Similar to leishmania major. l411.4-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

similar to leishmania major. l411.4-like protein

Species:

Leishmania major

UniProt:

Q4Q129_LEIMA

TriTrypDb:

LmjF.36.3860 , LMJLV39_360049300 , LMJSD75_360049100

Length:

576

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	11
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q129

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q129

Function

Biological processes
Term	Name	Level	Count
GO:0007338	single fertilization	3	11
GO:0009566	fertilization	2	11
GO:0022414	reproductive process	1	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0008289	lipid binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	521	523	PF00675	0.453
CLV_NRD_NRD_1	88	90	PF00675	0.440
CLV_PCSK_KEX2_1	521	523	PF00082	0.509
CLV_PCSK_KEX2_1	88	90	PF00082	0.461
CLV_PCSK_SKI1_1	113	117	PF00082	0.445
CLV_PCSK_SKI1_1	254	258	PF00082	0.406
CLV_PCSK_SKI1_1	451	455	PF00082	0.505
CLV_PCSK_SKI1_1	522	526	PF00082	0.527
CLV_PCSK_SKI1_1	529	533	PF00082	0.489
DEG_APCC_DBOX_1	94	102	PF00400	0.309
DEG_SPOP_SBC_1	193	197	PF00917	0.321
DEG_SPOP_SBC_1	458	462	PF00917	0.253
DOC_CKS1_1	19	24	PF01111	0.510
DOC_CYCLIN_yCln2_LP_2	284	290	PF00134	0.309
DOC_MAPK_MEF2A_6	28	35	PF00069	0.239
DOC_MAPK_RevD_3	76	89	PF00069	0.281
DOC_PP1_RVXF_1	252	258	PF00149	0.309
DOC_PP2B_LxvP_1	256	259	PF13499	0.221
DOC_PP2B_LxvP_1	284	287	PF13499	0.273
DOC_USP7_MATH_1	155	159	PF00917	0.281
DOC_USP7_MATH_1	192	196	PF00917	0.296
DOC_USP7_MATH_1	242	246	PF00917	0.340
DOC_USP7_MATH_1	261	265	PF00917	0.352
DOC_USP7_MATH_1	266	270	PF00917	0.334
DOC_USP7_MATH_1	289	293	PF00917	0.303
DOC_USP7_MATH_1	435	439	PF00917	0.349
DOC_USP7_MATH_1	458	462	PF00917	0.314
DOC_USP7_MATH_1	72	76	PF00917	0.324
DOC_USP7_MATH_2	473	479	PF00917	0.167
DOC_WW_Pin1_4	15	20	PF00397	0.506
DOC_WW_Pin1_4	194	199	PF00397	0.308
DOC_WW_Pin1_4	301	306	PF00397	0.309
DOC_WW_Pin1_4	506	511	PF00397	0.294
DOC_WW_Pin1_4	550	555	PF00397	0.186
LIG_14-3-3_CanoR_1	268	275	PF00244	0.224
LIG_14-3-3_CanoR_1	380	384	PF00244	0.309
LIG_14-3-3_CanoR_1	416	422	PF00244	0.329
LIG_14-3-3_CanoR_1	529	538	PF00244	0.342
LIG_14-3-3_CanoR_1	95	101	PF00244	0.310
LIG_Actin_WH2_2	364	382	PF00022	0.276
LIG_Actin_WH2_2	94	111	PF00022	0.318
LIG_BIR_III_4	67	71	PF00653	0.167
LIG_CSL_BTD_1	551	554	PF09270	0.219
LIG_deltaCOP1_diTrp_1	537	543	PF00928	0.274
LIG_FHA_1	133	139	PF00498	0.270
LIG_FHA_1	155	161	PF00498	0.314
LIG_FHA_1	213	219	PF00498	0.291
LIG_FHA_1	246	252	PF00498	0.296
