Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q155_LEIMA

TriTrypDb:

LmjF.36.3630 , LMJLV39_360046700 , LMJSD75_360046400

Length:

290

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4Q155

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q155

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.589
CLV_C14_Caspase3-7	246	250	PF00656	0.774
CLV_NRD_NRD_1	113	115	PF00675	0.460
CLV_NRD_NRD_1	191	193	PF00675	0.573
CLV_NRD_NRD_1	240	242	PF00675	0.600
CLV_NRD_NRD_1	271	273	PF00675	0.579
CLV_PCSK_FUR_1	111	115	PF00082	0.435
CLV_PCSK_FUR_1	189	193	PF00082	0.459
CLV_PCSK_KEX2_1	110	112	PF00082	0.396
CLV_PCSK_KEX2_1	113	115	PF00082	0.407
CLV_PCSK_KEX2_1	191	193	PF00082	0.573
CLV_PCSK_KEX2_1	240	242	PF00082	0.600
CLV_PCSK_KEX2_1	271	273	PF00082	0.579
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.380
CLV_PCSK_SKI1_1	113	117	PF00082	0.431
CLV_PCSK_SKI1_1	3	7	PF00082	0.754
CLV_PCSK_SKI1_1	83	87	PF00082	0.497
DEG_MDM2_SWIB_1	105	112	PF02201	0.379
DEG_SPOP_SBC_1	14	18	PF00917	0.543
DEG_SPOP_SBC_1	178	182	PF00917	0.642
DEG_SPOP_SBC_1	244	248	PF00917	0.688
DEG_SPOP_SBC_1	74	78	PF00917	0.524
DOC_MAPK_HePTP_8	80	92	PF00069	0.435
DOC_MAPK_MEF2A_6	83	92	PF00069	0.435
DOC_USP7_MATH_1	177	181	PF00917	0.720
DOC_USP7_MATH_1	69	73	PF00917	0.613
DOC_USP7_MATH_1	75	79	PF00917	0.525
DOC_USP7_MATH_1	81	85	PF00917	0.385
DOC_USP7_UBL2_3	116	120	PF12436	0.661
DOC_WW_Pin1_4	273	278	PF00397	0.848
DOC_WW_Pin1_4	63	68	PF00397	0.551
LIG_deltaCOP1_diTrp_1	40	47	PF00928	0.481
LIG_FHA_1	43	49	PF00498	0.528
LIG_FHA_1	75	81	PF00498	0.570
LIG_FHA_2	15	21	PF00498	0.593
LIG_FHA_2	263	269	PF00498	0.842
LIG_LIR_Nem_3	248	254	PF02991	0.774
LIG_PCNA_yPIPBox_3	161	171	PF02747	0.720
LIG_Pex14_2	105	109	PF04695	0.354
LIG_SH2_CRK	280	284	PF00017	0.786
LIG_SH2_STAP1	207	211	PF00017	0.764
LIG_SH2_STAP1	254	258	PF00017	0.688
LIG_SH2_STAP1	280	284	PF00017	0.758
LIG_SH2_STAT5	106	109	PF00017	0.492
LIG_SH2_STAT5	262	265	PF00017	0.780
LIG_SH2_STAT5	57	60	PF00017	0.508
LIG_SH3_3	230	236	PF00018	0.826
LIG_Sin3_3	91	98	PF02671	0.413
LIG_SUMO_SIM_anti_2	84	89	PF11976	0.435
LIG_TRAF2_1	115	118	PF00917	0.657
LIG_TRAF2_1	128	131	PF00917	0.540
LIG_WW_1	277	280	PF00397	0.780
MOD_CK1_1	172	178	PF00069	0.730
MOD_CK1_1	18	24	PF00069	0.509
MOD_CK1_1	182	188	PF00069	0.732
MOD_CK1_1	260	266	PF00069	0.809
MOD_CK1_1	62	68	PF00069	0.576
MOD_CK1_1	70	76	PF00069	0.525
MOD_CK2_1	215	221	PF00069	0.794
MOD_CK2_1	262	268	PF00069	0.842
MOD_GlcNHglycan	184	187	PF01048	0.552
MOD_GlcNHglycan	72	75	PF01048	0.793
MOD_GSK3_1	12	19	PF00069	0.599
MOD_GSK3_1	178	185	PF00069	0.685
MOD_GSK3_1	215	222	PF00069	0.796
MOD_GSK3_1	257	264	PF00069	0.790
MOD_GSK3_1	59	66	PF00069	0.436
MOD_GSK3_1	69	76	PF00069	0.503
MOD_N-GLC_1	252	257	PF02516	0.489
MOD_N-GLC_1	30	35	PF02516	0.551
MOD_N-GLC_1	70	75	PF02516	0.819
MOD_NEK2_1	13	18	PF00069	0.544
MOD_NEK2_1	184	189	PF00069	0.763
MOD_PIKK_1	179	185	PF00454	0.815
MOD_PIKK_1	225	231	PF00454	0.796
MOD_PIKK_1	59	65	PF00454	0.430
MOD_PKA_2	7	13	PF00069	0.522
MOD_Plk_1	30	36	PF00069	0.347
MOD_Plk_1	81	87	PF00069	0.470
MOD_Plk_4	257	263	PF00069	0.829
MOD_Plk_4	75	81	PF00069	0.590
MOD_ProDKin_1	273	279	PF00069	0.844
MOD_ProDKin_1	63	69	PF00069	0.554
MOD_SUMO_for_1	115	118	PF00179	0.657
MOD_SUMO_rev_2	117	122	PF00179	0.662
TRG_ENDOCYTIC_2	254	257	PF00928	0.772
TRG_ENDOCYTIC_2	280	283	PF00928	0.789
TRG_ER_diArg_1	111	114	PF00400	0.692
TRG_ER_diArg_1	189	192	PF00400	0.707
TRG_ER_diArg_1	239	241	PF00400	0.844
TRG_ER_diArg_1	270	272	PF00400	0.771
TRG_NLS_MonoExtC_3	109	114	PF00514	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJD1	Leishmania donovani	89%	98%
A4HPN0	Leishmania braziliensis	61%	100%
A4ID36	Leishmania infantum	89%	98%
E9ATE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%