F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q157_LEIMA

TriTrypDb:

LmjF.36.3610 , LMJLV39_360046500 , LMJSD75_360046200

Length:

534

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q157

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q157

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	429	433	PF00656	0.442
CLV_C14_Caspase3-7	479	483	PF00656	0.468
CLV_NRD_NRD_1	29	31	PF00675	0.594
CLV_NRD_NRD_1	350	352	PF00675	0.560
CLV_PCSK_KEX2_1	200	202	PF00082	0.642
CLV_PCSK_KEX2_1	350	352	PF00082	0.560
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.642
CLV_PCSK_SKI1_1	131	135	PF00082	0.528
CLV_PCSK_SKI1_1	177	181	PF00082	0.538
CLV_PCSK_SKI1_1	394	398	PF00082	0.526
DEG_Nend_UBRbox_2	1	3	PF02207	0.455
DEG_ODPH_VHL_1	58	69	PF01847	0.398
DEG_SPOP_SBC_1	237	241	PF00917	0.402
DEG_SPOP_SBC_1	513	517	PF00917	0.313
DOC_CKS1_1	321	326	PF01111	0.405
DOC_CYCLIN_RxL_1	489	499	PF00134	0.462
DOC_MAPK_FxFP_2	118	121	PF00069	0.361
DOC_MAPK_gen_1	136	144	PF00069	0.363
DOC_MAPK_gen_1	16	22	PF00069	0.414
DOC_MAPK_gen_1	72	80	PF00069	0.387
DOC_MAPK_MEF2A_6	72	80	PF00069	0.387
DOC_PP1_RVXF_1	175	182	PF00149	0.342
DOC_PP1_RVXF_1	42	49	PF00149	0.375
DOC_PP2B_LxvP_1	494	497	PF13499	0.476
DOC_PP2B_LxvP_1	58	61	PF13499	0.394
DOC_PP4_FxxP_1	118	121	PF00568	0.361
DOC_SPAK_OSR1_1	492	496	PF12202	0.389
DOC_USP7_MATH_1	119	123	PF00917	0.377
DOC_USP7_MATH_1	232	236	PF00917	0.456
DOC_USP7_MATH_1	307	311	PF00917	0.316
DOC_USP7_MATH_1	460	464	PF00917	0.458
DOC_WW_Pin1_4	162	167	PF00397	0.358
DOC_WW_Pin1_4	192	197	PF00397	0.483
DOC_WW_Pin1_4	303	308	PF00397	0.330
DOC_WW_Pin1_4	320	325	PF00397	0.405
LIG_14-3-3_CanoR_1	30	40	PF00244	0.366
LIG_14-3-3_CanoR_1	301	306	PF00244	0.435
LIG_14-3-3_CanoR_1	340	345	PF00244	0.350
LIG_14-3-3_CanoR_1	350	359	PF00244	0.316
LIG_14-3-3_CanoR_1	380	384	PF00244	0.371
LIG_14-3-3_CanoR_1	420	426	PF00244	0.446
LIG_AP2alpha_2	231	233	PF02296	0.435
LIG_AP2alpha_2	469	471	PF02296	0.480
LIG_BRCT_BRCA1_1	33	37	PF00533	0.374
LIG_eIF4E_1	95	101	PF01652	0.366
LIG_EVH1_2	255	259	PF00568	0.378
LIG_FHA_1	181	187	PF00498	0.305
LIG_FHA_1	351	357	PF00498	0.395
LIG_FHA_1	380	386	PF00498	0.365
LIG_FHA_1	4	10	PF00498	0.423
LIG_FHA_1	403	409	PF00498	0.381
LIG_FHA_1	425	431	PF00498	0.401
LIG_FHA_1	472	478	PF00498	0.497
