cobW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CobW/HypB/UreG, nucleotide-binding domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q1A2_LEIMA

TriTrypDb:

LmjF.36.3170 , LMJLV39_360041200 , LMJSD75_360041100

Length:

344

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1A2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1A2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.452
CLV_PCSK_SKI1_1	162	166	PF00082	0.251
CLV_PCSK_SKI1_1	169	173	PF00082	0.242
CLV_PCSK_SKI1_1	184	188	PF00082	0.247
CLV_PCSK_SKI1_1	211	215	PF00082	0.424
CLV_PCSK_SKI1_1	220	224	PF00082	0.522
CLV_PCSK_SKI1_1	333	337	PF00082	0.378
CLV_PCSK_SKI1_1	338	342	PF00082	0.400
CLV_PCSK_SKI1_1	59	63	PF00082	0.258
CLV_Separin_Metazoa	275	279	PF03568	0.344
DEG_SIAH_1	194	202	PF03145	0.413
DOC_CYCLIN_RxL_1	289	298	PF00134	0.275
DOC_CYCLIN_RxL_1	55	67	PF00134	0.458
DOC_CYCLIN_yClb5_NLxxxL_5	206	214	PF00134	0.383
DOC_PP1_RVXF_1	209	216	PF00149	0.418
DOC_USP7_MATH_1	251	255	PF00917	0.475
DOC_USP7_MATH_1	260	264	PF00917	0.458
DOC_USP7_MATH_1	92	96	PF00917	0.488
DOC_USP7_UBL2_3	55	59	PF12436	0.457
DOC_USP7_UBL2_3	64	68	PF12436	0.460
DOC_WW_Pin1_4	303	308	PF00397	0.406
LIG_14-3-3_CanoR_1	14	20	PF00244	0.408
LIG_14-3-3_CanoR_1	220	228	PF00244	0.655
LIG_Actin_WH2_2	320	335	PF00022	0.373
LIG_Actin_WH2_2	50	66	PF00022	0.458
LIG_APCC_ABBAyCdc20_2	211	217	PF00400	0.515
LIG_BIR_II_1	1	5	PF00653	0.623
LIG_BRCT_BRCA1_1	239	243	PF00533	0.375
LIG_BRCT_BRCA1_1	311	315	PF00533	0.538
LIG_Clathr_ClatBox_1	105	109	PF01394	0.447
LIG_FHA_1	100	106	PF00498	0.388
LIG_FHA_1	108	114	PF00498	0.440
LIG_FHA_1	19	25	PF00498	0.451
LIG_FHA_1	221	227	PF00498	0.592
LIG_FHA_1	27	33	PF00498	0.453
LIG_FHA_1	304	310	PF00498	0.516
LIG_FHA_1	316	322	PF00498	0.371
LIG_FHA_1	85	91	PF00498	0.493
LIG_FHA_2	138	144	PF00498	0.458
LIG_LIR_Gen_1	102	108	PF02991	0.447
LIG_LIR_Gen_1	271	282	PF02991	0.369
LIG_LIR_Gen_1	70	81	PF02991	0.458
LIG_LIR_Nem_3	102	106	PF02991	0.447
LIG_LIR_Nem_3	253	258	PF02991	0.403
LIG_LIR_Nem_3	271	277	PF02991	0.384
LIG_LIR_Nem_3	288	294	PF02991	0.470
LIG_LIR_Nem_3	334	339	PF02991	0.466
LIG_LIR_Nem_3	70	76	PF02991	0.458
LIG_Rb_pABgroove_1	297	305	PF01858	0.364
LIG_SH2_CRK	291	295	PF00017	0.415
LIG_SH2_STAT5	134	137	PF00017	0.476
LIG_SH2_STAT5	150	153	PF00017	0.377
LIG_SH2_STAT5	339	342	PF00017	0.407
LIG_SH2_STAT5	34	37	PF00017	0.458
LIG_SUMO_SIM_anti_2	104	111	PF11976	0.447
LIG_SUMO_SIM_par_1	104	111	PF11976	0.447
LIG_SUMO_SIM_par_1	136	143	PF11976	0.447
LIG_SUMO_SIM_par_1	15	21	PF11976	0.301
MOD_CK1_1	202	208	PF00069	0.430
MOD_CK1_1	234	240	PF00069	0.413
MOD_CK1_1	26	32	PF00069	0.458
MOD_CK2_1	92	98	PF00069	0.552
MOD_GlcNHglycan	109	113	PF01048	0.247
MOD_GlcNHglycan	11	14	PF01048	0.498
MOD_GlcNHglycan	135	138	PF01048	0.247
MOD_GlcNHglycan	236	239	PF01048	0.438
MOD_GlcNHglycan	25	28	PF01048	0.258
MOD_GlcNHglycan	36	39	PF01048	0.258
MOD_GSK3_1	133	140	PF00069	0.461
MOD_GSK3_1	195	202	PF00069	0.546
MOD_GSK3_1	216	223	PF00069	0.551
MOD_GSK3_1	23	30	PF00069	0.458
MOD_GSK3_1	59	66	PF00069	0.449
MOD_N-GLC_2	146	148	PF02516	0.288
MOD_N-GLC_2	173	175	PF02516	0.258
MOD_N-GLC_2	78	80	PF02516	0.258
MOD_NEK2_1	107	112	PF00069	0.447
MOD_NEK2_1	133	138	PF00069	0.449
MOD_NEK2_1	215	220	PF00069	0.444
MOD_NEK2_1	23	28	PF00069	0.454
MOD_NEK2_1	250	255	PF00069	0.490
MOD_NEK2_1	315	320	PF00069	0.371
MOD_NEK2_1	81	86	PF00069	0.515
MOD_PIKK_1	84	90	PF00454	0.446
MOD_PKA_2	99	105	PF00069	0.528
MOD_Plk_1	202	208	PF00069	0.503
MOD_Plk_4	137	143	PF00069	0.510
MOD_Plk_4	15	21	PF00069	0.315
MOD_Plk_4	195	201	PF00069	0.497
MOD_Plk_4	27	33	PF00069	0.458
MOD_Plk_4	92	98	PF00069	0.472
MOD_ProDKin_1	303	309	PF00069	0.421
MOD_SUMO_rev_2	328	332	PF00179	0.486
TRG_DiLeu_BaEn_1	161	166	PF01217	0.552
TRG_DiLeu_BaEn_1	6	11	PF01217	0.601
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.423
TRG_ENDOCYTIC_2	255	258	PF00928	0.475
TRG_ENDOCYTIC_2	291	294	PF00928	0.417
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.275
TRG_Pf-PMV_PEXEL_1	292	297	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD31	Leptomonas seymouri	80%	100%
A0A0S4JEN9	Bodo saltans	45%	100%
A0A1X0P3M7	Trypanosomatidae	70%	97%
A0A3R7NQA1	Trypanosoma rangeli	68%	97%
A0A3S7XBA8	Leishmania donovani	95%	100%
A4HPI3	Leishmania braziliensis	89%	100%
A4IDA5	Leishmania infantum	95%	100%
D0A8E5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9AT95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P24203	Escherichia coli (strain K12)	29%	100%
P94400	Bacillus subtilis (strain 168)	30%	87%
Q4V339	Homo sapiens	32%	87%
Q5JTY5	Homo sapiens	32%	87%
Q5RIA9	Homo sapiens	32%	87%
Q869Q0	Dictyostelium discoideum	30%	72%
Q8IUF1	Homo sapiens	33%	87%
Q8VEH6	Mus musculus	38%	88%
Q99MB4	Rattus norvegicus	33%	87%
Q9BRT8	Homo sapiens	33%	87%
V5AU61	Trypanosoma cruzi	71%	81%