LeishMANIAdb
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Mitogen activated kinase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mitogen activated kinase-like protein
Gene product:
mitogen activated kinase-like protein
Species:
Leishmania major
UniProt:
Q4Q147_LEIMA
TriTrypDb:
LmjF.36.3680 , LMJLV39_360047500 * , LMJSD75_360047200 *
Length:
977

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 3
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

Q4Q147
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q147

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 13
GO:0006793 phosphorus metabolic process 3 13
GO:0006796 phosphate-containing compound metabolic process 4 13
GO:0006807 nitrogen compound metabolic process 2 13
GO:0008152 metabolic process 1 13
GO:0009987 cellular process 1 13
GO:0016310 phosphorylation 5 13
GO:0019538 protein metabolic process 3 13
GO:0036211 protein modification process 4 13
GO:0043170 macromolecule metabolic process 3 13
GO:0043412 macromolecule modification 4 13
GO:0044237 cellular metabolic process 2 13
GO:0044238 primary metabolic process 2 13
GO:0071704 organic substance metabolic process 2 13
GO:1901564 organonitrogen compound metabolic process 3 13
GO:0006355 regulation of DNA-templated transcription 6 3
GO:0009889 regulation of biosynthetic process 4 3
GO:0010468 regulation of gene expression 5 3
GO:0010556 regulation of macromolecule biosynthetic process 5 3
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 3
GO:0019222 regulation of metabolic process 3 3
GO:0031323 regulation of cellular metabolic process 4 3
GO:0031326 regulation of cellular biosynthetic process 5 3
GO:0050789 regulation of biological process 2 3
GO:0050794 regulation of cellular process 3 3
GO:0051171 regulation of nitrogen compound metabolic process 4 3
GO:0051252 regulation of RNA metabolic process 5 3
GO:0060255 regulation of macromolecule metabolic process 4 3
GO:0065007 biological regulation 1 3
GO:0080090 regulation of primary metabolic process 4 3
GO:1903506 regulation of nucleic acid-templated transcription 7 3
GO:2001141 regulation of RNA biosynthetic process 6 3
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 13
GO:0003824 catalytic activity 1 13
GO:0004672 protein kinase activity 3 13
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0005488 binding 1 13
GO:0005524 ATP binding 5 13
GO:0016301 kinase activity 4 13
GO:0016740 transferase activity 2 13
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 13
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 13
GO:0017076 purine nucleotide binding 4 13
GO:0030554 adenyl nucleotide binding 5 13
GO:0032553 ribonucleotide binding 3 13
GO:0032555 purine ribonucleotide binding 4 13
GO:0032559 adenyl ribonucleotide binding 5 13
GO:0035639 purine ribonucleoside triphosphate binding 4 13
GO:0036094 small molecule binding 2 13
GO:0043167 ion binding 2 13
GO:0043168 anion binding 3 13
GO:0097159 organic cyclic compound binding 2 13
GO:0097367 carbohydrate derivative binding 2 13
GO:0140096 catalytic activity, acting on a protein 2 13
GO:1901265 nucleoside phosphate binding 3 13
GO:1901363 heterocyclic compound binding 2 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 213 217 PF00656 0.594
CLV_C14_Caspase3-7 392 396 PF00656 0.383
CLV_C14_Caspase3-7 637 641 PF00656 0.665
CLV_C14_Caspase3-7 856 860 PF00656 0.456
CLV_C14_Caspase3-7 965 969 PF00656 0.720
CLV_NRD_NRD_1 138 140 PF00675 0.719
CLV_NRD_NRD_1 229 231 PF00675 0.414
CLV_NRD_NRD_1 25 27 PF00675 0.292
CLV_NRD_NRD_1 59 61 PF00675 0.416
CLV_NRD_NRD_1 593 595 PF00675 0.350
CLV_NRD_NRD_1 659 661 PF00675 0.395
CLV_NRD_NRD_1 683 685 PF00675 0.446
CLV_PCSK_FUR_1 227 231 PF00082 0.488
CLV_PCSK_KEX2_1 229 231 PF00082 0.476
CLV_PCSK_KEX2_1 59 61 PF00082 0.326
CLV_PCSK_KEX2_1 644 646 PF00082 0.363
CLV_PCSK_KEX2_1 669 671 PF00082 0.399
CLV_PCSK_KEX2_1 674 676 PF00082 0.412
CLV_PCSK_KEX2_1 682 684 PF00082 0.447
CLV_PCSK_KEX2_1 784 786 PF00082 0.350
CLV_PCSK_KEX2_1 883 885 PF00082 0.239
CLV_PCSK_PC1ET2_1 644 646 PF00082 0.363
CLV_PCSK_PC1ET2_1 669 671 PF00082 0.415
CLV_PCSK_PC1ET2_1 674 676 PF00082 0.445
CLV_PCSK_PC1ET2_1 682 684 PF00082 0.447
CLV_PCSK_PC1ET2_1 784 786 PF00082 0.242
CLV_PCSK_PC1ET2_1 883 885 PF00082 0.256
CLV_PCSK_PC7_1 55 61 PF00082 0.299
CLV_PCSK_PC7_1 665 671 PF00082 0.269
CLV_PCSK_SKI1_1 330 334 PF00082 0.429
CLV_PCSK_SKI1_1 352 356 PF00082 0.636
CLV_PCSK_SKI1_1 426 430 PF00082 0.610
CLV_PCSK_SKI1_1 530 534 PF00082 0.432
CLV_PCSK_SKI1_1 594 598 PF00082 0.321
CLV_PCSK_SKI1_1 684 688 PF00082 0.390
CLV_PCSK_SKI1_1 799 803 PF00082 0.263
CLV_PCSK_SKI1_1 816 820 PF00082 0.313
DEG_APCC_DBOX_1 107 115 PF00400 0.671
DEG_APCC_DBOX_1 425 433 PF00400 0.437
DEG_APCC_DBOX_1 504 512 PF00400 0.359
DEG_APCC_DBOX_1 593 601 PF00400 0.578
DOC_CKS1_1 100 105 PF01111 0.533
DOC_CYCLIN_RxL_1 320 329 PF00134 0.646
DOC_CYCLIN_RxL_1 421 431 PF00134 0.471
DOC_CYCLIN_yCln2_LP_2 109 115 PF00134 0.565
DOC_CYCLIN_yCln2_LP_2 531 537 PF00134 0.298
DOC_MAPK_gen_1 352 362 PF00069 0.435
DOC_MAPK_gen_1 434 442 PF00069 0.403
DOC_MAPK_gen_1 59 70 PF00069 0.506
DOC_MAPK_gen_1 816 825 PF00069 0.464
DOC_MAPK_MEF2A_6 436 444 PF00069 0.423
DOC_MAPK_MEF2A_6 762 771 PF00069 0.454
DOC_PP1_RVXF_1 275 282 PF00149 0.551
DOC_PP2B_LxvP_1 109 112 PF13499 0.670
DOC_PP2B_LxvP_1 531 534 PF13499 0.298
DOC_USP7_MATH_1 79 83 PF00917 0.518
DOC_USP7_MATH_1 95 99 PF00917 0.523
DOC_USP7_MATH_1 962 966 PF00917 0.727
DOC_USP7_MATH_2 895 901 PF00917 0.522
DOC_USP7_UBL2_3 720 724 PF12436 0.448
DOC_USP7_UBL2_3 861 865 PF12436 0.548
DOC_WW_Pin1_4 690 695 PF00397 0.595
