LeishMANIAdb
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Glycine--tRNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glycine--tRNA ligase
Gene product:
glycyl tRNA synthetase, putative
Species:
Leishmania major
UniProt:
Q4Q131_LEIMA
TriTrypDb:
LmjF.36.3840 , LMJLV39_360049100 * , LMJSD75_360048900
Length:
628

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. yes yes: 2
Pissara et al. yes yes: 8
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. yes yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 4
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 12
GO:0005739 mitochondrion 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 12
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Expansion

Sequence features

Q4Q131
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q131

Function

Biological processes
TermNameLevelCount
GO:0000959 mitochondrial RNA metabolic process 6 2
GO:0006082 organic acid metabolic process 3 12
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006399 tRNA metabolic process 7 12
GO:0006418 tRNA aminoacylation for protein translation 6 12
GO:0006426 glycyl-tRNA aminoacylation 7 12
GO:0006520 amino acid metabolic process 3 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004812 aminoacyl-tRNA ligase activity 4 12
GO:0004820 glycine-tRNA ligase activity 5 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016874 ligase activity 2 12
GO:0016875 ligase activity, forming carbon-oxygen bonds 3 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 25 27 PF00675 0.600
CLV_NRD_NRD_1 490 492 PF00675 0.442
CLV_PCSK_KEX2_1 203 205 PF00082 0.416
CLV_PCSK_KEX2_1 24 26 PF00082 0.604
CLV_PCSK_KEX2_1 490 492 PF00082 0.442
CLV_PCSK_KEX2_1 499 501 PF00082 0.419
CLV_PCSK_PC1ET2_1 203 205 PF00082 0.416
CLV_PCSK_PC1ET2_1 499 501 PF00082 0.419
CLV_PCSK_SKI1_1 150 154 PF00082 0.678
CLV_PCSK_SKI1_1 232 236 PF00082 0.418
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HZB0 Leptomonas seymouri 85% 95%
A0A0S4JJA5 Bodo saltans 66% 100%
A0A1X0P3R2 Trypanosomatidae 72% 100%
A0A3Q8IPA6 Leishmania donovani 97% 100%
A0A422MT81 Trypanosoma rangeli 70% 100%
A0B5U4 Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) 37% 100%
A4FZX1 Methanococcus maripaludis (strain C5 / ATCC BAA-1333) 37% 100%
A4HPQ1 Leishmania braziliensis 93% 100%
A4ID12 Leishmania infantum 98% 100%
A6URK3 Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) 37% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS