Nudix hydrolase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1A5_LEIMA

TriTrypDb:

LmjF.36.3140 , LMJLV39_360040900 , LMJSD75_360040800

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1A5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1A5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.620
CLV_PCSK_KEX2_1	119	121	PF00082	0.599
CLV_PCSK_KEX2_1	73	75	PF00082	0.535
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.614
CLV_PCSK_SKI1_1	11	15	PF00082	0.589
CLV_PCSK_SKI1_1	206	210	PF00082	0.594
DEG_SPOP_SBC_1	25	29	PF00917	0.694
DOC_USP7_MATH_1	42	46	PF00917	0.673
DOC_USP7_MATH_1	79	83	PF00917	0.562
DOC_USP7_MATH_1	9	13	PF00917	0.572
DOC_USP7_MATH_1	96	100	PF00917	0.649
DOC_WW_Pin1_4	132	137	PF00397	0.704
DOC_WW_Pin1_4	161	166	PF00397	0.718
DOC_WW_Pin1_4	37	42	PF00397	0.613
LIG_14-3-3_CanoR_1	111	117	PF00244	0.539
LIG_14-3-3_CanoR_1	126	136	PF00244	0.632
LIG_14-3-3_CanoR_1	181	188	PF00244	0.549
LIG_14-3-3_CanoR_1	60	68	PF00244	0.663
LIG_Actin_WH2_2	6	24	PF00022	0.612
LIG_BIR_II_1	1	5	PF00653	0.662
LIG_BIR_III_2	162	166	PF00653	0.659
LIG_BRCT_BRCA1_1	163	167	PF00533	0.644
LIG_BRCT_BRCA1_1	39	43	PF00533	0.695
LIG_deltaCOP1_diTrp_1	201	205	PF00928	0.507
LIG_deltaCOP1_diTrp_1	211	217	PF00928	0.523
LIG_FHA_1	108	114	PF00498	0.615
LIG_FHA_1	150	156	PF00498	0.650
LIG_FHA_2	171	177	PF00498	0.547
LIG_IRF3_LxIS_1	228	235	PF10401	0.450
LIG_LIR_Gen_1	211	219	PF02991	0.565
LIG_LIR_Gen_1	64	75	PF02991	0.517
LIG_LIR_Nem_3	137	142	PF02991	0.703
LIG_LIR_Nem_3	164	170	PF02991	0.639
LIG_LIR_Nem_3	203	208	PF02991	0.538
LIG_LIR_Nem_3	211	217	PF02991	0.535
LIG_LIR_Nem_3	64	70	PF02991	0.515
LIG_PDZ_Class_3	244	249	PF00595	0.596
LIG_SH2_PTP2	67	70	PF00017	0.491
LIG_SH2_STAP1	170	174	PF00017	0.511
LIG_SH2_STAT5	116	119	PF00017	0.609
LIG_SH2_STAT5	199	202	PF00017	0.649
LIG_SH2_STAT5	67	70	PF00017	0.491
LIG_SH3_3	162	168	PF00018	0.652
LIG_SH3_3	35	41	PF00018	0.551
LIG_SH3_3	99	105	PF00018	0.633
LIG_SUMO_SIM_anti_2	66	72	PF11976	0.569
LIG_SUMO_SIM_par_1	145	153	PF11976	0.651
LIG_TRAF2_1	236	239	PF00917	0.516
MOD_CDK_SPxxK_3	37	44	PF00069	0.641
MOD_CK1_1	100	106	PF00069	0.591
MOD_CK1_1	107	113	PF00069	0.554
MOD_CK1_1	134	140	PF00069	0.616
MOD_CK1_1	29	35	PF00069	0.712
MOD_CK1_1	3	9	PF00069	0.628
MOD_CK2_1	170	176	PF00069	0.552
MOD_CK2_1	215	221	PF00069	0.505
MOD_CK2_1	232	238	PF00069	0.623
MOD_CMANNOS	202	205	PF00535	0.489
MOD_DYRK1A_RPxSP_1	37	41	PF00069	0.516
MOD_GlcNHglycan	102	105	PF01048	0.608
MOD_GlcNHglycan	217	220	PF01048	0.602
MOD_GlcNHglycan	234	237	PF01048	0.473
MOD_GlcNHglycan	44	47	PF01048	0.727
MOD_GlcNHglycan	75	78	PF01048	0.624
MOD_GSK3_1	127	134	PF00069	0.727
MOD_GSK3_1	24	31	PF00069	0.703
MOD_GSK3_1	59	66	PF00069	0.623
MOD_GSK3_1	96	103	PF00069	0.597
MOD_NEK2_1	112	117	PF00069	0.572
MOD_NEK2_1	149	154	PF00069	0.636
MOD_NEK2_1	232	237	PF00069	0.603
MOD_NEK2_2	121	126	PF00069	0.435
MOD_NEK2_2	79	84	PF00069	0.644
MOD_PIKK_1	134	140	PF00454	0.748
MOD_PIKK_1	3	9	PF00454	0.663
MOD_PKA_1	73	79	PF00069	0.637
MOD_PKA_2	180	186	PF00069	0.600
MOD_PKA_2	36	42	PF00069	0.697
MOD_PKA_2	59	65	PF00069	0.645
MOD_PKA_2	73	79	PF00069	0.482
MOD_Plk_4	112	118	PF00069	0.573
MOD_Plk_4	63	69	PF00069	0.637
MOD_Plk_4	9	15	PF00069	0.617
MOD_Plk_4	97	103	PF00069	0.608
MOD_ProDKin_1	132	138	PF00069	0.705
MOD_ProDKin_1	161	167	PF00069	0.721
MOD_ProDKin_1	37	43	PF00069	0.611
TRG_DiLeu_BaEn_4	238	244	PF01217	0.506
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.597
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.661
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.565
TRG_ENDOCYTIC_2	67	70	PF00928	0.491
TRG_NLS_MonoExtN_4	105	112	PF00514	0.628
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1D7	Leptomonas seymouri	51%	100%
A0A1X0P4K6	Trypanosomatidae	29%	100%
A0A3Q8IW55	Leishmania donovani	92%	100%
A0A3R7NG27	Trypanosoma rangeli	32%	100%
A4HPI0	Leishmania braziliensis	82%	100%
A4IDA2	Leishmania infantum	92%	100%
D0A8E2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AT92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DA52	Trypanosoma cruzi	33%	100%