Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q128_LEIMA

TriTrypDb:

LmjF.36.3870 , LMJLV39_360049400 , LMJSD75_360049200

Length:

841

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	7
GO:0005929	cilium	4	5
GO:0042995	cell projection	2	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0120025	plasma membrane bounded cell projection	3	5

Expansion

Sequence features

Q4Q128

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q128

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	528	532	PF00656	0.697
CLV_MEL_PAP_1	670	676	PF00089	0.481
CLV_NRD_NRD_1	141	143	PF00675	0.465
CLV_NRD_NRD_1	603	605	PF00675	0.633
CLV_NRD_NRD_1	680	682	PF00675	0.564
CLV_NRD_NRD_1	731	733	PF00675	0.466
CLV_NRD_NRD_1	79	81	PF00675	0.657
CLV_PCSK_KEX2_1	141	143	PF00082	0.465
CLV_PCSK_KEX2_1	603	605	PF00082	0.633
CLV_PCSK_KEX2_1	79	81	PF00082	0.665
CLV_PCSK_SKI1_1	307	311	PF00082	0.526
CLV_PCSK_SKI1_1	357	361	PF00082	0.461
CLV_PCSK_SKI1_1	521	525	PF00082	0.531
CLV_PCSK_SKI1_1	681	685	PF00082	0.556
DEG_APCC_DBOX_1	680	688	PF00400	0.553
DEG_APCC_DBOX_1	720	728	PF00400	0.467
DEG_Nend_UBRbox_2	1	3	PF02207	0.418
DEG_SCF_FBW7_1	473	480	PF00400	0.588
DEG_SPOP_SBC_1	341	345	PF00917	0.387
DOC_CKS1_1	220	225	PF01111	0.485
DOC_CKS1_1	474	479	PF01111	0.591
DOC_CKS1_1	605	610	PF01111	0.724
DOC_MAPK_DCC_7	544	553	PF00069	0.682
DOC_MAPK_gen_1	681	687	PF00069	0.555
DOC_MAPK_MEF2A_6	30	38	PF00069	0.479
DOC_MAPK_MEF2A_6	544	553	PF00069	0.682
DOC_PP1_RVXF_1	103	109	PF00149	0.381
DOC_USP7_MATH_1	167	171	PF00917	0.432
DOC_USP7_MATH_1	225	229	PF00917	0.649
DOC_USP7_MATH_1	268	272	PF00917	0.546
DOC_USP7_MATH_1	392	396	PF00917	0.488
DOC_USP7_MATH_1	420	424	PF00917	0.766
DOC_USP7_MATH_1	477	481	PF00917	0.687
DOC_USP7_MATH_1	526	530	PF00917	0.812
DOC_USP7_MATH_1	534	538	PF00917	0.620
DOC_USP7_MATH_1	594	598	PF00917	0.747
DOC_USP7_MATH_1	618	622	PF00917	0.748
DOC_USP7_MATH_1	627	631	PF00917	0.696
DOC_USP7_MATH_1	664	668	PF00917	0.558
DOC_USP7_MATH_1	67	71	PF00917	0.640
DOC_USP7_MATH_1	693	697	PF00917	0.566
DOC_USP7_MATH_1	757	761	PF00917	0.509
DOC_WW_Pin1_4	122	127	PF00397	0.671
DOC_WW_Pin1_4	17	22	PF00397	0.509
DOC_WW_Pin1_4	219	224	PF00397	0.540
DOC_WW_Pin1_4	416	421	PF00397	0.734
DOC_WW_Pin1_4	434	439	PF00397	0.524
DOC_WW_Pin1_4	448	453	PF00397	0.630
DOC_WW_Pin1_4	473	478	PF00397	0.590
DOC_WW_Pin1_4	502	507	PF00397	0.633
DOC_WW_Pin1_4	54	59	PF00397	0.492
DOC_WW_Pin1_4	583	588	PF00397	0.675
DOC_WW_Pin1_4	595	600	PF00397	0.562
DOC_WW_Pin1_4	604	609	PF00397	0.656
DOC_WW_Pin1_4	62	67	PF00397	0.567
DOC_WW_Pin1_4	623	628	PF00397	0.759
DOC_WW_Pin1_4	803	808	PF00397	0.633
DOC_WW_Pin1_4	84	89	PF00397	0.661
LIG_14-3-3_CanoR_1	130	140	PF00244	0.392
LIG_14-3-3_CanoR_1	201	206	PF00244	0.399
LIG_14-3-3_CanoR_1	603	608	PF00244	0.690
LIG_14-3-3_CanoR_1	708	716	PF00244	0.459
LIG_14-3-3_CanoR_1	71	77	PF00244	0.636
LIG_14-3-3_CanoR_1	741	749	PF00244	0.445
LIG_14-3-3_CanoR_1	80	88	PF00244	0.565
LIG_14-3-3_CanoR_1	810	818	PF00244	0.567
LIG_Actin_WH2_2	400	416	PF00022	0.438
LIG_BRCT_BRCA1_1	375	379	PF00533	0.524
LIG_CSL_BTD_1	509	512	PF09270	0.552
LIG_CtBP_PxDLS_1	189	193	PF00389	0.440
LIG_FHA_1	191	197	PF00498	0.397
LIG_FHA_1	255	261	PF00498	0.322
LIG_FHA_1	296	302	PF00498	0.604
LIG_FHA_1	304	310	PF00498	0.483
LIG_FHA_1	427	433	PF00498	0.714
LIG_FHA_1	641	647	PF00498	0.737
LIG_FHA_1	697	703	PF00498	0.539
LIG_FHA_1	708	714	PF00498	0.454
LIG_FHA_1	741	747	PF00498	0.444
LIG_FHA_2	132	138	PF00498	0.499
LIG_FHA_2	361	367	PF00498	0.528
LIG_FHA_2	712	718	PF00498	0.456
LIG_FHA_2	820	826	PF00498	0.566
LIG_LIR_Gen_1	101	110	PF02991	0.482
LIG_LIR_Gen_1	35	46	PF02991	0.421
LIG_LIR_Nem_3	101	106	PF02991	0.490
LIG_LIR_Nem_3	237	241	PF02991	0.400
LIG_LIR_Nem_3	35	41	PF02991	0.427
LIG_MYND_1	554	558	PF01753	0.575
LIG_OCRL_FandH_1	102	114	PF00620	0.420
LIG_Pex14_1	510	514	PF04695	0.584
LIG_SH2_CRK	563	567	PF00017	0.654
LIG_SH2_GRB2like	338	341	PF00017	0.466
LIG_SH2_PTP2	546	549	PF00017	0.686
LIG_SH2_SRC	338	341	PF00017	0.385
LIG_SH2_SRC	546	549	PF00017	0.686
LIG_SH2_STAT3	10	13	PF00017	0.413
LIG_SH2_STAT5	10	13	PF00017	0.413
LIG_SH2_STAT5	338	341	PF00017	0.466
LIG_SH2_STAT5	546	549	PF00017	0.788
LIG_SH2_STAT5	563	566	PF00017	0.487
LIG_SH3_1	467	473	PF00018	0.629
LIG_SH3_2	66	71	PF14604	0.543
LIG_SH3_3	233	239	PF00018	0.480
LIG_SH3_3	441	447	PF00018	0.683
LIG_SH3_3	449	455	PF00018	0.764
LIG_SH3_3	465	471	PF00018	0.711
LIG_SH3_3	503	509	PF00018	0.691
LIG_SH3_3	544	550	PF00018	0.620
LIG_SH3_3	602	608	PF00018	0.741
LIG_SH3_3	63	69	PF00018	0.588
LIG_SH3_3	643	649	PF00018	0.577
LIG_SUMO_SIM_par_1	409	417	PF11976	0.453
LIG_SUMO_SIM_par_1	52	57	PF11976	0.400
LIG_SUMO_SIM_par_1	683	689	PF11976	0.493
LIG_TRAF2_1	240	243	PF00917	0.400
LIG_TYR_ITIM	336	341	PF00017	0.390
LIG_WRC_WIRS_1	158	163	PF05994	0.371
MOD_CDC14_SPxK_1	600	603	PF00782	0.581
MOD_CDK_SPK_2	221	226	PF00069	0.484
