LeishMANIAdb
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Eukaryotic translation initiation factor 3 subunit I

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Eukaryotic translation initiation factor 3 subunit I
Gene product:
eukaryotic translation initiation factor 3 subunit i
Species:
Leishmania major
UniProt:
Q4Q127_LEIMA
TriTrypDb:
LmjF.36.3880 * , LMJLV39_360049500 * , LMJSD75_360049300 *
Length:
419

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. yes yes: 2
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 5
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0005852 eukaryotic translation initiation factor 3 complex 2 12
GO:0016282 eukaryotic 43S preinitiation complex 4 12
GO:0032991 protein-containing complex 1 12
GO:0033290 eukaryotic 48S preinitiation complex 4 12
GO:0070993 translation preinitiation complex 3 12
GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m 3 2
GO:0110165 cellular anatomical entity 1 2
GO:1990904 ribonucleoprotein complex 2 12

Expansion

Sequence features

Q4Q127
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q127

Function

Biological processes
Term Name Level Count
GO:0001732 formation of cytoplasmic translation initiation complex 7 12
GO:0002183 cytoplasmic translational initiation 4 2
GO:0006413 translational initiation 3 2
GO:0006417 regulation of translation 6 2
GO:0006446 regulation of translational initiation 7 2
GO:0008152 metabolic process 1 2
GO:0009889 regulation of biosynthetic process 4 2
GO:0009987 cellular process 1 12
GO:0010468 regulation of gene expression 5 2
GO:0010556 regulation of macromolecule biosynthetic process 5 2
GO:0010608 post-transcriptional regulation of gene expression 6 2
GO:0016043 cellular component organization 3 12
GO:0019222 regulation of metabolic process 3 2
GO:0022607 cellular component assembly 4 12
GO:0022618 ribonucleoprotein complex assembly 6 12
GO:0031323 regulation of cellular metabolic process 4 2
GO:0031326 regulation of cellular biosynthetic process 5 2
GO:0034248 regulation of amide metabolic process 5 2
GO:0043933 protein-containing complex organization 4 12
GO:0044237 cellular metabolic process 2 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0051171 regulation of nitrogen compound metabolic process 4 2
GO:0051246 regulation of protein metabolic process 5 2
GO:0060255 regulation of macromolecule metabolic process 4 2
GO:0065003 protein-containing complex assembly 5 12
GO:0065007 biological regulation 1 2
GO:0071826 ribonucleoprotein complex subunit organization 5 12
GO:0071840 cellular component organization or biogenesis 2 12
GO:0080090 regulation of primary metabolic process 4 2
