DUF1619 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1619), putative

Species:

Leishmania major

UniProt:

Q4Q151_LEIMA

TriTrypDb:

LmjF.36.3657 , LMJLV39_360047100 , LMJSD75_360046800

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 3
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q151

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q151

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0030030	cell projection organization	4	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.435
CLV_C14_Caspase3-7	281	285	PF00656	0.417
CLV_NRD_NRD_1	104	106	PF00675	0.389
CLV_NRD_NRD_1	182	184	PF00675	0.417
CLV_NRD_NRD_1	375	377	PF00675	0.548
CLV_NRD_NRD_1	395	397	PF00675	0.494
CLV_NRD_NRD_1	560	562	PF00675	0.515
CLV_NRD_NRD_1	580	582	PF00675	0.317
CLV_PCSK_KEX2_1	101	103	PF00082	0.387
CLV_PCSK_KEX2_1	182	184	PF00082	0.387
CLV_PCSK_KEX2_1	395	397	PF00082	0.522
CLV_PCSK_KEX2_1	560	562	PF00082	0.537
CLV_PCSK_KEX2_1	580	582	PF00082	0.317
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.411
CLV_PCSK_SKI1_1	106	110	PF00082	0.387
CLV_PCSK_SKI1_1	72	76	PF00082	0.417
DEG_Nend_Nbox_1	1	3	PF02207	0.637
DEG_SPOP_SBC_1	274	278	PF00917	0.353
DOC_MAPK_FxFP_2	16	19	PF00069	0.624
DOC_MAPK_gen_1	182	189	PF00069	0.202
DOC_MAPK_MEF2A_6	483	492	PF00069	0.348
DOC_PP1_RVXF_1	201	208	PF00149	0.297
DOC_PP1_RVXF_1	542	548	PF00149	0.446
DOC_PP2B_LxvP_1	187	190	PF13499	0.243
DOC_PP4_FxxP_1	136	139	PF00568	0.295
DOC_PP4_FxxP_1	16	19	PF00568	0.624
DOC_PP4_FxxP_1	380	383	PF00568	0.358
DOC_PP4_FxxP_1	515	518	PF00568	0.342
DOC_USP7_MATH_1	274	278	PF00917	0.435
DOC_USP7_MATH_1	334	338	PF00917	0.359
DOC_WW_Pin1_4	175	180	PF00397	0.400
DOC_WW_Pin1_4	31	36	PF00397	0.494
DOC_WW_Pin1_4	347	352	PF00397	0.325
DOC_WW_Pin1_4	39	44	PF00397	0.402
DOC_WW_Pin1_4	470	475	PF00397	0.394
DOC_WW_Pin1_4	514	519	PF00397	0.463
DOC_WW_Pin1_4	82	87	PF00397	0.367
LIG_14-3-3_CanoR_1	395	400	PF00244	0.485
LIG_14-3-3_CanoR_1	580	584	PF00244	0.465
LIG_14-3-3_CanoR_1	72	78	PF00244	0.413
LIG_14-3-3_CanoR_1	96	101	PF00244	0.417
LIG_AP2alpha_2	58	60	PF02296	0.202
LIG_DLG_GKlike_1	395	403	PF00625	0.464
LIG_FHA_1	147	153	PF00498	0.422
LIG_FHA_1	252	258	PF00498	0.386
LIG_FHA_1	322	328	PF00498	0.266
LIG_FHA_1	423	429	PF00498	0.404
LIG_FHA_1	457	463	PF00498	0.477
LIG_FHA_1	487	493	PF00498	0.443
LIG_FHA_1	51	57	PF00498	0.353
LIG_FHA_1	520	526	PF00498	0.498
LIG_FHA_1	540	546	PF00498	0.180
LIG_FHA_2	107	113	PF00498	0.394
LIG_FHA_2	190	196	PF00498	0.417
LIG_FHA_2	279	285	PF00498	0.421
LIG_FHA_2	370	376	PF00498	0.367
LIG_FHA_2	440	446	PF00498	0.534
LIG_FHA_2	527	533	PF00498	0.545
LIG_LIR_Apic_2	13	19	PF02991	0.631
LIG_LIR_Apic_2	378	383	PF02991	0.402
LIG_LIR_Apic_2	76	80	PF02991	0.418
LIG_LIR_Apic_2	81	86	PF02991	0.431
LIG_LIR_Apic_2	89	93	PF02991	0.443
LIG_LIR_Gen_1	169	179	PF02991	0.455
LIG_LIR_Gen_1	26	35	PF02991	0.510
LIG_LIR_Gen_1	276	284	PF02991	0.367
LIG_LIR_Gen_1	324	334	PF02991	0.312
LIG_LIR_Gen_1	458	467	PF02991	0.338
LIG_LIR_Gen_1	537	545	PF02991	0.474
LIG_LIR_Nem_3	130	136	PF02991	0.276
LIG_LIR_Nem_3	169	175	PF02991	0.442
LIG_LIR_Nem_3	178	184	PF02991	0.370
LIG_LIR_Nem_3	249	253	PF02991	0.354
LIG_LIR_Nem_3	26	30	PF02991	0.467
LIG_LIR_Nem_3	276	282	PF02991	0.341
LIG_LIR_Nem_3	324	329	PF02991	0.312
LIG_LIR_Nem_3	458	464	PF02991	0.366
LIG_LIR_Nem_3	475	481	PF02991	0.425
LIG_LIR_Nem_3	537	541	PF02991	0.414
LIG_LIR_Nem_3	546	550	PF02991	0.355
LIG_LIR_Nem_3	573	579	PF02991	0.486
LIG_LIR_Nem_3	84	90	PF02991	0.384
LIG_LYPXL_yS_3	18	21	PF13949	0.583
LIG_MAD2	561	569	PF02301	0.568
LIG_MYND_1	566	570	PF01753	0.633
LIG_NRBOX	1	7	PF00104	0.651
LIG_PCNA_yPIPBox_3	319	327	PF02747	0.202
LIG_Pex14_2	331	335	PF04695	0.315
LIG_Pex14_2	543	547	PF04695	0.357
LIG_PTAP_UEV_1	147	152	PF05743	0.413
LIG_PTB_Apo_2	341	348	PF02174	0.202
LIG_SH2_CRK	118	122	PF00017	0.381
LIG_SH2_CRK	181	185	PF00017	0.435
LIG_SH2_CRK	232	236	PF00017	0.381
LIG_SH2_CRK	279	283	PF00017	0.341
LIG_SH2_CRK	494	498	PF00017	0.349
LIG_SH2_CRK	83	87	PF00017	0.432
LIG_SH2_CRK	90	94	PF00017	0.397
LIG_SH2_GRB2like	232	235	PF00017	0.353
LIG_SH2_NCK_1	279	283	PF00017	0.435
LIG_SH2_NCK_1	83	87	PF00017	0.435
LIG_SH2_PTP2	172	175	PF00017	0.435
LIG_SH2_PTP2	326	329	PF00017	0.435
LIG_SH2_SRC	353	356	PF00017	0.337
LIG_SH2_STAT3	481	484	PF00017	0.559
LIG_SH2_STAT3	505	508	PF00017	0.495
LIG_SH2_STAT5	135	138	PF00017	0.381
LIG_SH2_STAT5	172	175	PF00017	0.400
LIG_SH2_STAT5	326	329	PF00017	0.335
LIG_SH2_STAT5	353	356	PF00017	0.338
LIG_SH2_STAT5	44	47	PF00017	0.406
LIG_SH2_STAT5	481	484	PF00017	0.478
LIG_SH2_STAT5	77	80	PF00017	0.379
