WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q153_LEIMA

TriTrypDb:

LmjF.36.3650 , LMJLV39_360046900 , LMJSD75_360046600

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q153

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q153

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	317	319	PF00675	0.503
CLV_NRD_NRD_1	38	40	PF00675	0.578
CLV_PCSK_KEX2_1	316	318	PF00082	0.533
CLV_PCSK_SKI1_1	174	178	PF00082	0.236
CLV_PCSK_SKI1_1	29	33	PF00082	0.539
CLV_PCSK_SKI1_1	312	316	PF00082	0.493
CLV_PCSK_SKI1_1	51	55	PF00082	0.454
DEG_APCC_DBOX_1	28	36	PF00400	0.529
DEG_Nend_UBRbox_3	1	3	PF02207	0.482
DEG_SCF_FBW7_1	94	101	PF00400	0.482
DOC_CYCLIN_RxL_1	363	376	PF00134	0.525
DOC_MAPK_gen_1	180	188	PF00069	0.531
DOC_MAPK_gen_1	316	325	PF00069	0.463
DOC_MAPK_gen_1	368	374	PF00069	0.391
DOC_MAPK_gen_1	39	46	PF00069	0.556
DOC_MAPK_MEF2A_6	180	188	PF00069	0.531
DOC_PP1_RVXF_1	172	179	PF00149	0.450
DOC_PP2B_LxvP_1	332	335	PF13499	0.476
DOC_USP7_MATH_1	124	128	PF00917	0.594
DOC_USP7_MATH_1	232	236	PF00917	0.440
DOC_USP7_MATH_1	288	292	PF00917	0.368
DOC_USP7_MATH_1	336	340	PF00917	0.404
DOC_USP7_MATH_1	344	348	PF00917	0.308
DOC_WW_Pin1_4	135	140	PF00397	0.342
DOC_WW_Pin1_4	180	185	PF00397	0.482
DOC_WW_Pin1_4	20	25	PF00397	0.528
DOC_WW_Pin1_4	271	276	PF00397	0.481
DOC_WW_Pin1_4	94	99	PF00397	0.468
LIG_14-3-3_CanoR_1	10	14	PF00244	0.550
LIG_14-3-3_CanoR_1	317	323	PF00244	0.516
LIG_14-3-3_CanoR_1	363	367	PF00244	0.449
LIG_14-3-3_CanoR_1	45	53	PF00244	0.468
LIG_Actin_WH2_2	1	16	PF00022	0.489
LIG_Actin_WH2_2	105	120	PF00022	0.404
LIG_BRCT_BRCA1_1	14	18	PF00533	0.585
LIG_deltaCOP1_diTrp_1	171	178	PF00928	0.436
LIG_FHA_1	148	154	PF00498	0.383
LIG_FHA_1	155	161	PF00498	0.355
LIG_FHA_1	168	174	PF00498	0.401
LIG_FHA_1	21	27	PF00498	0.550
LIG_FHA_1	235	241	PF00498	0.435
LIG_FHA_1	249	255	PF00498	0.570
LIG_FHA_1	293	299	PF00498	0.311
LIG_FHA_1	304	310	PF00498	0.335
LIG_FHA_1	365	371	PF00498	0.393
LIG_FHA_1	54	60	PF00498	0.487
LIG_FHA_1	86	92	PF00498	0.408
LIG_FHA_2	189	195	PF00498	0.444
LIG_LIR_Gen_1	170	179	PF02991	0.436
LIG_LIR_Gen_1	321	329	PF02991	0.404
LIG_LIR_Nem_3	170	175	PF02991	0.442
LIG_LIR_Nem_3	225	230	PF02991	0.441
LIG_LIR_Nem_3	321	325	PF02991	0.450
LIG_NRBOX	31	37	PF00104	0.526
LIG_Pex14_2	322	326	PF04695	0.383
LIG_SH2_CRK	227	231	PF00017	0.524
LIG_SH2_SRC	111	114	PF00017	0.477
LIG_SH2_STAP1	128	132	PF00017	0.427
LIG_SH2_STAP1	366	370	PF00017	0.386
LIG_SH2_STAT3	243	246	PF00017	0.406
LIG_SH2_STAT5	11	14	PF00017	0.509
LIG_SH2_STAT5	111	114	PF00017	0.462
LIG_SH2_STAT5	143	146	PF00017	0.431
LIG_SH2_STAT5	243	246	PF00017	0.532
LIG_SH2_STAT5	273	276	PF00017	0.477
LIG_SH2_STAT5	300	303	PF00017	0.404
LIG_SH2_STAT5	366	369	PF00017	0.396
LIG_SH3_3	298	304	PF00018	0.401
LIG_SH3_3	353	359	PF00018	0.346
LIG_SUMO_SIM_anti_2	338	344	PF11976	0.344
LIG_SUMO_SIM_par_1	150	159	PF11976	0.346
LIG_SUMO_SIM_par_1	291	299	PF11976	0.317
LIG_SUMO_SIM_par_1	55	63	PF11976	0.336
LIG_TRFH_1	300	304	PF08558	0.334
LIG_WRC_WIRS_1	374	379	PF05994	0.477
MOD_CDK_SPxxK_3	135	142	PF00069	0.461
MOD_CK1_1	206	212	PF00069	0.476
MOD_CK1_1	225	231	PF00069	0.210
MOD_CK1_1	234	240	PF00069	0.370
MOD_CK1_1	247	253	PF00069	0.431
MOD_CK1_1	348	354	PF00069	0.386
MOD_CK1_1	89	95	PF00069	0.451
MOD_CK2_1	211	217	PF00069	0.405
MOD_CK2_1	286	292	PF00069	0.328
MOD_GlcNHglycan	14	17	PF01048	0.546
MOD_GlcNHglycan	227	230	PF01048	0.462
MOD_GlcNHglycan	234	237	PF01048	0.432
MOD_GlcNHglycan	288	291	PF01048	0.326
MOD_GlcNHglycan	90	94	PF01048	0.422
MOD_GSK3_1	143	150	PF00069	0.365
MOD_GSK3_1	151	158	PF00069	0.407
MOD_GSK3_1	211	218	PF00069	0.408
MOD_GSK3_1	231	238	PF00069	0.193
MOD_GSK3_1	244	251	PF00069	0.455
MOD_GSK3_1	288	295	PF00069	0.350
MOD_GSK3_1	344	351	PF00069	0.379
MOD_GSK3_1	358	365	PF00069	0.354
MOD_GSK3_1	40	47	PF00069	0.551
MOD_GSK3_1	85	92	PF00069	0.405
MOD_GSK3_1	94	101	PF00069	0.418
MOD_LATS_1	38	44	PF00433	0.517
MOD_N-GLC_1	248	253	PF02516	0.559
MOD_NEK2_1	102	107	PF00069	0.483
MOD_NEK2_1	133	138	PF00069	0.443
MOD_NEK2_1	203	208	PF00069	0.377
MOD_NEK2_1	215	220	PF00069	0.322
MOD_NEK2_1	222	227	PF00069	0.222
MOD_NEK2_1	231	236	PF00069	0.253
MOD_NEK2_1	31	36	PF00069	0.442
MOD_PIKK_1	281	287	PF00454	0.356
MOD_PK_1	40	46	PF00069	0.463
MOD_PKA_2	362	368	PF00069	0.442
MOD_PKA_2	44	50	PF00069	0.549
MOD_PKA_2	9	15	PF00069	0.539
MOD_PKB_1	316	324	PF00069	0.527
MOD_Plk_1	211	217	PF00069	0.453
MOD_Plk_1	222	228	PF00069	0.330
MOD_Plk_1	281	287	PF00069	0.386
MOD_Plk_1	292	298	PF00069	0.289
MOD_Plk_4	151	157	PF00069	0.327
MOD_Plk_4	203	209	PF00069	0.431
MOD_Plk_4	222	228	PF00069	0.229
MOD_Plk_4	235	241	PF00069	0.463
MOD_Plk_4	296	302	PF00069	0.359
MOD_Plk_4	31	37	PF00069	0.394
MOD_Plk_4	336	342	PF00069	0.435
MOD_Plk_4	348	354	PF00069	0.293
MOD_Plk_4	373	379	PF00069	0.490
MOD_Plk_4	73	79	PF00069	0.430
MOD_Plk_4	98	104	PF00069	0.473
MOD_ProDKin_1	135	141	PF00069	0.339
MOD_ProDKin_1	180	186	PF00069	0.482
MOD_ProDKin_1	20	26	PF00069	0.526
MOD_ProDKin_1	271	277	PF00069	0.478
MOD_ProDKin_1	94	100	PF00069	0.468
MOD_SUMO_rev_2	158	163	PF00179	0.501
TRG_ENDOCYTIC_2	227	230	PF00928	0.539
TRG_ER_diArg_1	316	318	PF00400	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAQ1	Leptomonas seymouri	79%	100%
A0A1X0P3H5	Trypanosomatidae	49%	100%
A0A3S7XBC0	Leishmania donovani	97%	100%
A0A422MYE0	Trypanosoma rangeli	47%	100%
A4HPN2	Leishmania braziliensis	92%	100%
A4ID34	Leishmania infantum	97%	100%
D0A8I7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ATE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5B728	Trypanosoma cruzi	49%	100%