LIG_FHA_1	270	276	PF00498	0.340
LIG_FHA_1	39	45	PF00498	0.252
LIG_FHA_1	406	412	PF00498	0.252
LIG_FHA_1	450	456	PF00498	0.285
LIG_FHA_1	458	464	PF00498	0.260
LIG_FHA_1	50	56	PF00498	0.166
LIG_FHA_1	6	12	PF00498	0.484
LIG_FHA_2	148	154	PF00498	0.298
LIG_FHA_2	32	38	PF00498	0.309
LIG_FHA_2	532	538	PF00498	0.351
LIG_LIR_Gen_1	130	139	PF02991	0.354
LIG_LIR_Gen_1	282	291	PF02991	0.207
LIG_LIR_Gen_1	537	546	PF02991	0.271
LIG_LIR_Gen_1	553	563	PF02991	0.186
LIG_LIR_Nem_3	282	286	PF02991	0.240
LIG_LIR_Nem_3	306	311	PF02991	0.197
LIG_LIR_Nem_3	420	424	PF02991	0.306
LIG_LIR_Nem_3	537	541	PF02991	0.347
LIG_LIR_Nem_3	551	555	PF02991	0.349
LIG_SH2_CRK	421	425	PF00017	0.279
LIG_SH2_CRK	555	559	PF00017	0.307
LIG_SH2_PTP2	412	415	PF00017	0.347
LIG_SH2_PTP2	426	429	PF00017	0.242
LIG_SH2_STAP1	555	559	PF00017	0.307
LIG_SH2_STAT5	10	13	PF00017	0.443
LIG_SH2_STAT5	100	103	PF00017	0.249
LIG_SH2_STAT5	307	310	PF00017	0.309
LIG_SH2_STAT5	348	351	PF00017	0.281
LIG_SH2_STAT5	412	415	PF00017	0.276
LIG_SH2_STAT5	426	429	PF00017	0.160
LIG_SH3_3	136	142	PF00018	0.319
LIG_SH3_3	16	22	PF00018	0.389
LIG_SH3_3	386	392	PF00018	0.167
LIG_SH3_3	509	515	PF00018	0.244
LIG_SH3_3	75	81	PF00018	0.309
LIG_Sin3_3	490	497	PF02671	0.167
LIG_SUMO_SIM_par_1	247	252	PF11976	0.180
LIG_SUMO_SIM_par_1	289	294	PF11976	0.224
LIG_SUMO_SIM_par_1	29	34	PF11976	0.217
LIG_TYR_ITIM	410	415	PF00017	0.344
LIG_TYR_ITIM	424	429	PF00017	0.267
LIG_WRC_WIRS_1	353	358	PF05994	0.258
MOD_CK1_1	130	136	PF00069	0.260
MOD_CK1_1	18	24	PF00069	0.413
MOD_CK1_1	245	251	PF00069	0.330
MOD_CK1_1	264	270	PF00069	0.321
MOD_CK1_1	310	316	PF00069	0.325
MOD_CK1_1	352	358	PF00069	0.344
MOD_CK1_1	38	44	PF00069	0.272
MOD_CK1_1	467	473	PF00069	0.318
MOD_CK1_1	478	484	PF00069	0.315
MOD_CK2_1	147	153	PF00069	0.224
MOD_CK2_1	40	46	PF00069	0.286
MOD_CK2_1	531	537	PF00069	0.329
MOD_GlcNHglycan	139	142	PF01048	0.501
MOD_GlcNHglycan	204	207	PF01048	0.463
MOD_GlcNHglycan	229	232	PF01048	0.448
MOD_GlcNHglycan	237	240	PF01048	0.434
MOD_GlcNHglycan	250	254	PF01048	0.471
MOD_GlcNHglycan	259	262	PF01048	0.479
MOD_GlcNHglycan	264	267	PF01048	0.491
MOD_GlcNHglycan	293	296	PF01048	0.503
MOD_GlcNHglycan	495	498	PF01048	0.452
MOD_GSK3_1	1	8	PF00069	0.484
MOD_GSK3_1	123	130	PF00069	0.251
MOD_GSK3_1	176	183	PF00069	0.295
MOD_GSK3_1	212	219	PF00069	0.305
MOD_GSK3_1	245	252	PF00069	0.328
MOD_GSK3_1	257	264	PF00069	0.301
MOD_GSK3_1	307	314	PF00069	0.328
MOD_GSK3_1	31	38	PF00069	0.311
MOD_GSK3_1	40	47	PF00069	0.253
MOD_GSK3_1	435	442	PF00069	0.314
