Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q136_LEIMA

TriTrypDb:

LmjF.36.3790 , LMJLV39_360048600 , LMJSD75_360048300

Length:

943

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q136

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q136

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.333
CLV_C14_Caspase3-7	448	452	PF00656	0.593
CLV_C14_Caspase3-7	50	54	PF00656	0.378
CLV_C14_Caspase3-7	576	580	PF00656	0.536
CLV_NRD_NRD_1	147	149	PF00675	0.502
CLV_NRD_NRD_1	476	478	PF00675	0.485
CLV_NRD_NRD_1	593	595	PF00675	0.505
CLV_NRD_NRD_1	61	63	PF00675	0.423
CLV_NRD_NRD_1	715	717	PF00675	0.439
CLV_NRD_NRD_1	79	81	PF00675	0.362
CLV_NRD_NRD_1	840	842	PF00675	0.627
CLV_NRD_NRD_1	931	933	PF00675	0.450
CLV_NRD_NRD_1	937	939	PF00675	0.482
CLV_PCSK_FUR_1	591	595	PF00082	0.557
CLV_PCSK_KEX2_1	147	149	PF00082	0.502
CLV_PCSK_KEX2_1	593	595	PF00082	0.510
CLV_PCSK_KEX2_1	61	63	PF00082	0.423
CLV_PCSK_KEX2_1	714	716	PF00082	0.446
CLV_PCSK_KEX2_1	79	81	PF00082	0.362
CLV_PCSK_KEX2_1	840	842	PF00082	0.627
CLV_PCSK_KEX2_1	931	933	PF00082	0.450
CLV_PCSK_SKI1_1	181	185	PF00082	0.634
CLV_PCSK_SKI1_1	266	270	PF00082	0.564
CLV_PCSK_SKI1_1	429	433	PF00082	0.497
CLV_PCSK_SKI1_1	45	49	PF00082	0.327
CLV_PCSK_SKI1_1	478	482	PF00082	0.490
CLV_PCSK_SKI1_1	486	490	PF00082	0.420
CLV_PCSK_SKI1_1	716	720	PF00082	0.533
CLV_PCSK_SKI1_1	731	735	PF00082	0.389
CLV_PCSK_SKI1_1	753	757	PF00082	0.514
CLV_PCSK_SKI1_1	883	887	PF00082	0.563
DEG_APCC_DBOX_1	319	327	PF00400	0.460
DEG_APCC_DBOX_1	485	493	PF00400	0.436
DEG_Nend_UBRbox_1	1	4	PF02207	0.512
DEG_SCF_TRCP1_1	176	182	PF00400	0.675
DEG_SPOP_SBC_1	216	220	PF00917	0.630
DOC_CYCLIN_RxL_1	42	51	PF00134	0.341
DOC_CYCLIN_RxL_1	483	494	PF00134	0.442
DOC_CYCLIN_RxL_1	747	759	PF00134	0.518
DOC_MAPK_gen_1	147	153	PF00069	0.531
DOC_MAPK_MEF2A_6	35	43	PF00069	0.318
DOC_MAPK_MEF2A_6	99	108	PF00069	0.378
DOC_MAPK_RevD_3	920	933	PF00069	0.559
DOC_PP2B_LxvP_1	205	208	PF13499	0.615
DOC_PP2B_LxvP_1	223	226	PF13499	0.562
DOC_PP2B_LxvP_1	293	296	PF13499	0.594
DOC_PP2B_LxvP_1	818	821	PF13499	0.532
DOC_PP2B_LxvP_1	896	899	PF13499	0.659
DOC_PP4_FxxP_1	124	127	PF00568	0.398
DOC_USP7_MATH_1	208	212	PF00917	0.784
DOC_USP7_MATH_1	216	220	PF00917	0.684
DOC_USP7_MATH_1	268	272	PF00917	0.667
DOC_USP7_MATH_1	281	285	PF00917	0.692
DOC_USP7_MATH_1	302	306	PF00917	0.570
DOC_USP7_MATH_1	442	446	PF00917	0.560
DOC_USP7_MATH_1	447	451	PF00917	0.709
DOC_USP7_MATH_1	531	535	PF00917	0.588
DOC_USP7_MATH_1	766	770	PF00917	0.636
DOC_USP7_MATH_1	773	777	PF00917	0.691
DOC_USP7_MATH_1	806	810	PF00917	0.606
DOC_USP7_MATH_1	827	831	PF00917	0.769
DOC_USP7_MATH_1	861	865	PF00917	0.623
DOC_USP7_MATH_1	903	907	PF00917	0.660
DOC_USP7_MATH_2	536	542	PF00917	0.542
