Intu_longin_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q193_LEIMA

TriTrypDb:

LmjF.36.3250 , LMJLV39_360042400 , LMJSD75_360042300

Length:

515

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q193

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q193

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0016192	vesicle-mediated transport	4	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	386	390	PF00656	0.577
CLV_NRD_NRD_1	138	140	PF00675	0.637
CLV_NRD_NRD_1	71	73	PF00675	0.441
CLV_NRD_NRD_1	75	77	PF00675	0.402
CLV_PCSK_KEX2_1	71	73	PF00082	0.388
CLV_PCSK_SKI1_1	168	172	PF00082	0.440
CLV_PCSK_SKI1_1	177	181	PF00082	0.384
CLV_PCSK_SKI1_1	247	251	PF00082	0.554
CLV_PCSK_SKI1_1	372	376	PF00082	0.553
CLV_Separin_Metazoa	244	248	PF03568	0.555
DEG_APCC_DBOX_1	128	136	PF00400	0.425
DEG_SPOP_SBC_1	2	6	PF00917	0.554
DEG_SPOP_SBC_1	458	462	PF00917	0.529
DOC_ANK_TNKS_1	435	442	PF00023	0.542
DOC_CKS1_1	152	157	PF01111	0.682
DOC_CYCLIN_RxL_1	369	376	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	409	415	PF00134	0.557
DOC_MAPK_FxFP_2	222	225	PF00069	0.483
DOC_MAPK_FxFP_2	37	40	PF00069	0.369
DOC_MAPK_gen_1	76	84	PF00069	0.308
DOC_MAPK_MEF2A_6	232	239	PF00069	0.562
DOC_PP1_RVXF_1	245	252	PF00149	0.492
DOC_PP2B_LxvP_1	130	133	PF13499	0.517
DOC_PP2B_LxvP_1	307	310	PF13499	0.494
DOC_PP2B_LxvP_1	409	412	PF13499	0.564
DOC_PP2B_LxvP_1	455	458	PF13499	0.563
DOC_PP2B_LxvP_1	512	515	PF13499	0.576
DOC_PP4_FxxP_1	222	225	PF00568	0.615
DOC_PP4_FxxP_1	279	282	PF00568	0.545
DOC_PP4_FxxP_1	37	40	PF00568	0.369
DOC_PP4_FxxP_1	481	484	PF00568	0.376
DOC_USP7_MATH_1	160	164	PF00917	0.629
DOC_USP7_MATH_1	170	174	PF00917	0.378
DOC_USP7_MATH_1	205	209	PF00917	0.558
DOC_USP7_MATH_1	312	316	PF00917	0.465
DOC_USP7_MATH_1	414	418	PF00917	0.566
DOC_USP7_MATH_1	57	61	PF00917	0.304
DOC_USP7_UBL2_3	406	410	PF12436	0.602
DOC_WW_Pin1_4	148	153	PF00397	0.677
DOC_WW_Pin1_4	354	359	PF00397	0.541
DOC_WW_Pin1_4	430	435	PF00397	0.654
DOC_WW_Pin1_4	83	88	PF00397	0.310
LIG_14-3-3_CanoR_1	129	133	PF00244	0.544
LIG_14-3-3_CanoR_1	177	182	PF00244	0.466
LIG_14-3-3_CanoR_1	227	235	PF00244	0.579
LIG_14-3-3_CanoR_1	365	375	PF00244	0.513
LIG_14-3-3_CanoR_1	471	476	PF00244	0.442
LIG_14-3-3_CanoR_1	76	85	PF00244	0.338
LIG_Actin_WH2_2	113	131	PF00022	0.368
LIG_APCC_ABBA_1	341	346	PF00400	0.503
LIG_BIR_II_1	1	5	PF00653	0.517
LIG_deltaCOP1_diTrp_1	467	476	PF00928	0.486
LIG_eIF4E_1	505	511	PF01652	0.500
LIG_FHA_1	105	111	PF00498	0.355
LIG_FHA_1	346	352	PF00498	0.598
LIG_FHA_1	393	399	PF00498	0.511
LIG_FHA_1	461	467	PF00498	0.524
LIG_FHA_2	129	135	PF00498	0.480
LIG_FHA_2	3	9	PF00498	0.599
LIG_FHA_2	426	432	PF00498	0.510
LIG_GBD_Chelix_1	297	305	PF00786	0.538
LIG_LIR_Apic_2	219	225	PF02991	0.607
LIG_LIR_Gen_1	444	450	PF02991	0.354
LIG_LIR_Gen_1	470	479	PF02991	0.465
LIG_LIR_Nem_3	300	306	PF02991	0.569
LIG_LIR_Nem_3	433	438	PF02991	0.528
LIG_LIR_Nem_3	444	448	PF02991	0.373
LIG_LIR_Nem_3	470	475	PF02991	0.485
LIG_NRBOX	116	122	PF00104	0.304
LIG_Pex14_2	224	228	PF04695	0.496
LIG_REV1ctd_RIR_1	172	181	PF16727	0.406
LIG_SH2_CRK	19	23	PF00017	0.369
LIG_SH2_CRK	308	312	PF00017	0.512
LIG_SH2_NCK_1	308	312	PF00017	0.483
LIG_SH2_SRC	308	311	PF00017	0.480
LIG_SH2_STAT3	505	508	PF00017	0.496
LIG_SH2_STAT5	19	22	PF00017	0.511
LIG_SH2_STAT5	304	307	PF00017	0.484
LIG_SH2_STAT5	38	41	PF00017	0.183
LIG_SH2_STAT5	445	448	PF00017	0.563
LIG_SH2_STAT5	478	481	PF00017	0.385
LIG_SH3_3	149	155	PF00018	0.634
LIG_SH3_3	15	21	PF00018	0.285
LIG_SH3_3	6	12	PF00018	0.536
LIG_SUMO_SIM_par_1	336	342	PF11976	0.419
LIG_TYR_ITIM	301	306	PF00017	0.544
LIG_TYR_ITIM	443	448	PF00017	0.361
LIG_WRC_WIRS_1	171	176	PF05994	0.398
MOD_CDK_SPxK_1	430	436	PF00069	0.555
MOD_CK1_1	123	129	PF00069	0.506
MOD_CK1_1	150	156	PF00069	0.631
MOD_CK1_1	162	168	PF00069	0.508
MOD_CK1_1	173	179	PF00069	0.358
MOD_CK1_1	459	465	PF00069	0.485
MOD_CK2_1	227	233	PF00069	0.652
MOD_CK2_1	356	362	PF00069	0.524
MOD_CK2_1	425	431	PF00069	0.502
MOD_CK2_1	461	467	PF00069	0.541
MOD_CK2_1	83	89	PF00069	0.441
MOD_CMANNOS	469	472	PF00535	0.436
MOD_Cter_Amidation	137	140	PF01082	0.632
MOD_DYRK1A_RPxSP_1	354	358	PF00069	0.553
MOD_GlcNHglycan	122	125	PF01048	0.629
MOD_GlcNHglycan	202	205	PF01048	0.787
MOD_GlcNHglycan	207	210	PF01048	0.654
MOD_GlcNHglycan	216	219	PF01048	0.497
MOD_GlcNHglycan	368	371	PF01048	0.407
MOD_GlcNHglycan	416	419	PF01048	0.557
MOD_GlcNHglycan	93	96	PF01048	0.304
MOD_GSK3_1	144	151	PF00069	0.641
MOD_GSK3_1	173	180	PF00069	0.430
MOD_GSK3_1	456	463	PF00069	0.571
MOD_GSK3_1	467	474	PF00069	0.376
MOD_GSK3_1	67	74	PF00069	0.304
MOD_LATS_1	363	369	PF00433	0.492
MOD_NEK2_1	1	6	PF00069	0.623
MOD_NEK2_1	111	116	PF00069	0.183
MOD_NEK2_1	128	133	PF00069	0.453
MOD_NEK2_1	181	186	PF00069	0.571
MOD_NEK2_1	200	205	PF00069	0.598
MOD_NEK2_1	288	293	PF00069	0.509
MOD_NEK2_1	425	430	PF00069	0.503
MOD_NEK2_1	449	454	PF00069	0.447
MOD_NEK2_1	91	96	PF00069	0.352
MOD_NEK2_2	170	175	PF00069	0.463
MOD_NEK2_2	270	275	PF00069	0.550
MOD_NEK2_2	312	317	PF00069	0.447
MOD_NEK2_2	405	410	PF00069	0.552
MOD_PKA_1	71	77	PF00069	0.388
MOD_PKA_2	128	134	PF00069	0.555
MOD_PKA_2	270	276	PF00069	0.541
MOD_PKA_2	425	431	PF00069	0.502
MOD_PKA_2	71	77	PF00069	0.347
MOD_PKA_2	78	84	PF00069	0.369
MOD_Plk_4	123	129	PF00069	0.457
MOD_Plk_4	177	183	PF00069	0.464
MOD_Plk_4	356	362	PF00069	0.497
MOD_Plk_4	425	431	PF00069	0.502
MOD_Plk_4	461	467	PF00069	0.562
MOD_Plk_4	471	477	PF00069	0.361
MOD_ProDKin_1	148	154	PF00069	0.676
MOD_ProDKin_1	354	360	PF00069	0.533
MOD_ProDKin_1	430	436	PF00069	0.663
MOD_ProDKin_1	83	89	PF00069	0.310
MOD_SUMO_rev_2	384	390	PF00179	0.510
TRG_DiLeu_BaEn_1	506	511	PF01217	0.497
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.285
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.466
TRG_ENDOCYTIC_2	19	22	PF00928	0.369
TRG_ENDOCYTIC_2	303	306	PF00928	0.523
TRG_ENDOCYTIC_2	308	311	PF00928	0.532
TRG_ENDOCYTIC_2	404	407	PF00928	0.592
TRG_ENDOCYTIC_2	445	448	PF00928	0.396
TRG_ENDOCYTIC_2	478	481	PF00928	0.385
TRG_ER_diArg_1	423	426	PF00400	0.476
TRG_Pf-PMV_PEXEL_1	501	506	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW11	Leptomonas seymouri	44%	100%
A0A3Q8IR86	Leishmania donovani	92%	100%
A4HPJ2	Leishmania braziliensis	76%	100%
A4ID71	Leishmania infantum	92%	100%
E9ATA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%