MOD_GSK3_1	476	483	PF00069	0.295
MOD_GSK3_1	493	500	PF00069	0.173
MOD_GSK3_1	68	75	PF00069	0.361
MOD_GSK3_1	96	103	PF00069	0.357
MOD_N-GLC_1	161	166	PF02516	0.509
MOD_N-GLC_1	417	422	PF02516	0.491
MOD_N-GLC_1	458	463	PF02516	0.473
MOD_N-GLC_1	497	502	PF02516	0.471
MOD_N-GLC_2	296	298	PF02516	0.505
MOD_NEK2_1	1	6	PF00069	0.385
MOD_NEK2_1	108	113	PF00069	0.312
MOD_NEK2_1	132	137	PF00069	0.263
MOD_NEK2_1	202	207	PF00069	0.286
MOD_NEK2_1	235	240	PF00069	0.210
MOD_NEK2_1	311	316	PF00069	0.231
MOD_NEK2_1	35	40	PF00069	0.224
MOD_NEK2_1	379	384	PF00069	0.286
MOD_NEK2_1	404	409	PF00069	0.314
MOD_NEK2_1	411	416	PF00069	0.292
MOD_NEK2_1	464	469	PF00069	0.321
MOD_NEK2_1	493	498	PF00069	0.287
MOD_NEK2_1	531	536	PF00069	0.343
MOD_NEK2_1	541	546	PF00069	0.396
MOD_NEK2_1	55	60	PF00069	0.221
MOD_NEK2_1	76	81	PF00069	0.318
MOD_NEK2_2	161	166	PF00069	0.309
MOD_NMyristoyl	1	7	PF02799	0.339
MOD_OFUCOSY	317	324	PF10250	0.430
MOD_PKA_2	108	114	PF00069	0.300
MOD_PKA_2	235	241	PF00069	0.224
MOD_PKA_2	379	385	PF00069	0.309
MOD_PKA_2	435	441	PF00069	0.296
MOD_Plk_1	161	167	PF00069	0.276
MOD_Plk_1	31	37	PF00069	0.293
MOD_Plk_1	417	423	PF00069	0.309
MOD_Plk_1	458	464	PF00069	0.309
MOD_Plk_1	497	503	PF00069	0.293
MOD_Plk_4	127	133	PF00069	0.340
MOD_Plk_4	134	140	PF00069	0.266
MOD_Plk_4	35	41	PF00069	0.311
MOD_Plk_4	459	465	PF00069	0.286
MOD_Plk_4	480	486	PF00069	0.289
MOD_Plk_4	55	61	PF00069	0.302
MOD_Plk_4	96	102	PF00069	0.301
MOD_ProDKin_1	15	21	PF00069	0.504
MOD_ProDKin_1	194	200	PF00069	0.308
MOD_ProDKin_1	301	307	PF00069	0.309
MOD_ProDKin_1	506	512	PF00069	0.294
MOD_ProDKin_1	550	556	PF00069	0.186
MOD_SUMO_for_1	515	518	PF00179	0.316
TRG_DiLeu_BaEn_1	363	368	PF01217	0.167
TRG_DiLeu_BaEn_1	537	542	PF01217	0.411
TRG_ENDOCYTIC_2	131	134	PF00928	0.309
TRG_ENDOCYTIC_2	199	202	PF00928	0.309
TRG_ENDOCYTIC_2	412	415	PF00928	0.314
TRG_ENDOCYTIC_2	421	424	PF00928	0.243
TRG_ENDOCYTIC_2	426	429	PF00928	0.209
TRG_ENDOCYTIC_2	555	558	PF00928	0.364
TRG_ENDOCYTIC_2	560	563	PF00928	0.577
TRG_ER_diArg_1	87	89	PF00400	0.281

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A060A682	Tetrahymena thermophila	21%	78%
A0A0N1I7I3	Leptomonas seymouri	51%	93%
A0A0S4KHY6	Bodo saltans	25%	86%
A0A1X0P0J5	Trypanosomatidae	25%	94%
A0A3Q8IW91	Leishmania donovani	93%	100%
A0A3R7NLN3	Trypanosoma rangeli	24%	98%
A4HPQ3	Leishmania braziliensis	75%	100%
A4ID10	Leishmania infantum	93%	100%
D0A4L4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	93%
V5BFV7	Trypanosoma cruzi	26%	98%