Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q149_LEIMA

TriTrypDb:

LmjF.36.3670 , LMJLV39_360047300 , LMJSD75_360047000

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q149

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q149

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.370
CLV_NRD_NRD_1	179	181	PF00675	0.364
CLV_NRD_NRD_1	186	188	PF00675	0.493
CLV_NRD_NRD_1	219	221	PF00675	0.459
CLV_NRD_NRD_1	338	340	PF00675	0.689
CLV_NRD_NRD_1	51	53	PF00675	0.680
CLV_NRD_NRD_1	59	61	PF00675	0.665
CLV_PCSK_KEX2_1	130	132	PF00082	0.374
CLV_PCSK_KEX2_1	138	140	PF00082	0.380
CLV_PCSK_KEX2_1	219	221	PF00082	0.459
CLV_PCSK_KEX2_1	51	53	PF00082	0.655
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.374
CLV_PCSK_SKI1_1	130	134	PF00082	0.408
CLV_PCSK_SKI1_1	180	184	PF00082	0.381
DEG_APCC_DBOX_1	33	41	PF00400	0.541
DEG_Nend_Nbox_1	1	3	PF02207	0.544
DEG_SPOP_SBC_1	90	94	PF00917	0.608
DOC_MAPK_gen_1	187	193	PF00069	0.392
DOC_PP1_RVXF_1	115	121	PF00149	0.495
DOC_PP1_RVXF_1	65	72	PF00149	0.573
DOC_PP2B_LxvP_1	272	275	PF13499	0.544
DOC_USP7_MATH_1	275	279	PF00917	0.558
DOC_USP7_MATH_1	292	296	PF00917	0.466
DOC_USP7_MATH_1	5	9	PF00917	0.471
DOC_USP7_MATH_1	90	94	PF00917	0.608
DOC_USP7_UBL2_3	188	192	PF12436	0.393
DOC_USP7_UBL2_3	57	61	PF12436	0.647
DOC_WW_Pin1_4	111	116	PF00397	0.514
DOC_WW_Pin1_4	124	129	PF00397	0.416
DOC_WW_Pin1_4	262	267	PF00397	0.572
DOC_WW_Pin1_4	32	37	PF00397	0.486
LIG_14-3-3_CanoR_1	117	121	PF00244	0.476
LIG_14-3-3_CanoR_1	131	135	PF00244	0.399
LIG_14-3-3_CanoR_1	219	227	PF00244	0.470
LIG_14-3-3_CanoR_1	45	53	PF00244	0.585
LIG_14-3-3_CanoR_1	7	12	PF00244	0.493
LIG_APCC_ABBAyCdc20_2	152	158	PF00400	0.396
LIG_BRCT_BRCA1_1	7	11	PF00533	0.559
LIG_DLG_GKlike_1	7	15	PF00625	0.453
LIG_FHA_1	131	137	PF00498	0.513
LIG_FHA_2	108	114	PF00498	0.688
LIG_FHA_2	207	213	PF00498	0.443
LIG_FHA_2	93	99	PF00498	0.711
LIG_LIR_Gen_1	122	129	PF02991	0.554
LIG_LIR_Gen_1	153	164	PF02991	0.558
LIG_LIR_Gen_1	168	176	PF02991	0.322
LIG_LIR_Gen_1	248	257	PF02991	0.643
LIG_LIR_Nem_3	119	123	PF02991	0.515
LIG_LIR_Nem_3	133	137	PF02991	0.394
LIG_LIR_Nem_3	146	150	PF02991	0.456
LIG_LIR_Nem_3	153	159	PF02991	0.488
LIG_LIR_Nem_3	168	172	PF02991	0.339
LIG_LIR_Nem_3	248	254	PF02991	0.517
LIG_LIR_Nem_3	300	306	PF02991	0.500
LIG_Pex14_1	147	151	PF04695	0.417
LIG_Pex14_2	71	75	PF04695	0.566
LIG_SH2_CRK	137	141	PF00017	0.455
LIG_SH2_CRK	251	255	PF00017	0.559
LIG_SH2_GRB2like	164	167	PF00017	0.440
LIG_SH2_SRC	156	159	PF00017	0.429
LIG_SH2_STAP1	329	333	PF00017	0.483
LIG_SH2_STAT3	121	124	PF00017	0.555
LIG_SH2_STAT3	164	167	PF00017	0.440
LIG_SH2_STAT5	164	167	PF00017	0.440
LIG_SH2_STAT5	251	254	PF00017	0.599
LIG_SH3_3	96	102	PF00018	0.628
LIG_TRAF2_1	110	113	PF00917	0.519