GO:2000112 obsolete regulation of cellular macromolecule biosynthetic process 6 2
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 2
GO:0003743 translation initiation factor activity 4 12
GO:0005488 binding 1 12
GO:0008135 translation factor activity, RNA binding 3 12
GO:0045182 translation regulator activity 1 12
GO:0090079 translation regulator activity, nucleic acid binding 2 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 280 286 PF00089 0.562
CLV_PCSK_SKI1_1 80 84 PF00082 0.316
DEG_SCF_FBW7_1 220 227 PF00400 0.676
DEG_SIAH_1 11 19 PF03145 0.504
DOC_CKS1_1 20 25 PF01111 0.442
DOC_CKS1_1 221 226 PF01111 0.678
DOC_CKS1_1 231 236 PF01111 0.310
DOC_MAPK_gen_1 48 57 PF00069 0.388
DOC_MAPK_gen_1 86 95 PF00069 0.531
DOC_PP4_FxxP_1 209 212 PF00568 0.509
DOC_PP4_FxxP_1 231 234 PF00568 0.578
DOC_USP7_MATH_1 10 14 PF00917 0.514
DOC_USP7_MATH_1 147 151 PF00917 0.553
DOC_USP7_MATH_1 294 298 PF00917 0.502
DOC_USP7_MATH_1 390 394 PF00917 0.604
DOC_USP7_UBL2_3 357 361 PF12436 0.424
DOC_WW_Pin1_4 14 19 PF00397 0.499
DOC_WW_Pin1_4 21 26 PF00397 0.423
DOC_WW_Pin1_4 220 225 PF00397 0.681
DOC_WW_Pin1_4 230 235 PF00397 0.307
DOC_WW_Pin1_4 325 330 PF00397 0.442
DOC_WW_Pin1_4 407 412 PF00397 0.541
LIG_14-3-3_CanoR_1 171 179 PF00244 0.573
LIG_14-3-3_CanoR_1 195 202 PF00244 0.608
LIG_14-3-3_CanoR_1 283 287 PF00244 0.478
LIG_14-3-3_CanoR_1 387 397 PF00244 0.597
LIG_14-3-3_CanoR_1 59 65 PF00244 0.430
LIG_BRCT_BRCA1_1 177 181 PF00533 0.508
LIG_BRCT_BRCA1_1 23 27 PF00533 0.427
LIG_FHA_1 110 116 PF00498 0.567
LIG_FHA_1 299 305 PF00498 0.424
LIG_FHA_1 310 316 PF00498 0.436
LIG_FHA_1 50 56 PF00498 0.374
LIG_FHA_1 63 69 PF00498 0.350
LIG_GBD_Chelix_1 36 44 PF00786 0.440
LIG_LIR_Apic_2 229 234 PF02991 0.614
LIG_LIR_Gen_1 118 125 PF02991 0.594
LIG_LIR_Gen_1 223 231 PF02991 0.608
LIG_LIR_Gen_1 253 264 PF02991 0.560
LIG_LIR_Gen_1 287 296 PF02991 0.501
LIG_LIR_Nem_3 118 122 PF02991 0.572
LIG_LIR_Nem_3 223 228 PF02991 0.597
LIG_LIR_Nem_3 253 259 PF02991 0.518
LIG_LIR_Nem_3 287 293 PF02991 0.443
LIG_LIR_Nem_3 306 310 PF02991 0.451
LIG_LIR_Nem_3 391 397 PF02991 0.522
LIG_MLH1_MIPbox_1 23 27 PF16413 0.427
LIG_NRBOX 35 41 PF00104 0.429
LIG_Pex14_1 286 290 PF04695 0.577
LIG_Pex14_2 354 358 PF04695 0.443
LIG_PTB_Apo_2 203 210 PF02174 0.490
LIG_REV1ctd_RIR_1 356 365 PF16727 0.587
LIG_SH2_CRK 119 123 PF00017 0.586
LIG_SH2_CRK 205 209 PF00017 0.487
LIG_SH2_CRK 256 260 PF00017 0.546
LIG_SH2_CRK 394 398 PF00017 0.606
LIG_SH2_GRB2like 256 259 PF00017 0.549
LIG_SH2_NCK_1 119 123 PF00017 0.586
LIG_SH2_NCK_1 205 209 PF00017 0.487
LIG_SH2_STAP1 130 134 PF00017 0.520
LIG_SH2_STAT5 119 122 PF00017 0.567
LIG_SH2_STAT5 290 293 PF00017 0.434
LIG_SH3_3 218 224 PF00018 0.664
LIG_SUMO_SIM_par_1 133 138 PF11976 0.496