LIG_FHA_1	84	90	PF00498	0.393
LIG_FHA_1	96	102	PF00498	0.292
LIG_FHA_2	13	19	PF00498	0.381
LIG_FHA_2	193	199	PF00498	0.391
LIG_FHA_2	499	505	PF00498	0.545
LIG_LIR_Apic_2	160	166	PF02991	0.361
LIG_LIR_Apic_2	319	324	PF02991	0.409
LIG_LIR_Gen_1	329	339	PF02991	0.336
LIG_LIR_Gen_1	507	514	PF02991	0.359
LIG_LIR_Gen_1	53	61	PF02991	0.424
LIG_LIR_Nem_3	265	271	PF02991	0.353
LIG_LIR_Nem_3	34	40	PF02991	0.408
LIG_LIR_Nem_3	382	386	PF02991	0.332
LIG_LIR_Nem_3	405	410	PF02991	0.375
LIG_LIR_Nem_3	436	441	PF02991	0.519
LIG_LIR_Nem_3	507	511	PF02991	0.382
LIG_LIR_Nem_3	53	58	PF02991	0.475
LIG_LYPXL_yS_3	294	297	PF13949	0.382
LIG_PDZ_Class_2	529	534	PF00595	0.549
LIG_SH2_CRK	321	325	PF00017	0.406
LIG_SH2_CRK	97	101	PF00017	0.369
LIG_SH2_NCK_1	163	167	PF00017	0.366
LIG_SH2_NCK_1	206	210	PF00017	0.469
LIG_SH2_PTP2	55	58	PF00017	0.429
LIG_SH2_STAP1	97	101	PF00017	0.323
LIG_SH2_STAT5	13	16	PF00017	0.420
LIG_SH2_STAT5	132	135	PF00017	0.313
LIG_SH2_STAT5	260	263	PF00017	0.386
LIG_SH2_STAT5	383	386	PF00017	0.348
LIG_SH2_STAT5	416	419	PF00017	0.424
LIG_SH2_STAT5	45	48	PF00017	0.409
LIG_SH2_STAT5	453	456	PF00017	0.437
LIG_SH2_STAT5	55	58	PF00017	0.527
LIG_SH2_STAT5	95	98	PF00017	0.316
LIG_SH3_3	150	156	PF00018	0.270
LIG_SH3_3	224	230	PF00018	0.324
LIG_SH3_3	250	256	PF00018	0.447
LIG_SUMO_SIM_anti_2	283	291	PF11976	0.357
LIG_SUMO_SIM_anti_2	393	401	PF11976	0.328
LIG_SUMO_SIM_anti_2	5	12	PF11976	0.421
LIG_SUMO_SIM_par_1	393	401	PF11976	0.355
LIG_SUMO_SIM_par_1	5	12	PF11976	0.410
LIG_SUMO_SIM_par_1	76	82	PF11976	0.377
LIG_TRAF2_1	39	42	PF00917	0.417
LIG_UBA3_1	64	72	PF00899	0.392
LIG_WRC_WIRS_1	452	457	PF05994	0.437
MOD_CDK_SPxK_1	320	326	PF00069	0.320
MOD_CK1_1	12	18	PF00069	0.419
MOD_CK1_1	23	29	PF00069	0.435
MOD_CK1_1	36	42	PF00069	0.410
MOD_CK1_1	367	373	PF00069	0.426
MOD_CK1_1	379	385	PF00069	0.335
MOD_CK1_1	400	406	PF00069	0.381
MOD_CK1_1	424	430	PF00069	0.395
MOD_CK2_1	12	18	PF00069	0.432
MOD_CK2_1	36	42	PF00069	0.368
MOD_CK2_1	498	504	PF00069	0.460
MOD_GlcNHglycan	127	130	PF01048	0.597
MOD_GlcNHglycan	214	217	PF01048	0.668
MOD_GlcNHglycan	22	25	PF01048	0.587
MOD_GlcNHglycan	240	243	PF01048	0.705
MOD_GlcNHglycan	264	267	PF01048	0.665
MOD_GlcNHglycan	276	279	PF01048	0.480
MOD_GlcNHglycan	478	481	PF01048	0.697
