CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q175_LEIMA

TriTrypDb:

LmjF.36.3430 , LMJLV39_360044400 , LMJSD75_360044300

Length:

792

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q175

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q175

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	298	304	PF00089	0.536
CLV_NRD_NRD_1	176	178	PF00675	0.482
CLV_NRD_NRD_1	219	221	PF00675	0.295
CLV_NRD_NRD_1	292	294	PF00675	0.440
CLV_NRD_NRD_1	295	297	PF00675	0.479
CLV_NRD_NRD_1	41	43	PF00675	0.454
CLV_NRD_NRD_1	516	518	PF00675	0.601
CLV_NRD_NRD_1	564	566	PF00675	0.433
CLV_NRD_NRD_1	575	577	PF00675	0.555
CLV_NRD_NRD_1	692	694	PF00675	0.616
CLV_NRD_NRD_1	93	95	PF00675	0.410
CLV_PCSK_FUR_1	293	297	PF00082	0.411
CLV_PCSK_KEX2_1	176	178	PF00082	0.360
CLV_PCSK_KEX2_1	219	221	PF00082	0.295
CLV_PCSK_KEX2_1	292	294	PF00082	0.440
CLV_PCSK_KEX2_1	295	297	PF00082	0.479
CLV_PCSK_KEX2_1	41	43	PF00082	0.454
CLV_PCSK_KEX2_1	516	518	PF00082	0.601
CLV_PCSK_KEX2_1	564	566	PF00082	0.502
CLV_PCSK_KEX2_1	577	579	PF00082	0.391
CLV_PCSK_KEX2_1	634	636	PF00082	0.741
CLV_PCSK_KEX2_1	652	654	PF00082	0.450
CLV_PCSK_KEX2_1	692	694	PF00082	0.616
CLV_PCSK_PC1ET2_1	577	579	PF00082	0.437
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.763
CLV_PCSK_PC1ET2_1	652	654	PF00082	0.496
CLV_PCSK_PC1ET2_1	692	694	PF00082	0.616
CLV_PCSK_SKI1_1	151	155	PF00082	0.354
CLV_PCSK_SKI1_1	219	223	PF00082	0.295
CLV_PCSK_SKI1_1	23	27	PF00082	0.362
CLV_PCSK_SKI1_1	330	334	PF00082	0.557
CLV_PCSK_SKI1_1	52	56	PF00082	0.419
CLV_PCSK_SKI1_1	577	581	PF00082	0.452
CLV_PCSK_SKI1_1	630	634	PF00082	0.607
CLV_PCSK_SKI1_1	653	657	PF00082	0.641
CLV_PCSK_SKI1_1	744	748	PF00082	0.409
CLV_Separin_Metazoa	216	220	PF03568	0.295
DEG_APCC_DBOX_1	159	167	PF00400	0.363
DEG_APCC_DBOX_1	603	611	PF00400	0.482
DEG_SPOP_SBC_1	11	15	PF00917	0.490
DEG_SPOP_SBC_1	338	342	PF00917	0.594
DEG_SPOP_SBC_1	382	386	PF00917	0.740
DEG_SPOP_SBC_1	400	404	PF00917	0.478
DOC_ANK_TNKS_1	294	301	PF00023	0.479
DOC_ANK_TNKS_1	596	603	PF00023	0.517
DOC_MAPK_DCC_7	131	139	PF00069	0.354
DOC_MAPK_gen_1	176	187	PF00069	0.353
DOC_MAPK_gen_1	235	245	PF00069	0.354
DOC_MAPK_gen_1	50	57	PF00069	0.443
DOC_MAPK_gen_1	571	581	PF00069	0.412
DOC_MAPK_gen_1	604	611	PF00069	0.474
DOC_MAPK_gen_1	634	644	PF00069	0.596
DOC_MAPK_gen_1	692	700	PF00069	0.589
DOC_MAPK_HePTP_8	632	644	PF00069	0.591
DOC_MAPK_MEF2A_6	131	139	PF00069	0.374
DOC_MAPK_MEF2A_6	235	243	PF00069	0.354
DOC_MAPK_MEF2A_6	366	373	PF00069	0.623
DOC_MAPK_MEF2A_6	604	611	PF00069	0.474
DOC_MAPK_MEF2A_6	635	644	PF00069	0.599
DOC_PP1_RVXF_1	218	225	PF00149	0.294
DOC_PP1_RVXF_1	246	252	PF00149	0.354
DOC_PP1_RVXF_1	694	701	PF00149	0.594
DOC_PP2B_LxvP_1	502	505	PF13499	0.407
DOC_SPAK_OSR1_1	71	75	PF12202	0.339
DOC_USP7_MATH_1	11	15	PF00917	0.485
DOC_USP7_MATH_1	3	7	PF00917	0.531
DOC_USP7_MATH_1	309	313	PF00917	0.567
DOC_USP7_MATH_1	401	405	PF00917	0.653
DOC_USP7_MATH_1	445	449	PF00917	0.622
DOC_USP7_MATH_1	456	460	PF00917	0.556
DOC_USP7_MATH_1	481	485	PF00917	0.471
DOC_USP7_MATH_1	534	538	PF00917	0.616
DOC_USP7_MATH_1	658	662	PF00917	0.649
DOC_USP7_MATH_1	702	706	PF00917	0.623
DOC_USP7_MATH_1	714	718	PF00917	0.604
DOC_USP7_UBL2_3	630	634	PF12436	0.578
DOC_USP7_UBL2_3	692	696	PF12436	0.604
DOC_USP7_UBL2_3	744	748	PF12436	0.431
DOC_WW_Pin1_4	113	118	PF00397	0.513
DOC_WW_Pin1_4	137	142	PF00397	0.346
DOC_WW_Pin1_4	300	305	PF00397	0.526
DOC_WW_Pin1_4	339	344	PF00397	0.583
DOC_WW_Pin1_4	347	352	PF00397	0.601
DOC_WW_Pin1_4	412	417	PF00397	0.636
DOC_WW_Pin1_4	430	435	PF00397	0.612
DOC_WW_Pin1_4	515	520	PF00397	0.659
DOC_WW_Pin1_4	686	691	PF00397	0.623
LIG_14-3-3_CanoR_1	180	184	PF00244	0.338
LIG_14-3-3_CanoR_1	322	328	PF00244	0.550
LIG_14-3-3_CanoR_1	92	102	PF00244	0.561
LIG_Actin_WH2_2	188	206	PF00022	0.370
LIG_APCC_ABBA_1	54	59	PF00400	0.424
LIG_BRCT_BRCA1_1	696	700	PF00533	0.597
LIG_CaM_NSCaTE_8	675	682	PF13499	0.628
LIG_CtBP_PxDLS_1	255	259	PF00389	0.227
LIG_FHA_1	180	186	PF00498	0.354
LIG_FHA_1	197	203	PF00498	0.354
LIG_FHA_1	323	329	PF00498	0.533
LIG_FHA_1	339	345	PF00498	0.625
LIG_FHA_1	376	382	PF00498	0.590
LIG_FHA_1	455	461	PF00498	0.821
LIG_FHA_1	472	478	PF00498	0.333
LIG_FHA_1	553	559	PF00498	0.329
LIG_FHA_1	639	645	PF00498	0.621
LIG_FHA_1	727	733	PF00498	0.556
LIG_FHA_2	11	17	PF00498	0.556
LIG_FHA_2	437	443	PF00498	0.555
LIG_FHA_2	456	462	PF00498	0.554
LIG_FHA_2	505	511	PF00498	0.591
LIG_LIR_Gen_1	169	178	PF02991	0.295
LIG_LIR_Gen_1	555	562	PF02991	0.298
LIG_LIR_Gen_1	580	590	PF02991	0.468
LIG_LIR_Gen_1	678	688	PF02991	0.625
LIG_LIR_Gen_1	89	97	PF02991	0.419
LIG_LIR_Nem_3	122	127	PF02991	0.227
LIG_LIR_Nem_3	169	174	PF02991	0.295
LIG_LIR_Nem_3	231	237	PF02991	0.349
LIG_LIR_Nem_3	427	431	PF02991	0.605
LIG_LIR_Nem_3	555	559	PF02991	0.353
LIG_LIR_Nem_3	580	585	PF02991	0.449
LIG_LIR_Nem_3	623	628	PF02991	0.425
LIG_LIR_Nem_3	67	73	PF02991	0.326
LIG_LIR_Nem_3	678	683	PF02991	0.627
LIG_LIR_Nem_3	739	745	PF02991	0.423
LIG_LIR_Nem_3	89	93	PF02991	0.416
LIG_LYPXL_yS_3	214	217	PF13949	0.295
LIG_MYND_1	519	523	PF01753	0.602
LIG_Pex14_1	17	21	PF04695	0.476
LIG_Pex14_1	493	497	PF04695	0.339
LIG_Pex14_2	224	228	PF04695	0.295
LIG_Pex14_2	755	759	PF04695	0.273
LIG_SH2_CRK	428	432	PF00017	0.628
LIG_SH2_CRK	70	74	PF00017	0.328
LIG_SH2_CRK	743	747	PF00017	0.423
LIG_SH2_CRK	90	94	PF00017	0.249
LIG_SH2_NCK_1	503	507	PF00017	0.433
LIG_SH2_PTP2	171	174	PF00017	0.340
LIG_SH2_SRC	503	506	PF00017	0.439
LIG_SH2_SRC	599	602	PF00017	0.513
LIG_SH2_STAP1	21	25	PF00017	0.466
LIG_SH2_STAT5	171	174	PF00017	0.422
LIG_SH2_STAT5	183	186	PF00017	0.290
LIG_SH2_STAT5	264	267	PF00017	0.363
LIG_SH2_STAT5	488	491	PF00017	0.461
LIG_SH2_STAT5	528	531	PF00017	0.517
LIG_SH2_STAT5	568	571	PF00017	0.424
LIG_SH2_STAT5	599	602	PF00017	0.513
LIG_SH3_3	111	117	PF00018	0.454
LIG_SH3_3	209	215	PF00018	0.363
LIG_SH3_3	233	239	PF00018	0.295
LIG_SH3_3	279	285	PF00018	0.427
LIG_SH3_3	428	434	PF00018	0.633
LIG_SH3_3	535	541	PF00018	0.522
LIG_SH3_3	606	612	PF00018	0.470
LIG_SH3_3	637	643	PF00018	0.598
LIG_SH3_3	705	711	PF00018	0.652
LIG_SUMO_SIM_anti_2	199	204	PF11976	0.340
LIG_SUMO_SIM_par_1	471	476	PF11976	0.471
LIG_SUMO_SIM_par_1	8	16	PF11976	0.522
LIG_TRAF2_1	37	40	PF00917	0.427
LIG_TYR_ITIM	212	217	PF00017	0.354
LIG_TYR_ITIM	68	73	PF00017	0.322
LIG_UBA3_1	146	151	PF00899	0.295
LIG_WRC_WIRS_1	553	558	PF05994	0.330
MOD_CDC14_SPxK_1	689	692	PF00782	0.587
MOD_CDK_SPxK_1	686	692	PF00069	0.587
MOD_CDK_SPxxK_3	113	120	PF00069	0.453
MOD_CDK_SPxxK_3	430	437	PF00069	0.628
MOD_CDK_SPxxK_3	686	693	PF00069	0.589
MOD_CK1_1	113	119	PF00069	0.516
MOD_CK1_1	318	324	PF00069	0.722
MOD_CK1_1	326	332	PF00069	0.503
MOD_CK1_1	337	343	PF00069	0.535
MOD_CK1_1	375	381	PF00069	0.592
MOD_CK1_1	385	391	PF00069	0.622
MOD_CK1_1	399	405	PF00069	0.529
MOD_CK1_1	433	439	PF00069	0.604
