Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q158_LEIMA

TriTrypDb:

LmjF.36.3600 , LMJLV39_360046400 , LMJSD75_360046100

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q158

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q158

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.435
CLV_NRD_NRD_1	125	127	PF00675	0.559
CLV_NRD_NRD_1	445	447	PF00675	0.799
CLV_NRD_NRD_1	465	467	PF00675	0.451
CLV_NRD_NRD_1	542	544	PF00675	0.492
CLV_NRD_NRD_1	99	101	PF00675	0.475
CLV_PCSK_KEX2_1	101	103	PF00082	0.448
CLV_PCSK_KEX2_1	125	127	PF00082	0.559
CLV_PCSK_KEX2_1	171	173	PF00082	0.770
CLV_PCSK_KEX2_1	28	30	PF00082	0.458
CLV_PCSK_KEX2_1	410	412	PF00082	0.685
CLV_PCSK_KEX2_1	445	447	PF00082	0.799
CLV_PCSK_KEX2_1	465	467	PF00082	0.451
CLV_PCSK_KEX2_1	531	533	PF00082	0.566
CLV_PCSK_KEX2_1	81	83	PF00082	0.501
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.448
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.774
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.458
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.685
CLV_PCSK_PC1ET2_1	531	533	PF00082	0.566
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.501
CLV_PCSK_PC7_1	167	173	PF00082	0.824
CLV_PCSK_SKI1_1	171	175	PF00082	0.776
CLV_PCSK_SKI1_1	458	462	PF00082	0.772
DEG_APCC_DBOX_1	258	266	PF00400	0.507
DEG_Nend_Nbox_1	1	3	PF02207	0.410
DEG_ODPH_VHL_1	373	386	PF01847	0.465
DEG_SCF_FBW7_1	31	37	PF00400	0.427
DEG_SCF_FBW7_1	426	433	PF00400	0.663
DEG_SCF_FBW7_2	243	249	PF00400	0.484
DEG_SPOP_SBC_1	158	162	PF00917	0.604
DEG_SPOP_SBC_1	338	342	PF00917	0.687
DEG_SPOP_SBC_1	34	38	PF00917	0.423
DOC_CKS1_1	243	248	PF01111	0.567
DOC_CKS1_1	31	36	PF01111	0.426
DOC_CKS1_1	539	544	PF01111	0.584
DOC_CYCLIN_RxL_1	455	464	PF00134	0.559
DOC_MAPK_gen_1	100	109	PF00069	0.436
DOC_MAPK_gen_1	125	131	PF00069	0.558
DOC_MAPK_gen_1	543	549	PF00069	0.547
DOC_MAPK_MEF2A_6	427	434	PF00069	0.549
DOC_PP2B_LxvP_1	129	132	PF13499	0.634
DOC_PP2B_LxvP_1	384	387	PF13499	0.611
DOC_PP4_FxxP_1	219	222	PF00568	0.589
DOC_USP7_MATH_1	105	109	PF00917	0.407
DOC_USP7_MATH_1	130	134	PF00917	0.498
DOC_USP7_MATH_1	158	162	PF00917	0.693
DOC_USP7_MATH_1	222	226	PF00917	0.663
DOC_USP7_MATH_1	338	342	PF00917	0.620
DOC_USP7_MATH_1	34	38	PF00917	0.423
DOC_USP7_MATH_1	390	394	PF00917	0.680
DOC_USP7_MATH_1	454	458	PF00917	0.692
DOC_USP7_MATH_1	494	498	PF00917	0.553
DOC_USP7_MATH_1	54	58	PF00917	0.402
DOC_WW_Pin1_4	159	164	PF00397	0.740
DOC_WW_Pin1_4	204	209	PF00397	0.648
DOC_WW_Pin1_4	242	247	PF00397	0.561
DOC_WW_Pin1_4	30	35	PF00397	0.431
DOC_WW_Pin1_4	426	431	PF00397	0.761
DOC_WW_Pin1_4	439	444	PF00397	0.671
DOC_WW_Pin1_4	50	55	PF00397	0.410