DOC_WW_Pin1_4	135	140	PF00397	0.391
DOC_WW_Pin1_4	185	190	PF00397	0.577
DOC_WW_Pin1_4	197	202	PF00397	0.579
DOC_WW_Pin1_4	23	28	PF00397	0.357
DOC_WW_Pin1_4	261	266	PF00397	0.691
DOC_WW_Pin1_4	306	311	PF00397	0.599
DOC_WW_Pin1_4	386	391	PF00397	0.576
DOC_WW_Pin1_4	758	763	PF00397	0.531
DOC_WW_Pin1_4	802	807	PF00397	0.634
DOC_WW_Pin1_4	823	828	PF00397	0.723
DOC_WW_Pin1_4	855	860	PF00397	0.629
DOC_WW_Pin1_4	899	904	PF00397	0.590
LIG_14-3-3_CanoR_1	147	153	PF00244	0.432
LIG_14-3-3_CanoR_1	185	189	PF00244	0.604
LIG_14-3-3_CanoR_1	2	10	PF00244	0.437
LIG_14-3-3_CanoR_1	279	289	PF00244	0.614
LIG_14-3-3_CanoR_1	347	353	PF00244	0.439
LIG_14-3-3_CanoR_1	808	815	PF00244	0.645
LIG_14-3-3_CanoR_1	825	834	PF00244	0.541
LIG_14-3-3_CanoR_1	873	882	PF00244	0.647
LIG_14-3-3_CanoR_1	883	891	PF00244	0.548
LIG_14-3-3_CanoR_1	905	914	PF00244	0.671
LIG_Actin_WH2_2	481	498	PF00022	0.434
LIG_APCC_ABBA_1	408	413	PF00400	0.470
LIG_BRCT_BRCA1_1	533	537	PF00533	0.551
LIG_eIF4E_1	100	106	PF01652	0.330
LIG_eIF4E_1	313	319	PF01652	0.525
LIG_FHA_1	307	313	PF00498	0.448
LIG_FHA_1	42	48	PF00498	0.339
LIG_FHA_1	566	572	PF00498	0.526
LIG_FHA_1	648	654	PF00498	0.505
LIG_FHA_1	732	738	PF00498	0.532
LIG_FHA_1	746	752	PF00498	0.425
LIG_FHA_1	885	891	PF00498	0.687
LIG_FHA_2	446	452	PF00498	0.472
LIG_FHA_2	752	758	PF00498	0.433
LIG_FHA_2	827	833	PF00498	0.690
LIG_FHA_2	873	879	PF00498	0.605
LIG_GBD_Chelix_1	570	578	PF00786	0.509
LIG_LIR_Apic_2	123	127	PF02991	0.386
LIG_LIR_Gen_1	524	531	PF02991	0.572
LIG_LIR_Gen_1	813	823	PF02991	0.532
LIG_LIR_Nem_3	29	34	PF02991	0.354
LIG_LIR_Nem_3	524	529	PF02991	0.572
LIG_LIR_Nem_3	813	818	PF02991	0.531
LIG_NRBOX	659	665	PF00104	0.432
LIG_PDZ_Class_3	938	943	PF00595	0.530
LIG_Pex14_2	120	124	PF04695	0.385
LIG_SH2_CRK	815	819	PF00017	0.666
LIG_SH2_STAP1	421	425	PF00017	0.431
LIG_SH2_STAP1	458	462	PF00017	0.557
LIG_SH2_STAT5	100	103	PF00017	0.363
LIG_SH2_STAT5	109	112	PF00017	0.286
LIG_SH2_STAT5	313	316	PF00017	0.531
LIG_SH2_STAT5	40	43	PF00017	0.289
LIG_SH2_STAT5	512	515	PF00017	0.483
LIG_SH2_STAT5	667	670	PF00017	0.474
LIG_SH3_2	201	206	PF14604	0.586
LIG_SH3_3	124	130	PF00018	0.389
LIG_SH3_3	198	204	PF00018	0.590
LIG_SUMO_SIM_anti_2	657	665	PF11976	0.499
LIG_SUMO_SIM_par_1	140	146	PF11976	0.445
LIG_SUMO_SIM_par_1	488	494	PF11976	0.463
LIG_SUMO_SIM_par_1	568	576	PF11976	0.498
LIG_TRAF2_1	457	460	PF00917	0.497
LIG_TRAF2_1	625	628	PF00917	0.415
LIG_TYR_ITIM	107	112	PF00017	0.312
LIG_TYR_ITIM	38	43	PF00017	0.309
LIG_WW_3	225	229	PF00397	0.558
MOD_CDC14_SPxK_1	902	905	PF00782	0.629
MOD_CDK_SPK_2	261	266	PF00069	0.632
MOD_CDK_SPxK_1	802	808	PF00069	0.667
MOD_CDK_SPxK_1	899	905	PF00069	0.621
MOD_CDK_SPxxK_3	23	30	PF00069	0.345
MOD_CK1_1	138	144	PF00069	0.387
