Short chain dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase-like protein

Species:

Leishmania major

UniProt:

Q4Q177_LEIMA

TriTrypDb:

LmjF.36.3410 , LMJLV39_360044200 , LMJSD75_360044100

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	5

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Expansion

Sequence features

Q4Q177

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q177

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016491	oxidoreductase activity	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	318	320	PF00675	0.533
CLV_NRD_NRD_1	366	368	PF00675	0.592
CLV_NRD_NRD_1	93	95	PF00675	0.304
CLV_PCSK_KEX2_1	318	320	PF00082	0.533
CLV_PCSK_KEX2_1	366	368	PF00082	0.553
CLV_PCSK_KEX2_1	93	95	PF00082	0.305
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.553
CLV_PCSK_PC7_1	89	95	PF00082	0.326
CLV_PCSK_SKI1_1	304	308	PF00082	0.591
CLV_PCSK_SKI1_1	354	358	PF00082	0.474

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7L3	Leptomonas seymouri	72%	100%
A0A140FAN3	Pinus massoniana	31%	100%
A0A1X0P3I1	Trypanosomatidae	57%	100%
A0A3S5IS03	Trypanosoma rangeli	58%	100%
A0A3S7XB64	Leishmania donovani	96%	100%
A4HPK8	Leishmania braziliensis	87%	100%
A4ID56	Leishmania infantum	96%	100%
A5DND6	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	25%	100%
A5JYX5	Caenorhabditis elegans	27%	100%
A6NNS2	Homo sapiens	26%	100%

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