MOD_GlcNHglycan	522	525	PF01048	0.302
MOD_GlcNHglycan	81	84	PF01048	0.597
MOD_GSK3_1	232	239	PF00069	0.575
MOD_GSK3_1	284	291	PF00069	0.381
MOD_GSK3_1	301	308	PF00069	0.374
MOD_GSK3_1	396	403	PF00069	0.320
MOD_GSK3_1	406	413	PF00069	0.353
MOD_GSK3_1	424	431	PF00069	0.335
MOD_GSK3_1	471	478	PF00069	0.523
MOD_GSK3_1	514	521	PF00069	0.304
MOD_GSK3_1	79	86	PF00069	0.356
MOD_N-GLC_1	237	242	PF02516	0.648
MOD_NEK2_1	180	185	PF00069	0.307
MOD_NEK2_1	20	25	PF00069	0.384
MOD_NEK2_1	217	222	PF00069	0.358
MOD_NEK2_1	261	266	PF00069	0.359
MOD_NEK2_1	273	278	PF00069	0.286
MOD_NEK2_1	288	293	PF00069	0.336
MOD_NEK2_1	402	407	PF00069	0.383
MOD_NEK2_1	471	476	PF00069	0.399
MOD_NEK2_1	518	523	PF00069	0.332
MOD_NEK2_1	79	84	PF00069	0.387
MOD_NEK2_1	9	14	PF00069	0.531
MOD_NEK2_2	182	187	PF00069	0.307
MOD_NEK2_2	411	416	PF00069	0.332
MOD_PIKK_1	59	65	PF00454	0.407
MOD_PIKK_1	95	101	PF00454	0.366
MOD_PK_1	406	412	PF00069	0.387
MOD_PKA_1	350	356	PF00069	0.337
MOD_PKA_2	300	306	PF00069	0.390
MOD_PKA_2	350	356	PF00069	0.380
MOD_PKA_2	367	373	PF00069	0.312
MOD_PKA_2	379	385	PF00069	0.360
MOD_Plk_1	400	406	PF00069	0.339
MOD_Plk_1	84	90	PF00069	0.501
MOD_Plk_4	120	126	PF00069	0.387
MOD_Plk_4	284	290	PF00069	0.395
MOD_Plk_4	3	9	PF00069	0.423
MOD_Plk_4	33	39	PF00069	0.376
MOD_Plk_4	342	348	PF00069	0.356
MOD_Plk_4	379	385	PF00069	0.350
MOD_Plk_4	421	427	PF00069	0.464
MOD_Plk_4	504	510	PF00069	0.257
MOD_Plk_4	514	520	PF00069	0.292
MOD_ProDKin_1	162	168	PF00069	0.355
MOD_ProDKin_1	192	198	PF00069	0.486
MOD_ProDKin_1	303	309	PF00069	0.329
MOD_ProDKin_1	320	326	PF00069	0.410
MOD_SUMO_rev_2	36	46	PF00179	0.361
TRG_DiLeu_BaEn_1	42	47	PF01217	0.353
TRG_DiLeu_BaEn_1	73	78	PF01217	0.379
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.387
TRG_ENDOCYTIC_2	294	297	PF00928	0.454
TRG_ENDOCYTIC_2	331	334	PF00928	0.325
TRG_ENDOCYTIC_2	55	58	PF00928	0.429
TRG_ENDOCYTIC_2	97	100	PF00928	0.346
TRG_ER_diArg_1	350	352	PF00400	0.329
TRG_NES_CRM1_1	146	160	PF08389	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJZ9	Leptomonas seymouri	62%	97%
A0A1X0P3D8	Trypanosomatidae	28%	100%
A0A3S7XB84	Leishmania donovani	92%	99%
A4HPM8	Leishmania braziliensis	83%	99%
A4ID38	Leishmania infantum	92%	99%
E9ATE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	98%