Putative ADP-ribosylation factor GTPase activating protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor GTPase activating protein, putative

Species:

Leishmania major

UniProt:

Q4Q1A4_LEIMA

TriTrypDb:

LmjF.36.3150 , LMJLV39_360041000 , LMJSD75_360040900

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1A4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1A4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	7
GO:0008047	enzyme activator activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.369
CLV_NRD_NRD_1	15	17	PF00675	0.304
CLV_NRD_NRD_1	5	7	PF00675	0.446
CLV_NRD_NRD_1	85	87	PF00675	0.259
CLV_PCSK_KEX2_1	117	119	PF00082	0.369
CLV_PCSK_SKI1_1	12	16	PF00082	0.433
CLV_PCSK_SKI1_1	62	66	PF00082	0.369
CLV_Separin_Metazoa	13	17	PF03568	0.325
DEG_APCC_DBOX_1	32	40	PF00400	0.294
DEG_Nend_UBRbox_3	1	3	PF02207	0.491
DEG_SCF_FBW7_1	195	202	PF00400	0.546
DEG_SCF_FBW7_1	337	344	PF00400	0.516
DEG_SPOP_SBC_1	212	216	PF00917	0.571
DOC_CKS1_1	338	343	PF01111	0.528
DOC_MAPK_MEF2A_6	107	114	PF00069	0.325
DOC_PP4_FxxP_1	189	192	PF00568	0.613
DOC_SPAK_OSR1_1	76	80	PF12202	0.369
DOC_USP7_MATH_1	155	159	PF00917	0.598
DOC_USP7_MATH_1	281	285	PF00917	0.622
DOC_USP7_MATH_1	341	345	PF00917	0.578
DOC_USP7_MATH_1	358	362	PF00917	0.565
DOC_USP7_MATH_1	374	378	PF00917	0.531
DOC_WW_Pin1_4	151	156	PF00397	0.580
DOC_WW_Pin1_4	172	177	PF00397	0.607
DOC_WW_Pin1_4	195	200	PF00397	0.674
DOC_WW_Pin1_4	217	222	PF00397	0.565
DOC_WW_Pin1_4	337	342	PF00397	0.525
DOC_WW_Pin1_4	370	375	PF00397	0.620
LIG_14-3-3_CanoR_1	117	125	PF00244	0.336
LIG_14-3-3_CanoR_1	4	14	PF00244	0.486
LIG_14-3-3_CanoR_1	76	80	PF00244	0.325
LIG_BRCT_BRCA1_1	345	349	PF00533	0.604
LIG_CtBP_PxDLS_1	143	147	PF00389	0.579
LIG_FHA_1	172	178	PF00498	0.682
LIG_FHA_1	229	235	PF00498	0.735
LIG_FHA_2	63	69	PF00498	0.328
LIG_FHA_2	90	96	PF00498	0.317
LIG_LIR_Apic_2	186	192	PF02991	0.613
LIG_LIR_Apic_2	307	311	PF02991	0.612
LIG_LIR_Gen_1	182	193	PF02991	0.743
LIG_LIR_Nem_3	182	188	PF02991	0.635
LIG_LIR_Nem_3	236	241	PF02991	0.706
LIG_LIR_Nem_3	40	45	PF02991	0.369
LIG_MYND_1	208	212	PF01753	0.516
LIG_Pex14_1	89	93	PF04695	0.304
LIG_Pex14_2	185	189	PF04695	0.618
LIG_SH2_CRK	252	256	PF00017	0.740
LIG_SH2_CRK	338	342	PF00017	0.633
LIG_SH2_NCK_1	338	342	PF00017	0.633
LIG_SH2_SRC	370	373	PF00017	0.621
LIG_SH2_STAT5	37	40	PF00017	0.304
LIG_SH3_2	173	178	PF14604	0.640
LIG_SH3_3	145	151	PF00018	0.640
LIG_SH3_3	157	163	PF00018	0.500
LIG_SH3_3	170	176	PF00018	0.625
LIG_SH3_3	189	195	PF00018	0.575
LIG_SH3_3	205	211	PF00018	0.595
LIG_SH3_3	216	222	PF00018	0.580
LIG_SH3_3	238	244	PF00018	0.626
LIG_SH3_3	376	382	PF00018	0.640
LIG_SH3_3	407	413	PF00018	0.608
LIG_SUMO_SIM_par_1	396	401	PF11976	0.623
LIG_TRAF2_1	121	124	PF00917	0.354
LIG_TRAF2_1	179	182	PF00917	0.693
LIG_TRAF2_1	381	384	PF00917	0.647
LIG_WRC_WIRS_1	90	95	PF05994	0.369
LIG_WW_2	208	211	PF00397	0.522
MOD_CDC14_SPxK_1	175	178	PF00782	0.553
MOD_CDK_SPxK_1	172	178	PF00069	0.607
MOD_CK1_1	331	337	PF00069	0.577
MOD_CK1_1	48	54	PF00069	0.369
MOD_CK1_1	67	73	PF00069	0.192
MOD_CK2_1	118	124	PF00069	0.360
MOD_CK2_1	155	161	PF00069	0.598
MOD_CK2_1	62	68	PF00069	0.340
MOD_GlcNHglycan	120	123	PF01048	0.447
MOD_GlcNHglycan	124	128	PF01048	0.461
MOD_GlcNHglycan	189	192	PF01048	0.637
MOD_GlcNHglycan	252	255	PF01048	0.712
MOD_GlcNHglycan	331	334	PF01048	0.630
MOD_GlcNHglycan	360	363	PF01048	0.614
MOD_GlcNHglycan	47	50	PF01048	0.365
MOD_GlcNHglycan	79	82	PF01048	0.403
MOD_GlcNHglycan	99	102	PF01048	0.295
MOD_GSK3_1	142	149	PF00069	0.682
MOD_GSK3_1	151	158	PF00069	0.660
MOD_GSK3_1	195	202	PF00069	0.614
MOD_GSK3_1	213	220	PF00069	0.611
MOD_GSK3_1	286	293	PF00069	0.649
MOD_GSK3_1	337	344	PF00069	0.546
MOD_GSK3_1	370	377	PF00069	0.599
MOD_N-GLC_1	275	280	PF02516	0.675
MOD_NEK2_1	146	151	PF00069	0.667
MOD_NEK2_1	213	218	PF00069	0.626
MOD_NEK2_1	291	296	PF00069	0.732
MOD_NEK2_1	328	333	PF00069	0.634
MOD_NEK2_1	400	405	PF00069	0.646
MOD_NEK2_1	45	50	PF00069	0.313
MOD_NEK2_1	77	82	PF00069	0.403
MOD_NEK2_2	89	94	PF00069	0.347
MOD_PIKK_1	16	22	PF00454	0.404
MOD_PIKK_1	275	281	PF00454	0.670
MOD_PIKK_1	286	292	PF00454	0.566
MOD_PIKK_1	295	301	PF00454	0.498
MOD_PIKK_1	341	347	PF00454	0.527
MOD_PKA_1	16	22	PF00069	0.304
MOD_PKA_2	5	11	PF00069	0.490
MOD_PKA_2	75	81	PF00069	0.369
MOD_Plk_1	123	129	PF00069	0.482
MOD_Plk_4	229	235	PF00069	0.713
MOD_Plk_4	281	287	PF00069	0.570
MOD_Plk_4	386	392	PF00069	0.536
MOD_ProDKin_1	151	157	PF00069	0.583
MOD_ProDKin_1	172	178	PF00069	0.607
MOD_ProDKin_1	195	201	PF00069	0.668
MOD_ProDKin_1	217	223	PF00069	0.564
MOD_ProDKin_1	337	343	PF00069	0.531
MOD_ProDKin_1	370	376	PF00069	0.621
TRG_ER_diArg_1	117	119	PF00400	0.325
TRG_ER_diArg_1	3	6	PF00400	0.536
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P3S6	Trypanosomatidae	39%	93%
A0A3S7XB38	Leishmania donovani	76%	90%
A4HPI1	Leishmania braziliensis	64%	99%
A4IDA3	Leishmania infantum	76%	90%
E9AT93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%