Intu_longin_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q193_LEIMA

TriTrypDb:

LmjF.36.3250 , LMJLV39_360042400 , LMJSD75_360042300

Length:

515

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q193

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q193

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0016192	vesicle-mediated transport	4	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	386	390	PF00656	0.577
CLV_NRD_NRD_1	138	140	PF00675	0.637
CLV_NRD_NRD_1	71	73	PF00675	0.441
CLV_NRD_NRD_1	75	77	PF00675	0.402
CLV_PCSK_KEX2_1	71	73	PF00082	0.388
CLV_PCSK_SKI1_1	168	172	PF00082	0.440
CLV_PCSK_SKI1_1	177	181	PF00082	0.384
CLV_PCSK_SKI1_1	247	251	PF00082	0.554
CLV_PCSK_SKI1_1	372	376	PF00082	0.553
CLV_Separin_Metazoa	244	248	PF03568	0.555

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW11	Leptomonas seymouri	44%	100%
A0A3Q8IR86	Leishmania donovani	92%	100%
A4HPJ2	Leishmania braziliensis	76%	100%
A4ID71	Leishmania infantum	92%	100%
E9ATA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%

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