LIG_SH2_STAT5	87	90	PF00017	0.294
LIG_SH3_3	139	145	PF00018	0.311
LIG_SH3_3	148	154	PF00018	0.311
LIG_SH3_3	160	166	PF00018	0.426
LIG_SH3_3	18	24	PF00018	0.485
LIG_SH3_3	337	343	PF00018	0.375
LIG_SH3_3	559	565	PF00018	0.516
LIG_SH3_5	86	90	PF00018	0.417
LIG_SUMO_SIM_par_1	153	158	PF11976	0.426
LIG_SUMO_SIM_par_1	7	14	PF11976	0.623
LIG_TYR_ITIM	492	497	PF00017	0.323
LIG_UBA3_1	225	231	PF00899	0.202
MOD_CDK_SPxxK_3	175	182	PF00069	0.435
MOD_CDK_SPxxK_3	31	38	PF00069	0.564
MOD_CK1_1	194	200	PF00069	0.430
MOD_CK1_1	300	306	PF00069	0.394
MOD_CK1_1	402	408	PF00069	0.413
MOD_CK1_1	422	428	PF00069	0.199
MOD_CK1_1	465	471	PF00069	0.441
MOD_CK1_1	486	492	PF00069	0.469
MOD_CK1_1	554	560	PF00069	0.582
MOD_CK2_1	106	112	PF00069	0.419
MOD_CK2_1	243	249	PF00069	0.428
MOD_CK2_1	30	36	PF00069	0.474
MOD_CK2_1	369	375	PF00069	0.377
MOD_GlcNHglycan	13	16	PF01048	0.635
MOD_GlcNHglycan	175	178	PF01048	0.439
MOD_GlcNHglycan	198	201	PF01048	0.372
MOD_GlcNHglycan	245	248	PF01048	0.409
MOD_GlcNHglycan	259	263	PF01048	0.253
MOD_GlcNHglycan	305	308	PF01048	0.417
MOD_GlcNHglycan	360	363	PF01048	0.455
MOD_GlcNHglycan	377	380	PF01048	0.249
MOD_GlcNHglycan	405	408	PF01048	0.399
MOD_GlcNHglycan	421	424	PF01048	0.342
MOD_GlcNHglycan	464	467	PF01048	0.453
MOD_GlcNHglycan	474	477	PF01048	0.505
MOD_GlcNHglycan	68	72	PF01048	0.387
MOD_GSK3_1	123	130	PF00069	0.372
MOD_GSK3_1	173	180	PF00069	0.430
MOD_GSK3_1	207	214	PF00069	0.375
MOD_GSK3_1	264	271	PF00069	0.377
MOD_GSK3_1	274	281	PF00069	0.405
MOD_GSK3_1	299	306	PF00069	0.362
MOD_GSK3_1	395	402	PF00069	0.452
MOD_GSK3_1	452	459	PF00069	0.386
MOD_GSK3_1	465	472	PF00069	0.437
MOD_GSK3_1	479	486	PF00069	0.400
MOD_GSK3_1	539	546	PF00069	0.429
MOD_N-GLC_1	243	248	PF02516	0.384
MOD_N-GLC_1	303	308	PF02516	0.316
MOD_N-GLC_1	31	36	PF02516	0.526
MOD_N-GLC_1	314	319	PF02516	0.262
MOD_N-GLC_1	433	438	PF02516	0.527
MOD_N-GLC_1	455	460	PF02516	0.390
MOD_N-GLC_1	486	491	PF02516	0.477
MOD_N-GLC_1	526	531	PF02516	0.508
MOD_NEK2_1	207	212	PF00069	0.393
MOD_NEK2_1	237	242	PF00069	0.371
MOD_NEK2_1	257	262	PF00069	0.321
MOD_NEK2_1	264	269	PF00069	0.341
MOD_NEK2_1	299	304	PF00069	0.375
MOD_NEK2_1	314	319	PF00069	0.311
MOD_NEK2_1	388	393	PF00069	0.538
MOD_NEK2_1	399	404	PF00069	0.389
MOD_NEK2_1	543	548	PF00069	0.391