LIG_SUMO_SIM_par_1 258 263 PF11976 0.449
LIG_TRAF2_1 151 154 PF00917 0.624
LIG_WRC_WIRS_1 225 230 PF05994 0.600
MOD_CK1_1 118 124 PF00069 0.592
MOD_CK1_1 159 165 PF00069 0.589
MOD_CK1_1 172 178 PF00069 0.470
MOD_CK1_1 197 203 PF00069 0.623
MOD_CK1_1 344 350 PF00069 0.640
MOD_CK1_1 406 412 PF00069 0.561
MOD_CK1_1 58 64 PF00069 0.437
MOD_CK2_1 147 153 PF00069 0.506
MOD_CK2_1 226 232 PF00069 0.595
MOD_CK2_1 349 355 PF00069 0.512
MOD_CMANNOS 239 242 PF00535 0.553
MOD_GlcNHglycan 103 106 PF01048 0.570
MOD_GlcNHglycan 12 15 PF01048 0.514
MOD_GlcNHglycan 149 152 PF01048 0.559
MOD_GlcNHglycan 161 164 PF01048 0.427
MOD_GlcNHglycan 174 177 PF01048 0.385
MOD_GlcNHglycan 199 202 PF01048 0.481
MOD_GlcNHglycan 390 393 PF01048 0.313
MOD_GlcNHglycan 60 63 PF01048 0.652
MOD_GlcNHglycan 96 99 PF01048 0.425
MOD_GSK3_1 10 17 PF00069 0.654
MOD_GSK3_1 141 148 PF00069 0.437
MOD_GSK3_1 165 172 PF00069 0.555
MOD_GSK3_1 175 182 PF00069 0.472
MOD_GSK3_1 189 196 PF00069 0.499
MOD_GSK3_1 220 227 PF00069 0.629
MOD_GSK3_1 245 252 PF00069 0.448
MOD_GSK3_1 294 301 PF00069 0.425
MOD_GSK3_1 31 38 PF00069 0.418
MOD_GSK3_1 403 410 PF00069 0.594
MOD_GSK3_1 58 65 PF00069 0.428
MOD_GSK3_1 94 101 PF00069 0.606
MOD_LATS_1 78 84 PF00433 0.520
MOD_N-GLC_1 101 106 PF02516 0.383
MOD_N-GLC_1 245 250 PF02516 0.478
MOD_NEK2_1 115 120 PF00069 0.572
MOD_NEK2_1 145 150 PF00069 0.422
MOD_NEK2_1 165 170 PF00069 0.576
MOD_NEK2_1 189 194 PF00069 0.462
MOD_NEK2_1 31 36 PF00069 0.532
MOD_NEK2_1 44 49 PF00069 0.537
MOD_NEK2_1 93 98 PF00069 0.510
MOD_NEK2_2 349 354 PF00069 0.645
MOD_PIKK_1 344 350 PF00454 0.587
MOD_PIKK_1 49 55 PF00454 0.383
MOD_PKA_2 140 146 PF00069 0.565
MOD_PKA_2 194 200 PF00069 0.622
MOD_PKA_2 282 288 PF00069 0.499
MOD_PKA_2 58 64 PF00069 0.437
MOD_Plk_1 141 147 PF00069 0.464
MOD_Plk_1 183 189 PF00069 0.532
MOD_Plk_1 245 251 PF00069 0.455
MOD_Plk_1 323 329 PF00069 0.490
MOD_Plk_2-3 126 132 PF00069 0.656
MOD_Plk_4 141 147 PF00069 0.432
MOD_Plk_4 183 189 PF00069 0.572
MOD_Plk_4 245 251 PF00069 0.467
MOD_Plk_4 349 355 PF00069 0.631
MOD_Plk_4 35 41 PF00069 0.562
MOD_Plk_4 80 86 PF00069 0.531
MOD_ProDKin_1 14 20 PF00069 0.496
MOD_ProDKin_1 21 27 PF00069 0.421
MOD_ProDKin_1 220 226 PF00069 0.679
MOD_ProDKin_1 230 236 PF00069 0.309
MOD_ProDKin_1 325 331 PF00069 0.445
MOD_ProDKin_1 407 413 PF00069 0.540
MOD_SUMO_rev_2 352 359 PF00179 0.531
TRG_DiLeu_BaEn_1 161 166 PF01217 0.576
TRG_DiLeu_BaLyEn_6 15 20 PF01217 0.492
TRG_ENDOCYTIC_2 119 122 PF00928 0.567
TRG_ENDOCYTIC_2 256 259 PF00928 0.469
TRG_ENDOCYTIC_2 290 293 PF00928 0.434
TRG_ENDOCYTIC_2 394 397 PF00928 0.606
TRG_ER_diArg_1 268 271 PF00400 0.619
TRG_ER_diArg_1 4 7 PF00400 0.523
TRG_Pf-PMV_PEXEL_1 271 275 PF00026 0.590