DOC_WW_Pin1_4 948 953 PF00397 0.704
DOC_WW_Pin1_4 956 961 PF00397 0.783
DOC_WW_Pin1_4 99 104 PF00397 0.671
LIG_14-3-3_CanoR_1 438 443 PF00244 0.418
LIG_14-3-3_CanoR_1 505 509 PF00244 0.457
LIG_14-3-3_CanoR_1 573 581 PF00244 0.508
LIG_14-3-3_CanoR_1 665 669 PF00244 0.520
LIG_14-3-3_CanoR_1 921 929 PF00244 0.481
LIG_14-3-3_CanoR_1 963 972 PF00244 0.631
LIG_APCC_ABBA_1 469 474 PF00400 0.489
LIG_APCC_ABBA_1 932 937 PF00400 0.601
LIG_BIR_II_1 1 5 PF00653 0.622
LIG_BRCT_BRCA1_1 249 253 PF00533 0.605
LIG_BRCT_BRCA1_1 728 732 PF00533 0.481
LIG_BRCT_BRCA1_1 972 976 PF00533 0.703
LIG_FHA_1 125 131 PF00498 0.357
LIG_FHA_1 205 211 PF00498 0.644
LIG_FHA_1 30 36 PF00498 0.603
LIG_FHA_1 339 345 PF00498 0.348
LIG_FHA_1 374 380 PF00498 0.439
LIG_FHA_1 456 462 PF00498 0.389
LIG_FHA_1 484 490 PF00498 0.366
LIG_FHA_1 526 532 PF00498 0.293
LIG_FHA_1 711 717 PF00498 0.491
LIG_FHA_1 764 770 PF00498 0.462
LIG_FHA_1 796 802 PF00498 0.433
LIG_FHA_1 837 843 PF00498 0.476
LIG_FHA_1 922 928 PF00498 0.483
LIG_FHA_1 95 101 PF00498 0.616
LIG_FHA_2 238 244 PF00498 0.593
LIG_FHA_2 270 276 PF00498 0.518
LIG_FHA_2 314 320 PF00498 0.625
LIG_FHA_2 505 511 PF00498 0.328
LIG_FHA_2 71 77 PF00498 0.627
LIG_FHA_2 776 782 PF00498 0.522
LIG_FHA_2 949 955 PF00498 0.716
LIG_Integrin_RGD_1 645 647 PF01839 0.395
LIG_LIR_Apic_2 195 199 PF02991 0.701
LIG_LIR_Apic_2 849 855 PF02991 0.448
LIG_LIR_Gen_1 14 24 PF02991 0.663
LIG_LIR_Gen_1 312 322 PF02991 0.587
LIG_LIR_Gen_1 487 496 PF02991 0.310
LIG_LIR_Nem_3 11 16 PF02991 0.539
LIG_LIR_Nem_3 166 172 PF02991 0.676
LIG_LIR_Nem_3 17 22 PF02991 0.631
LIG_LIR_Nem_3 195 200 PF02991 0.717
LIG_LIR_Nem_3 395 401 PF02991 0.408
LIG_LIR_Nem_3 41 47 PF02991 0.651
LIG_LIR_Nem_3 487 493 PF02991 0.317
LIG_LIR_Nem_3 685 690 PF02991 0.629
LIG_PAM2_1 411 423 PF00658 0.443
LIG_PCNA_PIPBox_1 377 386 PF02747 0.382
LIG_PCNA_yPIPBox_3 377 386 PF02747 0.444
LIG_PCNA_yPIPBox_3 776 788 PF02747 0.481
LIG_PTB_Apo_2 463 470 PF02174 0.345
LIG_REV1ctd_RIR_1 381 390 PF16727 0.311
LIG_SH2_CRK 197 201 PF00017 0.601
LIG_SH2_CRK 490 494 PF00017 0.336
LIG_SH2_CRK 706 710 PF00017 0.525
LIG_SH2_GRB2like 196 199 PF00017 0.575
LIG_SH2_NCK_1 706 710 PF00017 0.462
LIG_SH2_PTP2 439 442 PF00017 0.374
LIG_SH2_STAP1 16 20 PF00017 0.470
LIG_SH2_STAP1 31 35 PF00017 0.496
LIG_SH2_STAP1 706 710 PF00017 0.377
LIG_SH2_STAP1 74 78 PF00017 0.497
LIG_SH2_STAT3 172 175 PF00017 0.532
LIG_SH2_STAT5 31 34 PF00017 0.607
LIG_SH2_STAT5 314 317 PF00017 0.478
LIG_SH2_STAT5 439 442 PF00017 0.396
LIG_SH2_STAT5 631 634 PF00017 0.497
LIG_SH2_STAT5 757 760 PF00017 0.448
LIG_SH2_STAT5 807 810 PF00017 0.448
LIG_SH3_1 784 790 PF00018 0.420
LIG_SH3_3 3 9 PF00018 0.584
LIG_SH3_3 520 526 PF00018 0.220
LIG_SH3_3 784 790 PF00018 0.464
LIG_SH3_4 861 868 PF00018 0.420
LIG_SUMO_SIM_anti_2 127 132 PF11976 0.444
