Nucleoporin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP119

Species:

Leishmania major

UniProt:

Q4Q146_LEIMA

TriTrypDb:

LmjF.36.3690 , LMJLV39_360047600 , LMJSD75_360047300

Length:

1072

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	2
GO:0044611	nuclear pore inner ring	3	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

Q4Q146

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q146

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.379
CLV_C14_Caspase3-7	385	389	PF00656	0.411
CLV_C14_Caspase3-7	426	430	PF00656	0.490
CLV_C14_Caspase3-7	560	564	PF00656	0.533
CLV_C14_Caspase3-7	995	999	PF00656	0.451
CLV_NRD_NRD_1	1065	1067	PF00675	0.471
CLV_NRD_NRD_1	144	146	PF00675	0.480
CLV_NRD_NRD_1	668	670	PF00675	0.414
CLV_NRD_NRD_1	75	77	PF00675	0.544
CLV_NRD_NRD_1	90	92	PF00675	0.351
CLV_PCSK_KEX2_1	1059	1061	PF00082	0.359
CLV_PCSK_KEX2_1	220	222	PF00082	0.453
CLV_PCSK_KEX2_1	303	305	PF00082	0.615
CLV_PCSK_KEX2_1	668	670	PF00082	0.414
CLV_PCSK_KEX2_1	75	77	PF00082	0.544
CLV_PCSK_KEX2_1	90	92	PF00082	0.399
CLV_PCSK_PC1ET2_1	1059	1061	PF00082	0.468
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.492
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.596
CLV_PCSK_SKI1_1	1038	1042	PF00082	0.464
CLV_PCSK_SKI1_1	439	443	PF00082	0.399
CLV_PCSK_SKI1_1	46	50	PF00082	0.502
CLV_PCSK_SKI1_1	577	581	PF00082	0.501
CLV_PCSK_SKI1_1	620	624	PF00082	0.412
CLV_PCSK_SKI1_1	628	632	PF00082	0.369
CLV_PCSK_SKI1_1	669	673	PF00082	0.397
CLV_PCSK_SKI1_1	762	766	PF00082	0.438
CLV_PCSK_SKI1_1	91	95	PF00082	0.440
DEG_APCC_DBOX_1	1000	1008	PF00400	0.452
DEG_APCC_DBOX_1	230	238	PF00400	0.434
DEG_APCC_DBOX_1	303	311	PF00400	0.382
DEG_APCC_DBOX_1	668	676	PF00400	0.398
DEG_SPOP_SBC_1	360	364	PF00917	0.487
DEG_SPOP_SBC_1	721	725	PF00917	0.403
DOC_CYCLIN_yClb5_NLxxxL_5	809	818	PF00134	0.359
DOC_CYCLIN_yCln2_LP_2	463	469	PF00134	0.390
DOC_MAPK_gen_1	118	127	PF00069	0.475
DOC_MAPK_gen_1	229	237	PF00069	0.349
DOC_MAPK_gen_1	668	674	PF00069	0.393
DOC_MAPK_MEF2A_6	608	616	PF00069	0.511
DOC_MAPK_MEF2A_6	768	777	PF00069	0.371
DOC_MAPK_MEF2A_6	811	818	PF00069	0.377
DOC_PP1_RVXF_1	539	545	PF00149	0.432
DOC_PP1_RVXF_1	760	767	PF00149	0.378
DOC_PP1_RVXF_1	836	843	PF00149	0.351
DOC_PP1_RVXF_1	860	867	PF00149	0.510
