Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q185_LEIMA

TriTrypDb:

LmjF.36.3330 , LMJLV39_360043300 , LMJSD75_360043200

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005819	spindle	5	2
GO:0005930	axoneme	2	2
GO:0043226	organelle	2	4
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0072686	mitotic spindle	6	2
GO:0110165	cellular anatomical entity	1	4
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q185

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q185

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0000281	mitotic cytokinesis	4	2
GO:0000910	cytokinesis	3	2
GO:0001539	cilium or flagellum-dependent cell motility	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0007051	spindle organization	3	2
GO:0007052	mitotic spindle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022402	cell cycle process	2	2
GO:0048870	cell motility	2	2
GO:0060285	cilium-dependent cell motility	4	2
GO:0061640	cytoskeleton-dependent cytokinesis	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:1902850	microtubule cytoskeleton organization involved in mitosis	4	2
GO:1903047	mitotic cell cycle process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0043014	alpha-tubulin binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.456
CLV_NRD_NRD_1	364	366	PF00675	0.461
CLV_NRD_NRD_1	64	66	PF00675	0.532
CLV_PCSK_KEX2_1	120	122	PF00082	0.526
CLV_PCSK_KEX2_1	232	234	PF00082	0.508
CLV_PCSK_KEX2_1	246	248	PF00082	0.550
CLV_PCSK_KEX2_1	364	366	PF00082	0.461
CLV_PCSK_KEX2_1	64	66	PF00082	0.532
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.595
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.605
CLV_PCSK_SKI1_1	215	219	PF00082	0.468
CLV_PCSK_SKI1_1	271	275	PF00082	0.511
DOC_CKS1_1	44	49	PF01111	0.529
DOC_CYCLIN_RxL_1	268	276	PF00134	0.566
DOC_MAPK_MEF2A_6	131	138	PF00069	0.588
DOC_PP4_FxxP_1	189	192	PF00568	0.626
DOC_PP4_FxxP_1	236	239	PF00568	0.609
DOC_USP7_MATH_1	311	315	PF00917	0.668
DOC_USP7_MATH_1	318	322	PF00917	0.596
DOC_USP7_UBL2_3	226	230	PF12436	0.613
DOC_WW_Pin1_4	43	48	PF00397	0.440
LIG_APCC_ABBAyCdc20_2	96	102	PF00400	0.574
LIG_BIR_II_1	1	5	PF00653	0.577
LIG_BRCT_BRCA1_1	350	354	PF00533	0.390
LIG_FHA_1	103	109	PF00498	0.528
LIG_FHA_1	149	155	PF00498	0.624
LIG_FHA_1	211	217	PF00498	0.570
LIG_FHA_1	324	330	PF00498	0.669
LIG_FHA_1	390	396	PF00498	0.539
LIG_FHA_2	267	273	PF00498	0.673
LIG_FHA_2	29	35	PF00498	0.514
LIG_LIR_Gen_1	380	387	PF02991	0.382
LIG_LIR_Nem_3	380	386	PF02991	0.374
LIG_MLH1_MIPbox_1	350	354	PF16413	0.409
LIG_MYND_1	16	20	PF01753	0.572
LIG_SH2_GRB2like	4	7	PF00017	0.566
LIG_SH2_PTP2	344	347	PF00017	0.447
LIG_SH2_SRC	4	7	PF00017	0.643
LIG_SH2_STAP1	100	104	PF00017	0.562
LIG_SH2_STAP1	220	224	PF00017	0.455
LIG_SH2_STAT5	116	119	PF00017	0.419
LIG_SH2_STAT5	262	265	PF00017	0.670
LIG_SH2_STAT5	344	347	PF00017	0.388
LIG_SH2_STAT5	353	356	PF00017	0.396
LIG_SH3_1	71	77	PF00018	0.578
LIG_SH3_3	127	133	PF00018	0.533
LIG_SH3_3	160	166	PF00018	0.571
LIG_SH3_3	71	77	PF00018	0.578
LIG_SUMO_SIM_anti_2	160	165	PF11976	0.485
LIG_TRAF2_1	394	397	PF00917	0.509
LIG_WRC_WIRS_1	50	55	PF05994	0.574
MOD_CK1_1	150	156	PF00069	0.611
MOD_CK1_1	193	199	PF00069	0.646
MOD_CK1_1	302	308	PF00069	0.641
MOD_CK1_1	321	327	PF00069	0.649
MOD_CK1_1	391	397	PF00069	0.499
MOD_CK2_1	266	272	PF00069	0.566
MOD_CK2_1	28	34	PF00069	0.517
MOD_CK2_1	321	327	PF00069	0.536
MOD_CK2_1	391	397	PF00069	0.466
MOD_GlcNHglycan	192	195	PF01048	0.631
MOD_GlcNHglycan	207	210	PF01048	0.603
MOD_GlcNHglycan	281	284	PF01048	0.634
MOD_GlcNHglycan	290	293	PF01048	0.614
MOD_GlcNHglycan	301	304	PF01048	0.594
MOD_GlcNHglycan	312	316	PF01048	0.707
MOD_GlcNHglycan	320	323	PF01048	0.632
MOD_GSK3_1	111	118	PF00069	0.608
MOD_GSK3_1	193	200	PF00069	0.613
MOD_GSK3_1	207	214	PF00069	0.472
MOD_GSK3_1	258	265	PF00069	0.656
MOD_GSK3_1	273	280	PF00069	0.607
MOD_GSK3_1	368	375	PF00069	0.451
MOD_N-GLC_1	205	210	PF02516	0.671
MOD_NEK2_1	141	146	PF00069	0.622
MOD_NEK2_1	205	210	PF00069	0.611
MOD_NEK2_1	228	233	PF00069	0.548
MOD_NEK2_1	253	258	PF00069	0.722
MOD_NEK2_1	273	278	PF00069	0.386
MOD_NEK2_1	35	40	PF00069	0.562
MOD_PIKK_1	111	117	PF00454	0.479
MOD_PIKK_1	141	147	PF00454	0.602
MOD_PIKK_1	148	154	PF00454	0.603
MOD_PIKK_1	182	188	PF00454	0.450
MOD_PIKK_1	207	213	PF00454	0.588
MOD_PIKK_1	4	10	PF00454	0.647
MOD_PK_1	246	252	PF00069	0.553
MOD_PKA_1	246	252	PF00069	0.553
MOD_PKA_2	246	252	PF00069	0.640
MOD_Plk_1	220	226	PF00069	0.634
MOD_Plk_1	28	34	PF00069	0.461
MOD_Plk_2-3	266	272	PF00069	0.566
MOD_Plk_4	150	156	PF00069	0.543
MOD_Plk_4	258	264	PF00069	0.659
MOD_ProDKin_1	43	49	PF00069	0.439
MOD_SUMO_for_1	329	332	PF00179	0.499
MOD_SUMO_rev_2	346	354	PF00179	0.450
MOD_SUMO_rev_2	391	401	PF00179	0.532
TRG_ENDOCYTIC_2	158	161	PF00928	0.638
TRG_ENDOCYTIC_2	344	347	PF00928	0.403
TRG_ER_diArg_1	363	365	PF00400	0.447
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N3	Leptomonas seymouri	65%	100%
A0A0S4J2B8	Bodo saltans	27%	90%
A0A1X0P414	Trypanosomatidae	43%	97%
A0A3Q8IKI9	Leishmania donovani	95%	100%
A0A422NVL8	Trypanosoma rangeli	44%	98%
A4HPK0	Leishmania braziliensis	86%	100%
A4ID64	Leishmania infantum	95%	100%
D0A8L4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	98%
E9ATB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5B6X3	Trypanosoma cruzi	42%	96%