MOD_CK1_1	154	160	PF00069	0.577
MOD_CK1_1	188	194	PF00069	0.591
MOD_CK1_1	215	221	PF00069	0.605
MOD_CK1_1	251	257	PF00069	0.613
MOD_CK1_1	261	267	PF00069	0.634
MOD_CK1_1	445	451	PF00069	0.598
MOD_CK1_1	494	500	PF00069	0.561
MOD_CK1_1	524	530	PF00069	0.535
MOD_CK1_1	541	547	PF00069	0.557
MOD_CK1_1	813	819	PF00069	0.703
MOD_CK1_1	826	832	PF00069	0.582
MOD_CK1_1	862	868	PF00069	0.660
MOD_CK1_1	872	878	PF00069	0.614
MOD_CK1_1	906	912	PF00069	0.615
MOD_CK1_1	915	921	PF00069	0.614
MOD_CK2_1	281	287	PF00069	0.614
MOD_CK2_1	707	713	PF00069	0.534
MOD_CK2_1	729	735	PF00069	0.529
MOD_CK2_1	751	757	PF00069	0.428
MOD_CK2_1	827	833	PF00069	0.553
MOD_CK2_1	872	878	PF00069	0.609
MOD_CK2_1	922	928	PF00069	0.532
MOD_GlcNHglycan	176	179	PF01048	0.739
MOD_GlcNHglycan	214	217	PF01048	0.601
MOD_GlcNHglycan	236	239	PF01048	0.621
MOD_GlcNHglycan	283	286	PF01048	0.632
MOD_GlcNHglycan	348	351	PF01048	0.606
MOD_GlcNHglycan	451	454	PF01048	0.590
MOD_GlcNHglycan	550	553	PF01048	0.547
MOD_GlcNHglycan	575	578	PF01048	0.565
MOD_GlcNHglycan	731	734	PF01048	0.524
MOD_GlcNHglycan	763	766	PF01048	0.567
MOD_GlcNHglycan	768	771	PF01048	0.607
MOD_GlcNHglycan	774	778	PF01048	0.700
MOD_GlcNHglycan	789	792	PF01048	0.726
MOD_GlcNHglycan	849	852	PF01048	0.633
MOD_GlcNHglycan	865	868	PF01048	0.602
MOD_GlcNHglycan	914	917	PF01048	0.656
MOD_GlcNHglycan	924	927	PF01048	0.483
MOD_GSK3_1	151	158	PF00069	0.573
MOD_GSK3_1	181	188	PF00069	0.608
MOD_GSK3_1	191	198	PF00069	0.605
MOD_GSK3_1	208	215	PF00069	0.508
MOD_GSK3_1	229	236	PF00069	0.620
MOD_GSK3_1	251	258	PF00069	0.578
MOD_GSK3_1	302	309	PF00069	0.509
MOD_GSK3_1	445	452	PF00069	0.514
MOD_GSK3_1	490	497	PF00069	0.484
MOD_GSK3_1	512	519	PF00069	0.550
MOD_GSK3_1	643	650	PF00069	0.472
MOD_GSK3_1	69	76	PF00069	0.345
MOD_GSK3_1	741	748	PF00069	0.452
MOD_GSK3_1	756	763	PF00069	0.674
MOD_GSK3_1	773	780	PF00069	0.521
MOD_GSK3_1	802	809	PF00069	0.781
MOD_GSK3_1	810	817	PF00069	0.635
MOD_GSK3_1	82	89	PF00069	0.356
MOD_GSK3_1	823	830	PF00069	0.573
MOD_GSK3_1	855	862	PF00069	0.678
MOD_GSK3_1	865	872	PF00069	0.607
MOD_GSK3_1	899	906	PF00069	0.632
MOD_GSK3_1	908	915	PF00069	0.689
MOD_GSK3_1	918	925	PF00069	0.466
MOD_LATS_1	325	331	PF00433	0.482
MOD_LATS_1	845	851	PF00433	0.625
MOD_N-GLC_1	69	74	PF02516	0.347
MOD_N-GLC_1	741	746	PF02516	0.604
MOD_NEK2_1	209	214	PF00069	0.613
MOD_NEK2_1	269	274	PF00069	0.559
MOD_NEK2_1	332	337	PF00069	0.482
MOD_NEK2_1	346	351	PF00069	0.437
MOD_NEK2_1	370	375	PF00069	0.442
MOD_NEK2_1	41	46	PF00069	0.340
MOD_NEK2_1	488	493	PF00069	0.454
MOD_NEK2_1	495	500	PF00069	0.509
MOD_NEK2_1	529	534	PF00069	0.616
MOD_NEK2_1	643	648	PF00069	0.462
MOD_NEK2_1	73	78	PF00069	0.335
MOD_NEK2_1	751	756	PF00069	0.492
MOD_NEK2_1	814	819	PF00069	0.536