MOD_CDK_SPxK_1	597	603	PF00069	0.577
MOD_CDK_SPxxK_3	219	226	PF00069	0.494
MOD_CDK_SPxxK_3	54	61	PF00069	0.511
MOD_CDK_SPxxK_3	597	604	PF00069	0.608
MOD_CDK_SPxxK_3	803	810	PF00069	0.707
MOD_CDK_SPxxK_3	84	91	PF00069	0.660
MOD_CK1_1	154	160	PF00069	0.471
MOD_CK1_1	224	230	PF00069	0.538
MOD_CK1_1	271	277	PF00069	0.583
MOD_CK1_1	342	348	PF00069	0.471
MOD_CK1_1	416	422	PF00069	0.700
MOD_CK1_1	480	486	PF00069	0.699
MOD_CK1_1	586	592	PF00069	0.585
MOD_CK1_1	597	603	PF00069	0.654
MOD_CK1_1	626	632	PF00069	0.761
MOD_CK1_1	654	660	PF00069	0.629
MOD_CK1_1	696	702	PF00069	0.569
MOD_CK1_1	70	76	PF00069	0.676
MOD_CK1_1	84	90	PF00069	0.579
MOD_CK2_1	131	137	PF00069	0.507
MOD_CK2_1	2	8	PF00069	0.428
MOD_CK2_1	360	366	PF00069	0.455
MOD_CK2_1	381	387	PF00069	0.515
MOD_CK2_1	439	445	PF00069	0.651
MOD_CK2_1	458	464	PF00069	0.664
MOD_CK2_1	626	632	PF00069	0.721
MOD_CK2_1	662	668	PF00069	0.571
MOD_CK2_1	686	692	PF00069	0.459
MOD_CK2_1	711	717	PF00069	0.456
MOD_DYRK1A_RPxSP_1	604	608	PF00069	0.688
MOD_GlcNHglycan	153	156	PF01048	0.460
MOD_GlcNHglycan	229	233	PF01048	0.590
MOD_GlcNHglycan	270	273	PF01048	0.542
MOD_GlcNHglycan	303	306	PF01048	0.605
MOD_GlcNHglycan	333	336	PF01048	0.380
MOD_GlcNHglycan	383	386	PF01048	0.546
MOD_GlcNHglycan	393	397	PF01048	0.594
MOD_GlcNHglycan	441	444	PF01048	0.678
MOD_GlcNHglycan	482	485	PF01048	0.699
MOD_GlcNHglycan	487	490	PF01048	0.719
MOD_GlcNHglycan	495	498	PF01048	0.825
MOD_GlcNHglycan	528	531	PF01048	0.737
MOD_GlcNHglycan	537	540	PF01048	0.603
MOD_GlcNHglycan	629	632	PF01048	0.716
MOD_GlcNHglycan	664	667	PF01048	0.614
MOD_GlcNHglycan	73	76	PF01048	0.656
MOD_GlcNHglycan	759	762	PF01048	0.555
MOD_GSK3_1	122	129	PF00069	0.635
MOD_GSK3_1	153	160	PF00069	0.545
MOD_GSK3_1	221	228	PF00069	0.500
MOD_GSK3_1	266	273	PF00069	0.573
MOD_GSK3_1	297	304	PF00069	0.564
MOD_GSK3_1	340	347	PF00069	0.429
MOD_GSK3_1	349	356	PF00069	0.531
MOD_GSK3_1	416	423	PF00069	0.734
MOD_GSK3_1	473	480	PF00069	0.627
MOD_GSK3_1	485	492	PF00069	0.692
MOD_GSK3_1	521	528	PF00069	0.607
MOD_GSK3_1	578	585	PF00069	0.774
MOD_GSK3_1	623	630	PF00069	0.621
MOD_GSK3_1	660	667	PF00069	0.720
MOD_GSK3_1	67	74	PF00069	0.663
MOD_GSK3_1	707	714	PF00069	0.461
MOD_GSK3_1	809	816	PF00069	0.585
MOD_GSK3_1	83	90	PF00069	0.562
MOD_N-GLC_1	339	344	PF02516	0.457
MOD_N-GLC_1	71	76	PF02516	0.657
MOD_NEK2_1	218	223	PF00069	0.421
MOD_NEK2_1	301	306	PF00069	0.608
MOD_NEK2_1	312	317	PF00069	0.537
MOD_NEK2_1	339	344	PF00069	0.375
MOD_NEK2_1	349	354	PF00069	0.382
MOD_NEK2_1	360	365	PF00069	0.600
MOD_NEK2_1	368	373	PF00069	0.303
MOD_NEK2_1	391	396	PF00069	0.431
MOD_NEK2_1	425	430	PF00069	0.660
MOD_NEK2_1	513	518	PF00069	0.581
MOD_NEK2_1	745	750	PF00069	0.399
MOD_NEK2_1	764	769	PF00069	0.516
MOD_NEK2_1	828	833	PF00069	0.586
MOD_NEK2_1	98	103	PF00069	0.562
MOD_NEK2_2	275	280	PF00069	0.632
MOD_PIKK_1	131	137	PF00454	0.507
MOD_PIKK_1	312	318	PF00454	0.419
MOD_PIKK_1	654	660	PF00454	0.677
MOD_PIKK_1	830	836	PF00454	0.559
MOD_PIKK_1	98	104	PF00454	0.463
MOD_PKA_1	603	609	PF00069	0.660
MOD_PKA_2	2	8	PF00069	0.518
MOD_PKA_2	200	206	PF00069	0.406
MOD_PKA_2	413	419	PF00069	0.539
MOD_PKA_2	603	609	PF00069	0.687
MOD_PKA_2	672	678	PF00069	0.649
MOD_PKA_2	70	76	PF00069	0.648
MOD_PKA_2	707	713	PF00069	0.464
MOD_PKA_2	740	746	PF00069	0.472
MOD_PKA_2	809	815	PF00069	0.571
MOD_Plk_1	242	248	PF00069	0.382
MOD_Plk_1	392	398	PF00069	0.436
MOD_Plk_1	521	527	PF00069	0.536
MOD_Plk_1	819	825	PF00069	0.501
MOD_Plk_2-3	2	8	PF00069	0.357
MOD_Plk_4	2	8	PF00069	0.428
MOD_Plk_4	242	248	PF00069	0.434
MOD_Plk_4	349	355	PF00069	0.429
MOD_Plk_4	420	426	PF00069	0.771
MOD_Plk_4	458	464	PF00069	0.664
MOD_Plk_4	513	519	PF00069	0.544
MOD_Plk_4	764	770	PF00069	0.538
MOD_ProDKin_1	122	128	PF00069	0.665
MOD_ProDKin_1	17	23	PF00069	0.514
MOD_ProDKin_1	219	225	PF00069	0.555
MOD_ProDKin_1	416	422	PF00069	0.740
MOD_ProDKin_1	434	440	PF00069	0.523
MOD_ProDKin_1	448	454	PF00069	0.631
MOD_ProDKin_1	473	479	PF00069	0.591
MOD_ProDKin_1	502	508	PF00069	0.626
MOD_ProDKin_1	54	60	PF00069	0.502
MOD_ProDKin_1	583	589	PF00069	0.677
MOD_ProDKin_1	595	601	PF00069	0.558
MOD_ProDKin_1	604	610	PF00069	0.654
MOD_ProDKin_1	62	68	PF00069	0.566
MOD_ProDKin_1	623	629	PF00069	0.761
MOD_ProDKin_1	803	809	PF00069	0.634
MOD_ProDKin_1	84	90	PF00069	0.660
MOD_SUMO_rev_2	384	391	PF00179	0.469
MOD_SUMO_rev_2	675	684	PF00179	0.577
TRG_DiLeu_BaEn_1	2	7	PF01217	0.356
TRG_DiLeu_BaEn_2	241	247	PF01217	0.377
TRG_ENDOCYTIC_2	283	286	PF00928	0.595
TRG_ENDOCYTIC_2	338	341	PF00928	0.466
TRG_ENDOCYTIC_2	546	549	PF00928	0.686
TRG_ER_diArg_1	140	142	PF00400	0.467
TRG_ER_diArg_1	603	605	PF00400	0.677
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL79	Leptomonas seymouri	41%	94%
A0A3S7XBE3	Leishmania donovani	90%	100%
A4HPQ4	Leishmania braziliensis	67%	100%
A4ID09	Leishmania infantum	90%	100%
E9ATG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%