V7	Leishmania major	27%	100%
Q4QBH1	Leishmania major	38%	90%
Q4QBK2	Leishmania major	33%	100%
Q4QJ67	Leishmania major	38%	100%
Q4WCM6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	40%	100%
Q4WIF3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	43%	71%
Q4WP12	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	39%	100%
Q54SM3	Dictyostelium discoideum	38%	100%
Q5ACI8	Candida albicans (strain SC5314 / ATCC MYA-2876)	35%	72%
Q5AQL0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	39%	100%
Q5B4E7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	43%	72%
Q5B4R3	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	34%	100%
Q5R723	Pongo abelii	36%	88%
Q5U8Z7	Amanita muscaria	43%	72%
Q6BXZ7	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	38%	72%
Q6C4W6	Yarrowia lipolytica (strain CLIB 122 / E 150)	33%	100%
Q6CBP4	Yarrowia lipolytica (strain CLIB 122 / E 150)	38%	72%
Q6CL78	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	38%	72%
Q6DGG0	Rattus norvegicus	38%	72%
Q6FNU6	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	38%	72%
Q75A33	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	40%	72%
Q7S7Z6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	93%
Q7SG06	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	38%	100%
Q8IXY8	Homo sapiens	33%	86%
Q8L8W5	Arabidopsis thaliana	36%	100%
Q8LDP4	Arabidopsis thaliana	37%	100%
Q8X166	Aspergillus niger	39%	100%
Q99KR7	Mus musculus	36%	100%
Q9ASS6	Arabidopsis thaliana	35%	100%
Q9C566	Arabidopsis thaliana	39%	74%
Q9CR16	Mus musculus	38%	72%
Q9D6D8	Mus musculus	31%	85%
Q9LIK6	Arabidopsis thaliana	29%	100%
Q9P3X9	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	40%	71%
Q9QZH3	Mus musculus	35%	88%
Q9SP02	Arabidopsis thaliana	37%	100%
Q9TW32	Dictyostelium discoideum	36%	100%
Q9UNP9	Homo sapiens	36%	88%
Q9V3G3	Drosophila melanogaster	33%	89%
Q9ZVJ4	Arabidopsis thaliana	37%	100%
V5B2A0	Trypanosoma cruzi	38%	100%
V5B9Y6	Trypanosoma cruzi	34%	86%
V5BGX2	Trypanosoma cruzi	30%	100%
V5BHF5	Trypanosoma cruzi	36%	100%
V5D532	Trypanosoma cruzi	35%	100%
V5D7H4	Trypanosoma cruzi	38%	75%