DOC_PP1_RVXF_1	98	105	PF00149	0.502
DOC_PP2B_LxvP_1	814	817	PF13499	0.427
DOC_PP2B_LxvP_1	935	938	PF13499	0.391
DOC_PP4_FxxP_1	952	955	PF00568	0.474
DOC_USP7_MATH_1	10	14	PF00917	0.583
DOC_USP7_MATH_1	129	133	PF00917	0.450
DOC_USP7_MATH_1	153	157	PF00917	0.478
DOC_USP7_MATH_1	3	7	PF00917	0.613
DOC_USP7_MATH_1	332	336	PF00917	0.505
DOC_USP7_MATH_1	360	364	PF00917	0.676
DOC_USP7_MATH_1	721	725	PF00917	0.505
DOC_USP7_MATH_1	740	744	PF00917	0.563
DOC_USP7_MATH_1	831	835	PF00917	0.417
DOC_USP7_UBL2_3	633	637	PF12436	0.402
DOC_WW_Pin1_4	1019	1024	PF00397	0.440
DOC_WW_Pin1_4	11	16	PF00397	0.711
DOC_WW_Pin1_4	215	220	PF00397	0.489
DOC_WW_Pin1_4	911	916	PF00397	0.374
DOC_WW_Pin1_4	968	973	PF00397	0.486
LIG_14-3-3_CanoR_1	118	127	PF00244	0.556
LIG_14-3-3_CanoR_1	206	210	PF00244	0.463
LIG_14-3-3_CanoR_1	221	227	PF00244	0.428
LIG_14-3-3_CanoR_1	240	245	PF00244	0.451
LIG_14-3-3_CanoR_1	308	313	PF00244	0.515
LIG_14-3-3_CanoR_1	34	42	PF00244	0.655
LIG_14-3-3_CanoR_1	475	483	PF00244	0.492
LIG_14-3-3_CanoR_1	496	502	PF00244	0.408
LIG_14-3-3_CanoR_1	646	652	PF00244	0.432
LIG_14-3-3_CanoR_1	762	767	PF00244	0.401
LIG_14-3-3_CanoR_1	786	792	PF00244	0.378
LIG_14-3-3_CanoR_1	811	817	PF00244	0.444
LIG_Actin_WH2_2	916	933	PF00022	0.405
LIG_APCC_ABBA_1	104	109	PF00400	0.489
LIG_APCC_ABBA_1	244	249	PF00400	0.475
LIG_APCC_ABBA_1	908	913	PF00400	0.357
LIG_APCC_ABBA_1	958	963	PF00400	0.453
LIG_Clathr_ClatBox_1	822	826	PF01394	0.381
LIG_FHA_1	120	126	PF00498	0.418
LIG_FHA_1	189	195	PF00498	0.428
LIG_FHA_1	321	327	PF00498	0.507
LIG_FHA_1	342	348	PF00498	0.398
LIG_FHA_1	362	368	PF00498	0.276
LIG_FHA_1	392	398	PF00498	0.358
LIG_FHA_1	423	429	PF00498	0.379
LIG_FHA_1	505	511	PF00498	0.545
LIG_FHA_1	523	529	PF00498	0.364
LIG_FHA_1	611	617	PF00498	0.296
LIG_FHA_1	629	635	PF00498	0.452
LIG_FHA_1	681	687	PF00498	0.544
LIG_FHA_1	723	729	PF00498	0.410
LIG_FHA_1	922	928	PF00498	0.345
LIG_FHA_2	1049	1055	PF00498	0.441
LIG_FHA_2	108	114	PF00498	0.396
LIG_FHA_2	349	355	PF00498	0.479
LIG_FHA_2	755	761	PF00498	0.490
LIG_FHA_2	986	992	PF00498	0.498
LIG_GBD_Chelix_1	339	347	PF00786	0.346
LIG_GBD_Chelix_1	440	448	PF00786	0.325
LIG_GBD_Chelix_1	850	858	PF00786	0.456
LIG_GBD_Chelix_1	919	927	PF00786	0.450
LIG_IRF3_LxIS_1	447	454	PF10401	0.375
LIG_LIR_Apic_2	594	599	PF02991	0.497
LIG_LIR_Apic_2	951	955	PF02991	0.385
LIG_LIR_Gen_1	391	398	PF02991	0.447
LIG_LIR_Gen_1	727	736	PF02991	0.523
LIG_LIR_Gen_1	765	773	PF02991	0.389
LIG_LIR_Gen_1	82	87	PF02991	0.371
LIG_LIR_Gen_1	963	972	PF02991	0.546
LIG_LIR_Gen_1	988	997	PF02991	0.396
LIG_LIR_Nem_3	23	28	PF02991	0.579
LIG_LIR_Nem_3	391	395	PF02991	0.350
LIG_LIR_Nem_3	500	506	PF02991	0.417
LIG_LIR_Nem_3	727	732	PF02991	0.489
LIG_LIR_Nem_3	765	769	PF02991	0.380
LIG_LIR_Nem_3	82	86	PF02991	0.372
LIG_LIR_Nem_3	963	967	PF02991	0.467
LIG_LIR_Nem_3	988	993	PF02991	0.390
LIG_MYND_1	462	466	PF01753	0.482
LIG_NRBOX	568	574	PF00104	0.341
LIG_NRBOX	584	590	PF00104	0.258
LIG_NRBOX	601	607	PF00104	0.402
LIG_PCNA_PIPBox_1	942	951	PF02747	0.416
LIG_PCNA_yPIPBox_3	565	577	PF02747	0.462
LIG_PTB_Apo_2	48	55	PF02174	0.511
LIG_PTB_Apo_2	999	1006	PF02174	0.541
LIG_Rb_pABgroove_1	221	229	PF01858	0.404
LIG_Rb_pABgroove_1	580	588	PF01858	0.406
LIG_SH2_CRK	214	218	PF00017	0.562
LIG_SH2_CRK	586	590	PF00017	0.352
LIG_SH2_CRK	596	600	PF00017	0.376
LIG_SH2_CRK	677	681	PF00017	0.399
LIG_SH2_CRK	703	707	PF00017	0.396
LIG_SH2_CRK	729	733	PF00017	0.386
LIG_SH2_CRK	83	87	PF00017	0.363
LIG_SH2_CRK	895	899	PF00017	0.448
LIG_SH2_GRB2like	53	56	PF00017	0.416
LIG_SH2_GRB2like	79	82	PF00017	0.370
LIG_SH2_SRC	222	225	PF00017	0.409
LIG_SH2_SRC	707	710	PF00017	0.287
LIG_SH2_STAP1	586	590	PF00017	0.320
LIG_SH2_STAP1	682	686	PF00017	0.451
LIG_SH2_STAP1	707	711	PF00017	0.373
LIG_SH2_STAT3	455	458	PF00017	0.409
LIG_SH2_STAT5	101	104	PF00017	0.368
LIG_SH2_STAT5	115	118	PF00017	0.320
LIG_SH2_STAT5	216	219	PF00017	0.571
LIG_SH2_STAT5	222	225	PF00017	0.464
LIG_SH2_STAT5	233	236	PF00017	0.307
LIG_SH2_STAT5	398	401	PF00017	0.461
LIG_SH2_STAT5	455	458	PF00017	0.409
LIG_SH2_STAT5	53	56	PF00017	0.484
LIG_SH2_STAT5	666	669	PF00017	0.421
LIG_SH2_STAT5	682	685	PF00017	0.239
LIG_SH2_STAT5	79	82	PF00017	0.460
LIG_SH2_STAT5	882	885	PF00017	0.381
LIG_SH2_STAT5	948	951	PF00017	0.495
LIG_SH3_3	100	106	PF00018	0.380
LIG_SH3_3	1000	1006	PF00018	0.440
LIG_SH3_3	954	960	PF00018	0.381
LIG_SH3_3	979	985	PF00018	0.487
LIG_SUMO_SIM_anti_2	344	351	PF11976	0.427
LIG_SUMO_SIM_anti_2	650	657	PF11976	0.446
LIG_SUMO_SIM_anti_2	731	738	PF11976	0.383
LIG_SUMO_SIM_par_1	233	239	PF11976	0.445
LIG_SUMO_SIM_par_1	344	351	PF11976	0.376
LIG_SUMO_SIM_par_1	439	445	PF11976	0.332
LIG_SUMO_SIM_par_1	821	826	PF11976	0.377
LIG_TRAF2_1	20	23	PF00917	0.464
LIG_TRAF2_1	41	44	PF00917	0.460
LIG_TYR_ITIM	675	680	PF00017	0.400
LIG_UBA3_1	888	896	PF00899	0.369
LIG_WRC_WIRS_1	392	397	PF05994	0.442
LIG_WRC_WIRS_1	763	768	PF05994	0.390
LIG_WRC_WIRS_1	926	931	PF05994	0.387
LIG_WRC_WIRS_1	949	954	PF05994	0.545
LIG_WRC_WIRS_1	990	995	PF05994	0.418
MOD_CDC14_SPxK_1	218	221	PF00782	0.462
MOD_CDK_SPK_2	215	220	PF00069	0.489
MOD_CDK_SPxK_1	215	221	PF00069	0.486
MOD_CK1_1	13	19	PF00069	0.620
MOD_CK1_1	156	162	PF00069	0.373
MOD_CK1_1	205	211	PF00069	0.533
MOD_CK1_1	248	254	PF00069	0.479
MOD_CK1_1	362	368	PF00069	0.530
MOD_CK1_1	391	397	PF00069	0.457
MOD_CK1_1	423	429	PF00069	0.533
MOD_CK1_1	454	460	PF00069	0.430
MOD_CK1_1	492	498	PF00069	0.411
MOD_CK1_1	6	12	PF00069	0.722
MOD_CK1_1	681	687	PF00069	0.386
MOD_CK1_1	690	696	PF00069	0.331
MOD_CK1_1	710	716	PF00069	0.211
MOD_CK1_1	743	749	PF00069	0.351
MOD_CK1_1	812	818	PF00069	0.409
MOD_CK2_1	17	23	PF00069	0.561
MOD_CK2_1	308	314	PF00069	0.551
MOD_CK2_1	348	354	PF00069	0.467
MOD_CK2_1	512	518	PF00069	0.474
MOD_CK2_1	66	72	PF00069	0.449
MOD_CK2_1	714	720	PF00069	0.444
MOD_CK2_1	884	890	PF00069	0.476
MOD_Cter_Amidation	301	304	PF01082	0.541
MOD_GlcNHglycan	131	134	PF01048	0.387
MOD_GlcNHglycan	151	154	PF01048	0.238
MOD_GlcNHglycan	158	161	PF01048	0.378
MOD_GlcNHglycan	256	260	PF01048	0.559
MOD_GlcNHglycan	288	291	PF01048	0.552
MOD_GlcNHglycan	35	38	PF01048	0.666
MOD_GlcNHglycan	425	428	PF01048	0.509
MOD_GlcNHglycan	448	451	PF01048	0.438
MOD_GlcNHglycan	5	8	PF01048	0.592
MOD_GlcNHglycan	558	562	PF01048	0.459
MOD_GlcNHglycan	935	938	PF01048	0.411
MOD_GSK3_1	117	124	PF00069	0.420
MOD_GSK3_1	149	156	PF00069	0.376
MOD_GSK3_1	184	191	PF00069	0.406
MOD_GSK3_1	236	243	PF00069	0.475
MOD_GSK3_1	362	369	PF00069	0.610
MOD_GSK3_1	6	13	PF00069	0.699
MOD_GSK3_1	606	613	PF00069	0.332
MOD_GSK3_1	62	69	PF00069	0.530
MOD_GSK3_1	686	693	PF00069	0.419
MOD_GSK3_1	710	717	PF00069	0.470
MOD_GSK3_1	740	747	PF00069	0.428
MOD_GSK3_1	827	834	PF00069	0.461
MOD_GSK3_1	921	928	PF00069	0.495
MOD_GSK3_1	985	992	PF00069	0.442
MOD_LATS_1	626	632	PF00433	0.375
MOD_N-GLC_1	177	182	PF02516	0.462
MOD_N-GLC_1	240	245	PF02516	0.383
MOD_N-GLC_1	577	582	PF02516	0.238
MOD_N-GLC_1	812	817	PF02516	0.372
MOD_NEK2_1	1034	1039	PF00069	0.476
MOD_NEK2_1	107	112	PF00069	0.518
MOD_NEK2_1	154	159	PF00069	0.300
MOD_NEK2_1	17	22	PF00069	0.509
MOD_NEK2_1	188	193	PF00069	0.436
MOD_NEK2_1	235	240	PF00069	0.393
MOD_NEK2_1	255	260	PF00069	0.240
MOD_NEK2_1	285	290	PF00069	0.438
MOD_NEK2_1	297	302	PF00069	0.545
MOD_NEK2_1	343	348	PF00069	0.382
MOD_NEK2_1	420	425	PF00069	0.505
MOD_NEK2_1	497	502	PF00069	0.382
MOD_NEK2_1	510	515	PF00069	0.411
MOD_NEK2_1	517	522	PF00069	0.249
MOD_NEK2_1	571	576	PF00069	0.328
MOD_NEK2_1	589	594	PF00069	0.266
MOD_NEK2_1	647	652	PF00069	0.472
MOD_NEK2_1	66	71	PF00069	0.425
MOD_NEK2_1	664	669	PF00069	0.352
MOD_NEK2_1	686	691	PF00069	0.422
MOD_NEK2_1	728	733	PF00069	0.433
MOD_NEK2_1	787	792	PF00069	0.374
MOD_NEK2_1	809	814	PF00069	0.403
MOD_NEK2_1	86	91	PF00069	0.207
MOD_NEK2_2	222	227	PF00069	0.460
MOD_NEK2_2	467	472	PF00069	0.349
MOD_PIKK_1	1066	1072	PF00454	0.537
MOD_PIKK_1	277	283	PF00454	0.424
MOD_PIKK_1	366	372	PF00454	0.573
MOD_PIKK_1	454	460	PF00454	0.405
MOD_PIKK_1	691	697	PF00454	0.485
MOD_PIKK_1	796	802	PF00454	0.313
MOD_PK_1	308	314	PF00069	0.440
MOD_PKA_1	1066	1072	PF00069	0.585
MOD_PKA_2	117	123	PF00069	0.496
MOD_PKA_2	139	145	PF00069	0.453
MOD_PKA_2	205	211	PF00069	0.572
MOD_PKA_2	33	39	PF00069	0.624
MOD_PKA_2	474	480	PF00069	0.504
MOD_PKA_2	504	510	PF00069	0.530
MOD_PKA_2	867	873	PF00069	0.442
MOD_Plk_1	177	183	PF00069	0.422
MOD_Plk_1	240	246	PF00069	0.354
MOD_Plk_1	248	254	PF00069	0.393
MOD_Plk_1	382	388	PF00069	0.523
MOD_Plk_1	400	406	PF00069	0.295
MOD_Plk_1	492	498	PF00069	0.381
MOD_Plk_1	557	563	PF00069	0.528
MOD_Plk_1	577	583	PF00069	0.181
MOD_Plk_1	687	693	PF00069	0.495
MOD_Plk_1	707	713	PF00069	0.221
MOD_Plk_1	743	749	PF00069	0.463
MOD_Plk_1	812	818	PF00069	0.409
MOD_Plk_1	884	890	PF00069	0.367
MOD_Plk_2-3	177	183	PF00069	0.412
MOD_Plk_2-3	714	720	PF00069	0.492
MOD_Plk_2-3	754	760	PF00069	0.410
MOD_Plk_2-3	884	890	PF00069	0.279
MOD_Plk_4	1007	1013	PF00069	0.319
MOD_Plk_4	121	127	PF00069	0.370
MOD_Plk_4	222	228	PF00069	0.386
MOD_Plk_4	240	246	PF00069	0.224
MOD_Plk_4	322	328	PF00069	0.480
MOD_Plk_4	333	339	PF00069	0.281
MOD_Plk_4	343	349	PF00069	0.304