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P675 Leptomonas seymouri 83% 100%
A0A0S4JEJ1 Bodo saltans 48% 100%
A0A1X0P3N7 Trypanosomatidae 54% 100%
A0A3S7XBB2 Leishmania donovani 99% 100%
A0A422NKQ7 Trypanosoma rangeli 54% 100%
A1CJY4 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 33% 100%
A1D7I5 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 33% 100%
A2QEV8 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 31% 100%
A3LX18 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 32% 100%
A4HPQ5 Leishmania braziliensis 97% 100%
A4ID08 Leishmania infantum 100% 100%
A4RDD7 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 32% 100%
A5DGL8 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 32% 100%
A5DVY3 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) 31% 100%
A6RUL1 Botryotinia fuckeliana (strain B05.10) 31% 100%
A6ZMK5 Saccharomyces cerevisiae (strain YJM789) 28% 100%
A7EF03 Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) 31% 100%
A7RM20 Nematostella vectensis 31% 100%
A7TH19 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) 26% 100%
A8QBF3 Brugia malayi 29% 100%
A8WVX8 Caenorhabditis briggsae 31% 100%
B0BNA7 Rattus norvegicus 30% 100%
B0XFT7 Culex quinquefasciatus 32% 100%
B0XYC8 Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) 33% 100%
B3MVL6 Drosophila ananassae 32% 100%
B3N4C7 Drosophila erecta 32% 100%
B4GSH1 Drosophila persimilis 32% 100%
B4I195 Drosophila sechellia 32% 100%
B4JB43 Drosophila grimshawi 31% 100%
B4KGX9 Drosophila mojavensis 31% 100%
B4LUA5 Drosophila virilis 32% 100%
B4N0L0 Drosophila willistoni 34% 100%
B4NW98 Drosophila yakuba 32% 100%
B4Q354 Drosophila simulans 32% 100%
B5FZ19 Taeniopygia guttata 30% 100%
D0A8F9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
E3LB80 Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL) 26% 100%
E9ATH0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
O02195 Drosophila melanogaster 32% 100%
P0CS32 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 31% 100%
P0CS33 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 31% 100%
P40217 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 100%
P79083 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 32% 100%
Q0CXH9 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 33% 100%
Q0V320 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) 30% 100%
Q13347 Homo sapiens 30% 100%
Q16K15 Aedes aegypti 31% 100%
Q1DPU4 Coccidioides immitis (strain RS) 31% 100%
Q1HPW4 Bombyx mori 31% 100%
Q29L19 Drosophila pseudoobscura pseudoobscura 32% 100%
Q2GTM8 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 32% 100%
Q2UQ34 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 33% 100%
Q38884 Arabidopsis thaliana 34% 100%
Q4P6E2 Ustilago maydis (strain 521 / FGSC 9021) 32% 100%
Q4WX90 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 33% 100%
Q54MT0 Dictyostelium discoideum 34% 100%
Q5AI86 Candida albicans (strain SC5314 / ATCC MYA-2876) 32% 100%
Q5B8Y3 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 32% 100%
Q5E966 Bos taurus 30% 100%
Q5EBE8 Xenopus tropicalis 31% 100%
Q5IH81 Oryctolagus cuniculus 29% 100%
Q5R7R2 Pongo abelii 30% 100%
Q66J51 Xenopus laevis 31% 100%
Q6BSL7 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 32% 100%
Q6CI08 Yarrowia lipolytica (strain CLIB 122 / E 150) 31% 100%
Q6CKX3 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 29% 100%
Q6FL15 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 28% 100%
Q759L2 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 28% 100%
Q7PP77 Anopheles gambiae 31% 100%
Q7RXH4 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 31% 100%
Q7ZV55 Danio rerio 31% 100%
Q7ZVF0 Danio rerio 23% 100%
Q965S8 Caenorhabditis elegans 31% 100%
Q9QZD9 Mus musculus 30% 100%
V5BE86 Trypanosoma cruzi 54% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS