NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF498/DUF598), putative

Species:

Leishmania major

UniProt:

Q4Q143_LEIMA

TriTrypDb:

LmjF.36.3720 , LMJLV39_360047900 , LMJSD75_360047600

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005737	cytoplasm	2	2
GO:0005743	mitochondrial inner membrane	5	11
GO:0016020	membrane	2	11
GO:0019866	organelle inner membrane	4	11
GO:0031090	organelle membrane	3	11
GO:0031966	mitochondrial membrane	4	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q143

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q143

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0010257	NADH dehydrogenase complex assembly	6	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0032981	mitochondrial respiratory chain complex I assembly	7	11
GO:0033108	mitochondrial respiratory chain complex assembly	6	11
GO:0043933	protein-containing complex organization	4	11
GO:0065003	protein-containing complex assembly	5	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.400
CLV_C14_Caspase3-7	589	593	PF00656	0.513
CLV_NRD_NRD_1	144	146	PF00675	0.487
CLV_NRD_NRD_1	155	157	PF00675	0.481
CLV_NRD_NRD_1	175	177	PF00675	0.432
CLV_NRD_NRD_1	361	363	PF00675	0.286
CLV_NRD_NRD_1	501	503	PF00675	0.551
CLV_NRD_NRD_1	570	572	PF00675	0.471
CLV_NRD_NRD_1	614	616	PF00675	0.590
CLV_NRD_NRD_1	78	80	PF00675	0.537
CLV_PCSK_FUR_1	18	22	PF00082	0.451
CLV_PCSK_FUR_1	562	566	PF00082	0.503
CLV_PCSK_KEX2_1	144	146	PF00082	0.487
CLV_PCSK_KEX2_1	163	165	PF00082	0.480
CLV_PCSK_KEX2_1	174	176	PF00082	0.565
CLV_PCSK_KEX2_1	20	22	PF00082	0.448
CLV_PCSK_KEX2_1	207	209	PF00082	0.493
CLV_PCSK_KEX2_1	336	338	PF00082	0.259
CLV_PCSK_KEX2_1	361	363	PF00082	0.263
CLV_PCSK_KEX2_1	499	501	PF00082	0.545
CLV_PCSK_KEX2_1	564	566	PF00082	0.447
CLV_PCSK_KEX2_1	570	572	PF00082	0.438
CLV_PCSK_KEX2_1	614	616	PF00082	0.590
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.480
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.552
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.582
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.493
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.259
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.623
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.483
CLV_PCSK_PC7_1	16	22	PF00082	0.593
CLV_PCSK_PC7_1	610	616	PF00082	0.573
CLV_PCSK_SKI1_1	235	239	PF00082	0.501
CLV_PCSK_SKI1_1	331	335	PF00082	0.259
CLV_PCSK_SKI1_1	362	366	PF00082	0.259
CLV_PCSK_SKI1_1	486	490	PF00082	0.624
CLV_PCSK_SKI1_1	503	507	PF00082	0.580
CLV_PCSK_SKI1_1	586	590	PF00082	0.463
CLV_PCSK_SKI1_1	604	608	PF00082	0.545
CLV_PCSK_SKI1_1	86	90	PF00082	0.547
DEG_APCC_DBOX_1	361	369	PF00400	0.277
DEG_Nend_UBRbox_1	1	4	PF02207	0.560
DOC_CKS1_1	126	131	PF01111	0.507
DOC_CKS1_1	249	254	PF01111	0.586
DOC_CKS1_1	344	349	PF01111	0.241
DOC_CYCLIN_RxL_1	318	329	PF00134	0.277
DOC_MAPK_gen_1	361	367	PF00069	0.300
DOC_MAPK_MEF2A_6	300	308	PF00069	0.284
DOC_PP1_RVXF_1	319	326	PF00149	0.272
DOC_PP1_RVXF_1	329	335	PF00149	0.228
