LeishMANIAdb
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Putative 40S ribosomal protein S27-1

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative 40S ribosomal protein S27-1
Gene product:
40S ribosomal protein S27-1, putative
Species:
Leishmania major
UniProt:
Q4Q140_LEIMA
TriTrypDb:
LmjF.36.3750 , LMJLV39_360048200 , LMJSD75_180011400
Length:
86

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 40S ribosomal S27-1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 32
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0015935 small ribosomal subunit 4 2
GO:0022627 cytosolic small ribosomal subunit 5 2
GO:0032991 protein-containing complex 1 2
GO:0044391 ribosomal subunit 3 2
GO:1990904 ribonucleoprotein complex 2 2
GO:0005840 ribosome 5 6
GO:0043226 organelle 2 6
GO:0043228 non-membrane-bounded organelle 3 6
GO:0043229 intracellular organelle 3 6
GO:0043232 intracellular non-membrane-bounded organelle 4 6
GO:0110165 cellular anatomical entity 1 6

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

Q4Q140
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q140

PDB structure(s): 6az1_c

Function

Biological processes
Term Name Level Count
GO:0000028 ribosomal small subunit assembly 7 2
GO:0006412 translation 4 8
GO:0006518 peptide metabolic process 4 8
GO:0006807 nitrogen compound metabolic process 2 8
GO:0008152 metabolic process 1 8
GO:0009058 biosynthetic process 2 8
GO:0009059 macromolecule biosynthetic process 4 8
GO:0009987 cellular process 1 8
GO:0016043 cellular component organization 3 2
GO:0019538 protein metabolic process 3 8
GO:0022607 cellular component assembly 4 2
GO:0022618 ribonucleoprotein complex assembly 6 2
GO:0034641 cellular nitrogen compound metabolic process 3 8
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 8
GO:0043043 peptide biosynthetic process 5 8
GO:0043170 macromolecule metabolic process 3 8
GO:0043603 amide metabolic process 3 8
GO:0043604 amide biosynthetic process 4 8
GO:0043933 protein-containing complex organization 4 2
GO:0044237 cellular metabolic process 2 8
GO:0044238 primary metabolic process 2 8
GO:0044249 cellular biosynthetic process 3 8
GO:0044260 obsolete cellular macromolecule metabolic process 3 8
GO:0044271 cellular nitrogen compound biosynthetic process 4 8
GO:0065003 protein-containing complex assembly 5 2
GO:0071704 organic substance metabolic process 2 8
GO:0071826 ribonucleoprotein complex subunit organization 5 2
GO:0071840 cellular component organization or biogenesis 2 2
GO:1901564 organonitrogen compound metabolic process 3 8
GO:1901566 organonitrogen compound biosynthetic process 4 8
GO:1901576 organic substance biosynthetic process 3 8
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 2
GO:0003723 RNA binding 4 2
GO:0003735 structural constituent of ribosome 2 8
GO:0005198 structural molecule activity 1 8
GO:0005488 binding 1 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 23 25 PF00675 0.408
CLV_NRD_NRD_1 81 83 PF00675 0.237
CLV_PCSK_KEX2_1 21 23 PF00082 0.394
CLV_PCSK_KEX2_1 81 83 PF00082 0.314
CLV_PCSK_PC1ET2_1 21 23 PF00082 0.392
CLV_PCSK_PC7_1 17 23 PF00082 0.387
CLV_PCSK_SKI1_1 42 46 PF00082 0.293
CLV_PCSK_SKI1_1 71 75 PF00082 0.233
DOC_USP7_MATH_1 51 55 PF00917 0.262
DOC_USP7_UBL2_3 58 62 PF12436 0.314
LIG_14-3-3_CanoR_1 42 47 PF00244 0.314
LIG_FHA_1 50 56 PF00498 0.233
LIG_FHA_2 51 57 PF00498 0.314
LIG_LIR_Gen_1 31 39 PF02991 0.237
LIG_LIR_Nem_3 31 36 PF02991 0.237
LIG_LIR_Nem_3 7 13 PF02991 0.358
LIG_LYPXL_yS_3 10 13 PF13949 0.356
LIG_SH2_NCK_1 48 52 PF00017 0.233
LIG_SH2_STAT5 32 35 PF00017 0.269
LIG_SH3_3 23 29 PF00018 0.366
LIG_SH3_3 33 39 PF00018 0.233
LIG_TYR_ITIM 8 13 PF00017 0.359
MOD_CK1_1 49 55 PF00069 0.256
MOD_CK1_1 9 15 PF00069 0.372
MOD_CK2_1 50 56 PF00069 0.314
MOD_GSK3_1 42 49 PF00069 0.236
MOD_NEK2_1 34 39 PF00069 0.314
MOD_PKA_2 65 71 PF00069 0.233
MOD_PKB_1 40 48 PF00069 0.314
MOD_Plk_1 6 12 PF00069 0.361
MOD_Plk_4 28 34 PF00069 0.245
MOD_Plk_4 42 48 PF00069 0.243
TRG_ENDOCYTIC_2 10 13 PF00928 0.356
TRG_ER_diArg_1 22 24 PF00400 0.417
TRG_ER_diArg_1 39 42 PF00400 0.314
TRG_ER_diArg_1 80 82 PF00400 0.314
TRG_NLS_MonoCore_2 20 25 PF00514 0.378
TRG_NLS_MonoExtN_4 19 25 PF00514 0.375
TRG_Pf-PMV_PEXEL_1 23 27 PF00026 0.374

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1D8PTI7 Candida albicans (strain SC5314 / ATCC MYA-2876) 56% 100%
A0A381MWU3 Leishmania infantum 100% 100%
A0A3Q8ID11 Leishmania donovani 100% 100%
A4H9G9 Leishmania braziliensis 99% 100%
D0A8H1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 80% 100%
E9ATF7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 100% 100%
O64650 Arabidopsis thaliana 54% 100%
O74330 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 56% 100%
P24051 Rattus norvegicus 62% 100%
P35997 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 58% 100%
P38654 Entamoeba histolytica 42% 100%
P38711 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 58% 100%
P42677 Homo sapiens 62% 100%
P47903 Chlamydomonas reinhardtii 54% 100%
P47904 Xenopus laevis 64% 100%
P55833 Homarus americanus 54% 100%
Q2KHT7 Bos taurus 62% 100%
Q3T0B7 Bos taurus 62% 100%
Q5RBK1 Pongo abelii 61% 100%
Q6ZWU9 Mus musculus 62% 100%
Q6ZWY3 Mus musculus 62% 100%
Q71TY3 Rattus norvegicus 62% 100%
Q71UM5 Homo sapiens 62% 100%
Q7RVN2 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 54% 100%
Q8L953 Arabidopsis thaliana 54% 100%
Q8T1V4 Dictyostelium discoideum 49% 100%
Q96564 Hordeum vulgare 57% 100%
Q973F9 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 43% 100%
Q97Z80 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 41% 100%
Q9M2F1 Arabidopsis thaliana 56% 100%
Q9TXP0 Caenorhabditis elegans 54% 100%
V5BWH4 Trypanosoma cruzi 77% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS