Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2870), putative

Species:

Leishmania major

UniProt:

Q4Q169_LEIMA

TriTrypDb:

LmjF.36.3490 , LMJLV39_360045100 , LMJSD75_360045000

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q169

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q169

Function

Biological processes
Term	Name	Level	Count
GO:0003352	regulation of cilium movement	6	15
GO:0032886	regulation of microtubule-based process	4	15
GO:0050789	regulation of biological process	2	15
GO:0050794	regulation of cellular process	3	15
GO:0060632	regulation of microtubule-based movement	5	15
GO:0065007	biological regulation	1	15

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.449
CLV_NRD_NRD_1	235	237	PF00675	0.268
CLV_NRD_NRD_1	262	264	PF00675	0.230
CLV_NRD_NRD_1	329	331	PF00675	0.677
CLV_PCSK_KEX2_1	262	264	PF00082	0.269
CLV_PCSK_KEX2_1	64	66	PF00082	0.473
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.479
CLV_PCSK_SKI1_1	122	126	PF00082	0.466
CLV_PCSK_SKI1_1	141	145	PF00082	0.215
CLV_PCSK_SKI1_1	186	190	PF00082	0.378
CLV_PCSK_SKI1_1	19	23	PF00082	0.473
CLV_PCSK_SKI1_1	287	291	PF00082	0.279
CLV_PCSK_SKI1_1	325	329	PF00082	0.591
CLV_PCSK_SKI1_1	69	73	PF00082	0.369
DOC_CYCLIN_RxL_1	183	192	PF00134	0.386
DOC_MAPK_gen_1	223	233	PF00069	0.424
DOC_MAPK_gen_1	330	338	PF00069	0.574
DOC_MAPK_gen_1	64	72	PF00069	0.403
DOC_MAPK_MEF2A_6	226	233	PF00069	0.422
DOC_MAPK_MEF2A_6	64	72	PF00069	0.334
DOC_USP7_MATH_1	239	243	PF00917	0.457
DOC_USP7_MATH_1	295	299	PF00917	0.685
DOC_USP7_MATH_1	44	48	PF00917	0.615
DOC_USP7_MATH_1	97	101	PF00917	0.502
DOC_USP7_UBL2_3	228	232	PF12436	0.455
DOC_WW_Pin1_4	123	128	PF00397	0.448
DOC_WW_Pin1_4	237	242	PF00397	0.458
DOC_WW_Pin1_4	24	29	PF00397	0.587
DOC_WW_Pin1_4	312	317	PF00397	0.622
DOC_WW_Pin1_4	37	42	PF00397	0.674
LIG_14-3-3_CanoR_1	141	148	PF00244	0.444
LIG_14-3-3_CanoR_1	19	28	PF00244	0.427
LIG_EH1_1	65	73	PF00400	0.482
LIG_eIF4E_1	183	189	PF01652	0.372
LIG_FHA_1	124	130	PF00498	0.423
LIG_FHA_1	142	148	PF00498	0.260
LIG_FHA_1	176	182	PF00498	0.469
LIG_FHA_1	20	26	PF00498	0.590
LIG_FHA_1	283	289	PF00498	0.443
LIG_FHA_1	319	325	PF00498	0.622
LIG_FHA_1	49	55	PF00498	0.518
LIG_FHA_2	151	157	PF00498	0.475
LIG_FHA_2	165	171	PF00498	0.399
LIG_LIR_Apic_2	167	172	PF02991	0.308
LIG_LIR_Gen_1	108	118	PF02991	0.388
LIG_LIR_Gen_1	146	155	PF02991	0.530
LIG_LIR_LC3C_4	177	182	PF02991	0.463
LIG_LIR_Nem_3	108	113	PF02991	0.376
LIG_LIR_Nem_3	115	121	PF02991	0.404
LIG_LIR_Nem_3	146	151	PF02991	0.473
LIG_LIR_Nem_3	264	269	PF02991	0.457
LIG_PCNA_PIPBox_1	111	120	PF02747	0.350
LIG_PCNA_yPIPBox_3	109	118	PF02747	0.541
LIG_SH2_CRK	110	114	PF00017	0.433
LIG_SH2_CRK	118	122	PF00017	0.467
LIG_SH2_CRK	148	152	PF00017	0.362
LIG_SH2_NCK_1	169	173	PF00017	0.434
LIG_SH2_SRC	169	172	PF00017	0.366
LIG_SH2_STAT3	249	252	PF00017	0.436
LIG_SH2_STAT5	118	121	PF00017	0.362
LIG_SH2_STAT5	166	169	PF00017	0.591
LIG_SH2_STAT5	220	223	PF00017	0.511
LIG_SH3_2	326	331	PF14604	0.551
LIG_SH3_3	323	329	PF00018	0.545
LIG_SH3_3	35	41	PF00018	0.727
LIG_SUMO_SIM_par_1	313	322	PF11976	0.425
LIG_TRAF2_1	27	30	PF00917	0.537
LIG_TRAF2_1	74	77	PF00917	0.490
MOD_CK1_1	100	106	PF00069	0.565
MOD_CK1_1	116	122	PF00069	0.228
MOD_CK1_1	150	156	PF00069	0.432
MOD_CK1_1	282	288	PF00069	0.576
MOD_CK1_1	308	314	PF00069	0.661
MOD_CK1_1	315	321	PF00069	0.534
MOD_CK1_1	47	53	PF00069	0.432
MOD_CK2_1	164	170	PF00069	0.492
MOD_CK2_1	23	29	PF00069	0.547
MOD_CK2_1	295	301	PF00069	0.551
MOD_CK2_1	71	77	PF00069	0.354
MOD_GlcNHglycan	310	313	PF01048	0.664
MOD_GlcNHglycan	73	76	PF01048	0.374
MOD_GSK3_1	143	150	PF00069	0.497
MOD_GSK3_1	19	26	PF00069	0.518
MOD_GSK3_1	304	311	PF00069	0.666
MOD_GSK3_1	43	50	PF00069	0.655
MOD_NEK2_1	113	118	PF00069	0.476
MOD_NEK2_1	143	148	PF00069	0.480
MOD_NEK2_1	213	218	PF00069	0.478
MOD_NEK2_1	71	76	PF00069	0.419
MOD_PKA_2	282	288	PF00069	0.493
MOD_PKA_2	97	103	PF00069	0.610
MOD_Plk_1	13	19	PF00069	0.459
MOD_Plk_1	175	181	PF00069	0.489
MOD_Plk_1	213	219	PF00069	0.511
MOD_Plk_2-3	13	19	PF00069	0.484
MOD_Plk_4	113	119	PF00069	0.394
MOD_Plk_4	143	149	PF00069	0.481
MOD_Plk_4	44	50	PF00069	0.693
MOD_ProDKin_1	123	129	PF00069	0.454
MOD_ProDKin_1	237	243	PF00069	0.458
MOD_ProDKin_1	24	30	PF00069	0.598
MOD_ProDKin_1	312	318	PF00069	0.622
MOD_ProDKin_1	37	43	PF00069	0.676
MOD_SUMO_rev_2	190	195	PF00179	0.507
TRG_DiLeu_BaEn_1	176	181	PF01217	0.436
TRG_ENDOCYTIC_2	110	113	PF00928	0.377
TRG_ENDOCYTIC_2	118	121	PF00928	0.387
TRG_ENDOCYTIC_2	148	151	PF00928	0.521
TRG_ENDOCYTIC_2	256	259	PF00928	0.494
TRG_ENDOCYTIC_2	266	269	PF00928	0.399
TRG_ER_diArg_1	245	248	PF00400	0.542
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.341
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4K9	Leptomonas seymouri	60%	100%
A0A0N1IKY2	Leptomonas seymouri	24%	100%
A0A0S4JE13	Bodo saltans	40%	100%
A0A0S4JHQ4	Bodo saltans	40%	100%
A0A0S4JRV9	Bodo saltans	25%	100%
A0A1X0P4D1	Trypanosomatidae	43%	100%
A0A3S7XB90	Leishmania donovani	92%	100%
A0A422MZF7	Trypanosoma rangeli	45%	100%
A4HPL6	Leishmania braziliensis	77%	100%
A4ID48	Leishmania infantum	92%	100%
D0A8J8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ATC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B6Z0	Trypanosoma cruzi	42%	100%