TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF3846)/TPR repeat, putative

Species:

Leishmania major

UniProt:

Q4Q164_LEIMA

TriTrypDb:

LmjF.36.3540 , LMJLV39_360045800 , LMJSD75_360045500

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q164

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q164

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	253	257	PF00656	0.501
CLV_NRD_NRD_1	258	260	PF00675	0.397
CLV_PCSK_KEX2_1	258	260	PF00082	0.397
CLV_PCSK_SKI1_1	259	263	PF00082	0.401
CLV_PCSK_SKI1_1	305	309	PF00082	0.425
CLV_PCSK_SKI1_1	362	366	PF00082	0.484
DOC_CYCLIN_RxL_1	276	284	PF00134	0.361
DOC_MAPK_MEF2A_6	9	16	PF00069	0.423
DOC_PIKK_1	19	27	PF02985	0.470
DOC_PP1_RVXF_1	277	284	PF00149	0.362
DOC_PP2B_LxvP_1	14	17	PF13499	0.422
DOC_USP7_MATH_1	119	123	PF00917	0.537
DOC_USP7_MATH_1	66	70	PF00917	0.562
DOC_USP7_MATH_1	83	87	PF00917	0.651
DOC_USP7_UBL2_3	358	362	PF12436	0.496
DOC_USP7_UBL2_3	72	76	PF12436	0.576
LIG_14-3-3_CanoR_1	312	316	PF00244	0.366
LIG_14-3-3_CanoR_1	38	42	PF00244	0.480
LIG_14-3-3_CanoR_1	46	50	PF00244	0.566
LIG_BIR_II_1	1	5	PF00653	0.623
LIG_BIR_III_2	20	24	PF00653	0.420
LIG_BRCT_BRCA1_1	134	138	PF00533	0.378
LIG_BRCT_BRCA1_1	365	369	PF00533	0.415
LIG_FHA_1	121	127	PF00498	0.517
LIG_FHA_1	212	218	PF00498	0.389
LIG_FHA_1	249	255	PF00498	0.468
LIG_FHA_1	312	318	PF00498	0.384
LIG_Integrin_RGD_1	156	158	PF01839	0.357
LIG_LIR_Apic_2	184	190	PF02991	0.410
LIG_LIR_Gen_1	110	119	PF02991	0.410
LIG_LIR_Gen_1	331	339	PF02991	0.447
LIG_LIR_Nem_3	110	114	PF02991	0.421
LIG_LIR_Nem_3	135	141	PF02991	0.382
LIG_LIR_Nem_3	171	176	PF02991	0.396
LIG_LIR_Nem_3	331	336	PF02991	0.456
LIG_NRBOX	272	278	PF00104	0.330
LIG_PCNA_yPIPBox_3	270	279	PF02747	0.363
LIG_Pex14_2	365	369	PF04695	0.483
LIG_SH2_CRK	187	191	PF00017	0.508
LIG_SH2_CRK	333	337	PF00017	0.422
LIG_SH2_GRB2like	187	190	PF00017	0.507
LIG_SH2_NCK_1	111	115	PF00017	0.510
LIG_SH2_NCK_1	187	191	PF00017	0.540
LIG_SH2_NCK_1	222	226	PF00017	0.510
LIG_SH2_NCK_1	323	327	PF00017	0.358
LIG_SH2_SRC	111	114	PF00017	0.494
LIG_SH2_SRC	187	190	PF00017	0.487
LIG_SH2_SRC	195	198	PF00017	0.540
LIG_SH2_SRC	301	304	PF00017	0.427
LIG_SH2_STAP1	183	187	PF00017	0.391
LIG_SH2_STAP1	248	252	PF00017	0.328
LIG_SH2_STAP1	323	327	PF00017	0.392
LIG_SH2_STAT3	105	108	PF00017	0.489
LIG_SH2_STAT5	105	108	PF00017	0.470
LIG_SH2_STAT5	125	128	PF00017	0.359
LIG_SH2_STAT5	13	16	PF00017	0.329
LIG_SH2_STAT5	131	134	PF00017	0.310
LIG_SH2_STAT5	301	304	PF00017	0.533
LIG_SH3_3	113	119	PF00018	0.456
LIG_SH3_3	173	179	PF00018	0.537
LIG_SUMO_SIM_par_1	249	256	PF11976	0.490
LIG_SUMO_SIM_par_1	89	95	PF11976	0.521
LIG_TRAF2_1	23	26	PF00917	0.514
LIG_TRAF2_1	263	266	PF00917	0.486
MOD_CK1_1	48	54	PF00069	0.552
MOD_CK2_1	83	89	PF00069	0.755
MOD_Cter_Amidation	256	259	PF01082	0.403
MOD_GlcNHglycan	133	137	PF01048	0.404
MOD_GlcNHglycan	273	276	PF01048	0.331
MOD_GlcNHglycan	68	71	PF01048	0.575
MOD_GlcNHglycan	80	84	PF01048	0.699
MOD_GlcNHglycan	85	88	PF01048	0.749
MOD_GSK3_1	211	218	PF00069	0.425
MOD_GSK3_1	248	255	PF00069	0.435
MOD_GSK3_1	341	348	PF00069	0.498
MOD_GSK3_1	79	86	PF00069	0.745
MOD_N-GLC_2	278	280	PF02516	0.434
MOD_NEK2_1	1	6	PF00069	0.615
MOD_NEK2_1	120	125	PF00069	0.443
MOD_NEK2_1	160	165	PF00069	0.431
MOD_NEK2_1	271	276	PF00069	0.308
MOD_NEK2_1	281	286	PF00069	0.379
MOD_NEK2_1	37	42	PF00069	0.387
MOD_NEK2_1	45	50	PF00069	0.596
MOD_PIKK_1	1	7	PF00454	0.608
MOD_PIKK_1	120	126	PF00454	0.448
MOD_PIKK_1	201	207	PF00454	0.537
MOD_PIKK_1	266	272	PF00454	0.493
MOD_PKA_1	215	221	PF00069	0.421
MOD_PKA_2	120	126	PF00069	0.523
MOD_PKA_2	145	151	PF00069	0.366
MOD_PKA_2	209	215	PF00069	0.407
MOD_PKA_2	271	277	PF00069	0.355
MOD_PKA_2	311	317	PF00069	0.424
MOD_PKA_2	37	43	PF00069	0.387
MOD_PKA_2	45	51	PF00069	0.595
MOD_Plk_1	341	347	PF00069	0.483
MOD_Plk_2-3	107	113	PF00069	0.416
MOD_Plk_4	126	132	PF00069	0.345
MOD_Plk_4	45	51	PF00069	0.498
MOD_SUMO_rev_2	211	217	PF00179	0.396
MOD_SUMO_rev_2	354	360	PF00179	0.443
TRG_ENDOCYTIC_2	111	114	PF00928	0.509
TRG_ENDOCYTIC_2	13	16	PF00928	0.329
TRG_ENDOCYTIC_2	183	186	PF00928	0.356
TRG_ENDOCYTIC_2	310	313	PF00928	0.400
TRG_ENDOCYTIC_2	333	336	PF00928	0.404
TRG_NES_CRM1_1	5	20	PF08389	0.443
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F3	Leptomonas seymouri	78%	100%
A0A0S4JL72	Bodo saltans	40%	94%
A0A1X0P430	Trypanosomatidae	55%	100%
A0A3S7XBC5	Leishmania donovani	97%	100%
A0A422N1C1	Trypanosoma rangeli	55%	100%
A4HPM1	Leishmania braziliensis	89%	100%
A4ID44	Leishmania infantum	97%	100%
D0A8J4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
V5BWW6	Trypanosoma cruzi	53%	100%