RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania major

UniProt:

Q4Q132_LEIMA

TriTrypDb:

LmjF.36.3830 , LMJLV39_360048900 , LMJSD75_360048700

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q132

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q132

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.367
CLV_NRD_NRD_1	23	25	PF00675	0.697
CLV_PCSK_KEX2_1	23	25	PF00082	0.697
CLV_PCSK_KEX2_1	293	295	PF00082	0.446
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.434
CLV_PCSK_SKI1_1	76	80	PF00082	0.579
DEG_APCC_DBOX_1	148	156	PF00400	0.479
DOC_CKS1_1	239	244	PF01111	0.700
DOC_MAPK_gen_1	293	301	PF00069	0.357
DOC_PP2B_LxvP_1	171	174	PF13499	0.504
DOC_USP7_MATH_1	216	220	PF00917	0.697
DOC_USP7_MATH_1	257	261	PF00917	0.670
DOC_USP7_MATH_1	93	97	PF00917	0.684
DOC_USP7_UBL2_3	42	46	PF12436	0.646
DOC_WW_Pin1_4	153	158	PF00397	0.591
DOC_WW_Pin1_4	16	21	PF00397	0.663
DOC_WW_Pin1_4	230	235	PF00397	0.727
DOC_WW_Pin1_4	238	243	PF00397	0.672
LIG_14-3-3_CanoR_1	117	122	PF00244	0.436
LIG_14-3-3_CanoR_1	15	20	PF00244	0.731
LIG_14-3-3_CanoR_1	23	29	PF00244	0.624
LIG_14-3-3_CanoR_1	259	266	PF00244	0.623
LIG_14-3-3_CanoR_1	294	298	PF00244	0.353
LIG_14-3-3_CanoR_1	92	98	PF00244	0.487
LIG_BRCT_BRCA1_1	119	123	PF00533	0.434
LIG_BRCT_BRCA1_1	95	99	PF00533	0.696
LIG_Clathr_ClatBox_1	112	116	PF01394	0.434
LIG_DLG_GKlike_1	117	124	PF00625	0.402
LIG_FHA_1	256	262	PF00498	0.597
LIG_FHA_1	294	300	PF00498	0.349
LIG_FHA_1	45	51	PF00498	0.568
LIG_FHA_1	70	76	PF00498	0.532
LIG_FHA_2	173	179	PF00498	0.507
LIG_FHA_2	189	195	PF00498	0.607
LIG_FHA_2	59	65	PF00498	0.567
LIG_LIR_Gen_1	120	129	PF02991	0.448
LIG_LIR_Nem_3	120	124	PF02991	0.448
LIG_LIR_Nem_3	271	275	PF02991	0.441
LIG_SH2_CRK	121	125	PF00017	0.355
LIG_SH2_CRK	272	276	PF00017	0.447
LIG_SH2_STAT5	288	291	PF00017	0.480
LIG_SH2_STAT5	49	52	PF00017	0.568
LIG_SH3_3	206	212	PF00018	0.627
LIG_SH3_3	236	242	PF00018	0.778
LIG_SH3_3	274	280	PF00018	0.432
LIG_SH3_3	34	40	PF00018	0.576
MOD_CDK_SPxxK_3	16	23	PF00069	0.726
MOD_CK1_1	225	231	PF00069	0.704
MOD_CK1_1	248	254	PF00069	0.646
MOD_CK1_1	87	93	PF00069	0.615
MOD_CK2_1	188	194	PF00069	0.527
MOD_CK2_1	23	29	PF00069	0.775
MOD_GlcNHglycan	104	107	PF01048	0.595
MOD_GlcNHglycan	217	221	PF01048	0.709
MOD_GlcNHglycan	8	11	PF01048	0.531
MOD_GSK3_1	153	160	PF00069	0.615
MOD_GSK3_1	255	262	PF00069	0.649
MOD_GSK3_1	288	295	PF00069	0.382
MOD_GSK3_1	87	94	PF00069	0.539
MOD_N-GLC_1	157	162	PF02516	0.585
MOD_N-GLC_1	223	228	PF02516	0.777
MOD_NEK2_1	246	251	PF00069	0.699
MOD_NEK2_1	286	291	PF00069	0.447
MOD_NEK2_2	93	98	PF00069	0.489
MOD_NMyristoyl	1	7	PF02799	0.635
MOD_OFUCOSY	126	131	PF10250	0.391
MOD_OFUCOSY	290	297	PF10250	0.335
MOD_PIKK_1	188	194	PF00454	0.544
MOD_PIKK_1	288	294	PF00454	0.363
MOD_PK_1	24	30	PF00069	0.754
MOD_PKA_1	23	29	PF00069	0.759
MOD_PKA_1	293	299	PF00069	0.446
MOD_PKA_2	188	194	PF00069	0.619
MOD_PKA_2	23	29	PF00069	0.666
MOD_PKA_2	293	299	PF00069	0.344
MOD_PKA_2	91	97	PF00069	0.570
MOD_Plk_2-3	29	35	PF00069	0.754
MOD_Plk_4	172	178	PF00069	0.530
MOD_Plk_4	58	64	PF00069	0.582
MOD_ProDKin_1	153	159	PF00069	0.593
MOD_ProDKin_1	16	22	PF00069	0.665
MOD_ProDKin_1	230	236	PF00069	0.731
MOD_ProDKin_1	238	244	PF00069	0.671
TRG_ENDOCYTIC_2	121	124	PF00928	0.355
TRG_ENDOCYTIC_2	272	275	PF00928	0.447
TRG_ER_diArg_1	186	189	PF00400	0.587
TRG_ER_diArg_1	23	25	PF00400	0.697
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYK3	Leptomonas seymouri	52%	98%
A0A0S4JLL7	Bodo saltans	34%	100%
A0A1X0P3L1	Trypanosomatidae	41%	100%
A0A3Q8IJF1	Leishmania donovani	95%	100%
A4HPQ0	Leishmania braziliensis	77%	100%
A4ID13	Leishmania infantum	95%	100%
D0A8G4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ATG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BIP2	Trypanosoma cruzi	33%	100%