DNA topoisomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA topoisomerase

Gene product:

DNA topoisomerase III, putative

Species:

Leishmania major

UniProt:

Q4Q199_LEIMA

TriTrypDb:

LmjF.36.3200 , LMJLV39_360041600 , LMJSD75_360041500

Length:

947

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	3
GO:0005694	chromosome	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

Q4Q199

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q199

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006265	DNA topological change	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006996	organelle organization	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0051276	chromosome organization	5	12
GO:0071103	DNA conformation change	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0003916	DNA topoisomerase activity	3	12
GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	4	12
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	11
GO:0016853	isomerase activity	2	12
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0097159	organic cyclic compound binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.323
CLV_C14_Caspase3-7	492	496	PF00656	0.393
CLV_NRD_NRD_1	216	218	PF00675	0.393
CLV_NRD_NRD_1	284	286	PF00675	0.353
CLV_NRD_NRD_1	881	883	PF00675	0.690
CLV_NRD_NRD_1	922	924	PF00675	0.345
CLV_PCSK_FUR_1	928	932	PF00082	0.428
CLV_PCSK_KEX2_1	131	133	PF00082	0.305
CLV_PCSK_KEX2_1	138	140	PF00082	0.266
CLV_PCSK_KEX2_1	162	164	PF00082	0.407
CLV_PCSK_KEX2_1	216	218	PF00082	0.393
CLV_PCSK_KEX2_1	284	286	PF00082	0.337
CLV_PCSK_KEX2_1	519	521	PF00082	0.323
CLV_PCSK_KEX2_1	599	601	PF00082	0.541
CLV_PCSK_KEX2_1	881	883	PF00082	0.689
CLV_PCSK_KEX2_1	930	932	PF00082	0.334
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.310
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.265
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.428
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.290
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.541
CLV_PCSK_PC1ET2_1	930	932	PF00082	0.380
CLV_PCSK_PC7_1	280	286	PF00082	0.344
CLV_PCSK_PC7_1	515	521	PF00082	0.323
CLV_PCSK_SKI1_1	148	152	PF00082	0.393
CLV_PCSK_SKI1_1	191	195	PF00082	0.428
CLV_PCSK_SKI1_1	406	410	PF00082	0.316
CLV_PCSK_SKI1_1	46	50	PF00082	0.316
CLV_PCSK_SKI1_1	510	514	PF00082	0.342
CLV_PCSK_SKI1_1	930	934	PF00082	0.317
CLV_Separin_Metazoa	342	346	PF03568	0.392
DEG_APCC_DBOX_1	147	155	PF00400	0.439
DEG_APCC_DBOX_1	396	404	PF00400	0.316
DEG_APCC_DBOX_1	405	413	PF00400	0.291
DEG_APCC_DBOX_1	86	94	PF00400	0.516
DOC_ANK_TNKS_1	816	823	PF00023	0.588
DOC_MAPK_DCC_7	817	825	PF00069	0.582
DOC_MAPK_gen_1	131	137	PF00069	0.535
DOC_MAPK_gen_1	284	290	PF00069	0.374
DOC_MAPK_gen_1	397	405	PF00069	0.379
DOC_MAPK_gen_1	836	843	PF00069	0.500
DOC_MAPK_MEF2A_6	103	111	PF00069	0.469
DOC_MAPK_MEF2A_6	171	178	PF00069	0.323
DOC_MAPK_MEF2A_6	552	559	PF00069	0.307
DOC_MAPK_MEF2A_6	817	825	PF00069	0.582
DOC_MAPK_NFAT4_5	171	179	PF00069	0.323
DOC_MAPK_NFAT4_5	552	560	PF00069	0.307
DOC_PP2B_LxvP_1	157	160	PF13499	0.408
DOC_PP2B_LxvP_1	303	306	PF13499	0.411
DOC_PP4_FxxP_1	702	705	PF00568	0.409
DOC_PP4_FxxP_1	78	81	PF00568	0.541
DOC_USP7_MATH_1	30	34	PF00917	0.529
DOC_USP7_MATH_1	533	537	PF00917	0.307
DOC_USP7_MATH_1	790	794	PF00917	0.554
DOC_USP7_MATH_1	796	800	PF00917	0.552
DOC_USP7_MATH_1	803	807	PF00917	0.479
DOC_USP7_MATH_1	851	855	PF00917	0.657
DOC_USP7_MATH_1	859	863	PF00917	0.662
DOC_USP7_MATH_1	880	884	PF00917	0.724
DOC_USP7_UBL2_3	158	162	PF12436	0.523
DOC_USP7_UBL2_3	42	46	PF12436	0.515
DOC_WW_Pin1_4	410	415	PF00397	0.321
DOC_WW_Pin1_4	668	673	PF00397	0.535
DOC_WW_Pin1_4	701	706	PF00397	0.434
DOC_WW_Pin1_4	794	799	PF00397	0.505
DOC_WW_Pin1_4	899	904	PF00397	0.681
DOC_WW_Pin1_4	912	917	PF00397	0.308
LIG_14-3-3_CanoR_1	184	189	PF00244	0.347
LIG_14-3-3_CanoR_1	452	461	PF00244	0.289
LIG_14-3-3_CanoR_1	663	668	PF00244	0.578
LIG_14-3-3_CanoR_1	785	789	PF00244	0.436
LIG_14-3-3_CanoR_1	881	885	PF00244	0.747
LIG_14-3-3_CanoR_1	938	943	PF00244	0.372
LIG_Actin_WH2_2	161	179	PF00022	0.323
LIG_Actin_WH2_2	357	375	PF00022	0.433
LIG_APCC_ABBA_1	577	582	PF00400	0.387
LIG_BRCT_BRCA1_1	331	335	PF00533	0.323
LIG_BRCT_BRCA1_1	423	427	PF00533	0.428
LIG_Clathr_ClatBox_1	809	813	PF01394	0.480
LIG_eIF4E_1	72	78	PF01652	0.496
LIG_FHA_1	104	110	PF00498	0.468
LIG_FHA_1	229	235	PF00498	0.325
LIG_FHA_1	356	362	PF00498	0.406
LIG_FHA_1	418	424	PF00498	0.323
LIG_FHA_1	435	441	PF00498	0.323
LIG_FHA_1	45	51	PF00498	0.559
LIG_FHA_1	486	492	PF00498	0.350
LIG_FHA_1	527	533	PF00498	0.454
LIG_FHA_1	673	679	PF00498	0.544
LIG_FHA_1	751	757	PF00498	0.447
LIG_FHA_1	81	87	PF00498	0.484
LIG_FHA_1	826	832	PF00498	0.459
LIG_FHA_1	868	874	PF00498	0.579
LIG_FHA_2	144	150	PF00498	0.383
LIG_FHA_2	326	332	PF00498	0.335
LIG_FHA_2	391	397	PF00498	0.393
LIG_FHA_2	509	515	PF00498	0.322
LIG_GBD_Chelix_1	505	513	PF00786	0.342
LIG_Integrin_isoDGR_2	661	663	PF01839	0.489
LIG_LIR_Apic_2	868	874	PF02991	0.541
LIG_LIR_Gen_1	183	193	PF02991	0.331
LIG_LIR_Gen_1	247	257	PF02991	0.361
LIG_LIR_Gen_1	3	11	PF02991	0.366
LIG_LIR_Gen_1	536	546	PF02991	0.342
LIG_LIR_Gen_1	581	589	PF02991	0.414
LIG_LIR_Gen_1	839	847	PF02991	0.473
LIG_LIR_Gen_1	941	947	PF02991	0.379
LIG_LIR_Nem_3	183	188	PF02991	0.340
LIG_LIR_Nem_3	227	232	PF02991	0.342
LIG_LIR_Nem_3	247	252	PF02991	0.342
LIG_LIR_Nem_3	3	7	PF02991	0.366
LIG_LIR_Nem_3	33	38	PF02991	0.466
LIG_LIR_Nem_3	536	541	PF02991	0.342
LIG_LIR_Nem_3	581	587	PF02991	0.401
LIG_LIR_Nem_3	66	72	PF02991	0.499
LIG_LIR_Nem_3	712	717	PF02991	0.593
LIG_LIR_Nem_3	731	735	PF02991	0.363
LIG_LIR_Nem_3	839	843	PF02991	0.444
LIG_LIR_Nem_3	941	946	PF02991	0.379
LIG_NRBOX	542	548	PF00104	0.323
LIG_PCNA_yPIPBox_3	397	409	PF02747	0.323
LIG_Pex14_1	444	448	PF04695	0.307
LIG_Pex14_2	190	194	PF04695	0.323
LIG_Pex14_2	74	78	PF04695	0.541
LIG_PTB_Apo_2	33	40	PF02174	0.466
LIG_PTB_Phospho_1	33	39	PF10480	0.515
LIG_SH2_CRK	185	189	PF00017	0.428
LIG_SH2_CRK	249	253	PF00017	0.393
LIG_SH2_CRK	401	405	PF00017	0.323
LIG_SH2_CRK	714	718	PF00017	0.452
LIG_SH2_CRK	871	875	PF00017	0.433
LIG_SH2_NCK_1	249	253	PF00017	0.346
LIG_SH2_NCK_1	580	584	PF00017	0.411
LIG_SH2_NCK_1	871	875	PF00017	0.449
LIG_SH2_PTP2	840	843	PF00017	0.455
LIG_SH2_SRC	318	321	PF00017	0.307
LIG_SH2_SRC	461	464	PF00017	0.428
LIG_SH2_SRC	580	583	PF00017	0.481
LIG_SH2_STAP1	249	253	PF00017	0.346
LIG_SH2_STAP1	258	262	PF00017	0.350
LIG_SH2_STAP1	356	360	PF00017	0.406
LIG_SH2_STAP1	39	43	PF00017	0.515
LIG_SH2_STAP1	580	584	PF00017	0.411
LIG_SH2_STAT3	218	221	PF00017	0.428
LIG_SH2_STAT3	333	336	PF00017	0.428
LIG_SH2_STAT3	72	75	PF00017	0.559
LIG_SH2_STAT5	333	336	PF00017	0.396
LIG_SH2_STAT5	517	520	PF00017	0.307
LIG_SH2_STAT5	601	604	PF00017	0.499
LIG_SH2_STAT5	840	843	PF00017	0.436
LIG_SH2_STAT5	85	88	PF00017	0.541
LIG_SH2_STAT5	871	874	PF00017	0.455
LIG_SH3_2	383	388	PF14604	0.307
LIG_SH3_3	283	289	PF00018	0.319
LIG_SH3_3	365	371	PF00018	0.385
LIG_SH3_3	380	386	PF00018	0.207
LIG_SH3_3	666	672	PF00018	0.541
LIG_SH3_3	783	789	PF00018	0.410
LIG_SUMO_SIM_anti_2	337	345	PF11976	0.399
LIG_SUMO_SIM_par_1	486	496	PF11976	0.328
LIG_SxIP_EBH_1	452	464	PF03271	0.419
LIG_TRAF2_1	170	173	PF00917	0.342
LIG_TRAF2_1	334	337	PF00917	0.432
LIG_TYR_ITSM	181	188	PF00017	0.428
LIG_TYR_ITSM	710	717	PF00017	0.436
LIG_WRC_WIRS_1	200	205	PF05994	0.323
LIG_WRC_WIRS_1	809	814	PF05994	0.505
MOD_CDC14_SPxK_1	704	707	PF00782	0.584
MOD_CDK_SPxK_1	701	707	PF00069	0.560
MOD_CDK_SPxK_1	912	918	PF00069	0.227
MOD_CDK_SPxxK_3	794	801	PF00069	0.508
MOD_CK1_1	143	149	PF00069	0.521
MOD_CK1_1	244	250	PF00069	0.407
MOD_CK1_1	710	716	PF00069	0.429
MOD_CK1_1	862	868	PF00069	0.664
MOD_CK2_1	331	337	PF00069	0.324
MOD_CK2_1	390	396	PF00069	0.454
MOD_CK2_1	533	539	PF00069	0.323
MOD_CK2_1	919	925	PF00069	0.341
MOD_Cter_Amidation	928	931	PF01082	0.323
MOD_GlcNHglycan	142	145	PF01048	0.266
MOD_GlcNHglycan	21	24	PF01048	0.316
MOD_GlcNHglycan	423	426	PF01048	0.370
MOD_GlcNHglycan	479	482	PF01048	0.418
MOD_GlcNHglycan	535	538	PF01048	0.313
MOD_GlcNHglycan	766	769	PF01048	0.528
MOD_GlcNHglycan	78	81	PF01048	0.321
MOD_GlcNHglycan	805	808	PF01048	0.490
MOD_GlcNHglycan	813	817	PF01048	0.545
MOD_GlcNHglycan	848	851	PF01048	0.651
MOD_GlcNHglycan	853	856	PF01048	0.658
MOD_GlcNHglycan	857	860	PF01048	0.646
MOD_GlcNHglycan	867	870	PF01048	0.602
MOD_GlcNHglycan	878	881	PF01048	0.649
MOD_GlcNHglycan	903	906	PF01048	0.644
MOD_GSK3_1	180	187	PF00069	0.323
MOD_GSK3_1	236	243	PF00069	0.342
MOD_GSK3_1	321	328	PF00069	0.312
MOD_GSK3_1	331	338	PF00069	0.295
MOD_GSK3_1	417	424	PF00069	0.329
MOD_GSK3_1	430	437	PF00069	0.267
MOD_GSK3_1	44	51	PF00069	0.514
MOD_GSK3_1	485	492	PF00069	0.456
MOD_GSK3_1	521	528	PF00069	0.365
MOD_GSK3_1	533	540	PF00069	0.365
MOD_GSK3_1	63	70	PF00069	0.515
MOD_GSK3_1	668	675	PF00069	0.510
MOD_GSK3_1	76	83	PF00069	0.426
MOD_GSK3_1	790	797	PF00069	0.509
MOD_GSK3_1	808	815	PF00069	0.412
MOD_GSK3_1	846	853	PF00069	0.623
MOD_GSK3_1	855	862	PF00069	0.644
MOD_GSK3_1	863	870	PF00069	0.477
MOD_GSK3_1	872	879	PF00069	0.574
MOD_LATS_1	302	308	PF00433	0.365
MOD_N-GLC_1	390	395	PF02516	0.378
MOD_N-GLC_1	453	458	PF02516	0.380
MOD_N-GLC_1	67	72	PF02516	0.341
MOD_N-GLC_1	851	856	PF02516	0.678
MOD_N-GLC_2	119	121	PF02516	0.266
MOD_NEK2_1	17	22	PF00069	0.520
MOD_NEK2_1	241	246	PF00069	0.404
MOD_NEK2_1	298	303	PF00069	0.338
MOD_NEK2_1	313	318	PF00069	0.338
MOD_NEK2_1	408	413	PF00069	0.394
MOD_NEK2_1	431	436	PF00069	0.294
MOD_NEK2_1	48	53	PF00069	0.466
MOD_NEK2_1	485	490	PF00069	0.365
MOD_NEK2_1	493	498	PF00069	0.365
MOD_NEK2_1	588	593	PF00069	0.524
MOD_NEK2_1	772	777	PF00069	0.433
MOD_NEK2_1	784	789	PF00069	0.429
MOD_NEK2_1	812	817	PF00069	0.553
MOD_NEK2_1	825	830	PF00069	0.322
MOD_NEK2_2	790	795	PF00069	0.534
MOD_NEK2_2	880	885	PF00069	0.709
MOD_OFUCOSY	776	782	PF10250	0.499
MOD_PIKK_1	28	34	PF00454	0.544
MOD_PIKK_1	390	396	PF00454	0.419
MOD_PIKK_1	418	424	PF00454	0.392
MOD_PIKK_1	796	802	PF00454	0.542
MOD_PK_1	707	713	PF00069	0.574
MOD_PKA_1	162	168	PF00069	0.428
MOD_PKA_2	162	168	PF00069	0.407
MOD_PKA_2	244	250	PF00069	0.393
MOD_PKA_2	272	278	PF00069	0.360
MOD_PKA_2	279	285	PF00069	0.324
MOD_PKA_2	784	790	PF00069	0.503
MOD_PKA_2	880	886	PF00069	0.772
MOD_Plk_1	453	459	PF00069	0.385
MOD_Plk_1	501	507	PF00069	0.307
MOD_Plk_1	67	73	PF00069	0.559
MOD_Plk_1	851	857	PF00069	0.638
MOD_Plk_2-3	331	337	PF00069	0.316
MOD_Plk_4	103	109	PF00069	0.484
MOD_Plk_4	244	250	PF00069	0.391
MOD_Plk_4	252	258	PF00069	0.349
MOD_Plk_4	289	295	PF00069	0.393
MOD_Plk_4	313	319	PF00069	0.307
MOD_Plk_4	435	441	PF00069	0.357
MOD_Plk_4	44	50	PF00069	0.533
MOD_Plk_4	508	514	PF00069	0.307
MOD_Plk_4	521	527	PF00069	0.307
MOD_Plk_4	542	548	PF00069	0.323
MOD_Plk_4	613	619	PF00069	0.557
MOD_Plk_4	938	944	PF00069	0.379
MOD_ProDKin_1	410	416	PF00069	0.321
MOD_ProDKin_1	668	674	PF00069	0.527
MOD_ProDKin_1	701	707	PF00069	0.448
MOD_ProDKin_1	794	800	PF00069	0.507
MOD_ProDKin_1	899	905	PF00069	0.679
MOD_ProDKin_1	912	918	PF00069	0.308
MOD_SUMO_for_1	41	44	PF00179	0.515
MOD_SUMO_for_1	518	521	PF00179	0.290
MOD_SUMO_rev_2	40	48	PF00179	0.496
TRG_DiLeu_BaEn_1	339	344	PF01217	0.428
TRG_DiLeu_BaEn_1	521	526	PF01217	0.323
TRG_ENDOCYTIC_2	185	188	PF00928	0.428
TRG_ENDOCYTIC_2	249	252	PF00928	0.358
TRG_ENDOCYTIC_2	258	261	PF00928	0.374
TRG_ENDOCYTIC_2	401	404	PF00928	0.307
TRG_ENDOCYTIC_2	538	541	PF00928	0.342
TRG_ENDOCYTIC_2	580	583	PF00928	0.376
TRG_ENDOCYTIC_2	595	598	PF00928	0.394
TRG_ENDOCYTIC_2	714	717	PF00928	0.452
TRG_ENDOCYTIC_2	840	843	PF00928	0.436
TRG_ER_diArg_1	215	217	PF00400	0.393
TRG_ER_diArg_1	284	286	PF00400	0.351
TRG_ER_diArg_1	367	370	PF00400	0.299
TRG_ER_diArg_1	397	400	PF00400	0.392
TRG_ER_diArg_1	763	766	PF00400	0.401
TRG_NES_CRM1_1	149	161	PF08389	0.530
TRG_NES_CRM1_1	339	352	PF08389	0.412
TRG_Pf-PMV_PEXEL_1	600	605	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0P1	Leptomonas seymouri	33%	100%
A0A0N1PAL1	Leptomonas seymouri	77%	98%
A0A0S4J933	Bodo saltans	31%	100%
A0A0S4JI21	Bodo saltans	48%	97%
A0A1X0NSK9	Trypanosomatidae	32%	100%
A0A1X0P3I0	Trypanosomatidae	58%	100%
A0A3R7KDV1	Trypanosoma rangeli	59%	100%
A0A3S7WW83	Leishmania donovani	22%	100%
A0A3S7X1K1	Leishmania donovani	33%	100%
A0A3S7XB89	Leishmania donovani	97%	100%
A0A422NYW0	Trypanosoma rangeli	32%	100%
A0R979	Bacillus thuringiensis (strain Al Hakam)	22%	100%
A4HGN1	Leishmania braziliensis	33%	100%
A4HPI6	Leishmania braziliensis	87%	100%
A4I3Q5	Leishmania infantum	33%	100%
A4IDA8	Leishmania infantum	97%	100%
D0A8A5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A8E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AT98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AZZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
F4ISQ7	Arabidopsis thaliana	32%	100%
O27661	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	25%	100%
O28469	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	27%	100%
O58356	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	30%	100%
O67226	Aquifex aeolicus (strain VF5)	23%	82%
O95985	Homo sapiens	31%	100%
O96651	Drosophila melanogaster	33%	100%
P13099	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
P34184	Alkalihalophilus pseudofirmus (strain ATCC BAA-2126 / JCM 17055 / OF4)	23%	100%
P39814	Bacillus subtilis (strain 168)	22%	100%
P40114	Bacillus anthracis	22%	100%
P43012	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	23%	100%
P43704	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	26%	100%
P96583	Bacillus subtilis (strain 168)	24%	100%
Q0J0S6	Oryza sativa subsp. japonica	33%	100%
Q2FEN5	Staphylococcus aureus (strain USA300)	23%	100%
Q2FW03	Staphylococcus aureus (strain NCTC 8325 / PS 47)	23%	100%
Q49ZH2	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	21%	100%
Q4L8B8	Staphylococcus haemolyticus (strain JCSC1435)	21%	100%
Q4Q888	Leishmania major	33%	100%
Q59046	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	100%
Q5HDV4	Staphylococcus aureus (strain COL)	23%	100%
Q5HLZ4	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	21%	100%
Q5WAX6	Alkalihalobacillus clausii (strain KSM-K16)	26%	100%
Q63GK5	Bacillus cereus (strain ZK / E33L)	22%	100%
Q65N90	Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46)	24%	100%
Q6G767	Staphylococcus aureus (strain MSSA476)	23%	100%
Q6GEH9	Staphylococcus aureus (strain MRSA252)	23%	100%
Q6HP19	Bacillus thuringiensis subsp. konkukian (strain 97-27)	22%	100%
Q73E74	Bacillus cereus (strain ATCC 10987 / NRS 248)	22%	100%
Q7A075	Staphylococcus aureus (strain MW2)	23%	100%
Q7A455	Staphylococcus aureus (strain N315)	23%	100%
Q81IH1	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	23%	100%
Q81Z97	Bacillus anthracis	22%	100%
Q8CRF7	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	21%	100%
Q8T2T7	Dictyostelium discoideum	37%	100%
Q8ZXT5	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	23%	77%
Q99S17	Staphylococcus aureus (strain Mu50 / ATCC 700699)	23%	100%
Q9CN30	Pasteurella multocida (strain Pm70)	23%	100%
Q9CP53	Pasteurella multocida (strain Pm70)	24%	100%
Q9HM08	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	26%	100%
Q9KRB2	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	24%	100%
Q9LVP1	Arabidopsis thaliana	42%	100%
Q9UYS8	Pyrococcus abyssi (strain GE5 / Orsay)	29%	100%
Q9YB01	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	27%	100%
Q9Z321	Mus musculus	31%	100%
Q9ZMV7	Helicobacter pylori (strain J99 / ATCC 700824)	22%	100%
V5AV88	Trypanosoma cruzi	31%	100%
V5BE78	Trypanosoma cruzi	54%	100%