MOD_CK1_1	448	454	PF00069	0.618
MOD_CK1_1	614	620	PF00069	0.593
MOD_CK1_1	663	669	PF00069	0.615
MOD_CK1_1	670	676	PF00069	0.718
MOD_CK2_1	12	18	PF00069	0.510
MOD_CK2_1	34	40	PF00069	0.476
MOD_CK2_1	400	406	PF00069	0.763
MOD_CK2_1	444	450	PF00069	0.663
MOD_CK2_1	455	461	PF00069	0.686
MOD_DYRK1A_RPxSP_1	686	690	PF00069	0.561
MOD_GlcNHglycan	230	233	PF01048	0.361
MOD_GlcNHglycan	252	255	PF01048	0.295
MOD_GlcNHglycan	278	281	PF01048	0.441
MOD_GlcNHglycan	30	33	PF01048	0.520
MOD_GlcNHglycan	359	362	PF01048	0.584
MOD_GlcNHglycan	374	377	PF01048	0.579
MOD_GlcNHglycan	387	390	PF01048	0.597
MOD_GlcNHglycan	403	406	PF01048	0.632
MOD_GlcNHglycan	438	442	PF01048	0.657
MOD_GlcNHglycan	485	488	PF01048	0.421
MOD_GlcNHglycan	5	8	PF01048	0.632
MOD_GlcNHglycan	508	514	PF01048	0.602
MOD_GlcNHglycan	662	665	PF01048	0.619
MOD_GlcNHglycan	702	705	PF01048	0.596
MOD_GSK3_1	162	169	PF00069	0.318
MOD_GSK3_1	250	257	PF00069	0.295
MOD_GSK3_1	270	277	PF00069	0.171
MOD_GSK3_1	318	325	PF00069	0.737
MOD_GSK3_1	334	341	PF00069	0.510
MOD_GSK3_1	343	350	PF00069	0.582
MOD_GSK3_1	353	360	PF00069	0.538
MOD_GSK3_1	381	388	PF00069	0.588
MOD_GSK3_1	396	403	PF00069	0.524
MOD_GSK3_1	420	427	PF00069	0.604
MOD_GSK3_1	433	440	PF00069	0.691
MOD_GSK3_1	441	448	PF00069	0.634
MOD_GSK3_1	456	463	PF00069	0.669
MOD_GSK3_1	471	478	PF00069	0.342
MOD_GSK3_1	517	524	PF00069	0.588
MOD_GSK3_1	611	618	PF00069	0.497
MOD_GSK3_1	630	637	PF00069	0.488
MOD_GSK3_1	654	661	PF00069	0.730
MOD_GSK3_1	663	670	PF00069	0.597
MOD_GSK3_1	692	699	PF00069	0.705
MOD_GSK3_1	722	729	PF00069	0.534
MOD_GSK3_1	759	766	PF00069	0.387
MOD_GSK3_1	779	786	PF00069	0.523
MOD_N-GLC_1	614	619	PF02516	0.652
MOD_NEK2_1	166	171	PF00069	0.439
MOD_NEK2_1	274	279	PF00069	0.466
MOD_NEK2_1	357	362	PF00069	0.798
MOD_NEK2_1	381	386	PF00069	0.687
MOD_NEK2_1	396	401	PF00069	0.550
MOD_NEK2_1	648	653	PF00069	0.752
MOD_NEK2_1	667	672	PF00069	0.467
MOD_NEK2_1	700	705	PF00069	0.605
MOD_NEK2_1	759	764	PF00069	0.320
MOD_NEK2_2	675	680	PF00069	0.629
MOD_PIKK_1	522	528	PF00454	0.612
MOD_PIKK_1	667	673	PF00454	0.577
MOD_PIKK_1	726	732	PF00454	0.523
MOD_PIKK_1	759	765	PF00454	0.403
MOD_PK_1	694	700	PF00069	0.591
MOD_PKA_1	577	583	PF00069	0.410
MOD_PKA_1	634	640	PF00069	0.644
MOD_PKA_1	692	698	PF00069	0.570
MOD_PKA_2	179	185	PF00069	0.338
MOD_PKA_2	315	321	PF00069	0.722
MOD_PKA_2	436	442	PF00069	0.633
MOD_PKA_2	448	454	PF00069	0.529
MOD_PKA_2	570	576	PF00069	0.489
MOD_PKA_2	577	583	PF00069	0.440
MOD_PKA_2	634	640	PF00069	0.643
MOD_PKA_2	692	698	PF00069	0.658
MOD_PKA_2	93	99	PF00069	0.562
MOD_Plk_1	166	172	PF00069	0.295
MOD_Plk_1	394	400	PF00069	0.597
MOD_Plk_1	509	515	PF00069	0.587
MOD_Plk_1	726	732	PF00069	0.519
MOD_Plk_2-3	722	728	PF00069	0.594
MOD_Plk_4	110	116	PF00069	0.423
MOD_Plk_4	179	185	PF00069	0.354
MOD_Plk_4	309	315	PF00069	0.604
MOD_Plk_4	323	329	PF00069	0.553
MOD_Plk_4	331	337	PF00069	0.557
MOD_Plk_4	517	523	PF00069	0.654
MOD_Plk_4	552	558	PF00069	0.346
MOD_Plk_4	577	583	PF00069	0.598
MOD_Plk_4	675	681	PF00069	0.619
MOD_ProDKin_1	113	119	PF00069	0.516
MOD_ProDKin_1	137	143	PF00069	0.346
MOD_ProDKin_1	300	306	PF00069	0.527
MOD_ProDKin_1	339	345	PF00069	0.584
MOD_ProDKin_1	347	353	PF00069	0.601
MOD_ProDKin_1	412	418	PF00069	0.631
MOD_ProDKin_1	430	436	PF00069	0.613
MOD_ProDKin_1	515	521	PF00069	0.660
MOD_ProDKin_1	686	692	PF00069	0.625
MOD_SUMO_for_1	249	252	PF00179	0.354
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.354
TRG_ENDOCYTIC_2	171	174	PF00928	0.340
TRG_ENDOCYTIC_2	214	217	PF00928	0.295
TRG_ENDOCYTIC_2	428	431	PF00928	0.629
TRG_ENDOCYTIC_2	582	585	PF00928	0.455
TRG_ENDOCYTIC_2	70	73	PF00928	0.324
TRG_ENDOCYTIC_2	743	746	PF00928	0.373
TRG_ENDOCYTIC_2	90	93	PF00928	0.255
TRG_ER_diArg_1	176	178	PF00400	0.446
TRG_ER_diArg_1	218	220	PF00400	0.295
TRG_ER_diArg_1	291	293	PF00400	0.437
TRG_ER_diArg_1	294	296	PF00400	0.450
TRG_ER_diArg_1	515	517	PF00400	0.605
TRG_ER_diArg_1	564	567	PF00400	0.438
TRG_ER_diArg_1	575	578	PF00400	0.414
TRG_NLS_Bipartite_1	564	580	PF00514	0.423
TRG_NLS_MonoExtC_3	691	696	PF00514	0.614
TRG_NLS_MonoExtN_4	574	580	PF00514	0.459
TRG_NLS_MonoExtN_4	690	697	PF00514	0.614
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	567	572	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P689	Leptomonas seymouri	49%	97%
A0A1X0P424	Trypanosomatidae	35%	100%
A0A3S7XBD6	Leishmania donovani	92%	100%
A4HPL0	Leishmania braziliensis	66%	100%
A4ID54	Leishmania infantum	93%	100%
E9ATC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%