Cysteine synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Cysteine synthase

Gene product:

cysteine synthase

Species:

Leishmania major

UniProt:

Q4Q159_LEIMA

TriTrypDb:

LmjF.36.3590 , LMJLV39_360046300 , LMJSD75_360046000

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q159

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q159

PDB structure(s): 4air_A , 4air_B

Function

Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	10
GO:0000097	sulfur amino acid biosynthetic process	5	10
GO:0006082	organic acid metabolic process	3	10
GO:0006520	amino acid metabolic process	3	10
GO:0006534	cysteine metabolic process	5	10
GO:0006535	cysteine biosynthetic process from serine	7	10
GO:0006563	L-serine metabolic process	6	10
GO:0006790	sulfur compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0008652	amino acid biosynthetic process	4	10
GO:0009058	biosynthetic process	2	10
GO:0009069	serine family amino acid metabolic process	5	10
GO:0009070	serine family amino acid biosynthetic process	6	10
GO:0009987	cellular process	1	10
GO:0016053	organic acid biosynthetic process	4	10
GO:0019344	cysteine biosynthetic process	6	10
GO:0019752	carboxylic acid metabolic process	5	10
GO:0043436	oxoacid metabolic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044272	sulfur compound biosynthetic process	4	10
GO:0044281	small molecule metabolic process	2	10
GO:0044283	small molecule biosynthetic process	3	10
GO:0046394	carboxylic acid biosynthetic process	5	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901566	organonitrogen compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10
GO:1901605	alpha-amino acid metabolic process	4	10
GO:1901607	alpha-amino acid biosynthetic process	5	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004124	cysteine synthase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	264	268	PF00656	0.378
CLV_NRD_NRD_1	110	112	PF00675	0.319
CLV_PCSK_KEX2_1	110	112	PF00082	0.319
CLV_PCSK_SKI1_1	111	115	PF00082	0.342
CLV_PCSK_SKI1_1	139	143	PF00082	0.351
CLV_PCSK_SKI1_1	196	200	PF00082	0.332
CLV_PCSK_SKI1_1	36	40	PF00082	0.384
DEG_APCC_DBOX_1	109	117	PF00400	0.367
DEG_SPOP_SBC_1	76	80	PF00917	0.435
DOC_CKS1_1	122	127	PF01111	0.319
DOC_MAPK_gen_1	110	116	PF00069	0.319
DOC_MAPK_MEF2A_6	34	41	PF00069	0.347
DOC_MAPK_MEF2A_6	94	102	PF00069	0.319
DOC_PP1_RVXF_1	51	57	PF00149	0.340
DOC_USP7_MATH_1	46	50	PF00917	0.319
DOC_USP7_MATH_1	70	74	PF00917	0.354
DOC_USP7_UBL2_3	36	40	PF12436	0.378
DOC_WW_Pin1_4	121	126	PF00397	0.354
DOC_WW_Pin1_4	19	24	PF00397	0.319
DOC_WW_Pin1_4	212	217	PF00397	0.669
LIG_14-3-3_CanoR_1	306	316	PF00244	0.378
LIG_BIR_II_1	1	5	PF00653	0.506
LIG_BIR_III_1	1	5	PF00653	0.544
LIG_BIR_III_3	1	5	PF00653	0.544
LIG_CtBP_PxDLS_1	103	107	PF00389	0.378
LIG_FHA_1	20	26	PF00498	0.364
LIG_FHA_2	164	170	PF00498	0.319
LIG_FHA_2	262	268	PF00498	0.383
LIG_FHA_2	99	105	PF00498	0.357
LIG_LIR_Gen_1	155	161	PF02991	0.439
LIG_LIR_Nem_3	155	160	PF02991	0.439
LIG_LIR_Nem_3	267	273	PF02991	0.324
LIG_LIR_Nem_3	310	316	PF02991	0.382
LIG_SH2_CRK	157	161	PF00017	0.435
LIG_SH2_CRK	280	284	PF00017	0.393
LIG_SH2_CRK	313	317	PF00017	0.391
LIG_SH2_CRK	96	100	PF00017	0.367
LIG_SH2_GRB2like	26	29	PF00017	0.383
LIG_SH2_NCK_1	59	63	PF00017	0.342
LIG_SH2_STAT5	26	29	PF00017	0.327
LIG_SH2_STAT5	307	310	PF00017	0.371
LIG_SUMO_SIM_anti_2	295	302	PF11976	0.344
LIG_SUMO_SIM_par_1	206	211	PF11976	0.342
LIG_WRC_WIRS_1	300	305	PF05994	0.382
MOD_CK1_1	80	86	PF00069	0.319
MOD_CK2_1	163	169	PF00069	0.319
MOD_CK2_1	299	305	PF00069	0.357
MOD_CK2_1	98	104	PF00069	0.378
MOD_GlcNHglycan	218	221	PF01048	0.669
MOD_GlcNHglycan	273	276	PF01048	0.319
MOD_GlcNHglycan	79	82	PF01048	0.338
MOD_GSK3_1	212	219	PF00069	0.669
MOD_GSK3_1	295	302	PF00069	0.357
MOD_GSK3_1	76	83	PF00069	0.319
MOD_GSK3_1	98	105	PF00069	0.342
MOD_N-GLC_1	30	35	PF02516	0.355
MOD_NEK2_1	240	245	PF00069	0.367
MOD_NEK2_1	261	266	PF00069	0.435
MOD_NEK2_1	30	35	PF00069	0.384
MOD_NEK2_1	312	317	PF00069	0.340
MOD_NEK2_1	5	10	PF00069	0.490
MOD_NEK2_2	46	51	PF00069	0.319
MOD_Plk_1	240	246	PF00069	0.367
MOD_Plk_1	318	324	PF00069	0.460
MOD_Plk_2-3	104	110	PF00069	0.319
MOD_Plk_4	292	298	PF00069	0.342
MOD_Plk_4	70	76	PF00069	0.319
MOD_ProDKin_1	121	127	PF00069	0.354
MOD_ProDKin_1	19	25	PF00069	0.319
MOD_ProDKin_1	212	218	PF00069	0.669
MOD_SUMO_for_1	39	42	PF00179	0.319
MOD_SUMO_rev_2	287	296	PF00179	0.378
MOD_SUMO_rev_2	60	69	PF00179	0.386
TRG_DiLeu_BaEn_1	109	114	PF01217	0.319
TRG_ENDOCYTIC_2	157	160	PF00928	0.435
TRG_ENDOCYTIC_2	280	283	PF00928	0.393
TRG_ENDOCYTIC_2	313	316	PF00928	0.388
TRG_ENDOCYTIC_2	96	99	PF00928	0.367
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4H0	Leptomonas seymouri	36%	92%
A0A0N0P4U0	Leptomonas seymouri	86%	100%
A0A0S4JDZ7	Bodo saltans	64%	99%
A0A0S4JNJ6	Bodo saltans	32%	89%
A0A1X0NVD2	Trypanosomatidae	32%	93%
A0A1X0P4R1	Trypanosomatidae	75%	99%
A0A3S5H833	Leishmania donovani	97%	100%
A0A3S7WUC4	Leishmania donovani	36%	93%
A0A422N6U8	Trypanosoma rangeli	35%	89%
A2XWA9	Oryza sativa subsp. indica	25%	98%
A4HPM6	Leishmania braziliensis	90%	100%
A4HX92	Leishmania infantum	37%	93%
A4ID39	Leishmania infantum	97%	100%
A5INY7	Staphylococcus aureus (strain JH9)	34%	100%
A5U908	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	26%	90%
A6QDA0	Staphylococcus aureus (strain Newman)	34%	100%
A6TXQ1	Staphylococcus aureus (strain JH1)	34%	100%
A7WX68	Staphylococcus aureus (strain Mu3 / ATCC 700698)	34%	100%
A8YZ41	Staphylococcus aureus (strain USA300 / TCH1516)	34%	100%
D0A7T9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	92%
D0K799	Staphylococcus aureus (strain ED98)	34%	100%
D1GUM7	Staphylococcus aureus (strain TW20 / 0582)	34%	100%
D2N3G7	Staphylococcus aureus (strain MRSA ST398 / isolate S0385)	34%	100%
D2Z027	Streptomyces lavendulae	40%	100%
D3ERF5	Staphylococcus aureus (strain 04-02981)	34%	100%
E9AQZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	93%
E9ATD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
F4K5T2	Arabidopsis thaliana	49%	100%
O01592	Caenorhabditis elegans	48%	99%
O05393	Bacillus subtilis (strain 168)	38%	100%
O22682	Arabidopsis thaliana	46%	82%
O23733	Brassica juncea	49%	100%
O23735	Brassica juncea	51%	100%
O32978	Mycobacterium leprae (strain TN)	49%	100%
O34476	Bacillus subtilis (strain 168)	44%	100%
O45679	Caenorhabditis elegans	51%	99%
O59265	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	26%	73%
O59701	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	95%
O67507	Aquifex aeolicus (strain VF5)	34%	100%
O69652	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	90%
O81154	Solanum tuberosum	50%	100%
O81155	Solanum tuberosum	51%	86%
P0A1E3	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	51%	100%
P0A1E4	Salmonella typhi	51%	100%
P0A535	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	50%	100%
P0ABK5	Escherichia coli (strain K12)	51%	100%
P0ABK6	Escherichia coli O157:H7	51%	100%
P16703	Escherichia coli (strain K12)	37%	100%
P29848	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	37%	100%
P31300	Capsicum annuum	49%	89%
P32260	Spinacia oleracea	50%	87%
P37887	Bacillus subtilis (strain 168)	51%	100%
P38076	Triticum aestivum	48%	100%
P45040	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	49%	100%
P46794	Dictyostelium discoideum	34%	67%
P47998	Arabidopsis thaliana	50%	100%
P47999	Arabidopsis thaliana	51%	85%
P50867	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	35%	90%
