Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q168_LEIMA

TriTrypDb:

LmjF.36.3500 , LMJLV39_360045200 , LMJSD75_360045100

Length:

820

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q168

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q168

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	354	358	PF00656	0.565
CLV_C14_Caspase3-7	493	497	PF00656	0.649
CLV_C14_Caspase3-7	529	533	PF00656	0.595
CLV_C14_Caspase3-7	756	760	PF00656	0.633
CLV_NRD_NRD_1	519	521	PF00675	0.573
CLV_NRD_NRD_1	58	60	PF00675	0.669
CLV_PCSK_FUR_1	309	313	PF00082	0.691
CLV_PCSK_KEX2_1	311	313	PF00082	0.634
CLV_PCSK_KEX2_1	519	521	PF00082	0.573
CLV_PCSK_KEX2_1	58	60	PF00082	0.669
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.634
CLV_PCSK_PC7_1	54	60	PF00082	0.640
CLV_PCSK_SKI1_1	196	200	PF00082	0.413
CLV_PCSK_SKI1_1	239	243	PF00082	0.744
CLV_PCSK_SKI1_1	248	252	PF00082	0.648
CLV_PCSK_SKI1_1	474	478	PF00082	0.403
CLV_PCSK_SKI1_1	781	785	PF00082	0.541
CLV_PCSK_SKI1_1	797	801	PF00082	0.541
DEG_SCF_FBW7_1	39	46	PF00400	0.717
DEG_SPOP_SBC_1	231	235	PF00917	0.748
DEG_SPOP_SBC_1	363	367	PF00917	0.695
DEG_SPOP_SBC_1	454	458	PF00917	0.507
DOC_CDC14_PxL_1	726	734	PF14671	0.528
DOC_CYCLIN_yCln2_LP_2	340	346	PF00134	0.691
DOC_CYCLIN_yCln2_LP_2	439	445	PF00134	0.620
DOC_CYCLIN_yCln2_LP_2	449	455	PF00134	0.533
DOC_MAPK_gen_1	311	321	PF00069	0.728
DOC_MAPK_gen_1	32	39	PF00069	0.664
DOC_MAPK_gen_1	329	337	PF00069	0.531
DOC_MAPK_gen_1	627	634	PF00069	0.497
DOC_MAPK_MEF2A_6	430	439	PF00069	0.514
DOC_MAPK_MEF2A_6	627	634	PF00069	0.598
DOC_MAPK_NFAT4_5	430	438	PF00069	0.557
DOC_MIT_MIM_1	642	652	PF04212	0.377
DOC_PP2B_LxvP_1	340	343	PF13499	0.725
DOC_PP2B_LxvP_1	449	452	PF13499	0.668
DOC_PP2B_LxvP_1	666	669	PF13499	0.644
DOC_USP7_MATH_1	207	211	PF00917	0.613
DOC_USP7_MATH_1	223	227	PF00917	0.537
DOC_USP7_MATH_1	230	234	PF00917	0.684
DOC_USP7_MATH_1	313	317	PF00917	0.698
DOC_USP7_MATH_1	324	328	PF00917	0.636
DOC_USP7_MATH_1	349	353	PF00917	0.651
DOC_USP7_MATH_1	363	367	PF00917	0.667
DOC_USP7_MATH_1	377	381	PF00917	0.687
DOC_USP7_MATH_1	41	45	PF00917	0.718
DOC_USP7_MATH_1	490	494	PF00917	0.686
DOC_USP7_MATH_1	92	96	PF00917	0.699
DOC_USP7_UBL2_3	75	79	PF12436	0.747
DOC_WW_Pin1_4	216	221	PF00397	0.669
DOC_WW_Pin1_4	283	288	PF00397	0.739
DOC_WW_Pin1_4	342	347	PF00397	0.657
DOC_WW_Pin1_4	380	385	PF00397	0.674
DOC_WW_Pin1_4	39	44	PF00397	0.712
DOC_WW_Pin1_4	605	610	PF00397	0.606
DOC_WW_Pin1_4	68	73	PF00397	0.691
DOC_WW_Pin1_4	690	695	PF00397	0.360
DOC_WW_Pin1_4	713	718	PF00397	0.549
DOC_WW_Pin1_4	93	98	PF00397	0.706
LIG_14-3-3_CanoR_1	18	26	PF00244	0.678
LIG_14-3-3_CanoR_1	312	321	PF00244	0.697
LIG_14-3-3_CanoR_1	329	337	PF00244	0.539
LIG_14-3-3_CanoR_1	34	40	PF00244	0.486
LIG_14-3-3_CanoR_1	386	396	PF00244	0.592
LIG_14-3-3_CanoR_1	402	410	PF00244	0.466
LIG_14-3-3_CanoR_1	430	436	PF00244	0.492
LIG_14-3-3_CanoR_1	54	58	PF00244	0.703
LIG_14-3-3_CanoR_1	627	633	PF00244	0.384
LIG_14-3-3_CanoR_1	719	727	PF00244	0.500
LIG_14-3-3_CanoR_1	731	739	PF00244	0.456
LIG_14-3-3_CanoR_1	754	762	PF00244	0.535
LIG_14-3-3_CanoR_1	770	777	PF00244	0.528
LIG_Actin_WH2_2	798	814	PF00022	0.521
LIG_AP2alpha_2	3	5	PF02296	0.674
LIG_APCC_ABBA_1	165	170	PF00400	0.530
LIG_BIR_II_1	1	5	PF00653	0.681
LIG_BIR_III_1	1	5	PF00653	0.713
LIG_BIR_III_3	1	5	PF00653	0.713
LIG_BIR_III_4	391	395	PF00653	0.566
LIG_BRCT_BRCA1_1	344	348	PF00533	0.687
LIG_BRCT_BRCA1_1	502	506	PF00533	0.523
LIG_BRCT_BRCA1_1	630	634	PF00533	0.406
LIG_Clathr_ClatBox_1	741	745	PF01394	0.547
LIG_FHA_1	105	111	PF00498	0.709
LIG_FHA_1	444	450	PF00498	0.613
LIG_FHA_1	534	540	PF00498	0.543
LIG_FHA_1	61	67	PF00498	0.681
LIG_FHA_1	675	681	PF00498	0.438
LIG_FHA_2	150	156	PF00498	0.505
LIG_FHA_2	264	270	PF00498	0.767
LIG_FHA_2	719	725	PF00498	0.513
LIG_FHA_2	754	760	PF00498	0.647
LIG_LIR_Gen_1	157	168	PF02991	0.568
LIG_LIR_Gen_1	395	401	PF02991	0.607
LIG_LIR_Gen_1	503	513	PF02991	0.473
LIG_LIR_Gen_1	679	689	PF02991	0.378
LIG_LIR_Gen_1	724	732	PF02991	0.548
LIG_LIR_LC3C_4	646	651	PF02991	0.486
LIG_LIR_Nem_3	157	163	PF02991	0.615
LIG_LIR_Nem_3	395	400	PF02991	0.552
LIG_LIR_Nem_3	407	413	PF02991	0.560
LIG_LIR_Nem_3	503	509	PF02991	0.453
LIG_LIR_Nem_3	569	573	PF02991	0.452
LIG_LIR_Nem_3	679	684	PF02991	0.374
LIG_LIR_Nem_3	724	729	PF02991	0.549
LIG_NRBOX	395	401	PF00104	0.607
LIG_NRBOX	435	441	PF00104	0.461
LIG_NRBOX	731	737	PF00104	0.513
LIG_Pex14_2	410	414	PF04695	0.549
LIG_Pex14_2	506	510	PF04695	0.482
LIG_Pex14_2	579	583	PF04695	0.450
LIG_SH2_GRB2like	554	557	PF00017	0.537
LIG_SH2_STAP1	573	577	PF00017	0.468
LIG_SH2_STAP1	681	685	PF00017	0.429
LIG_SH2_STAT3	542	545	PF00017	0.546
LIG_SH2_STAT3	573	576	PF00017	0.468
LIG_SH2_STAT5	554	557	PF00017	0.612
LIG_SH2_STAT5	573	576	PF00017	0.520
LIG_SH2_STAT5	711	714	PF00017	0.401
LIG_SH3_2	220	225	PF14604	0.705
LIG_SH3_3	217	223	PF00018	0.667
LIG_SH3_3	275	281	PF00018	0.604
LIG_SH3_3	340	346	PF00018	0.665
LIG_SH3_3	456	462	PF00018	0.612
LIG_SH3_3	724	730	PF00018	0.486
