Short chain dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase-like protein

Species:

Leishmania major

UniProt:

Q4Q177_LEIMA

TriTrypDb:

LmjF.36.3410 , LMJLV39_360044200 , LMJSD75_360044100

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	5
GO:0016020	membrane	2	3

Expansion

Sequence features

Q4Q177

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q177

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016491	oxidoreductase activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	318	320	PF00675	0.533
CLV_NRD_NRD_1	366	368	PF00675	0.592
CLV_NRD_NRD_1	93	95	PF00675	0.304
CLV_PCSK_KEX2_1	318	320	PF00082	0.533
CLV_PCSK_KEX2_1	366	368	PF00082	0.553
CLV_PCSK_KEX2_1	93	95	PF00082	0.305
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.553
CLV_PCSK_PC7_1	89	95	PF00082	0.326
CLV_PCSK_SKI1_1	304	308	PF00082	0.591
CLV_PCSK_SKI1_1	354	358	PF00082	0.474
CLV_PCSK_SKI1_1	368	372	PF00082	0.486
CLV_PCSK_SKI1_1	39	43	PF00082	0.509
CLV_PCSK_SKI1_1	73	77	PF00082	0.281
DEG_APCC_DBOX_1	353	361	PF00400	0.350
DEG_APCC_DBOX_1	366	374	PF00400	0.310
DEG_Nend_UBRbox_1	1	4	PF02207	0.318
DOC_CYCLIN_yCln2_LP_2	186	192	PF00134	0.228
DOC_CYCLIN_yCln2_LP_2	6	9	PF00134	0.313
DOC_MAPK_DCC_7	2	12	PF00069	0.305
DOC_MAPK_gen_1	2	12	PF00069	0.305
DOC_MAPK_MEF2A_6	282	291	PF00069	0.213
DOC_MAPK_MEF2A_6	39	48	PF00069	0.304
DOC_MAPK_MEF2A_6	5	12	PF00069	0.302
DOC_PP1_RVXF_1	71	77	PF00149	0.212
DOC_PP1_SILK_1	260	265	PF00149	0.259
DOC_PP2B_LxvP_1	186	189	PF13499	0.228
DOC_PP2B_LxvP_1	6	9	PF13499	0.313
DOC_USP7_MATH_1	23	27	PF00917	0.334
DOC_WW_Pin1_4	17	22	PF00397	0.368
DOC_WW_Pin1_4	242	247	PF00397	0.311
DOC_WW_Pin1_4	319	324	PF00397	0.384
LIG_14-3-3_CanoR_1	170	179	PF00244	0.308
LIG_14-3-3_CanoR_1	264	274	PF00244	0.215
LIG_14-3-3_CanoR_1	367	371	PF00244	0.347
LIG_14-3-3_CanoR_1	43	49	PF00244	0.300
LIG_Actin_WH2_1	248	266	PF00022	0.269
LIG_Actin_WH2_2	126	143	PF00022	0.226
LIG_Actin_WH2_2	251	266	PF00022	0.269
LIG_BRCT_BRCA1_1	44	48	PF00533	0.299
LIG_CtBP_PxDLS_1	116	121	PF00389	0.380
LIG_EVH1_1	7	11	PF00568	0.298
LIG_EVH1_2	8	12	PF00568	0.300
LIG_FHA_1	166	172	PF00498	0.228
LIG_FHA_1	356	362	PF00498	0.309
LIG_FHA_1	61	67	PF00498	0.334
LIG_FHA_2	50	56	PF00498	0.303
LIG_LIR_Gen_1	173	179	PF02991	0.308
LIG_LIR_Gen_1	208	219	PF02991	0.329
LIG_LIR_Nem_3	173	178	PF02991	0.294
LIG_LIR_Nem_3	208	214	PF02991	0.290
LIG_LIR_Nem_3	45	51	PF02991	0.302
LIG_MLH1_MIPbox_1	46	50	PF16413	0.303
LIG_MYND_1	4	8	PF01753	0.300
LIG_SH2_CRK	175	179	PF00017	0.294
LIG_SH2_CRK	92	96	PF00017	0.543
LIG_SH2_STAP1	175	179	PF00017	0.308
LIG_SH2_STAT5	157	160	PF00017	0.269
LIG_SH2_STAT5	192	195	PF00017	0.220
LIG_SH2_STAT5	223	226	PF00017	0.254
LIG_SH2_STAT5	267	270	PF00017	0.213
LIG_SH2_STAT5	296	299	PF00017	0.213
LIG_SH3_1	5	11	PF00018	0.301
LIG_SH3_3	5	11	PF00018	0.313
LIG_Sin3_3	76	83	PF02671	0.246
LIG_SUMO_SIM_anti_2	129	134	PF11976	0.269
LIG_SUMO_SIM_anti_2	247	254	PF11976	0.213
LIG_TRFH_1	351	355	PF08558	0.273
LIG_TYR_ITIM	190	195	PF00017	0.269
LIG_UBA3_1	360	368	PF00899	0.349
LIG_WW_2	8	11	PF00397	0.298
MOD_CDC14_SPxK_1	245	248	PF00782	0.308
MOD_CDK_SPxK_1	242	248	PF00069	0.308
MOD_CK1_1	242	248	PF00069	0.320
MOD_CK1_1	265	271	PF00069	0.221
MOD_CK1_1	369	375	PF00069	0.313
MOD_CK1_1	62	68	PF00069	0.413
MOD_CK2_1	123	129	PF00069	0.228
MOD_CK2_1	160	166	PF00069	0.300
MOD_CK2_1	49	55	PF00069	0.325
MOD_GlcNHglycan	112	115	PF01048	0.247
MOD_GlcNHglycan	264	267	PF01048	0.430
MOD_GSK3_1	106	113	PF00069	0.247
MOD_GSK3_1	235	242	PF00069	0.277
MOD_GSK3_1	258	265	PF00069	0.235
MOD_GSK3_1	296	303	PF00069	0.246
MOD_GSK3_1	60	67	PF00069	0.436
MOD_LATS_1	302	308	PF00433	0.393
MOD_LATS_1	59	65	PF00433	0.309
MOD_N-GLC_1	239	244	PF02516	0.459
MOD_N-GLC_1	59	64	PF02516	0.510
MOD_NEK2_1	123	128	PF00069	0.228
MOD_NEK2_1	69	74	PF00069	0.317
MOD_NEK2_2	44	49	PF00069	0.300
MOD_PIKK_1	235	241	PF00454	0.279
MOD_PKA_1	366	372	PF00069	0.302
MOD_PKA_2	366	372	PF00069	0.345
MOD_PKA_2	42	48	PF00069	0.301
MOD_Plk_4	258	264	PF00069	0.243
MOD_Plk_4	44	50	PF00069	0.301
MOD_ProDKin_1	17	23	PF00069	0.369
MOD_ProDKin_1	242	248	PF00069	0.311
MOD_ProDKin_1	319	325	PF00069	0.381
MOD_SUMO_rev_2	303	313	PF00179	0.415
TRG_DiLeu_BaLyEn_6	2	7	PF01217	0.309
TRG_DiLeu_BaLyEn_6	225	230	PF01217	0.213
TRG_ENDOCYTIC_2	175	178	PF00928	0.282
TRG_ENDOCYTIC_2	192	195	PF00928	0.148
TRG_ENDOCYTIC_2	92	95	PF00928	0.521
TRG_ER_diArg_1	351	354	PF00400	0.284
TRG_ER_diArg_1	92	94	PF00400	0.502
TRG_ER_diArg_1	97	100	PF00400	0.480
TRG_NES_CRM1_1	220	231	PF08389	0.149
TRG_Pf-PMV_PEXEL_1	304	309	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7L3	Leptomonas seymouri	72%	100%
A0A140FAN3	Pinus massoniana	31%	100%
A0A1X0P3I1	Trypanosomatidae	57%	100%
A0A3S5IS03	Trypanosoma rangeli	58%	100%
A0A3S7XB64	Leishmania donovani	96%	100%
A4HPK8	Leishmania braziliensis	87%	100%
A4ID56	Leishmania infantum	96%	100%
A5DND6	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	25%	100%
A5JYX5	Caenorhabditis elegans	27%	100%
A6NNS2	Homo sapiens	26%	100%
A7LB60	Arachis hypogaea	27%	100%
D0A8K5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9ATC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
E9B5S1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
P0DKC5	Arabidopsis thaliana	31%	100%
P0DKC6	Arabidopsis thaliana	31%	100%
P54554	Bacillus subtilis (strain 168)	29%	100%
P9WGP8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	25%	100%
P9WGP9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	25%	100%
Q0IH28	Xenopus laevis	32%	100%
Q0VFE7	Xenopus tropicalis	33%	100%
Q29608	Saimiri sciureus	27%	100%
Q3T0R4	Bos taurus	30%	100%
Q4JK73	Macaca fascicularis	28%	100%
Q566S6	Danio rerio	29%	100%
Q5BL28	Danio rerio	27%	100%
Q5M875	Rattus norvegicus	26%	100%
Q5R6U1	Pongo abelii	31%	100%
Q5RJY4	Rattus norvegicus	29%	100%
Q6AYS8	Rattus norvegicus	29%	100%
Q6CE86	Yarrowia lipolytica (strain CLIB 122 / E 150)	26%	100%
Q6IAN0	Homo sapiens	31%	100%
Q6P7J1	Xenopus laevis	27%	100%
Q7Q732	Anopheles gambiae	27%	100%
Q7SYS6	Xenopus laevis	26%	100%
Q7T2D1	Danio rerio	26%	100%
Q7TQA3	Mus musculus	31%	100%
Q7Z5P4	Homo sapiens	23%	100%
Q8LKV5	Sesamum indicum	28%	100%
Q8NBQ5	Homo sapiens	28%	100%
Q8T197	Dictyostelium discoideum	29%	100%
Q8VCR2	Mus musculus	26%	100%
Q99J47	Mus musculus	31%	100%
Q9EQ06	Mus musculus	29%	100%
Q9STY8	Arabidopsis thaliana	27%	100%
Q9T0G0	Arabidopsis thaliana	28%	97%
Q9Y140	Drosophila melanogaster	26%	100%
Q9Y394	Homo sapiens	24%	100%
V5BS47	Trypanosoma cruzi	55%	100%