C-CAP/cofactor C-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin binding cofactor c, putative

Species:

Leishmania major

UniProt:

Q4Q1A3_LEIMA

TriTrypDb:

LmjF.36.3160 , LMJLV39_360041100 , LMJSD75_360041000

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4Q1A3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1A3

PDB structure(s): 5aj8_A , 5aj8_B

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0007021	tubulin complex assembly	6	2
GO:0007023	post-chaperonin tubulin folding pathway	3	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.553
CLV_PCSK_KEX2_1	16	18	PF00082	0.553
CLV_PCSK_KEX2_1	295	297	PF00082	0.304
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.304
CLV_PCSK_PC7_1	12	18	PF00082	0.539
CLV_PCSK_SKI1_1	105	109	PF00082	0.541
CLV_PCSK_SKI1_1	175	179	PF00082	0.262
CLV_PCSK_SKI1_1	4	8	PF00082	0.505
DEG_Nend_UBRbox_2	1	3	PF02207	0.532
DEG_SCF_FBW7_1	123	129	PF00400	0.566
DEG_SPOP_SBC_1	322	326	PF00917	0.403
DOC_CKS1_1	123	128	PF01111	0.567
DOC_MAPK_gen_1	19	28	PF00069	0.605
DOC_MAPK_gen_1	214	223	PF00069	0.267
DOC_MAPK_HePTP_8	213	225	PF00069	0.235
DOC_MAPK_MEF2A_6	216	225	PF00069	0.271
DOC_USP7_MATH_1	124	128	PF00917	0.579
DOC_USP7_MATH_1	322	326	PF00917	0.542
DOC_WW_Pin1_4	122	127	PF00397	0.632
DOC_WW_Pin1_4	227	232	PF00397	0.250
DOC_WW_Pin1_4	295	300	PF00397	0.349
LIG_14-3-3_CanoR_1	310	316	PF00244	0.352
LIG_BIR_III_2	120	124	PF00653	0.585
LIG_FHA_1	140	146	PF00498	0.731
LIG_FHA_1	21	27	PF00498	0.567
LIG_FHA_1	228	234	PF00498	0.250
LIG_FHA_2	163	169	PF00498	0.535
LIG_FHA_2	217	223	PF00498	0.314
LIG_FHA_2	261	267	PF00498	0.359
LIG_FHA_2	75	81	PF00498	0.429
LIG_LIR_Gen_1	2	11	PF02991	0.478
LIG_LIR_Gen_1	281	290	PF02991	0.390
LIG_LIR_Gen_1	298	305	PF02991	0.280
LIG_LIR_Nem_3	154	160	PF02991	0.478
LIG_LIR_Nem_3	2	8	PF02991	0.531
LIG_LIR_Nem_3	281	287	PF02991	0.356
LIG_LIR_Nem_3	288	293	PF02991	0.372
LIG_LIR_Nem_3	298	304	PF02991	0.348
LIG_SH2_CRK	188	192	PF00017	0.326
LIG_SH2_PTP2	284	287	PF00017	0.403
LIG_SH2_STAP1	261	265	PF00017	0.454
LIG_SH2_STAP1	33	37	PF00017	0.476
LIG_SH2_STAT5	188	191	PF00017	0.326
LIG_SH2_STAT5	207	210	PF00017	0.250
LIG_SH2_STAT5	224	227	PF00017	0.250
LIG_SH2_STAT5	284	287	PF00017	0.403
LIG_SH3_3	120	126	PF00018	0.692
LIG_SH3_3	157	163	PF00018	0.478
LIG_SH3_3	312	318	PF00018	0.433
LIG_TRAF2_1	305	308	PF00917	0.424
MOD_CK1_1	164	170	PF00069	0.490
MOD_CK1_1	199	205	PF00069	0.309
MOD_CK1_1	20	26	PF00069	0.555
MOD_CK1_1	252	258	PF00069	0.423
MOD_CK1_1	323	329	PF00069	0.499
MOD_CK2_1	116	122	PF00069	0.704
MOD_CK2_1	250	256	PF00069	0.332
MOD_CK2_1	260	266	PF00069	0.368
MOD_CK2_1	74	80	PF00069	0.457
MOD_GlcNHglycan	194	197	PF01048	0.403
MOD_GlcNHglycan	99	102	PF01048	0.540
MOD_GSK3_1	122	129	PF00069	0.655
MOD_GSK3_1	133	140	PF00069	0.524
MOD_GSK3_1	147	154	PF00069	0.525
MOD_GSK3_1	192	199	PF00069	0.284
MOD_GSK3_1	20	27	PF00069	0.555
MOD_GSK3_1	317	324	PF00069	0.518
MOD_GSK3_1	68	75	PF00069	0.480
MOD_N-GLC_1	199	204	PF02516	0.420
MOD_N-GLC_1	51	56	PF02516	0.522
MOD_N-GLC_2	180	182	PF02516	0.376
MOD_NEK2_1	107	112	PF00069	0.523
MOD_NEK2_1	169	174	PF00069	0.430
MOD_NEK2_1	250	255	PF00069	0.296
MOD_NEK2_2	311	316	PF00069	0.377
MOD_PIKK_1	53	59	PF00454	0.463
MOD_PKA_2	309	315	PF00069	0.350
MOD_Plk_4	311	317	PF00069	0.479
MOD_ProDKin_1	122	128	PF00069	0.635
MOD_ProDKin_1	227	233	PF00069	0.250
MOD_ProDKin_1	295	301	PF00069	0.344
MOD_SUMO_rev_2	252	260	PF00179	0.403
TRG_AP2beta_CARGO_1	2	12	PF09066	0.526
TRG_DiLeu_BaEn_1	43	48	PF01217	0.477
TRG_ENDOCYTIC_2	284	287	PF00928	0.342
TRG_ER_diArg_1	16	19	PF00400	0.658
TRG_NLS_MonoExtN_4	104	109	PF00514	0.653
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J8	Leptomonas seymouri	65%	100%
A0A0S4JHW0	Bodo saltans	34%	100%
A0A1X0P3G4	Trypanosomatidae	44%	100%
A0A3Q8IG96	Leishmania donovani	95%	100%
A0A3R7L226	Trypanosoma rangeli	46%	100%
A4HPI2	Leishmania braziliensis	81%	100%
A4IDA4	Leishmania infantum	95%	100%
D0A8E4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AT94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q15814	Homo sapiens	26%	97%
Q3SZE9	Bos taurus	26%	97%
Q5R5J7	Pongo abelii	26%	97%
Q8VCN9	Mus musculus	24%	98%
V5B9L2	Trypanosoma cruzi	46%	100%