MOD_NEK2_1	922	927	PF00069	0.609
MOD_NEK2_2	348	353	PF00069	0.454
MOD_NEK2_2	903	908	PF00069	0.552
MOD_PIKK_1	311	317	PF00454	0.576
MOD_PIKK_1	327	333	PF00454	0.466
MOD_PIKK_1	351	357	PF00454	0.383
MOD_PIKK_1	414	420	PF00454	0.506
MOD_PIKK_1	603	609	PF00454	0.572
MOD_PIKK_1	627	633	PF00454	0.493
MOD_PIKK_1	736	742	PF00454	0.513
MOD_PIKK_1	780	786	PF00454	0.650
MOD_PIKK_1	86	92	PF00454	0.396
MOD_PKA_1	61	67	PF00069	0.398
MOD_PKA_2	146	152	PF00069	0.415
MOD_PKA_2	184	190	PF00069	0.599
MOD_PKA_2	209	215	PF00069	0.613
MOD_PKA_2	251	257	PF00069	0.639
MOD_PKA_2	337	343	PF00069	0.503
MOD_PKA_2	346	352	PF00069	0.467
MOD_PKA_2	495	501	PF00069	0.502
MOD_PKA_2	565	571	PF00069	0.528
MOD_PKA_2	61	67	PF00069	0.398
MOD_PKA_2	670	676	PF00069	0.536
MOD_PKA_2	780	786	PF00069	0.650
MOD_PKA_2	807	813	PF00069	0.664
MOD_PKA_2	872	878	PF00069	0.646
MOD_PKA_2	907	913	PF00069	0.659
MOD_Plk_1	269	275	PF00069	0.624
MOD_Plk_1	370	376	PF00069	0.514
MOD_Plk_1	403	409	PF00069	0.602
MOD_Plk_1	421	427	PF00069	0.326
MOD_Plk_1	458	464	PF00069	0.549
MOD_Plk_1	69	75	PF00069	0.346
MOD_Plk_1	741	747	PF00069	0.425
MOD_Plk_1	756	762	PF00069	0.426
MOD_Plk_4	138	144	PF00069	0.386
MOD_Plk_4	269	275	PF00069	0.624
MOD_Plk_4	295	301	PF00069	0.635
MOD_Plk_4	4	10	PF00069	0.408
MOD_Plk_4	810	816	PF00069	0.622
MOD_Plk_4	918	924	PF00069	0.633
MOD_ProDKin_1	135	141	PF00069	0.385
MOD_ProDKin_1	185	191	PF00069	0.577
MOD_ProDKin_1	197	203	PF00069	0.579
MOD_ProDKin_1	23	29	PF00069	0.362
MOD_ProDKin_1	261	267	PF00069	0.690
MOD_ProDKin_1	306	312	PF00069	0.593
MOD_ProDKin_1	386	392	PF00069	0.573
MOD_ProDKin_1	758	764	PF00069	0.535
MOD_ProDKin_1	802	808	PF00069	0.637
MOD_ProDKin_1	823	829	PF00069	0.724
MOD_ProDKin_1	855	861	PF00069	0.626
MOD_ProDKin_1	899	905	PF00069	0.596
MOD_SUMO_for_1	357	360	PF00179	0.512
TRG_DiLeu_BaEn_1	659	664	PF01217	0.496
TRG_DiLeu_BaEn_1	838	843	PF01217	0.643
TRG_DiLeu_LyEn_5	838	843	PF01217	0.643
TRG_ENDOCYTIC_2	109	112	PF00928	0.315
TRG_ENDOCYTIC_2	31	34	PF00928	0.336
TRG_ENDOCYTIC_2	40	43	PF00928	0.309
TRG_ENDOCYTIC_2	815	818	PF00928	0.533
TRG_ER_diArg_1	591	594	PF00400	0.501
TRG_ER_diArg_1	714	716	PF00400	0.601
TRG_ER_diArg_1	78	80	PF00400	0.359
TRG_ER_diArg_1	840	842	PF00400	0.691
TRG_NES_CRM1_1	33	46	PF08389	0.325
TRG_Pf-PMV_PEXEL_1	2	6	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	45	50	PF00026	0.277
TRG_Pf-PMV_PEXEL_1	753	757	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	840	844	PF00026	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3T9	Leptomonas seymouri	38%	96%
A0A3S7XBB6	Leishmania donovani	88%	98%
A4HPP7	Leishmania braziliensis	65%	99%
A4ID17	Leishmania infantum	88%	98%
E9ATG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%