LIG_SUMO_SIM_anti_2 149 155 PF11976 0.391
LIG_SUMO_SIM_anti_2 559 565 PF11976 0.522
LIG_SUMO_SIM_par_1 340 345 PF11976 0.361
LIG_SUMO_SIM_par_1 346 351 PF11976 0.336
LIG_SUMO_SIM_par_1 507 512 PF11976 0.317
LIG_SUMO_SIM_par_1 561 567 PF11976 0.474
LIG_SUMO_SIM_par_1 609 614 PF11976 0.559
LIG_SUMO_SIM_par_1 923 931 PF11976 0.526
LIG_TRAF2_1 599 602 PF00917 0.476
LIG_TRAF2_1 676 679 PF00917 0.604
LIG_TRAF2_1 894 897 PF00917 0.474
LIG_TRAF2_1 952 955 PF00917 0.726
LIG_TYR_ITSM 40 47 PF00017 0.358
LIG_UBA3_1 159 168 PF00899 0.533
LIG_UBA3_1 532 538 PF00899 0.464
LIG_UBA3_1 561 568 PF00899 0.374
LIG_WRC_WIRS_1 380 385 PF05994 0.506
MOD_CDK_SPK_2 956 961 PF00069 0.544
MOD_CDK_SPxxK_3 956 963 PF00069 0.536
MOD_CK1_1 149 155 PF00069 0.384
MOD_CK1_1 2 8 PF00069 0.496
MOD_CK1_1 367 373 PF00069 0.648
MOD_CK1_1 389 395 PF00069 0.642
MOD_CK1_1 39 45 PF00069 0.509
MOD_CK1_1 50 56 PF00069 0.273
MOD_CK1_1 579 585 PF00069 0.525
MOD_CK1_1 693 699 PF00069 0.341
MOD_CK1_1 714 720 PF00069 0.293
MOD_CK1_1 900 906 PF00069 0.342
MOD_CK1_1 964 970 PF00069 0.563
MOD_CK2_1 237 243 PF00069 0.603
MOD_CK2_1 313 319 PF00069 0.534
MOD_CK2_1 70 76 PF00069 0.518
MOD_CK2_1 860 866 PF00069 0.391
MOD_CK2_1 948 954 PF00069 0.503
MOD_GlcNHglycan 1 4 PF01048 0.508
MOD_GlcNHglycan 200 203 PF01048 0.497
MOD_GlcNHglycan 291 294 PF01048 0.451
MOD_GlcNHglycan 344 347 PF01048 0.391
MOD_GlcNHglycan 412 416 PF01048 0.525
MOD_GlcNHglycan 421 424 PF01048 0.530
MOD_GlcNHglycan 486 489 PF01048 0.541
MOD_GlcNHglycan 499 503 PF01048 0.470
MOD_GlcNHglycan 513 516 PF01048 0.371
MOD_GlcNHglycan 576 579 PF01048 0.467
MOD_GlcNHglycan 728 731 PF01048 0.316
MOD_GlcNHglycan 862 865 PF01048 0.279
MOD_GlcNHglycan 884 887 PF01048 0.390
MOD_GlcNHglycan 901 905 PF01048 0.347
MOD_GSK3_1 338 345 PF00069 0.358
MOD_GSK3_1 360 367 PF00069 0.493
MOD_GSK3_1 389 396 PF00069 0.663
MOD_GSK3_1 455 462 PF00069 0.553
MOD_GSK3_1 46 53 PF00069 0.405
MOD_GSK3_1 579 586 PF00069 0.459
MOD_GSK3_1 710 717 PF00069 0.303
MOD_GSK3_1 830 837 PF00069 0.300
MOD_GSK3_1 860 867 PF00069 0.470
MOD_GSK3_1 916 923 PF00069 0.299
MOD_GSK3_1 95 102 PF00069 0.528
MOD_GSK3_1 962 969 PF00069 0.621
MOD_N-GLC_1 574 579 PF02516 0.398
MOD_NEK2_1 146 151 PF00069 0.353
MOD_NEK2_1 20 25 PF00069 0.459
MOD_NEK2_1 289 294 PF00069 0.476
MOD_NEK2_1 313 318 PF00069 0.457
MOD_NEK2_1 364 369 PF00069 0.460
MOD_NEK2_1 373 378 PF00069 0.509
MOD_NEK2_1 455 460 PF00069 0.467
MOD_NEK2_1 70 75 PF00069 0.314
MOD_NEK2_1 823 828 PF00069 0.322
MOD_NEK2_1 966 971 PF00069 0.585
MOD_NEK2_2 284 289 PF00069 0.422
MOD_NEK2_2 583 588 PF00069 0.498
MOD_PIKK_1 371 377 PF00454 0.501
MOD_PIKK_1 386 392 PF00454 0.416
MOD_PIKK_1 393 399 PF00454 0.578
MOD_PIKK_1 693 699 PF00454 0.279
MOD_PIKK_1 823 829 PF00454 0.391
MOD_PIKK_1 938 944 PF00454 0.503
MOD_PIKK_1 95 101 PF00454 0.399
MOD_PK_1 438 444 PF00069 0.590
MOD_PKA_1 59 65 PF00069 0.393
MOD_PKA_2 504 510 PF00069 0.633
MOD_PKA_2 59 65 PF00069 0.555
MOD_PKA_2 664 670 PF00069 0.334
MOD_PKA_2 726 732 PF00069 0.336
MOD_PKA_2 920 926 PF00069 0.303
MOD_PKA_2 962 968 PF00069 0.554
MOD_PKB_1 436 444 PF00069 0.494
MOD_Plk_1 307 313 PF00069 0.433
MOD_Plk_1 386 392 PF00069 0.540
MOD_Plk_1 411 417 PF00069 0.511
MOD_Plk_1 47 53 PF00069 0.530
MOD_Plk_1 763 769 PF00069 0.309
MOD_Plk_1 938 944 PF00069 0.503
MOD_Plk_1 967 973 PF00069 0.610
MOD_Plk_2-3 775 781 PF00069 0.298
MOD_Plk_4 113 119 PF00069 0.341
MOD_Plk_4 124 130 PF00069 0.221
MOD_Plk_4 149 155 PF00069 0.333
MOD_Plk_4 192 198 PF00069 0.704
MOD_Plk_4 20 26 PF00069 0.505
MOD_Plk_4 242 248 PF00069 0.438
MOD_Plk_4 344 350 PF00069 0.285
MOD_Plk_4 379 385 PF00069 0.546
MOD_Plk_4 39 45 PF00069 0.603
MOD_Plk_4 504 510 PF00069 0.650
MOD_Plk_4 576 582 PF00069 0.490
MOD_Plk_4 923 929 PF00069 0.278
MOD_Plk_4 967 973 PF00069 0.593
MOD_ProDKin_1 690 696 PF00069 0.487
MOD_ProDKin_1 948 954 PF00069 0.654
MOD_ProDKin_1 956 962 PF00069 0.754
MOD_ProDKin_1 99 105 PF00069 0.607
MOD_SUMO_for_1 537 540 PF00179 0.585
MOD_SUMO_rev_2 273 279 PF00179 0.483
MOD_SUMO_rev_2 351 356 PF00179 0.439
MOD_SUMO_rev_2 441 449 PF00179 0.604
MOD_SUMO_rev_2 612 618 PF00179 0.500
MOD_SUMO_rev_2 671 676 PF00179 0.493
MOD_SUMO_rev_2 856 863 PF00179 0.391
TRG_AP2beta_CARGO_1 17 26 PF09066 0.358
TRG_DiLeu_BaLyEn_6 158 163 PF01217 0.370
TRG_DiLeu_BaLyEn_6 557 562 PF01217 0.522
TRG_DiLeu_BaLyEn_6 585 590 PF01217 0.297
TRG_DiLeu_BaLyEn_6 696 701 PF01217 0.279
TRG_ENDOCYTIC_2 16 19 PF00928 0.294
TRG_ENDOCYTIC_2 197 200 PF00928 0.505
TRG_ENDOCYTIC_2 314 317 PF00928 0.416
TRG_ENDOCYTIC_2 439 442 PF00928 0.495
TRG_ENDOCYTIC_2 44 47 PF00928 0.428
TRG_ENDOCYTIC_2 490 493 PF00928 0.414
TRG_ENDOCYTIC_2 706 709 PF00928 0.395
TRG_ER_diArg_1 227 230 PF00400 0.461
TRG_ER_diArg_1 248 251 PF00400 0.461
TRG_ER_diArg_1 436 439 PF00400 0.641
TRG_ER_diArg_1 476 479 PF00400 0.445
TRG_ER_diArg_1 58 60 PF00400 0.516
TRG_NES_CRM1_1 605 619 PF08389 0.319
TRG_Pf-PMV_PEXEL_1 234 238 PF00026 0.406
TRG_Pf-PMV_PEXEL_1 26 30 PF00026 0.557
TRG_Pf-PMV_PEXEL_1 33 37 PF00026 0.382
TRG_Pf-PMV_PEXEL_1 399 403 PF00026 0.425
TRG_Pf-PMV_PEXEL_1 426 431 PF00026 0.561

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7Q2 Leptomonas seymouri 29% 95%
A0A0N1HX31 Leptomonas seymouri 64% 100%
A0A0S4JAS0 Bodo saltans 42% 97%
A0A0S4JMC0 Bodo saltans 46% 100%
A0A1X0P3F4 Trypanosomatidae 49% 98%
A0A3Q8IGC6 Leishmania donovani 93% 100%
A0A3R7K5X0 Trypanosoma rangeli 28% 97%
A4HPN6 Leishmania braziliensis 81% 100%
A4ID28 Leishmania infantum 94% 100%
E9ATF0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q920 Leishmania major 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS