LeishMANIAdb
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ATP pyrophosphate-lyase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ATP pyrophosphate-lyase
Gene product:
receptor-type adenylate cyclase a-like protein
Species:
Leishmania major
UniProt:
Q4Q1A1_LEIMA
TriTrypDb:
LmjF.36.3180 * , LMJLV39_360041300 * , LMJSD75_360041200 *
Length:
1401

Annotations

LeishMANIAdb annotations

Carries an ATP pyrophosphate-lyase domain on its cytoplasmic segment. Likely acts as a receptor for some unknown extracellular stimulus. Extremely expanded kinetoplastid protein family.. Expressed in the insect stage (promastigote) but not in the mammalian host stage of the parasite life cycle.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 42
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 41, no: 22
NetGPI no yes: 0, no: 63
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 61
GO:0110165 cellular anatomical entity 1 64
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Expansion

Sequence features

Q4Q1A1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
TermNameLevelCount
GO:0006139 nucleobase-containing compound metabolic process 3 64
GO:0006163 purine nucleotide metabolic process 5 64
GO:0006164 purine nucleotide biosynthetic process 6 64
GO:0006171 cAMP biosynthetic process 8 64
GO:0006725 cellular aromatic compound metabolic process 3 64
GO:0006753 nucleoside phosphate metabolic process 4 64
GO:0006793 phosphorus metabolic process 3 64
GO:0006796 phosphate-containing compound metabolic process 4 64
GO:0006807 nitrogen compound metabolic process 2 64
GO:0007165 signal transduction 2 64
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 55
GO:0016829 lyase activity 2 55
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 1221 1225 PF00656 0.673
CLV_C14_Caspase3-7 321 325 PF00656 0.383
CLV_C14_Caspase3-7 455 459 PF00656 0.385
CLV_C14_Caspase3-7 850 854 PF00656 0.607
CLV_C14_Caspase3-7 911 915 PF00656 0.485
CLV_NRD_NRD_1 1150 1152 PF00675 0.310
CLV_NRD_NRD_1 1179 1181 PF00675 0.377
CLV_NRD_NRD_1 1213 1215 PF00675 0.434
CLV_NRD_NRD_1 1234 1236 PF00675 0.525
CLV_NRD_NRD_1 137 139 PF00675 0.533
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P457 Leptomonas seymouri 40% 100%
A0A1X0P171 Trypanosomatidae 29% 100%
A0A3Q8IJB0 Leishmania donovani 27% 100%
A0A3S5H6Z8 Leishmania donovani 27% 100%
A0A3S7WU91 Leishmania donovani 28% 99%
A0A3S7WU95 Leishmania donovani 27% 100%
A0A3S7XB85 Leishmania donovani 86% 99%
A4H8U6 Leishmania braziliensis 29% 100%
A4H8V5 Leishmania braziliensis 29% 100%
A4H8V7 Leishmania braziliensis 31% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS