Small acidic protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Small acidic protein family, putative

Species:

Leishmania major

UniProt:

Q4Q170_LEIMA

TriTrypDb:

LmjF.36.3480 , LMJLV39_360045000 , LMJSD75_360044900

Length:

208

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q170

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q170

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.820
CLV_NRD_NRD_1	76	78	PF00675	0.538
CLV_PCSK_KEX2_1	146	148	PF00082	0.345
CLV_PCSK_KEX2_1	184	186	PF00082	0.391
CLV_PCSK_KEX2_1	57	59	PF00082	0.686
CLV_PCSK_KEX2_1	98	100	PF00082	0.730
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.345
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.436
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.712
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.730
CLV_PCSK_SKI1_1	146	150	PF00082	0.357
CLV_PCSK_SKI1_1	77	81	PF00082	0.501
DEG_SPOP_SBC_1	108	112	PF00917	0.745
DOC_USP7_MATH_1	109	113	PF00917	0.739
DOC_USP7_MATH_1	120	124	PF00917	0.580
DOC_USP7_MATH_1	79	83	PF00917	0.547
LIG_14-3-3_CanoR_1	172	177	PF00244	0.492
LIG_BRCT_BRCA1_1	136	140	PF00533	0.492
LIG_FHA_1	14	20	PF00498	0.558
LIG_FHA_1	40	46	PF00498	0.446
LIG_PDZ_Class_2	203	208	PF00595	0.357
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.469
LIG_TRAF2_1	35	38	PF00917	0.604
LIG_WRC_WIRS_1	1	6	PF05994	0.584
MOD_CK1_1	123	129	PF00069	0.623
MOD_CK1_1	196	202	PF00069	0.414
MOD_CK1_1	84	90	PF00069	0.688
MOD_CK2_1	176	182	PF00069	0.401
MOD_CK2_1	189	195	PF00069	0.349
MOD_CK2_1	62	68	PF00069	0.646
MOD_Cter_Amidation	201	204	PF01082	0.357
MOD_GlcNHglycan	116	119	PF01048	0.715
MOD_GlcNHglycan	121	125	PF01048	0.725
MOD_GlcNHglycan	195	198	PF01048	0.482
MOD_GlcNHglycan	83	86	PF01048	0.675
MOD_GSK3_1	110	117	PF00069	0.649
MOD_GSK3_1	168	175	PF00069	0.372
MOD_GSK3_1	189	196	PF00069	0.452
MOD_GSK3_1	99	106	PF00069	0.776
MOD_LATS_1	170	176	PF00433	0.492
MOD_NEK2_1	176	181	PF00069	0.492
MOD_PIKK_1	189	195	PF00454	0.451
MOD_PIKK_1	62	68	PF00454	0.609
MOD_PKA_1	99	105	PF00069	0.741
MOD_PKA_2	114	120	PF00069	0.717
MOD_PKA_2	99	105	PF00069	0.752
MOD_SUMO_rev_2	138	148	PF00179	0.435
MOD_SUMO_rev_2	179	186	PF00179	0.492
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.546
TRG_ER_diArg_1	99	101	PF00400	0.811
TRG_NES_CRM1_1	38	52	PF08389	0.545
TRG_NLS_MonoCore_2	97	102	PF00514	0.734
TRG_NLS_MonoExtC_3	97	103	PF00514	0.759
TRG_NLS_MonoExtN_4	97	102	PF00514	0.761
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDM8	Leptomonas seymouri	56%	100%
A0A1X0P3N2	Trypanosomatidae	35%	100%
A0A3S7XB92	Leishmania donovani	89%	100%
A0A422MZK0	Trypanosoma rangeli	37%	100%
A4HPL5	Leishmania braziliensis	75%	99%
A4ID49	Leishmania infantum	89%	100%
E9ATC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%