LIG_TRAF2_1	210	213	PF00917	0.457
LIG_TYR_ITIM	249	254	PF00017	0.544
LIG_UBA3_1	293	301	PF00899	0.513
LIG_ULM_U2AF65_1	180	185	PF00076	0.363
MOD_CDC14_SPxK_1	127	130	PF00782	0.406
MOD_CDK_SPxK_1	111	117	PF00069	0.514
MOD_CDK_SPxK_1	124	130	PF00069	0.414
MOD_CDK_SPxxK_3	124	131	PF00069	0.433
MOD_CDK_SPxxK_3	32	39	PF00069	0.443
MOD_CK1_1	10	16	PF00069	0.544
MOD_CK1_1	250	256	PF00069	0.556
MOD_CK1_1	32	38	PF00069	0.650
MOD_CK1_1	83	89	PF00069	0.601
MOD_CK1_1	92	98	PF00069	0.588
MOD_CK2_1	107	113	PF00069	0.544
MOD_CK2_1	206	212	PF00069	0.439
MOD_CK2_1	292	298	PF00069	0.529
MOD_CK2_1	92	98	PF00069	0.696
MOD_GlcNHglycan	158	162	PF01048	0.515
MOD_GlcNHglycan	20	23	PF01048	0.571
MOD_GlcNHglycan	290	293	PF01048	0.514
MOD_GlcNHglycan	3	6	PF01048	0.627
MOD_GlcNHglycan	31	34	PF01048	0.723
MOD_GlcNHglycan	85	88	PF01048	0.786
MOD_GSK3_1	1	8	PF00069	0.493
MOD_GSK3_1	107	114	PF00069	0.528
MOD_GSK3_1	28	35	PF00069	0.691
MOD_GSK3_1	288	295	PF00069	0.533
MOD_GSK3_1	306	313	PF00069	0.489
MOD_GSK3_1	86	93	PF00069	0.671
MOD_N-GLC_1	165	170	PF02516	0.410
MOD_NEK2_1	1	6	PF00069	0.501
MOD_NEK2_1	11	16	PF00069	0.546
MOD_NEK2_1	239	244	PF00069	0.533
MOD_NEK2_1	28	33	PF00069	0.722
MOD_NEK2_1	280	285	PF00069	0.660
MOD_OFUCOSY	44	49	PF10250	0.567
MOD_PIKK_1	310	316	PF00454	0.544
MOD_PKA_1	130	136	PF00069	0.423
MOD_PKA_2	116	122	PF00069	0.482
MOD_PKA_2	130	136	PF00069	0.400
MOD_PKA_2	218	224	PF00069	0.464
MOD_PKA_2	280	286	PF00069	0.606
MOD_PKB_1	308	316	PF00069	0.547
MOD_Plk_1	165	171	PF00069	0.408
MOD_Plk_1	193	199	PF00069	0.445
MOD_Plk_1	247	253	PF00069	0.499
MOD_Plk_4	116	122	PF00069	0.476
MOD_Plk_4	193	199	PF00069	0.445
MOD_Plk_4	20	26	PF00069	0.680
MOD_Plk_4	239	245	PF00069	0.565
MOD_ProDKin_1	111	117	PF00069	0.514
MOD_ProDKin_1	124	130	PF00069	0.414
MOD_ProDKin_1	262	268	PF00069	0.571
MOD_ProDKin_1	32	38	PF00069	0.486
MOD_SUMO_rev_2	295	302	PF00179	0.603
MOD_SUMO_rev_2	59	69	PF00179	0.726
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.615
TRG_ENDOCYTIC_2	137	140	PF00928	0.409
TRG_ENDOCYTIC_2	151	154	PF00928	0.393
TRG_ENDOCYTIC_2	156	159	PF00928	0.320
TRG_ENDOCYTIC_2	202	205	PF00928	0.383
TRG_ENDOCYTIC_2	251	254	PF00928	0.555
TRG_ER_diArg_1	137	139	PF00400	0.376
TRG_ER_diArg_1	307	310	PF00400	0.519
TRG_ER_diArg_1	51	53	PF00400	0.606
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	45	50	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4T7	Leptomonas seymouri	76%	100%
A0A1X0P4T0	Trypanosomatidae	78%	98%
A0A3S7XBA9	Leishmania donovani	93%	100%
A4HPN4	Leishmania braziliensis	85%	100%
A4ID30	Leishmania infantum	93%	100%
D0A8H9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ATE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BIQ3	Trypanosoma cruzi	78%	96%