DOC_WW_Pin1_4	508	513	PF00397	0.490
DOC_WW_Pin1_4	538	543	PF00397	0.586
LIG_14-3-3_CanoR_1	172	179	PF00244	0.623
LIG_14-3-3_CanoR_1	240	244	PF00244	0.454
LIG_14-3-3_CanoR_1	299	307	PF00244	0.502
LIG_14-3-3_CanoR_1	445	452	PF00244	0.770
LIG_14-3-3_CanoR_1	465	473	PF00244	0.454
LIG_Actin_WH2_2	225	242	PF00022	0.347
LIG_Actin_WH2_2	312	330	PF00022	0.539
LIG_Actin_WH2_2	448	464	PF00022	0.720
LIG_BRCT_BRCA1_1	135	139	PF00533	0.556
LIG_CSL_BTD_1	243	246	PF09270	0.502
LIG_FHA_1	322	328	PF00498	0.542
LIG_FHA_1	344	350	PF00498	0.555
LIG_FHA_1	427	433	PF00498	0.746
LIG_FHA_1	517	523	PF00498	0.470
LIG_FHA_1	573	579	PF00498	0.545
LIG_FHA_1	63	69	PF00498	0.448
LIG_FHA_2	243	249	PF00498	0.567
LIG_FHA_2	262	268	PF00498	0.480
LIG_FHA_2	367	373	PF00498	0.583
LIG_FHA_2	53	59	PF00498	0.535
LIG_GBD_Chelix_1	186	194	PF00786	0.625
LIG_LIR_Apic_2	20	26	PF02991	0.434
LIG_LIR_Apic_2	217	222	PF02991	0.624
LIG_LIR_Gen_1	115	122	PF02991	0.497
LIG_LIR_Gen_1	140	150	PF02991	0.586
LIG_LIR_Gen_1	561	570	PF02991	0.584
LIG_LIR_Nem_3	110	116	PF02991	0.485
LIG_LIR_Nem_3	136	142	PF02991	0.582
LIG_LIR_Nem_3	289	293	PF02991	0.458
LIG_LIR_Nem_3	561	566	PF02991	0.531
LIG_LIR_Nem_3	58	64	PF02991	0.448
LIG_NRBOX	283	289	PF00104	0.418
LIG_PCNA_yPIPBox_3	299	313	PF02747	0.458
LIG_PDZ_Class_2	575	580	PF00595	0.557
LIG_SH2_CRK	23	27	PF00017	0.441
LIG_SH2_PTP2	503	506	PF00017	0.373
LIG_SH2_SRC	152	155	PF00017	0.541
LIG_SH2_SRC	503	506	PF00017	0.583
LIG_SH2_STAP1	414	418	PF00017	0.742
LIG_SH2_STAT5	152	155	PF00017	0.527
LIG_SH2_STAT5	503	506	PF00017	0.557
LIG_SH2_STAT5	516	519	PF00017	0.449
LIG_SH3_3	372	378	PF00018	0.579
LIG_SH3_3	384	390	PF00018	0.381
LIG_SH3_3	453	459	PF00018	0.722
LIG_SH3_3	509	515	PF00018	0.364
LIG_Sin3_3	64	71	PF02671	0.448
LIG_SUMO_SIM_par_1	345	351	PF11976	0.637
LIG_TRAF2_1	214	217	PF00917	0.649
LIG_TRAF2_1	264	267	PF00917	0.560
LIG_TRAF2_1	437	440	PF00917	0.697
LIG_TRAF2_2	75	80	PF00917	0.466
LIG_UBA3_1	522	531	PF00899	0.463
LIG_WRC_WIRS_1	113	118	PF05994	0.532
MOD_CDC14_SPxK_1	442	445	PF00782	0.688
MOD_CDK_SPK_2	538	543	PF00069	0.586
MOD_CDK_SPxK_1	439	445	PF00069	0.718
MOD_CDK_SPxK_1	50	56	PF00069	0.433
MOD_CDK_SPxK_1	538	544	PF00069	0.584
MOD_CDK_SPxxK_3	439	446	PF00069	0.696
MOD_CK1_1	133	139	PF00069	0.514
MOD_CK1_1	197	203	PF00069	0.590
MOD_CK1_1	204	210	PF00069	0.555
MOD_CK1_1	321	327	PF00069	0.527
MOD_CK1_1	337	343	PF00069	0.428
MOD_CK1_1	393	399	PF00069	0.707
MOD_CK2_1	197	203	PF00069	0.581
MOD_CK2_1	261	267	PF00069	0.520
MOD_CK2_1	434	440	PF00069	0.691
MOD_CMANNOS	536	539	PF00535	0.570
MOD_GlcNHglycan	119	122	PF01048	0.570
MOD_GlcNHglycan	181	184	PF01048	0.667
MOD_GlcNHglycan	203	206	PF01048	0.706