DOC_PP1_RVXF_1	84	90	PF00149	0.459
DOC_USP7_MATH_1	162	166	PF00917	0.619
DOC_USP7_MATH_1	178	182	PF00917	0.491
DOC_USP7_MATH_1	196	200	PF00917	0.497
DOC_USP7_MATH_1	43	47	PF00917	0.580
DOC_USP7_MATH_1	442	446	PF00917	0.547
DOC_USP7_MATH_1	522	526	PF00917	0.549
DOC_USP7_MATH_1	66	70	PF00917	0.459
DOC_USP7_UBL2_3	170	174	PF12436	0.562
DOC_USP7_UBL2_3	414	418	PF12436	0.502
DOC_USP7_UBL2_3	499	503	PF12436	0.553
DOC_WW_Pin1_4	125	130	PF00397	0.480
DOC_WW_Pin1_4	188	193	PF00397	0.550
DOC_WW_Pin1_4	248	253	PF00397	0.655
DOC_WW_Pin1_4	261	266	PF00397	0.230
DOC_WW_Pin1_4	343	348	PF00397	0.241
DOC_WW_Pin1_4	397	402	PF00397	0.640
DOC_WW_Pin1_4	403	408	PF00397	0.648
LIG_14-3-3_CanoR_1	2	6	PF00244	0.568
LIG_14-3-3_CanoR_1	253	259	PF00244	0.470
LIG_14-3-3_CanoR_1	361	368	PF00244	0.393
LIG_14-3-3_CanoR_1	420	427	PF00244	0.670
LIG_14-3-3_CanoR_1	441	451	PF00244	0.594
LIG_14-3-3_CanoR_1	614	624	PF00244	0.589
LIG_AP2alpha_2	186	188	PF02296	0.511
LIG_EH_1	242	246	PF12763	0.521
LIG_FHA_1	138	144	PF00498	0.520
LIG_FHA_1	255	261	PF00498	0.479
LIG_FHA_1	299	305	PF00498	0.259
LIG_FHA_1	445	451	PF00498	0.633
LIG_FHA_1	525	531	PF00498	0.648
LIG_FHA_1	547	553	PF00498	0.462
LIG_FHA_1	620	626	PF00498	0.606
LIG_FHA_1	8	14	PF00498	0.559
LIG_FHA_2	482	488	PF00498	0.606
LIG_FHA_2	587	593	PF00498	0.494
LIG_FHA_2	98	104	PF00498	0.402
LIG_LIR_Gen_1	114	122	PF02991	0.478
LIG_LIR_Gen_1	293	302	PF02991	0.273
LIG_LIR_Gen_1	458	468	PF02991	0.456
LIG_LIR_Nem_3	114	119	PF02991	0.490
LIG_LIR_Nem_3	152	158	PF02991	0.474
LIG_LIR_Nem_3	182	188	PF02991	0.551
LIG_LIR_Nem_3	293	297	PF02991	0.273
LIG_LIR_Nem_3	379	384	PF02991	0.492
LIG_LIR_Nem_3	458	464	PF02991	0.452
LIG_LIR_Nem_3	466	471	PF02991	0.473
LIG_LIR_Nem_3	483	488	PF02991	0.547
LIG_LYPXL_L_2	308	317	PF13949	0.259
LIG_MYND_1	451	455	PF01753	0.553
LIG_MYND_1	518	522	PF01753	0.589
LIG_MYND_3	450	454	PF01753	0.545
LIG_NRBOX	301	307	PF00104	0.301
LIG_Pex14_2	607	611	PF04695	0.559
LIG_PTB_Apo_2	384	391	PF02174	0.478
LIG_RPA_C_Fungi	356	368	PF08784	0.336
LIG_SH2_CRK	431	435	PF00017	0.573
LIG_SH2_CRK	603	607	PF00017	0.536
LIG_SH2_STAT3	194	197	PF00017	0.514
LIG_SH2_STAT5	30	33	PF00017	0.518
LIG_SH2_STAT5	479	482	PF00017	0.544
LIG_SH2_STAT5	587	590	PF00017	0.594
LIG_SH3_3	123	129	PF00018	0.435
LIG_SH3_3	177	183	PF00018	0.510
LIG_SH3_3	28	34	PF00018	0.516
LIG_SH3_3	541	547	PF00018	0.472
LIG_SUMO_SIM_anti_2	301	306	PF11976	0.277
LIG_SUMO_SIM_anti_2	363	369	PF11976	0.422
LIG_SUMO_SIM_anti_2	539	546	PF11976	0.467
LIG_SUMO_SIM_par_1	539	546	PF11976	0.467
LIG_TRAF2_1	293	296	PF00917	0.259
LIG_TRAF2_1	472	475	PF00917	0.617
LIG_TRFH_1	188	192	PF08558	0.584
LIG_WRC_WIRS_1	291	296	PF05994	0.259
MOD_CDC14_SPxK_1	400	403	PF00782	0.646
MOD_CDK_SPK_2	248	253	PF00069	0.564
MOD_CDK_SPxK_1	397	403	PF00069	0.643
MOD_CDK_SPxxK_3	125	132	PF00069	0.488
MOD_CDK_SPxxK_3	188	195	PF00069	0.544
MOD_CK1_1	212	218	PF00069	0.531
MOD_CK1_1	220	226	PF00069	0.500
MOD_CK1_1	264	270	PF00069	0.285
MOD_CK1_1	360	366	PF00069	0.393
MOD_CK2_1	290	296	PF00069	0.277
MOD_CK2_1	481	487	PF00069	0.606
MOD_GlcNHglycan	120	123	PF01048	0.607
MOD_GlcNHglycan	211	214	PF01048	0.518
MOD_GlcNHglycan	216	219	PF01048	0.560
MOD_GlcNHglycan	362	365	PF01048	0.393
MOD_GlcNHglycan	524	527	PF01048	0.549
MOD_GSK3_1	254	261	PF00069	0.554
MOD_GSK3_1	275	282	PF00069	0.259
MOD_GSK3_1	388	395	PF00069	0.464
MOD_GSK3_1	43	50	PF00069	0.602
MOD_GSK3_1	524	531	PF00069	0.547
MOD_GSK3_1	615	622	PF00069	0.588
MOD_N-GLC_1	481	486	PF02516	0.550
MOD_NEK2_1	1	6	PF00069	0.596
MOD_NEK2_1	258	263	PF00069	0.317
MOD_NEK2_1	316	321	PF00069	0.294
MOD_NEK2_1	357	362	PF00069	0.302
MOD_NEK2_1	392	397	PF00069	0.487
MOD_NEK2_1	596	601	PF00069	0.447
MOD_NEK2_2	169	174	PF00069	0.586
MOD_NEK2_2	254	259	PF00069	0.560
MOD_PIKK_1	235	241	PF00454	0.506
MOD_PIKK_1	392	398	PF00454	0.476
MOD_PIKK_1	419	425	PF00454	0.662
MOD_PKA_1	336	342	PF00069	0.259
MOD_PKA_2	1	7	PF00069	0.569
MOD_PKA_2	209	215	PF00069	0.512
MOD_PKA_2	258	264	PF00069	0.245
MOD_PKA_2	336	342	PF00069	0.283
MOD_PKA_2	360	366	PF00069	0.393
MOD_PKA_2	419	425	PF00069	0.662
MOD_PKA_2	490	496	PF00069	0.658
MOD_PKA_2	556	562	PF00069	0.424
MOD_Plk_1	137	143	PF00069	0.560
MOD_Plk_1	197	203	PF00069	0.546
MOD_Plk_1	298	304	PF00069	0.471
MOD_Plk_1	480	486	PF00069	0.603
MOD_Plk_2-3	388	394	PF00069	0.463
MOD_Plk_2-3	481	487	PF00069	0.548
MOD_Plk_2-3	556	562	PF00069	0.424
MOD_Plk_4	264	270	PF00069	0.315
MOD_Plk_4	336	342	PF00069	0.259
MOD_Plk_4	405	411	PF00069	0.559
MOD_Plk_4	463	469	PF00069	0.478
MOD_ProDKin_1	125	131	PF00069	0.478
MOD_ProDKin_1	188	194	PF00069	0.547
MOD_ProDKin_1	248	254	PF00069	0.652
MOD_ProDKin_1	261	267	PF00069	0.230
MOD_ProDKin_1	343	349	PF00069	0.241
MOD_ProDKin_1	397	403	PF00069	0.643
MOD_SUMO_for_1	472	475	PF00179	0.638
MOD_SUMO_rev_2	228	237	PF00179	0.507
MOD_SUMO_rev_2	540	549	PF00179	0.460
MOD_SUMO_rev_2	72	82	PF00179	0.406
TRG_DiLeu_BaEn_1	138	143	PF01217	0.479
TRG_DiLeu_BaEn_2	153	159	PF01217	0.491
TRG_DiLeu_BaEn_4	138	144	PF01217	0.558
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.459
TRG_ENDOCYTIC_2	116	119	PF00928	0.452
TRG_ENDOCYTIC_2	155	158	PF00928	0.481
TRG_ENDOCYTIC_2	185	188	PF00928	0.520
TRG_ENDOCYTIC_2	431	434	PF00928	0.579
TRG_ENDOCYTIC_2	603	606	PF00928	0.534
TRG_ER_diArg_1	143	145	PF00400	0.489
TRG_ER_diArg_1	15	18	PF00400	0.439
TRG_ER_diArg_1	175	177	PF00400	0.560
TRG_ER_diArg_1	5	8	PF00400	0.601
TRG_ER_diArg_1	613	615	PF00400	0.563
TRG_NLS_Bipartite_1	156	178	PF00514	0.496
TRG_NLS_MonoExtC_3	173	178	PF00514	0.554
TRG_Pf-PMV_PEXEL_1	145	150	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	604	608	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDJ3	Leptomonas seymouri	85%	100%
A0A0S4JNA4	Bodo saltans	71%	100%
A0A1X0P3D3	Trypanosomatidae	75%	100%
A0A3S7XBD0	Leishmania donovani	98%	100%
A4HPP0	Leishmania braziliensis	94%	100%
A4ID24	Leishmania infantum	98%	100%
D0A8H4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
E9ATF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5B9N8	Trypanosoma cruzi	77%	100%