P53206	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	85%
P55708	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	34%	99%
P56067	Helicobacter pylori (strain ATCC 700392 / 26695)	36%	100%
P57171	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	46%	100%
P63870	Staphylococcus aureus (strain Mu50 / ATCC 700699)	48%	100%
P63871	Staphylococcus aureus (strain N315)	48%	100%
P63872	Staphylococcus aureus (strain MW2)	48%	100%
P63874	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	32%	100%
P71128	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	45%	100%
P73410	Synechocystis sp. (strain PCC 6803 / Kazusa)	50%	100%
P80608	Zea mays	48%	100%
P87131	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	84%
P9WP50	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	38%	72%
P9WP51	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	38%	72%
P9WP52	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	32%	100%
P9WP53	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	32%	100%
P9WP54	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	50%	100%
P9WP55	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	50%	100%
Q00834	Spinacia oleracea	51%	100%
Q1KLZ1	Malus domestica	45%	89%
Q1KLZ2	Malus domestica	45%	89%
Q2FKE3	Staphylococcus aureus (strain USA300)	34%	100%
Q2G1N3	Staphylococcus aureus (strain NCTC 8325 / PS 47)	34%	100%
Q2V0C9	Apis mellifera	37%	66%
Q2YUU0	Staphylococcus aureus (strain bovine RF122 / ET3-1)	33%	100%
Q43153	Spinacia oleracea	47%	90%
Q43317	Citrullus lanatus	50%	100%
Q43725	Arabidopsis thaliana	51%	77%
Q44004	Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)	33%	98%
Q4QEG9	Leishmania major	37%	93%
Q54CN7	Dictyostelium discoideum	31%	88%
Q59447	Flavobacterium sp. (strain K3-15 / DSM ID92-509)	45%	100%
Q59966	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	48%	100%
Q5BD67	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	31%	78%
Q5HIG2	Staphylococcus aureus (strain COL)	48%	100%
Q5HJQ3	Staphylococcus aureus (strain COL)	34%	100%
Q5HRP1	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	49%	100%
Q5XAQ3	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	47%	100%
Q6GBX5	Staphylococcus aureus (strain MSSA476)	48%	100%
Q6GD09	Staphylococcus aureus (strain MSSA476)	34%	100%
Q6GJF8	Staphylococcus aureus (strain MRSA252)	48%	100%
Q6GKI9	Staphylococcus aureus (strain MRSA252)	34%	100%
Q76MX2	Solanum tuberosum	46%	95%
Q79FV4	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	24%	90%
Q7A1Z6	Staphylococcus aureus (strain MW2)	34%	100%
Q7DDL5	Neisseria meningitidis serogroup B (strain MC58)	53%	100%
Q7RYW6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	89%
Q7SHQ1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	33%	73%
Q7XSN8	Oryza sativa subsp. japonica	25%	98%
Q8CMT6	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	49%	100%
Q8KA48	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	48%	100%
Q8U0J5	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	28%	75%
Q8XSQ0	Ralstonia solanacearum (strain GMI1000)	34%	99%
Q93244	Caenorhabditis elegans	49%	98%
Q932K9	Staphylococcus aureus (strain Mu50 / ATCC 700699)	34%	100%
Q99X99	Staphylococcus aureus (strain N315)	34%	100%
Q9FS29	Solanum tuberosum	45%	96%
Q9I526	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	37%	100%
Q9S6Z7	Arabidopsis thaliana	49%	100%
Q9S757	Arabidopsis thaliana	46%	90%
Q9SXS7	Arabidopsis thaliana	48%	100%
Q9XEA6	Oryza sativa subsp. japonica	49%	100%
Q9XEA8	Oryza sativa subsp. japonica	48%	100%
Q9Y9H2	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	28%	74%
Q9YBL2	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	28%	86%
Q9ZMW6	Helicobacter pylori (strain J99 / ATCC 700824)	34%	100%
V5BWY7	Trypanosoma cruzi	74%	100%