Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q186_LEIMA

TriTrypDb:

LmjF.36.3320 , LMJLV39_360043200 , LMJSD75_360043100

Length:

154

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q186

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q186

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.486
CLV_NRD_NRD_1	3	5	PF00675	0.414
CLV_NRD_NRD_1	51	53	PF00675	0.422
CLV_PCSK_FUR_1	49	53	PF00082	0.413
CLV_PCSK_KEX2_1	3	5	PF00082	0.400
CLV_PCSK_KEX2_1	51	53	PF00082	0.422
CLV_PCSK_SKI1_1	111	115	PF00082	0.595
CLV_PCSK_SKI1_1	26	30	PF00082	0.338
CLV_PCSK_SKI1_1	54	58	PF00082	0.270
CLV_PCSK_SKI1_1	8	12	PF00082	0.407
DEG_Nend_Nbox_1	1	3	PF02207	0.623
DOC_MAPK_gen_1	49	58	PF00069	0.534
DOC_MAPK_MEF2A_6	51	60	PF00069	0.550
DOC_PP2B_LxvP_1	60	63	PF13499	0.276
DOC_PP4_FxxP_1	139	142	PF00568	0.412
DOC_USP7_MATH_1	113	117	PF00917	0.392
DOC_USP7_MATH_1	21	25	PF00917	0.613
DOC_WW_Pin1_4	144	149	PF00397	0.438
DOC_WW_Pin1_4	15	20	PF00397	0.594
LIG_14-3-3_CanoR_1	111	116	PF00244	0.394
LIG_14-3-3_CanoR_1	22	30	PF00244	0.666
LIG_14-3-3_CanoR_1	3	10	PF00244	0.574
LIG_14-3-3_CanoR_1	31	35	PF00244	0.671
LIG_APCC_ABBA_1	119	124	PF00400	0.415
LIG_BRCT_BRCA1_1	115	119	PF00533	0.427
LIG_CaM_IQ_9	41	56	PF13499	0.574
LIG_FHA_1	53	59	PF00498	0.555
LIG_FHA_1	73	79	PF00498	0.165
LIG_FHA_2	127	133	PF00498	0.463
LIG_FHA_2	48	54	PF00498	0.558
LIG_LIR_Apic_2	143	148	PF02991	0.469
LIG_LIR_Gen_1	55	63	PF02991	0.482
LIG_LIR_Gen_1	64	74	PF02991	0.266
LIG_LIR_Nem_3	55	60	PF02991	0.482
LIG_LIR_Nem_3	64	70	PF02991	0.266
LIG_Pex14_2	13	17	PF04695	0.630
LIG_SH2_CRK	145	149	PF00017	0.418
LIG_SH2_CRK	9	13	PF00017	0.607
LIG_SH2_GRB2like	34	37	PF00017	0.662
LIG_SH2_STAP1	109	113	PF00017	0.505
LIG_SH3_3	148	154	PF00018	0.490
LIG_SUMO_SIM_par_1	58	64	PF11976	0.267
LIG_UBA3_1	118	123	PF00899	0.427
MOD_CDK_SPxxK_3	15	22	PF00069	0.602
MOD_CK1_1	140	146	PF00069	0.409
MOD_CK1_1	43	49	PF00069	0.579
MOD_CK2_1	126	132	PF00069	0.455
MOD_CK2_1	47	53	PF00069	0.572
MOD_GlcNHglycan	139	142	PF01048	0.644
MOD_GlcNHglycan	148	151	PF01048	0.561
MOD_GlcNHglycan	4	7	PF01048	0.394
MOD_GlcNHglycan	99	102	PF01048	0.656
MOD_GSK3_1	140	147	PF00069	0.414
MOD_GSK3_1	40	47	PF00069	0.695
MOD_N-GLC_1	111	116	PF02516	0.594
MOD_NEK2_1	2	7	PF00069	0.550
MOD_PIKK_1	113	119	PF00454	0.446
MOD_PKA_2	2	8	PF00069	0.579
MOD_PKA_2	21	27	PF00069	0.686
MOD_PKA_2	30	36	PF00069	0.575
MOD_Plk_1	111	117	PF00069	0.396
MOD_Plk_1	52	58	PF00069	0.608
MOD_Plk_4	30	36	PF00069	0.621
MOD_ProDKin_1	144	150	PF00069	0.439
MOD_ProDKin_1	15	21	PF00069	0.589
TRG_DiLeu_BaEn_2	52	58	PF01217	0.548
TRG_ER_diArg_1	2	4	PF00400	0.630
TRG_ER_diArg_1	49	52	PF00400	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKX9	Leptomonas seymouri	62%	100%
A0A0S4IXN1	Bodo saltans	46%	100%
A0A1X0P3B6	Trypanosomatidae	57%	97%
A0A3Q8IL19	Leishmania donovani	98%	100%
A4HPJ9	Leishmania braziliensis	81%	100%
A4ID65	Leishmania infantum	98%	100%
D0A8L5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	96%
E9ATB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%