MOD_GlcNHglycan	224	227	PF01048	0.654
MOD_GlcNHglycan	336	339	PF01048	0.632
MOD_GlcNHglycan	342	345	PF01048	0.624
MOD_GlcNHglycan	359	362	PF01048	0.362
MOD_GlcNHglycan	467	470	PF01048	0.711
MOD_GlcNHglycan	473	476	PF01048	0.724
MOD_GlcNHglycan	489	492	PF01048	0.636
MOD_GSK3_1	105	112	PF00069	0.368
MOD_GSK3_1	133	140	PF00069	0.560
MOD_GSK3_1	177	184	PF00069	0.752
MOD_GSK3_1	197	204	PF00069	0.529
MOD_GSK3_1	30	37	PF00069	0.430
MOD_GSK3_1	334	341	PF00069	0.586
MOD_GSK3_1	426	433	PF00069	0.704
MOD_GSK3_1	461	468	PF00069	0.666
MOD_GSK3_1	471	478	PF00069	0.620
MOD_GSK3_1	483	490	PF00069	0.502
MOD_GSK3_1	50	57	PF00069	0.408
MOD_GSK3_1	89	96	PF00069	0.489
MOD_NEK2_1	194	199	PF00069	0.590
MOD_NEK2_1	239	244	PF00069	0.428
MOD_NEK2_1	461	466	PF00069	0.571
MOD_NEK2_1	62	67	PF00069	0.541
MOD_NEK2_2	430	435	PF00069	0.626
MOD_NEK2_2	516	521	PF00069	0.476
MOD_OFUCOSY	514	520	PF10250	0.485
MOD_PIKK_1	152	158	PF00454	0.586
MOD_PIKK_1	197	203	PF00454	0.695
MOD_PIKK_1	444	450	PF00454	0.699
MOD_PIKK_1	475	481	PF00454	0.689
MOD_PIKK_1	494	500	PF00454	0.484
MOD_PK_1	81	87	PF00069	0.502
MOD_PKA_1	465	471	PF00069	0.638
MOD_PKA_1	81	87	PF00069	0.502
MOD_PKA_2	239	245	PF00069	0.478
MOD_PKA_2	444	450	PF00069	0.760
MOD_PKA_2	464	470	PF00069	0.657
MOD_PKA_2	471	477	PF00069	0.651
MOD_PKA_2	81	87	PF00069	0.502
MOD_Plk_1	109	115	PF00069	0.566
MOD_Plk_2-3	348	354	PF00069	0.516
MOD_Plk_4	239	245	PF00069	0.481
MOD_Plk_4	351	357	PF00069	0.514
MOD_Plk_4	393	399	PF00069	0.744
MOD_Plk_4	551	557	PF00069	0.454
MOD_ProDKin_1	159	165	PF00069	0.746
MOD_ProDKin_1	204	210	PF00069	0.645
MOD_ProDKin_1	242	248	PF00069	0.561
MOD_ProDKin_1	30	36	PF00069	0.430
MOD_ProDKin_1	426	432	PF00069	0.762
MOD_ProDKin_1	439	445	PF00069	0.674
MOD_ProDKin_1	50	56	PF00069	0.410
MOD_ProDKin_1	508	514	PF00069	0.482
MOD_ProDKin_1	538	544	PF00069	0.584
MOD_SUMO_for_1	173	176	PF00179	0.820
MOD_SUMO_rev_2	342	352	PF00179	0.432
MOD_SUMO_rev_2	404	412	PF00179	0.685
TRG_DiLeu_BaEn_1	379	384	PF01217	0.556
TRG_DiLeu_BaLyEn_6	456	461	PF01217	0.556
TRG_ENDOCYTIC_2	142	145	PF00928	0.513
TRG_ENDOCYTIC_2	275	278	PF00928	0.503
TRG_ER_diArg_1	257	260	PF00400	0.502
TRG_NLS_Bipartite_1	531	547	PF00514	0.511
TRG_NLS_MonoExtC_3	170	176	PF00514	0.772
TRG_NLS_MonoExtN_4	168	175	PF00514	0.771
TRG_NLS_MonoExtN_4	540	547	PF00514	0.486
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I528	Leptomonas seymouri	49%	100%
A0A1X0P3J4	Trypanosomatidae	28%	100%
A0A3S7XBB1	Leishmania donovani	93%	100%
A4HPM7	Leishmania braziliensis	73%	100%
D0A8J0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AHX7	Leishmania infantum	93%	100%
E9ATD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%