LIG_SH3_4	75	82	PF00018	0.689
LIG_SUMO_SIM_anti_2	464	471	PF11976	0.525
LIG_SUMO_SIM_anti_2	686	691	PF11976	0.454
LIG_SUMO_SIM_par_1	10	15	PF11976	0.678
LIG_TRAF2_1	266	269	PF00917	0.685
MOD_CDC14_SPxK_1	383	386	PF00782	0.643
MOD_CDC14_SPxK_1	693	696	PF00782	0.377
MOD_CDC14_SPxK_1	716	719	PF00782	0.567
MOD_CDK_SPK_2	93	98	PF00069	0.687
MOD_CDK_SPxK_1	380	386	PF00069	0.648
MOD_CDK_SPxK_1	690	696	PF00069	0.369
MOD_CDK_SPxK_1	713	719	PF00069	0.555
MOD_CDK_SPxxK_3	218	225	PF00069	0.664
MOD_CDK_SPxxK_3	283	290	PF00069	0.741
MOD_CDK_SPxxK_3	68	75	PF00069	0.686
MOD_CK1_1	221	227	PF00069	0.662
MOD_CK1_1	233	239	PF00069	0.766
MOD_CK1_1	259	265	PF00069	0.725
MOD_CK1_1	305	311	PF00069	0.695
MOD_CK1_1	317	323	PF00069	0.626
MOD_CK1_1	352	358	PF00069	0.649
MOD_CK1_1	367	373	PF00069	0.738
MOD_CK1_1	380	386	PF00069	0.557
MOD_CK1_1	52	58	PF00069	0.716
MOD_CK1_1	569	575	PF00069	0.462
MOD_CK1_1	585	591	PF00069	0.457
MOD_CK1_1	608	614	PF00069	0.606
MOD_CK1_1	746	752	PF00069	0.692
MOD_CK1_1	755	761	PF00069	0.537
MOD_CK1_1	85	91	PF00069	0.713
MOD_CK2_1	134	140	PF00069	0.558
MOD_CK2_1	149	155	PF00069	0.383
MOD_CK2_1	221	227	PF00069	0.637
MOD_CK2_1	263	269	PF00069	0.707
MOD_CK2_1	586	592	PF00069	0.600
MOD_CK2_1	718	724	PF00069	0.459
MOD_GlcNHglycan	235	238	PF01048	0.738
MOD_GlcNHglycan	316	319	PF01048	0.729
MOD_GlcNHglycan	322	325	PF01048	0.650
MOD_GlcNHglycan	332	335	PF01048	0.535
MOD_GlcNHglycan	351	354	PF01048	0.482
MOD_GlcNHglycan	367	370	PF01048	0.721
MOD_GlcNHglycan	379	382	PF01048	0.649
MOD_GlcNHglycan	43	46	PF01048	0.639
MOD_GlcNHglycan	502	505	PF01048	0.568
MOD_GlcNHglycan	589	592	PF01048	0.555
MOD_GlcNHglycan	721	724	PF01048	0.479
MOD_GlcNHglycan	759	762	PF01048	0.481
MOD_GlcNHglycan	789	792	PF01048	0.543
MOD_GlcNHglycan	813	817	PF01048	0.562
MOD_GSK3_1	207	214	PF00069	0.681
MOD_GSK3_1	259	266	PF00069	0.754
MOD_GSK3_1	313	320	PF00069	0.776
MOD_GSK3_1	35	42	PF00069	0.627
MOD_GSK3_1	363	370	PF00069	0.690
MOD_GSK3_1	45	52	PF00069	0.686
MOD_GSK3_1	464	471	PF00069	0.578
MOD_GSK3_1	581	588	PF00069	0.540
MOD_GSK3_1	601	608	PF00069	0.521
MOD_GSK3_1	690	697	PF00069	0.372
MOD_GSK3_1	749	756	PF00069	0.666
MOD_GSK3_1	82	89	PF00069	0.766
MOD_N-GLC_1	259	264	PF02516	0.715
MOD_N-GLC_1	283	288	PF02516	0.675
MOD_N-GLC_1	555	560	PF02516	0.586
MOD_NEK2_1	14	19	PF00069	0.672
MOD_NEK2_1	148	153	PF00069	0.523
MOD_NEK2_1	319	324	PF00069	0.812
MOD_NEK2_1	330	335	PF00069	0.553
MOD_NEK2_1	455	460	PF00069	0.696
MOD_NEK2_1	505	510	PF00069	0.468
MOD_NEK2_1	566	571	PF00069	0.494
MOD_NEK2_1	583	588	PF00069	0.515
MOD_NEK2_1	601	606	PF00069	0.467
MOD_NEK2_1	801	806	PF00069	0.656
MOD_NEK2_2	514	519	PF00069	0.518
MOD_NEK2_2	643	648	PF00069	0.376
MOD_NEK2_2	814	819	PF00069	0.671
MOD_PIKK_1	134	140	PF00454	0.608
MOD_PIKK_1	17	23	PF00454	0.646
MOD_PIKK_1	264	270	PF00454	0.765
MOD_PKA_2	17	23	PF00069	0.704
MOD_PKA_2	313	319	PF00069	0.789
MOD_PKA_2	325	331	PF00069	0.654
MOD_PKA_2	35	41	PF00069	0.437
MOD_PKA_2	401	407	PF00069	0.699
MOD_PKA_2	420	426	PF00069	0.329
MOD_PKA_2	53	59	PF00069	0.706
MOD_PKA_2	628	634	PF00069	0.392
MOD_PKA_2	718	724	PF00069	0.517
MOD_PKA_2	730	736	PF00069	0.460
MOD_PKA_2	753	759	PF00069	0.656
MOD_PKA_2	769	775	PF00069	0.547
MOD_PKA_2	787	793	PF00069	0.343
MOD_PKA_2	801	807	PF00069	0.537
MOD_PKA_2	86	92	PF00069	0.683
MOD_PKB_1	312	320	PF00069	0.757
MOD_Plk_1	14	20	PF00069	0.658
MOD_Plk_1	443	449	PF00069	0.601
MOD_Plk_1	52	58	PF00069	0.676
MOD_Plk_1	555	561	PF00069	0.669
MOD_Plk_4	505	511	PF00069	0.419
MOD_Plk_4	566	572	PF00069	0.510
MOD_Plk_4	801	807	PF00069	0.586
MOD_ProDKin_1	216	222	PF00069	0.662
MOD_ProDKin_1	283	289	PF00069	0.739
MOD_ProDKin_1	342	348	PF00069	0.660
MOD_ProDKin_1	380	386	PF00069	0.674
MOD_ProDKin_1	39	45	PF00069	0.713
MOD_ProDKin_1	605	611	PF00069	0.607
MOD_ProDKin_1	68	74	PF00069	0.692
MOD_ProDKin_1	690	696	PF00069	0.369
MOD_ProDKin_1	713	719	PF00069	0.555
MOD_ProDKin_1	93	99	PF00069	0.703
MOD_SUMO_for_1	117	120	PF00179	0.540
TRG_DiLeu_BaEn_4	172	178	PF01217	0.510
TRG_DiLeu_BaLyEn_6	471	476	PF01217	0.506
TRG_DiLeu_BaLyEn_6	806	811	PF01217	0.609
TRG_ENDOCYTIC_2	160	163	PF00928	0.516
TRG_ENDOCYTIC_2	653	656	PF00928	0.450
TRG_ENDOCYTIC_2	681	684	PF00928	0.431
TRG_ER_diArg_1	33	36	PF00400	0.684
TRG_ER_diArg_1	518	520	PF00400	0.558
TRG_ER_diArg_1	57	59	PF00400	0.666
TRG_ER_diArg_1	627	630	PF00400	0.553
TRG_NES_CRM1_1	679	691	PF08389	0.388
TRG_NLS_MonoCore_2	310	315	PF00514	0.752
TRG_NLS_MonoExtN_4	239	246	PF00514	0.753
TRG_NLS_MonoExtN_4	309	315	PF00514	0.691
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	474	479	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	775	780	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	809	813	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P691	Leptomonas seymouri	49%	93%
A0A3S7XB99	Leishmania donovani	93%	100%
A4HPL7	Leishmania braziliensis	82%	100%
A4ID47	Leishmania infantum	93%	100%
E9ATC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DNK6	Trypanosoma cruzi	27%	100%