MOD_NEK2_1	571	576	PF00069	0.511
MOD_NEK2_1	579	584	PF00069	0.532
MOD_NEK2_1	9	14	PF00069	0.644
MOD_PIKK_1	155	161	PF00454	0.435
MOD_PIKK_1	321	327	PF00454	0.421
MOD_PIKK_1	551	557	PF00454	0.530
MOD_PKA_1	395	401	PF00069	0.524
MOD_PKA_2	375	381	PF00069	0.447
MOD_PKA_2	395	401	PF00069	0.203
MOD_PKA_2	579	585	PF00069	0.664
MOD_PKA_2	95	101	PF00069	0.423
MOD_Plk_1	106	112	PF00069	0.370
MOD_Plk_1	314	320	PF00069	0.435
MOD_Plk_1	433	439	PF00069	0.561
MOD_Plk_1	456	462	PF00069	0.384
MOD_Plk_1	486	492	PF00069	0.477
MOD_Plk_1	571	577	PF00069	0.471
MOD_Plk_4	106	112	PF00069	0.389
MOD_Plk_4	268	274	PF00069	0.391
MOD_Plk_4	360	366	PF00069	0.447
MOD_Plk_4	369	375	PF00069	0.430
MOD_Plk_4	395	401	PF00069	0.476
MOD_Plk_4	439	445	PF00069	0.564
MOD_Plk_4	457	463	PF00069	0.225
MOD_Plk_4	554	560	PF00069	0.552
MOD_Plk_4	571	577	PF00069	0.345
MOD_ProDKin_1	175	181	PF00069	0.400
MOD_ProDKin_1	31	37	PF00069	0.493
MOD_ProDKin_1	347	353	PF00069	0.325
MOD_ProDKin_1	39	45	PF00069	0.397
MOD_ProDKin_1	470	476	PF00069	0.391
MOD_ProDKin_1	514	520	PF00069	0.470
MOD_ProDKin_1	82	88	PF00069	0.367
MOD_SUMO_rev_2	107	115	PF00179	0.449
MOD_SUMO_rev_2	283	287	PF00179	0.435
MOD_SUMO_rev_2	371	378	PF00179	0.294
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.435
TRG_DiLeu_BaLyEn_6	424	429	PF01217	0.267
TRG_ENDOCYTIC_2	118	121	PF00928	0.377
TRG_ENDOCYTIC_2	133	136	PF00928	0.301
TRG_ENDOCYTIC_2	172	175	PF00928	0.454
TRG_ENDOCYTIC_2	18	21	PF00928	0.569
TRG_ENDOCYTIC_2	181	184	PF00928	0.410
TRG_ENDOCYTIC_2	232	235	PF00928	0.353
TRG_ENDOCYTIC_2	279	282	PF00928	0.341
TRG_ENDOCYTIC_2	326	329	PF00928	0.417
TRG_ENDOCYTIC_2	494	497	PF00928	0.408
TRG_ENDOCYTIC_2	538	541	PF00928	0.511
TRG_ER_diArg_1	181	183	PF00400	0.417
TRG_ER_diArg_1	394	396	PF00400	0.526
TRG_ER_diArg_1	559	561	PF00400	0.533
TRG_ER_diArg_1	579	581	PF00400	0.311
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2E7	Leptomonas seymouri	60%	100%
A0A0S4J6N9	Bodo saltans	34%	82%
A0A1X0P3E6	Trypanosomatidae	40%	99%
A0A3Q8IJL4	Leishmania donovani	91%	100%
A0A3R7KNL3	Trypanosoma rangeli	38%	91%
A4ID32	Leishmania infantum	92%	100%
D0A8I5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ATE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q8R2Q6	Mus musculus	25%	98%
V5DNN8	Trypanosoma cruzi	41%	100%