Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q197_LEIMA

TriTrypDb:

LmjF.36.3220 , LMJLV39_360041800 , LMJSD75_360041700

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q197

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q197

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.704
CLV_C14_Caspase3-7	335	339	PF00656	0.655
CLV_C14_Caspase3-7	97	101	PF00656	0.530
CLV_MEL_PAP_1	212	218	PF00089	0.480
CLV_NRD_NRD_1	200	202	PF00675	0.497
CLV_NRD_NRD_1	239	241	PF00675	0.592
CLV_NRD_NRD_1	291	293	PF00675	0.622
CLV_NRD_NRD_1	40	42	PF00675	0.582
CLV_NRD_NRD_1	457	459	PF00675	0.559
CLV_NRD_NRD_1	478	480	PF00675	0.535
CLV_NRD_NRD_1	56	58	PF00675	0.580
CLV_PCSK_FUR_1	476	480	PF00082	0.670
CLV_PCSK_KEX2_1	121	123	PF00082	0.660
CLV_PCSK_KEX2_1	200	202	PF00082	0.497
CLV_PCSK_KEX2_1	238	240	PF00082	0.594
CLV_PCSK_KEX2_1	457	459	PF00082	0.567
CLV_PCSK_KEX2_1	478	480	PF00082	0.583
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.644
CLV_PCSK_PC7_1	196	202	PF00082	0.494
CLV_PCSK_SKI1_1	145	149	PF00082	0.609
CLV_PCSK_SKI1_1	458	462	PF00082	0.528
CLV_PCSK_SKI1_1	480	484	PF00082	0.598
CLV_PCSK_SKI1_1	501	505	PF00082	0.674
CLV_PCSK_SKI1_1	58	62	PF00082	0.555
DEG_APCC_DBOX_1	237	245	PF00400	0.558
DEG_APCC_DBOX_1	393	401	PF00400	0.632
DEG_APCC_DBOX_1	56	64	PF00400	0.597
DOC_CYCLIN_RxL_1	172	182	PF00134	0.541
DOC_CYCLIN_RxL_1	497	508	PF00134	0.623
DOC_MAPK_gen_1	57	63	PF00069	0.651
DOC_MAPK_MEF2A_6	24	32	PF00069	0.564
DOC_MAPK_RevD_3	28	42	PF00069	0.551
DOC_MIT_MIM_1	539	548	PF04212	0.587
DOC_PP1_RVXF_1	327	333	PF00149	0.631
DOC_USP7_MATH_1	350	354	PF00917	0.593
DOC_USP7_MATH_1	94	98	PF00917	0.512
DOC_USP7_UBL2_3	461	465	PF12436	0.538
DOC_USP7_UBL2_3	58	62	PF12436	0.401
LIG_14-3-3_CanoR_1	137	141	PF00244	0.651
LIG_14-3-3_CanoR_1	145	150	PF00244	0.575
LIG_14-3-3_CanoR_1	159	165	PF00244	0.462
LIG_14-3-3_CanoR_1	215	222	PF00244	0.575
LIG_14-3-3_CanoR_1	269	274	PF00244	0.541
LIG_14-3-3_CanoR_1	306	311	PF00244	0.665
LIG_14-3-3_CanoR_1	501	506	PF00244	0.672
LIG_14-3-3_CanoR_1	532	541	PF00244	0.570
LIG_Actin_WH2_2	327	344	PF00022	0.588
LIG_BIR_II_1	1	5	PF00653	0.553
LIG_BIR_III_4	69	73	PF00653	0.536
LIG_FHA_1	137	143	PF00498	0.639
LIG_FHA_1	272	278	PF00498	0.639
LIG_FHA_1	33	39	PF00498	0.500
LIG_FHA_1	409	415	PF00498	0.620
LIG_FHA_1	416	422	PF00498	0.660
LIG_FHA_1	481	487	PF00498	0.557
LIG_FHA_1	541	547	PF00498	0.628
LIG_FHA_1	82	88	PF00498	0.569
LIG_FHA_2	123	129	PF00498	0.699
LIG_FHA_2	8	14	PF00498	0.529
LIG_LIR_Gen_1	16	25	PF02991	0.445
LIG_LIR_Gen_1	3	12	PF02991	0.487
LIG_LIR_Gen_1	521	531	PF02991	0.679
LIG_LIR_Nem_3	16	21	PF02991	0.446
LIG_LIR_Nem_3	22	28	PF02991	0.324
LIG_LIR_Nem_3	3	7	PF02991	0.491
LIG_LIR_Nem_3	521	527	PF02991	0.693
LIG_LYPXL_SIV_4	523	531	PF13949	0.732
LIG_Pex14_2	14	18	PF04695	0.472
LIG_SH2_CRK	25	29	PF00017	0.484
LIG_SH2_STAP1	4	8	PF00017	0.494
LIG_SH2_STAP1	524	528	PF00017	0.658
LIG_SH2_STAT3	463	466	PF00017	0.643
LIG_SUMO_SIM_par_1	138	144	PF11976	0.564
LIG_TRAF2_1	262	265	PF00917	0.530
LIG_TRAF2_1	297	300	PF00917	0.637
LIG_TRAF2_1	373	376	PF00917	0.605
LIG_TRAF2_1	424	427	PF00917	0.605
LIG_TRAF2_1	51	54	PF00917	0.588
LIG_UBA3_1	481	488	PF00899	0.592
LIG_UBA3_1	60	65	PF00899	0.638
MOD_CK1_1	19	25	PF00069	0.562
MOD_CK1_1	496	502	PF00069	0.655
MOD_CK1_1	522	528	PF00069	0.657
MOD_CK2_1	279	285	PF00069	0.609
MOD_CK2_1	294	300	PF00069	0.577
MOD_CK2_1	306	312	PF00069	0.519
MOD_CK2_1	421	427	PF00069	0.638
MOD_CK2_1	7	13	PF00069	0.558
MOD_GlcNHglycan	18	21	PF01048	0.608
MOD_GlcNHglycan	296	299	PF01048	0.592
MOD_GlcNHglycan	312	316	PF01048	0.474
MOD_GlcNHglycan	446	451	PF01048	0.650
MOD_GlcNHglycan	514	517	PF01048	0.765
MOD_GlcNHglycan	521	524	PF01048	0.692
MOD_GlcNHglycan	96	99	PF01048	0.589
MOD_GSK3_1	214	221	PF00069	0.631
MOD_GSK3_1	350	357	PF00069	0.633
MOD_GSK3_1	508	515	PF00069	0.728
MOD_LATS_1	267	273	PF00433	0.566
MOD_N-GLC_1	16	21	PF02516	0.565
MOD_N-GLC_1	306	311	PF02516	0.679
MOD_N-GLC_1	422	427	PF02516	0.582
MOD_N-GLC_1	532	537	PF02516	0.669
MOD_NEK2_1	32	37	PF00069	0.547
MOD_NEK2_1	362	367	PF00069	0.654
MOD_NEK2_1	437	442	PF00069	0.636
MOD_NEK2_1	519	524	PF00069	0.707
MOD_NEK2_1	7	12	PF00069	0.559
MOD_PIKK_1	158	164	PF00454	0.503
MOD_PIKK_1	300	306	PF00454	0.496
MOD_PIKK_1	362	368	PF00454	0.555
MOD_PIKK_1	437	443	PF00454	0.637
MOD_PIKK_1	532	538	PF00454	0.665
MOD_PIKK_1	86	92	PF00454	0.639
MOD_PK_1	306	312	PF00069	0.679
MOD_PKA_1	200	206	PF00069	0.547
MOD_PKA_2	136	142	PF00069	0.635
MOD_PKA_2	158	164	PF00069	0.503
MOD_PKA_2	199	205	PF00069	0.491
MOD_PKA_2	214	220	PF00069	0.491
MOD_PKA_2	493	499	PF00069	0.713
MOD_Plk_1	16	22	PF00069	0.564
MOD_Plk_1	286	292	PF00069	0.583
MOD_Plk_1	306	312	PF00069	0.485
MOD_Plk_1	325	331	PF00069	0.476
MOD_Plk_1	408	414	PF00069	0.526
MOD_Plk_1	446	452	PF00069	0.649
MOD_Plk_1	99	105	PF00069	0.658
MOD_Plk_4	306	312	PF00069	0.630
MOD_Plk_4	514	520	PF00069	0.676
MOD_SUMO_for_1	323	326	PF00179	0.622
MOD_SUMO_for_1	63	66	PF00179	0.495
MOD_SUMO_rev_2	29	35	PF00179	0.615
MOD_SUMO_rev_2	297	303	PF00179	0.642
MOD_SUMO_rev_2	455	462	PF00179	0.623
TRG_DiLeu_BaEn_4	285	291	PF01217	0.425
TRG_DiLeu_BaEn_4	325	331	PF01217	0.624
TRG_DiLeu_BaEn_4	446	452	PF01217	0.649
TRG_ENDOCYTIC_2	25	28	PF00928	0.491
TRG_ENDOCYTIC_2	291	294	PF00928	0.519
TRG_ENDOCYTIC_2	4	7	PF00928	0.495
TRG_ENDOCYTIC_2	524	527	PF00928	0.658
TRG_ER_diArg_1	199	201	PF00400	0.501
TRG_ER_diArg_1	238	240	PF00400	0.559
TRG_ER_diArg_1	456	458	PF00400	0.595
TRG_ER_diArg_1	476	479	PF00400	0.335
TRG_Pf-PMV_PEXEL_1	177	182	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	454	459	PF00026	0.638
TRG_Pf-PMV_PEXEL_1	501	506	PF00026	0.675

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Z1	Leptomonas seymouri	67%	99%
A0A0S4JEL3	Bodo saltans	34%	99%
A0A3Q8IHG3	Leishmania donovani	93%	100%
A4HPI8	Leishmania braziliensis	84%	100%
A4IDB0	Leishmania infantum	94%	100%
D0A8F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ATA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5AU66	Trypanosoma cruzi	41%	100%