Charged multivesicular body protein 4b

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Snf7, putative

Species:

Leishmania major

UniProt:

Q4Q130_LEIMA

TriTrypDb:

LmjF.36.3850 , LMJLV39_360049200 , LMJSD75_360049000

Length:

225

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000815	ESCRT III complex	3	2
GO:0005768	endosome	7	2
GO:0005770	late endosome	8	2
GO:0005771	multivesicular body	9	2
GO:0009898	cytoplasmic side of plasma membrane	4	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0032991	protein-containing complex	1	2
GO:0036452	ESCRT complex	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0098552	side of membrane	2	2
GO:0098562	cytoplasmic side of membrane	3	2
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q130

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q130

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006900	vesicle budding from membrane	5	2
GO:0006996	organelle organization	4	2
GO:0007034	vacuolar transport	4	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0016192	vesicle-mediated transport	4	2
GO:0016197	endosomal transport	4	2
GO:0032509	endosome transport via multivesicular body sorting pathway	5	2
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	2
GO:0045324	late endosome to vacuole transport	5	2
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0061024	membrane organization	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0071985	multivesicular body sorting pathway	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.323
CLV_NRD_NRD_1	74	76	PF00675	0.245
CLV_PCSK_KEX2_1	121	123	PF00082	0.318
CLV_PCSK_KEX2_1	41	43	PF00082	0.245
CLV_PCSK_KEX2_1	48	50	PF00082	0.245
CLV_PCSK_KEX2_1	74	76	PF00082	0.245
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.350
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.245
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.245
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.245
CLV_PCSK_SKI1_1	125	129	PF00082	0.411
CLV_Separin_Metazoa	108	112	PF03568	0.306
DEG_Nend_Nbox_1	1	3	PF02207	0.505
DEG_SPOP_SBC_1	206	210	PF00917	0.471
DOC_PIKK_1	163	171	PF02985	0.303
DOC_USP7_MATH_1	14	18	PF00917	0.528
DOC_USP7_MATH_1	195	199	PF00917	0.291
DOC_USP7_UBL2_3	117	121	PF12436	0.287
LIG_Actin_WH2_2	107	123	PF00022	0.371
LIG_APCC_ABBAyCdc20_2	75	81	PF00400	0.287
LIG_FHA_2	207	213	PF00498	0.617
LIG_FHA_2	26	32	PF00498	0.508
LIG_PDZ_Class_3	220	225	PF00595	0.606
LIG_Pex14_2	2	6	PF04695	0.538
LIG_SH2_STAP1	79	83	PF00017	0.287
LIG_SH2_STAT3	79	82	PF00017	0.287
LIG_SH3_2	202	207	PF14604	0.610
LIG_SH3_3	188	194	PF00018	0.262
LIG_SH3_3	199	205	PF00018	0.583
LIG_TRAF2_1	209	212	PF00917	0.552
LIG_UBA3_1	1	10	PF00899	0.584
LIG_UBA3_1	139	145	PF00899	0.336
MOD_CK1_1	15	21	PF00069	0.618
MOD_CK1_1	22	28	PF00069	0.534
MOD_CK2_1	206	212	PF00069	0.615
MOD_GlcNHglycan	17	20	PF01048	0.532
MOD_GSK3_1	15	22	PF00069	0.515
MOD_GSK3_1	92	99	PF00069	0.256
MOD_N-GLC_1	101	106	PF02516	0.294
MOD_NEK2_1	120	125	PF00069	0.361
MOD_NEK2_1	180	185	PF00069	0.263
MOD_NEK2_1	96	101	PF00069	0.252
MOD_PIKK_1	180	186	PF00454	0.366
MOD_PIKK_1	195	201	PF00454	0.415
MOD_PIKK_1	207	213	PF00454	0.601
MOD_PIKK_1	63	69	PF00454	0.287
MOD_PKA_1	63	69	PF00069	0.287
MOD_PKA_2	15	21	PF00069	0.619
MOD_Plk_1	101	107	PF00069	0.294
MOD_Plk_1	180	186	PF00069	0.263
MOD_SUMO_for_1	116	119	PF00179	0.263
MOD_SUMO_for_1	127	130	PF00179	0.263
MOD_SUMO_rev_2	118	123	PF00179	0.336
MOD_SUMO_rev_2	181	191	PF00179	0.324
TRG_NES_CRM1_1	170	182	PF08389	0.323
TRG_NLS_Bipartite_1	63	79	PF00514	0.258
TRG_NLS_MonoCore_2	73	78	PF00514	0.245
TRG_NLS_MonoExtC_3	74	80	PF00514	0.245
TRG_NLS_MonoExtN_4	74	79	PF00514	0.245

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5W8	Leptomonas seymouri	80%	100%
A0A0S4J9L8	Bodo saltans	27%	100%
A0A0S4JI05	Bodo saltans	54%	93%
A0A1X0NJR2	Trypanosomatidae	30%	100%
A0A1X0P4I7	Trypanosomatidae	60%	99%
A0A3Q8IJN8	Leishmania donovani	96%	100%
A0A3R7NQB4	Trypanosoma rangeli	57%	99%
A0A3S7WU01	Leishmania donovani	32%	100%
A0A422NAN8	Trypanosoma rangeli	31%	100%
A2VDY3	Bos taurus	29%	100%
A4H8L7	Leishmania braziliensis	33%	100%
A4HPQ2	Leishmania braziliensis	88%	100%
A4HWY8	Leishmania infantum	32%	100%
A4ID11	Leishmania infantum	96%	100%
C9ZW12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0A2A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A8G1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	99%
E9AQQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ATG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O82197	Arabidopsis thaliana	33%	100%
P0CR54	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	34%	100%
P0CR55	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	34%	100%
P39929	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	94%
P59074	Homo sapiens	31%	100%
Q4QES7	Leishmania major	33%	100%
Q4QQV8	Rattus norvegicus	30%	100%
Q569C1	Rattus norvegicus	34%	97%
Q5FW29	Xenopus tropicalis	30%	100%
Q5RBR3	Pongo abelii	31%	100%
Q5XGW6	Xenopus laevis	31%	100%
Q5ZHP5	Gallus gallus	31%	99%
Q6BSH2	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	30%	100%
Q6CJL0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	26%	97%
Q6DD52	Xenopus laevis	30%	100%
Q6FW96	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	27%	99%
Q6GL11	Xenopus tropicalis	31%	100%
Q6GNN8	Xenopus laevis	34%	99%
Q753W3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	95%
Q7T339	Danio rerio	29%	100%
Q7ZVC4	Danio rerio	34%	100%
Q86H98	Dictyostelium discoideum	25%	100%
Q96CF2	Homo sapiens	31%	97%
Q9BY43	Homo sapiens	29%	100%
Q9D7F7	Mus musculus	34%	97%
Q9D7S9	Mus musculus	30%	100%
Q9D8B3	Mus musculus	32%	100%
Q9H444	Homo sapiens	32%	100%
Q9LPN5	Arabidopsis thaliana	28%	96%
Q9NZZ3	Homo sapiens	31%	100%
Q9P7F7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
Q9SZE4	Arabidopsis thaliana	30%	100%
Q9VVI9	Drosophila melanogaster	29%	100%