Putative signal recognition particle receptor like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

signal recognition particle receptor like protein, putative

Species:

Leishmania major

UniProt:

Q4Q161_LEIMA

TriTrypDb:

LmjF.36.3570 , LMJLV39_360046100 , LMJSD75_360045800

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	2
GO:0005783	endoplasmic reticulum	5	2
GO:0005785	signal recognition particle receptor complex	3	10
GO:0005789	endoplasmic reticulum membrane	4	4
GO:0016020	membrane	2	4
GO:0031090	organelle membrane	3	4
GO:0031967	organelle envelope	3	2
GO:0031975	envelope	2	2
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098796	membrane protein complex	2	10
GO:0110165	cellular anatomical entity	1	4
GO:0140534	endoplasmic reticulum protein-containing complex	2	10

Expansion

Sequence features

Q4Q161

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q161

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	12
GO:0006612	protein targeting to membrane	5	12
GO:0006613	cotranslational protein targeting to membrane	6	12
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	12
GO:0045047	protein targeting to ER	6	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0051668	localization within membrane	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0070972	protein localization to endoplasmic reticulum	6	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0072594	establishment of protein localization to organelle	4	12
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	12
GO:0072657	protein localization to membrane	4	12
GO:0090150	establishment of protein localization to membrane	4	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	10
GO:0003924	GTPase activity	7	10
GO:0005047	signal recognition particle binding	4	10
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	10
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043021	ribonucleoprotein complex binding	3	10
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0044877	protein-containing complex binding	2	10
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.315
CLV_NRD_NRD_1	203	205	PF00675	0.253
CLV_NRD_NRD_1	25	27	PF00675	0.389
CLV_NRD_NRD_1	374	376	PF00675	0.402
CLV_NRD_NRD_1	530	532	PF00675	0.244
CLV_PCSK_KEX2_1	203	205	PF00082	0.344
CLV_PCSK_KEX2_1	231	233	PF00082	0.342
CLV_PCSK_KEX2_1	25	27	PF00082	0.403
CLV_PCSK_KEX2_1	277	279	PF00082	0.527
CLV_PCSK_KEX2_1	353	355	PF00082	0.387
CLV_PCSK_KEX2_1	374	376	PF00082	0.402
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.342
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.558
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.387
CLV_PCSK_SKI1_1	203	207	PF00082	0.323
CLV_PCSK_SKI1_1	257	261	PF00082	0.594
CLV_PCSK_SKI1_1	374	378	PF00082	0.396
CLV_PCSK_SKI1_1	55	59	PF00082	0.302
CLV_PCSK_SKI1_1	72	76	PF00082	0.230
DEG_Nend_Nbox_1	1	3	PF02207	0.336
DOC_CYCLIN_yCln2_LP_2	575	581	PF00134	0.241
DOC_MAPK_gen_1	72	81	PF00069	0.387
DOC_MAPK_MEF2A_6	478	485	PF00069	0.262
DOC_MAPK_MEF2A_6	592	600	PF00069	0.257
DOC_MAPK_MEF2A_6	75	83	PF00069	0.349
DOC_PP2B_LxvP_1	452	455	PF13499	0.257
DOC_PP4_FxxP_1	73	76	PF00568	0.387
DOC_SPAK_OSR1_1	63	67	PF12202	0.262
DOC_USP7_MATH_1	153	157	PF00917	0.343
DOC_USP7_MATH_1	165	169	PF00917	0.406
DOC_USP7_MATH_1	266	270	PF00917	0.603
DOC_USP7_MATH_1	474	478	PF00917	0.407
DOC_USP7_MATH_1	542	546	PF00917	0.387
DOC_USP7_UBL2_3	230	234	PF12436	0.289
DOC_USP7_UBL2_3	328	332	PF12436	0.241
DOC_USP7_UBL2_3	393	397	PF12436	0.407
DOC_USP7_UBL2_3	92	96	PF12436	0.344
LIG_Actin_WH2_2	358	376	PF00022	0.275
LIG_Actin_WH2_2	577	594	PF00022	0.335
LIG_FHA_1	2	8	PF00498	0.302
LIG_FHA_1	308	314	PF00498	0.387
LIG_FHA_2	133	139	PF00498	0.349
LIG_FHA_2	17	23	PF00498	0.450
LIG_FHA_2	235	241	PF00498	0.221
LIG_FHA_2	258	264	PF00498	0.479
LIG_FHA_2	362	368	PF00498	0.446
LIG_FHA_2	554	560	PF00498	0.253
LIG_FHA_2	585	591	PF00498	0.256
LIG_LIR_Gen_1	123	133	PF02991	0.337
LIG_LIR_Gen_1	357	365	PF02991	0.241
LIG_LIR_Gen_1	556	565	PF02991	0.241
LIG_LIR_Gen_1	587	596	PF02991	0.241
LIG_LIR_Nem_3	102	107	PF02991	0.288
LIG_LIR_Nem_3	123	129	PF02991	0.337
LIG_LIR_Nem_3	357	361	PF02991	0.241
LIG_LIR_Nem_3	539	543	PF02991	0.241
LIG_LIR_Nem_3	556	561	PF02991	0.256
LIG_LIR_Nem_3	587	591	PF02991	0.259
LIG_LIR_Nem_3	61	67	PF02991	0.258
LIG_LYPXL_S_1	69	73	PF13949	0.275
LIG_PCNA_yPIPBox_3	25	37	PF02747	0.257
LIG_Pex14_1	303	307	PF04695	0.241
LIG_REV1ctd_RIR_1	71	75	PF16727	0.387
LIG_SH2_CRK	126	130	PF00017	0.387
LIG_SH2_CRK	399	403	PF00017	0.247
LIG_SH2_STAP1	126	130	PF00017	0.273
LIG_SH2_STAP1	399	403	PF00017	0.241
LIG_SH2_STAT3	420	423	PF00017	0.241
LIG_SH2_STAT3	94	97	PF00017	0.306
LIG_SH2_STAT5	275	278	PF00017	0.705
LIG_SH2_STAT5	307	310	PF00017	0.257
LIG_SH3_1	182	188	PF00018	0.175
LIG_SH3_3	182	188	PF00018	0.262
LIG_SH3_3	590	596	PF00018	0.257
LIG_SUMO_SIM_anti_2	3	11	PF11976	0.320
LIG_SUMO_SIM_par_1	3	11	PF11976	0.320
LIG_SUMO_SIM_par_1	482	488	PF11976	0.242
LIG_TRAF2_1	135	138	PF00917	0.337
LIG_UBA3_1	321	328	PF00899	0.387
LIG_WRC_WIRS_1	355	360	PF05994	0.241
MOD_CK1_1	156	162	PF00069	0.362
MOD_CK1_1	217	223	PF00069	0.291
MOD_CK1_1	6	12	PF00069	0.335
MOD_CK2_1	132	138	PF00069	0.267
MOD_CK2_1	16	22	PF00069	0.510
MOD_CK2_1	257	263	PF00069	0.510
MOD_Cter_Amidation	201	204	PF01082	0.271
MOD_Cter_Amidation	23	26	PF01082	0.439
MOD_Cter_Amidation	232	235	PF01082	0.306
MOD_Cter_Amidation	351	354	PF01082	0.301
MOD_GlcNHglycan	10	13	PF01048	0.453
MOD_GlcNHglycan	121	125	PF01048	0.272
MOD_GlcNHglycan	155	158	PF01048	0.367
MOD_GlcNHglycan	167	170	PF01048	0.175
MOD_GlcNHglycan	216	219	PF01048	0.399
MOD_GlcNHglycan	225	228	PF01048	0.247
MOD_GlcNHglycan	600	603	PF01048	0.272
MOD_GSK3_1	103	110	PF00069	0.384
MOD_GSK3_1	16	23	PF00069	0.408
MOD_GSK3_1	163	170	PF00069	0.334
MOD_GSK3_1	299	306	PF00069	0.612
MOD_GSK3_1	342	349	PF00069	0.278
MOD_GSK3_1	357	364	PF00069	0.339
MOD_GSK3_1	460	467	PF00069	0.188
MOD_GSK3_1	553	560	PF00069	0.256
MOD_LATS_1	255	261	PF00433	0.632
MOD_N-GLC_1	133	138	PF02516	0.339
MOD_N-GLC_1	214	219	PF02516	0.275
MOD_N-GLC_2	534	536	PF02516	0.241
MOD_NEK2_1	1	6	PF00069	0.317
MOD_NEK2_1	103	108	PF00069	0.341
MOD_NEK2_1	369	374	PF00069	0.395
MOD_NEK2_1	485	490	PF00069	0.235
MOD_NEK2_2	266	271	PF00069	0.542
MOD_NEK2_2	433	438	PF00069	0.241
MOD_PIKK_1	542	548	PF00454	0.175
MOD_PK_1	397	403	PF00069	0.241
MOD_PKA_1	203	209	PF00069	0.423
MOD_PKA_1	234	240	PF00069	0.257
MOD_PKA_1	257	263	PF00069	0.616
MOD_PKA_2	203	209	PF00069	0.431
MOD_PKA_2	271	277	PF00069	0.544
MOD_Plk_1	346	352	PF00069	0.241
MOD_Plk_4	271	277	PF00069	0.580
MOD_Plk_4	299	305	PF00069	0.531
MOD_Plk_4	3	9	PF00069	0.320
MOD_Plk_4	357	363	PF00069	0.387
MOD_Plk_4	397	403	PF00069	0.241
MOD_Plk_4	425	431	PF00069	0.248
MOD_Plk_4	567	573	PF00069	0.241
MOD_SUMO_for_1	379	382	PF00179	0.389
MOD_SUMO_rev_2	312	321	PF00179	0.434
MOD_SUMO_rev_2	559	565	PF00179	0.241
TRG_DiLeu_BaEn_1	125	130	PF01217	0.369
TRG_ENDOCYTIC_2	126	129	PF00928	0.344
TRG_ENDOCYTIC_2	362	365	PF00928	0.416
TRG_ENDOCYTIC_2	399	402	PF00928	0.247
TRG_ENDOCYTIC_2	588	591	PF00928	0.289
TRG_ENDOCYTIC_2	70	73	PF00928	0.252
TRG_ENDOCYTIC_2	78	81	PF00928	0.228
TRG_ER_diArg_1	203	205	PF00400	0.342
TRG_ER_diArg_1	25	27	PF00400	0.393
TRG_ER_diArg_1	373	375	PF00400	0.355
TRG_NES_CRM1_1	559	574	PF08389	0.241
TRG_NLS_MonoExtC_3	229	234	PF00514	0.262
TRG_NLS_MonoExtN_4	230	235	PF00514	0.288
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Q5	Leptomonas seymouri	76%	99%
A0A0S4JKS8	Bodo saltans	56%	100%
A0A1X0P3D4	Trypanosomatidae	61%	100%
A0A3R7RBB0	Trypanosoma rangeli	60%	100%
A0A3S7XBC9	Leishmania donovani	95%	100%
A4HPM4	Leishmania braziliensis	85%	100%
A4ID41	Leishmania infantum	95%	100%
D0A8J2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9ATD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P06625	Canis lupus familiaris	37%	95%
Q8CWX8	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	25%	100%
Q9DBG7	Mus musculus	37%	95%
V5DNM6	Trypanosoma cruzi	59%	100%