MOD_Plk_4	388	394	PF00069	0.386
MOD_Plk_4	400	406	PF00069	0.331
MOD_Plk_4	519	525	PF00069	0.472
MOD_Plk_4	62	68	PF00069	0.527
MOD_Plk_4	647	653	PF00069	0.380
MOD_Plk_4	714	720	PF00069	0.469
MOD_Plk_4	728	734	PF00069	0.296
MOD_Plk_4	744	750	PF00069	0.408
MOD_Plk_4	849	855	PF00069	0.338
MOD_Plk_4	884	890	PF00069	0.450
MOD_Plk_4	925	931	PF00069	0.402
MOD_Plk_4	985	991	PF00069	0.443
MOD_Plk_4	992	998	PF00069	0.400
MOD_ProDKin_1	1019	1025	PF00069	0.439
MOD_ProDKin_1	11	17	PF00069	0.706
MOD_ProDKin_1	215	221	PF00069	0.486
MOD_ProDKin_1	911	917	PF00069	0.375
MOD_ProDKin_1	968	974	PF00069	0.489
MOD_SUMO_rev_2	547	557	PF00179	0.417
TRG_DiLeu_BaEn_1	567	572	PF01217	0.446
TRG_DiLeu_BaEn_1	82	87	PF01217	0.371
TRG_DiLeu_BaEn_3	43	49	PF01217	0.544
TRG_DiLeu_BaLyEn_6	459	464	PF01217	0.394
TRG_DiLeu_BaLyEn_6	696	701	PF01217	0.322
TRG_DiLeu_BaLyEn_6	818	823	PF01217	0.449
TRG_ENDOCYTIC_2	101	104	PF00928	0.240
TRG_ENDOCYTIC_2	214	217	PF00928	0.564
TRG_ENDOCYTIC_2	233	236	PF00928	0.362
TRG_ENDOCYTIC_2	503	506	PF00928	0.451
TRG_ENDOCYTIC_2	53	56	PF00928	0.484
TRG_ENDOCYTIC_2	586	589	PF00928	0.334
TRG_ENDOCYTIC_2	677	680	PF00928	0.393
TRG_ENDOCYTIC_2	729	732	PF00928	0.507
TRG_ENDOCYTIC_2	83	86	PF00928	0.363
TRG_ENDOCYTIC_2	895	898	PF00928	0.475
TRG_ER_diArg_1	514	517	PF00400	0.400
TRG_ER_diArg_1	539	542	PF00400	0.451
TRG_ER_diArg_1	644	647	PF00400	0.362
TRG_ER_diArg_1	696	699	PF00400	0.460
TRG_ER_diArg_1	90	92	PF00400	0.468
TRG_NES_CRM1_1	848	863	PF08389	0.376
TRG_Pf-PMV_PEXEL_1	1066	1070	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	481	485	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	669	673	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	821	826	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	876	880	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	943	947	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Q1	Leptomonas seymouri	59%	100%
A0A1X0P467	Trypanosomatidae	28%	99%
A0A3R7KQG4	Trypanosoma rangeli	28%	100%
A0A3S7XBA5	Leishmania donovani	95%	100%
A4HPN7	Leishmania braziliensis	85%	100%
A4ID27	Leishmania infantum	95%	100%
D0A8H7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ATF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BEA1	Trypanosoma cruzi	29%	100%