Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q195_LEIMA

TriTrypDb:

LmjF.36.3235 , LMJLV39_360042000 , LMJSD75_360041900

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12
GO:0016020	membrane	2	10

Expansion

Sequence features

Q4Q195

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q195

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.453
CLV_NRD_NRD_1	140	142	PF00675	0.553
CLV_NRD_NRD_1	226	228	PF00675	0.440
CLV_NRD_NRD_1	249	251	PF00675	0.337
CLV_PCSK_KEX2_1	140	142	PF00082	0.554
CLV_PCSK_KEX2_1	180	182	PF00082	0.392
CLV_PCSK_KEX2_1	226	228	PF00082	0.397
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.345
CLV_PCSK_SKI1_1	180	184	PF00082	0.325
CLV_PCSK_SKI1_1	226	230	PF00082	0.481
CLV_PCSK_SKI1_1	304	308	PF00082	0.517
CLV_PCSK_SKI1_1	91	95	PF00082	0.325
DEG_APCC_DBOX_1	289	297	PF00400	0.613
DEG_Nend_UBRbox_2	1	3	PF02207	0.517
DOC_ANK_TNKS_1	139	146	PF00023	0.388
DOC_PP1_RVXF_1	133	139	PF00149	0.417
DOC_PP4_MxPP_1	217	220	PF00568	0.594
DOC_USP7_MATH_1	143	147	PF00917	0.394
DOC_USP7_MATH_1	175	179	PF00917	0.530
DOC_USP7_MATH_1	253	257	PF00917	0.617
DOC_USP7_MATH_1	54	58	PF00917	0.513
LIG_14-3-3_CterR_2	304	308	PF00244	0.624
LIG_Actin_WH2_2	185	203	PF00022	0.531
LIG_APCC_ABBA_1	19	24	PF00400	0.517
LIG_BRCT_BRCA1_1	2	6	PF00533	0.622
LIG_FHA_1	115	121	PF00498	0.343
LIG_FHA_1	154	160	PF00498	0.303
LIG_FHA_1	195	201	PF00498	0.610
LIG_FHA_1	33	39	PF00498	0.585
LIG_FHA_1	61	67	PF00498	0.542
LIG_FHA_1	94	100	PF00498	0.563
LIG_FHA_2	239	245	PF00498	0.614
LIG_FHA_2	293	299	PF00498	0.666
LIG_LIR_Apic_2	49	54	PF02991	0.523
LIG_LIR_Gen_1	110	119	PF02991	0.313
LIG_LIR_Nem_3	27	33	PF02991	0.498
LIG_LIR_Nem_3	49	53	PF02991	0.543
LIG_LIR_Nem_3	85	90	PF02991	0.500
LIG_MLH1_MIPbox_1	2	6	PF16413	0.622
LIG_Pex14_1	107	111	PF04695	0.555
LIG_SH2_CRK	87	91	PF00017	0.494
LIG_SH2_CRK	92	96	PF00017	0.386
LIG_SH2_GRB2like	50	53	PF00017	0.496
LIG_SH2_PTP2	72	75	PF00017	0.505
LIG_SH2_STAT5	198	201	PF00017	0.517
LIG_SH2_STAT5	224	227	PF00017	0.672
LIG_SH2_STAT5	5	8	PF00017	0.547
LIG_SH2_STAT5	59	62	PF00017	0.525
LIG_SH2_STAT5	72	75	PF00017	0.464
LIG_SH3_3	215	221	PF00018	0.640
LIG_SUMO_SIM_par_1	116	122	PF11976	0.351
LIG_SUMO_SIM_par_1	276	283	PF11976	0.566
LIG_TRAF2_1	220	223	PF00917	0.596
LIG_TYR_ITIM	90	95	PF00017	0.470
LIG_WRC_WIRS_1	128	133	PF05994	0.523
LIG_WRC_WIRS_1	148	153	PF05994	0.145
MOD_CK2_1	238	244	PF00069	0.550
MOD_GlcNHglycan	56	59	PF01048	0.335
MOD_GlcNHglycan	96	99	PF01048	0.314
MOD_GSK3_1	110	117	PF00069	0.345
MOD_GSK3_1	143	150	PF00069	0.394
MOD_N-GLC_1	114	119	PF02516	0.333
MOD_NEK2_1	114	119	PF00069	0.145
MOD_NEK2_1	155	160	PF00069	0.369
MOD_NEK2_1	60	65	PF00069	0.523
MOD_NEK2_1	83	88	PF00069	0.516
MOD_NEK2_1	94	99	PF00069	0.571
MOD_Plk_1	114	120	PF00069	0.318
MOD_Plk_4	143	149	PF00069	0.328
MOD_Plk_4	155	161	PF00069	0.284
MOD_SUMO_rev_2	204	208	PF00179	0.613
MOD_SUMO_rev_2	298	303	PF00179	0.738
MOD_SUMO_rev_2	76	81	PF00179	0.583
TRG_DiLeu_BaEn_1	244	249	PF01217	0.543
TRG_DiLeu_BaEn_1	273	278	PF01217	0.630
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.579
TRG_DiLeu_LyEn_5	244	249	PF01217	0.543
TRG_ENDOCYTIC_2	109	112	PF00928	0.454
TRG_ENDOCYTIC_2	30	33	PF00928	0.504
TRG_ENDOCYTIC_2	50	53	PF00928	0.496
TRG_ENDOCYTIC_2	72	75	PF00928	0.501
TRG_ENDOCYTIC_2	87	90	PF00928	0.449
TRG_ENDOCYTIC_2	92	95	PF00928	0.384
TRG_ER_diArg_1	133	136	PF00400	0.343
TRG_ER_diArg_1	139	141	PF00400	0.337
TRG_ER_diArg_1	225	227	PF00400	0.643
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P459	Leptomonas seymouri	82%	100%
A0A0S4JIL7	Bodo saltans	49%	100%
A0A1X0P3F8	Trypanosomatidae	59%	100%
A0A3R7NG42	Trypanosoma rangeli	59%	100%
A0A3S5H831	Leishmania donovani	96%	100%
A4HPJ0	Leishmania braziliensis	90%	100%
A4ID73	Leishmania infantum	96%	100%
D0A8F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9ATA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5BIN2	Trypanosoma cruzi	55%	100%